| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Santhi D Konduri, Rajesh Medisetty, Wensheng Liu, Benny Abraham Kaipparettu, Pratima Srivastava, Hiltrud Brauch, Peter Fritz, Wendy M Swetzig, Amanda E Gardner, Sohaib A Khan, Gokul M Da. Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 34. 2010-09-23. PMID:20696891. |
estrogen receptor alpha (eralpha) plays an important role in the onset and progression of breast cancer, whereas p53 functions as a major tumor suppressor. |
2010-09-23 |
2023-08-12 |
human |
| Ralf Janknech. Multi-talented DEAD-box proteins and potential tumor promoters: p68 RNA helicase (DDX5) and its paralog, p72 RNA helicase (DDX17). American journal of translational research. vol 2. issue 3. 2010-08-12. PMID:20589163. |
this is especially common to their role in gene regulation, where p68/p72 coactivate various transcription factors, including the tumor suppressor p53, estrogen receptor alpha and beta-catenin. |
2010-08-12 |
2023-08-12 |
mouse |
| Xiu-feng Liu, Rui-hua Shi, Guo-xin Zhang, Hong Zhu, Heng-jun Gao, Shu-kui Qi. [A study on the expression and correlation of HIF-1 alpha and p53 with clinical pathological characteristics of HCC using tissue microarray technique]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. vol 16. issue 7. 2010-08-05. PMID:18647535. |
[a study on the expression and correlation of hif-1 alpha and p53 with clinical pathological characteristics of hcc using tissue microarray technique]. |
2010-08-05 |
2023-08-12 |
Not clear |
| Ke-Da Yu, Gen-Hong Di, Wen-Feng Li, Nan-Yan Rao, Lei Fan, Wen-Tao Yuan, Zhen Hu, Jiong Wu, Zhen-Zhou Shen, Wei Huang, Zhi-Ming Sha. Genetic contribution of GADD45A to susceptibility to sporadic and non-BRCA1/2 familial breast cancers: a systematic evaluation in Chinese populations. Breast cancer research and treatment. vol 121. issue 1. 2010-07-13. PMID:19728081. |
growth arrest and dna damage-induced 45, alpha (gadd45a) is a candidate breast cancer susceptibility gene because its product participates in dna repair and it is a downstream gene of p53 and brca1, both of which are breast cancer susceptibility genes. |
2010-07-13 |
2023-08-12 |
Not clear |
| Xu Zhu, Wei Zhou, Yongyao Cui, Liang Zhu, Juan Li, Xuemei Feng, Biyun Shao, Hong Qi, Jun Zheng, Hao Wang, Hongzhuan Che. Pilocarpine protects cobalt chloride-induced apoptosis of RGC-5 cells: involvement of muscarinic receptors and HIF-1 alpha pathway. Cellular and molecular neurobiology. vol 30. issue 3. 2010-07-01. PMID:19816768. |
expressions of hypoxia-induced factor-1 alpha (hif-1 alpha), p53, and bnip3 were investigated by quantitative real-time pcr and western blot analysis. |
2010-07-01 |
2023-08-12 |
human |
| Xu Zhu, Wei Zhou, Yongyao Cui, Liang Zhu, Juan Li, Xuemei Feng, Biyun Shao, Hong Qi, Jun Zheng, Hao Wang, Hongzhuan Che. Pilocarpine protects cobalt chloride-induced apoptosis of RGC-5 cells: involvement of muscarinic receptors and HIF-1 alpha pathway. Cellular and molecular neurobiology. vol 30. issue 3. 2010-07-01. PMID:19816768. |
meanwhile, pretreatment of 1 microm pilocarpine could significantly prevent cocl(2)-induced hif-1 alpha translocation from cytoplasm to nucleus and down-regulate the expression of hif-1 alpha, p53, and bnip3. |
2010-07-01 |
2023-08-12 |
human |
| Edgar S Díaz-Cruz, Priscilla A Furt. Deregulated estrogen receptor alpha and p53 heterozygosity collaborate in the development of mammary hyperplasia. Cancer research. vol 70. issue 10. 2010-06-21. PMID:20466998. |
deregulated estrogen receptor alpha and p53 heterozygosity collaborate in the development of mammary hyperplasia. |
2010-06-21 |
2023-08-12 |
mouse |
| Edgar S Díaz-Cruz, Priscilla A Furt. Deregulated estrogen receptor alpha and p53 heterozygosity collaborate in the development of mammary hyperplasia. Cancer research. vol 70. issue 10. 2010-06-21. PMID:20466998. |
both increased estrogen receptor alpha (er(alpha)) expression and germline disruption of one p53 allele increase breast cancer risk in women. |
2010-06-21 |
2023-08-12 |
mouse |
| Edgar S Díaz-Cruz, Priscilla A Furt. Deregulated estrogen receptor alpha and p53 heterozygosity collaborate in the development of mammary hyperplasia. Cancer research. vol 70. issue 10. 2010-06-21. PMID:20466998. |
genetically engineered mouse models of deregulated er(alpha) expression and p53 haploinsufficiency were used to investigate similarities and differences of each genetic lesion alone and in combination on mammary preneoplasia development. |
2010-06-21 |
2023-08-12 |
mouse |
| Edgar S Díaz-Cruz, Priscilla A Furt. Deregulated estrogen receptor alpha and p53 heterozygosity collaborate in the development of mammary hyperplasia. Cancer research. vol 70. issue 10. 2010-06-21. PMID:20466998. |
each genetic lesion independently and in combination led to development of age-dependent preneoplasia, but the highest prevalence was found in compound mice with increased er(alpha) expression coupled with p53 heterozygosity. |
2010-06-21 |
2023-08-12 |
mouse |
| Edgar S Díaz-Cruz, Priscilla A Furt. Deregulated estrogen receptor alpha and p53 heterozygosity collaborate in the development of mammary hyperplasia. Cancer research. vol 70. issue 10. 2010-06-21. PMID:20466998. |
the highest levels of cell proliferation were found in compound mice, but increased levels were also found with either increased er(alpha) expression or p53 heterozygosity. |
2010-06-21 |
2023-08-12 |
mouse |
| Edgar S Díaz-Cruz, Priscilla A Furt. Deregulated estrogen receptor alpha and p53 heterozygosity collaborate in the development of mammary hyperplasia. Cancer research. vol 70. issue 10. 2010-06-21. PMID:20466998. |
parity protection was limited to p53 heterozygous mice and not found in mice with increased er(alpha) alone. |
2010-06-21 |
2023-08-12 |
mouse |
| Edgar S Díaz-Cruz, Priscilla A Furt. Deregulated estrogen receptor alpha and p53 heterozygosity collaborate in the development of mammary hyperplasia. Cancer research. vol 70. issue 10. 2010-06-21. PMID:20466998. |
in summary, increased and deregulated er(alpha) collaborates with p53 heterozygosity in increasing the risk of mammary preneoplasia development. |
2010-06-21 |
2023-08-12 |
mouse |
| Weizhong Li, Gefei Wang, Heng Zhang, Gang Xin, Dangui Zhang, Jun Zeng, Xiaoxuan Chen, Yanxuan Xu, Youhong Cui, Kangsheng L. Effects of NS1 variants of H5N1 influenza virus on interferon induction, TNFalpha response and p53 activity. Cellular & molecular immunology. vol 7. issue 3. 2010-06-10. PMID:20228833. |
we examined the effects of these mutations on interferon (ifn) induction, tumor-necrosis factor (tnf)alpha response, p53 activity and apoptosis. |
2010-06-10 |
2023-08-12 |
Not clear |
| Samantha M Nicol, Frances V Fuller-Pac. Analysis of the RNA helicase p68 (Ddx5) as a transcriptional regulator. Methods in molecular biology (Clifton, N.J.). vol 587. 2010-05-31. PMID:20225156. |
estrogen receptor alpha and the tumour suppressor p53) and to be recruited to promoters of genes that are responsive to activation of these transcription factors, suggesting that it may play a role in transcription initiation. |
2010-05-31 |
2023-08-12 |
Not clear |
| Doris M Benbrook, Stan Lightfoot, James Ranger-Moore, Tongzu Liu, Shylet Chengedza, William L Berry, Igor Dozmoro. Gene expression analysis of biological systems driving an organotypic model of endometrial carcinogenesis and chemoprevention. Gene regulation and systems biology. vol 2. 2010-05-20. PMID:19784388. |
cluster analysis of functional associations of hypervariable genes demonstrated that carcinogenesis is accompanied by a stimulating association between a module of genes that includes tumor necrosis factor alpha (tnfalpha), c-myc, and epidermal growth factor-receptor (egf-r) and a module that includes insulin-like growth factor i-receptor (igf-ir), p53, and jun genes. |
2010-05-20 |
2023-08-12 |
Not clear |
| Danielle M Pastor, Rosalyn B Irby, Lisa S Porit. Tumor necrosis factor alpha induces p53 up-regulated modulator of apoptosis expression in colorectal cancer cell lines. Diseases of the colon and rectum. vol 53. issue 3. 2010-03-23. PMID:20173470. |
tumor necrosis factor alpha induces p53 up-regulated modulator of apoptosis expression in colorectal cancer cell lines. |
2010-03-23 |
2023-08-12 |
Not clear |
| Danielle M Pastor, Rosalyn B Irby, Lisa S Porit. Tumor necrosis factor alpha induces p53 up-regulated modulator of apoptosis expression in colorectal cancer cell lines. Diseases of the colon and rectum. vol 53. issue 3. 2010-03-23. PMID:20173470. |
the purpose of the current study was to evaluate the effects of tumor necrosis factor alpha (tnf-alpha) on p53 and p53 up-regulated modulator of apoptosis (puma), a downstream effector of p53 in the apoptotic pathway in colorectal cancer cells. |
2010-03-23 |
2023-08-12 |
Not clear |
| Federica Saletta, Yohan Suryo Rahmanto, Egarit Noulsri, Des R Richardso. Iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53. Molecular pharmacology. vol 77. issue 3. 2010-03-19. PMID:20023006. |
iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53. |
2010-03-19 |
2023-08-12 |
Not clear |
| Gou Watanabe, Shunsuke Kato, Hideyuki Nakata, Takanori Ishida, Noriaki Ohuchi, Chikashi Ishiok. alphaB-crystallin: a novel p53-target gene required for p53-dependent apoptosis. Cancer science. vol 100. issue 12. 2010-03-18. PMID:19799611. |
here, we report on crystallin alpha b gene (cryab), which encodes alphab-crystallin, and is one of the genes directly trans-activated by p53. |
2010-03-18 |
2023-08-12 |
Not clear |