| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Kakiuchi, H Tsukada, D Fukumoto, S Nishiyam. Effects of aging on serotonin transporter availability and its response to fluvoxamine in the living brain: PET study with [(11)C](+)McN5652 and [(11)C](-)McN5652 in conscious monkeys. Synapse (New York, N.Y.). vol 40. issue 3. 2005-05-09. PMID:11304754. |
higher specific binding of sert was observed in the thalamus and striatum, regions known to contain high densities of sert by in vitro assay, with intermediate levels in the pons, hippocampus, cingulate gyrus, and cortical regions and lower levels in the cerebellum in both young and aged monkeys. |
2005-05-09 |
2023-08-12 |
monkey |
| Brian J Piper, Jerrold S Meye. Memory deficit and reduced anxiety in young adult rats given repeated intermittent MDMA treatment during the periadolescent period. Pharmacology, biochemistry, and behavior. vol 79. issue 4. 2005-04-29. PMID:15582680. |
brain tissues were collected at pd 70 for determination of radiolabeled paroxetine binding to the serotonin transporter (sert) in the neocortex and hippocampus. |
2005-04-29 |
2023-08-12 |
human |
| Brian J Piper, Jerrold S Meye. Memory deficit and reduced anxiety in young adult rats given repeated intermittent MDMA treatment during the periadolescent period. Pharmacology, biochemistry, and behavior. vol 79. issue 4. 2005-04-29. PMID:15582680. |
only modest decreases in sert binding were observed, although there was a significant negative correlation between hippocampal sert levels and open-arm duration within the mdma group. |
2005-04-29 |
2023-08-12 |
human |
| Matthew E Szapacs, Tiffany A Mathews, Lino Tessarollo, W Ernest Lyons, Laura A Mamounas, Anne M Andrew. Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589338. |
by contrast, 4-month-old male and female mice with partial (sert(+/-)) or complete (sert(-/-)) reductions in sert expression showed no differences in bdnf protein levels compared to sert(+/+) mice, although male sert knockout mice of all genotypes had higher bdnf levels in hippocampus, frontal cortex, and brain stem than female animals. |
2005-04-12 |
2023-08-12 |
mouse |
| Yiyun Huang, Raj Narendran, Sung-A Bae, David Erritzoe, Ningning Guo, Zhihong Zhu, Dah-Ren Hwang, Marc Laruell. A PET imaging agent with fast kinetics: synthesis and in vivo evaluation of the serotonin transporter ligand [11C]2-[2-dimethylaminomethylphenylthio)]-5-fluorophenylamine ([11C]AFA). Nuclear medicine and biology. vol 31. issue 6. 2005-02-25. PMID:15246363. |
imaging experiments in baboons demonstrated that the uptake pattern of [11c]afa in the baboon brain is consistent with the known distribution of sert, with highest activity levels in the midbrain and thalamus, followed by striatum, hippocampus, and cortical regions. |
2005-02-25 |
2023-08-12 |
rat |
| Ping Fang, Grace G Shiue, Tomokazu Shimazu, Joel H Greenberg, Chyng-Yann Shiu. Synthesis and evaluation of N,N-dimethyl-2-(2-amino-5-[18F]fluorophenylthio)benzylamine (5-[18F]-ADAM) as a serotonin transporter imaging agent. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. vol 61. issue 6. 2004-12-22. PMID:15388117. |
blocking experiments showed that there were significant decreases in the uptake of 5-[18f]-adam in the brain regions (hypothalamus, hippocampus and striatum) where sert concentrations are high when rats were pretreated with (+)mcn 5652 (2 mg/kg, 5 min prior to iv injection of 5-[18f]-adam). |
2004-12-22 |
2023-08-12 |
rat |
| Yiyun Huang, Dah-Ren Hwang, Sung-A Bae, Yasuhiko Sudo, Ningning Guo, Zhihong Zhu, Raj Narendran, Marc Laruell. A new positron emission tomography imaging agent for the serotonin transporter: synthesis, pharmacological characterization, and kinetic analysis of [11C]2-[2-(dimethylaminomethyl)phenylthio]-5-fluoromethylphenylamine ([11C]AFM). Nuclear medicine and biology. vol 31. issue 5. 2004-12-14. PMID:15219271. |
pet imaging experiments in baboons showed a brain distribution pattern of [(11)c]afm consistent with the regional concentrations of sert, with the highest levels of radioactivity detected in the midbrain and thalamus, moderate levels in the hippocampus and striatum, and the low levels in the cortical regions. |
2004-12-14 |
2023-08-12 |
human |
| Adam L Numis, Erica L Unger, Douglas L Sheridan, Angela C Chisnell, Anne M Andrew. The role of membrane and vesicular monoamine transporters in the neurotoxic and hypothermic effects of 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH(2)-MPTP). Molecular pharmacology. vol 66. issue 3. 2004-11-03. PMID:15322265. |
in addition, complete loss of sert attenuated cortical and hippocampal depletions in 5-ht but not ne. |
2004-11-03 |
2023-08-12 |
mouse |
| Tammy L Awtry, Linda L Werlin. Acute and chronic effects of nicotine on serotonin uptake in prefrontal cortex and hippocampus of rats. Synapse (New York, N.Y.). vol 50. issue 3. 2004-01-06. PMID:14515338. |
sert binding studies, using prefrontocortical or hippocampal membrane preparations, revealed that chronic nicotine exposure significantly increased b(max) which correlated to an increase in sert density. |
2004-01-06 |
2023-08-12 |
rat |
| Iain S McGregor, Kelly J Clemens, Geoffrey Van der Plasse, Kong M Li, Glenn E Hunt, Feng Chen, Andrew J Lawrenc. Increased anxiety 3 months after brief exposure to MDMA ("Ecstasy") in rats: association with altered 5-HT transporter and receptor density. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 8. 2003-09-12. PMID:12700695. |
quantitative autoradiography showed loss of sert binding in cortical, hippocampal, thalamic, and hypothalamic sites with the high-dose mdma regime, while low-dose mdma only produced significant loss in the medial hypothalamus. |
2003-09-12 |
2023-08-12 |
rat |
| Yiyun Huang, Dah-Ren Hwang, Zhihong Zhu, Sung-A Bae, Ningning Guo, Yasuhiko Sudo, Lawrence S Kegeles, Marc Laruell. Synthesis and pharmacological characterization of a new PET ligand for the serotonin transporter: [11C]5-bromo-2-[2-(dimethylaminomethylphenylsulfanyl)]phenylamine ([11C]DAPA). Nuclear medicine and biology. vol 29. issue 7. 2003-05-19. PMID:12381454. |
imaging experiments in baboons indicated that [11c]dapa binding is consistent with the known distribution of sert in the baboon brain, with highest levels of radioactivity detected in the midbrain and thalamus, intermediate levels in the hippocampus and striatum, and lower levels in the cortical regions. |
2003-05-19 |
2023-08-12 |
rat |
| Sylvia Montañez, Lynette C Daws, Georgianna G Gould, Greg A Gerhardt, Alan Fraze. Differential in vivo clearance of serotonin in rat dorsal raphe nucleus and CA3 region. Brain research. vol 955. issue 1-2. 2003-01-31. PMID:12419542. |
this was achieved by comparing the clearance of exogenously applied serotonin (5-ht) from the extracellular fluid (ecf) of the drn to that in the ca3 region of the hippocampus, an area with lower sert density. |
2003-01-31 |
2023-08-12 |
rat |
| Saloua Benmansour, William A Owens, Marco Cecchi, David A Morilak, Alan Fraze. Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 15. 2002-09-03. PMID:12151556. |
to determine if there was a temporal correlation between the time when sertraline induced downregulation of the sert and when marked alteration in sert function occurred, clearance of locally applied 5-ht into the ca3 region of hippocampus was achieved using in vivo electrochemistry. |
2002-09-03 |
2023-08-12 |
rat |
| Jerrold S Meyer, Syed F Al. Serotonergic neurotoxicity of MDMA (ecstasy) in the developing rat brain. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105113. |
pups subsequently remained undisturbed until sacrifice at pd 25 and pd 60 for assessment of serotonergic damage by measuring 5-ht transporter (sert) binding in the hippocampus and neocortex as well as 5-ht and 5-hiaa concentrations (pd 25 only). |
2002-08-02 |
2023-08-12 |
rat |
| Jerrold S Meyer, Syed F Al. Serotonergic neurotoxicity of MDMA (ecstasy) in the developing rat brain. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105113. |
neonatal mdma exposure led to significant reductions in both sert binding and 5-ht levels in the hippocampus at pd 25, independent of body temperature during treatment. |
2002-08-02 |
2023-08-12 |
rat |
| Jerrold S Meyer, Syed F Al. Serotonergic neurotoxicity of MDMA (ecstasy) in the developing rat brain. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105113. |
hippocampal sert binding increased between pd 25 and pd 60 in both the mdma and saline groups, but the mdma-related deficit remained unchanged. |
2002-08-02 |
2023-08-12 |
rat |
| R Weitzdoerfer, N Gerstl, H Hoeger, W Mosgoeller, W Dreher, E Engidawork, J Overgaard-Larsen, B Lube. Long-term sequelae of perinatal asphyxia in the aging rat. Cellular and molecular life sciences : CMLS. vol 59. issue 3. 2002-05-16. PMID:11964129. |
increased serotonin transporter (sert) immunoreactivity in the ca2 region of the hippocampus and a significant difference in the escape latency, when the platform of the mwm was moved to a new location, were observed in asphyxiated rats. |
2002-05-16 |
2023-08-12 |
human |
| R Weitzdoerfer, N Gerstl, H Hoeger, W Mosgoeller, W Dreher, E Engidawork, J Overgaard-Larsen, B Lube. Long-term sequelae of perinatal asphyxia in the aging rat. Cellular and molecular life sciences : CMLS. vol 59. issue 3. 2002-05-16. PMID:11964129. |
we showed that deteriorated cognitive functions accompanied by aberrant expression of hippocampal sert and impaired relearning are long-term sequelae of perinatal asphyxia, a finding that may form the basis for understanding cns pathology in the aging subject, animal or human. |
2002-05-16 |
2023-08-12 |
human |
| S R Choi, C Hou, S Oya, M Mu, M P Kung, M Siciliano, P D Acton, H F Kun. Selective in vitro and in vivo binding of [(125)I]ADAM to serotonin transporters in rat brain. Synapse (New York, N.Y.). vol 38. issue 4. 2000-12-14. PMID:11044887. |
biodistribution of [(125)i]adam in rat brain after an iv injection showed a high specific binding in the regions of hypothalamus, cortex, striatum, and hippocampus, where sert are concentrated and the specific binding peaked at 120-240 min postinjection [(hypothalamus-cerebellum)/cerebellum = 4.3 at 120 min post-iv injection]. |
2000-12-14 |
2023-08-12 |
rat |
| H M Haughey, A E Fleckenstein, R R Metzger, G R Hanso. The effects of methamphetamine on serotonin transporter activity: role of dopamine and hyperthermia. Journal of neurochemistry. vol 75. issue 4. 2000-10-05. PMID:10987842. |
multiple administrations of methamphetamine (meth) rapidly decreased serotonin (5ht) transporter (sert) function in rat striatum and hippocampus. |
2000-10-05 |
2023-08-12 |
rat |