| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Eizenberg, M Ore. Reduced levels of alpha 1 (I) collagen mRNA in cells immortalized by mutant p53 or transformed by ras. Biochimica et biophysica acta. vol 1129. issue 1. 1992-02-05. PMID:1756178. |
this may reflect a co-selection during the establishment of the cell lines, rather than a direct effect of p53 on alpha 1 (i) collagen gene expression. |
1992-02-05 |
2023-08-11 |
Not clear |
| J V Gannon, D P Lan. Interactions between SV40 T antigen and DNA polymerase alpha. The New biologist. vol 2. issue 1. 1991-05-01. PMID:1964085. |
the interaction between sv40 large t antigen (tag) and dna polymerase alpha has been shown previously to be inhibited by murine p53, the nuclear protein product of a cellular anti-oncogene. |
1991-05-01 |
2023-08-11 |
Not clear |
| J V Gannon, D P Lan. Interactions between SV40 T antigen and DNA polymerase alpha. The New biologist. vol 2. issue 1. 1991-05-01. PMID:1964085. |
using monoclonal antibodies to tag, p53, and polymerase alpha, we developed immunoassays to measure the complexes formed between tag and polymerase alpha and between tag and p53. |
1991-05-01 |
2023-08-11 |
Not clear |
| J V Gannon, D P Lan. Interactions between SV40 T antigen and DNA polymerase alpha. The New biologist. vol 2. issue 1. 1991-05-01. PMID:1964085. |
finally, we found that the tsa58 and 5080 point mutations in tag, previously shown to inhibit the binding of tag to p53, also inhibit its binding to polymerase alpha. |
1991-05-01 |
2023-08-11 |
Not clear |
| H Tsuchiy. [Application of flow cytometry to the study of hematologic disorders: analysis of oncogene products]. [Rinsho ketsueki] The Japanese journal of clinical hematology. vol 31. issue 6. 1990-11-13. PMID:2145449. |
the examples of oncogene products analyzed by fcm are ras, myc, p53, myb and fos; those of cell-proliferation-related proteins are ki-67, pcna and dna polymerase alpha. |
1990-11-13 |
2023-08-11 |
human |
| K Fuchs, D Adamiker, W Sieghar. Identification of alpha 2- and alpha 3-subunits of the GABAA-benzodiazepine receptor complex purified from the brains of young rats. FEBS letters. vol 261. issue 1. 1990-04-06. PMID:2155135. |
anti-peptide alpha 2(416-424) and anti-peptide alpha 3(459-467) antibodies immunoprecipitated gabaa receptors and recognized a protein of 53 kda (p53) and 59 kda (p59), respectively, in western blots of gabaa receptors purified from the brains of 5-10 day old rats. |
1990-04-06 |
2023-08-11 |
rat |
| S E Mole, J V Gannon, I A Anton, M J Ford, D P Lan. Host proteins that bind to or mimic SV40 large T antigen: using antibodies to look at protein interactions and their significance. Immunology. Supplement. vol 2. 1989-12-06. PMID:2478459. |
we have also studied the binding and interaction of large t with two particular host components: the replicative enzyme dna polymerase alpha and the proto-oncogene p53. |
1989-12-06 |
2023-08-11 |
Not clear |
| S E Mole, J V Gannon, I A Anton, M J Ford, D P Lan. Host proteins that bind to or mimic SV40 large T antigen: using antibodies to look at protein interactions and their significance. Immunology. Supplement. vol 2. 1989-12-06. PMID:2478459. |
we found that p53 can block the binding of dna polymerase alpha to t as well as co-existing with dna polymerase alpha in a trimeric complex with t. this suggests that these interactions may be important in the oncogenic and replicative action of large t. |
1989-12-06 |
2023-08-11 |
Not clear |
| A W Braithwaite, H W Sturzbecher, C Addison, C Palmer, K Rudge, J R Jenkin. Mouse p53 inhibits SV40 origin-dependent DNA replication. Nature. vol 329. issue 6138. 1987-11-03. PMID:2821401. |
in an accompanying paper gannon and lane report that in in vitro plate-binding assays, mouse p53 can displace polymerase alpha from complex with t-antigen. |
1987-11-03 |
2023-08-11 |
mouse |
| J V Gannon, D P Lan. p53 and DNA polymerase alpha compete for binding to SV40 T antigen. Nature. vol 329. issue 6138. 1987-11-03. PMID:3309672. |
p53 and dna polymerase alpha compete for binding to sv40 t antigen. |
1987-11-03 |
2023-08-11 |
Not clear |
| J V Gannon, D P Lan. p53 and DNA polymerase alpha compete for binding to SV40 T antigen. Nature. vol 329. issue 6138. 1987-11-03. PMID:3309672. |
we now extend this analysis to a larger collection of anti-t antibodies and formally establish that p53 and dna polymerase alpha can compete for binding to the sv40 t antigen. |
1987-11-03 |
2023-08-11 |
Not clear |
| J V Gannon, D P Lan. p53 and DNA polymerase alpha compete for binding to SV40 T antigen. Nature. vol 329. issue 6138. 1987-11-03. PMID:3309672. |
at a critical concentration of the three components it is possible to detect a trimeric complex of t, p53 and dna polymerase alpha. |
1987-11-03 |
2023-08-11 |
Not clear |
| H Hagiwara, H J Huang, N Arai, L A Herzenberg, K Arai, A Zlotni. Interleukin 1 modulates messenger RNA levels of lymphokines and of other molecules associated with T cell activation in the T cell lymphoma LBRM33-1A5. Journal of immunology (Baltimore, Md. : 1950). vol 138. issue 8. 1987-05-06. PMID:3494073. |
using cloned genes for il 2, il 3, tgf-beta, ty5, il 2 receptor, ly-1, c-myc, and p53 as probes in the s1 nuclease protection assay, we compared the amount of specific transcripts among total rna prepared from unstimulated cells, il 1 alpha or pha-stimulated cells, and pha plus il 1 alpha-stimulated cells. |
1987-05-06 |
2023-08-11 |
Not clear |