| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Q Wang, G P Zambetti, D P Suttl. Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor. Molecular and cellular biology. vol 17. issue 1. 1997-01-22. PMID:8972219. |
transcription from the full-length (bp -557 to +90) topo ii alpha promoter was decreased 15-fold by wt p53 in a concentration-dependent manner, whereas mutant p53 exerted much weaker inhibition. |
1997-01-22 |
2023-08-12 |
human |
| Q Wang, G P Zambetti, D P Suttl. Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor. Molecular and cellular biology. vol 17. issue 1. 1997-01-22. PMID:8972219. |
when point mutations were introduced into the most proximal ice (-68), the inhibitory effect of wt p53 was alleviated and stimulation of topo ii alpha expression resulted. |
1997-01-22 |
2023-08-12 |
human |
| Q Wang, G P Zambetti, D P Suttl. Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor. Molecular and cellular biology. vol 17. issue 1. 1997-01-22. PMID:8972219. |
our study suggests that wt p53 functions as a transcriptional repressor of topo ii alpha gene expression, possibly through a functional interaction with specific ices. |
1997-01-22 |
2023-08-12 |
human |
| Q Wang, G P Zambetti, D P Suttl. Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor. Molecular and cellular biology. vol 17. issue 1. 1997-01-22. PMID:8972219. |
inactivation of wt p53 may reduce normal regulatory suppression of topo ii alpha and contribute to abortive cell cycle checkpoints, accelerated cell proliferation, and alterations in genomic stability associated with neoplasia. |
1997-01-22 |
2023-08-12 |
human |
| S Kato, T Morita, T Hori, M Kato, A Hirano, F Herz, E Oham. Brain tumor: immunohistochemical studies on the stress-response proteins, p53 protein and proliferating cell nuclear antigen. Noshuyo byori = Brain tumor pathology. vol 12. issue 2. 1997-01-03. PMID:8867693. |
this retrospective immunohistochemical study compares the expression of five stress-response (heat-shock) proteins (srp's) [srp 90, srp 72, srp 27, alpha b-crystallin and ubiquitin], p53 protein and proliferating cell nuclear antigen (pcna) in 118 primary brain tumors and 21 carcinoma metastases to the central nervous system. |
1997-01-03 |
2023-08-12 |
Not clear |
| S Gorina, N P Pavletic. Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. Science (New York, N.Y.). vol 274. issue 5289. 1996-12-06. PMID:8875926. |
the crystal structure of the p53 core domain bound to the 53bp2 protein, which contains an sh3 (src homology 3) domain and four ankyrin repeats, revealed that (i) the sh3 domain binds the l3 loop of p53 in a manner distinct from that of previously characterized sh3-polyproline peptide complexes, and (ii) an ankyrin repeat, which forms an l-shaped structure consisting of a beta hairpin and two alpha helices, binds the l2 loop of p53. |
1996-12-06 |
2023-08-12 |
human |
| P H Kussie, S Gorina, V Marechal, B Elenbaas, J Moreau, A J Levine, N P Pavletic. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science (New York, N.Y.). vol 274. issue 5289. 1996-12-06. PMID:8875929. |
the crystal structure of the 109-residue amino-terminal domain of mdm2 bound to a 15-residue transactivation domain peptide of p53 revealed that mdm2 has a deep hydrophobic cleft on which the p53 peptide binds as an amphipathic alpha helix. |
1996-12-06 |
2023-08-12 |
Not clear |
| P H Kussie, S Gorina, V Marechal, B Elenbaas, J Moreau, A J Levine, N P Pavletic. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science (New York, N.Y.). vol 274. issue 5289. 1996-12-06. PMID:8875929. |
the interface relies on the steric complementarity between the mdm2 cleft and the hydrophobic face of the p53 alpha helix and, in particular, on a triad of p53 amino acids-phe19, trp23, and leu26-which insert deep into the mdm2 cleft. |
1996-12-06 |
2023-08-12 |
Not clear |
| D A Greenhalgh, X J Wang, L A Donehower, D R Roo. Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasHa, v-fos, or human transforming growth factor alpha. Cancer research. vol 56. issue 19. 1996-11-21. PMID:8813135. |
paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasha, v-fos, or human transforming growth factor alpha. |
1996-11-21 |
2023-08-12 |
mouse |
| T Mahdi, J Tanzer, A Brizard, F Guilhot, P Babin, A Kitzi. Cell-mediated cytotoxicity can be regulated by p53 tumor suppressor gene activity in vitro. Biology of the cell. vol 84. issue 3. 1996-10-16. PMID:8720438. |
this stimulation significantly increased the percentage of cells expressing p53, which was at its maximum when induced by il-2 combined with ifn alpha 2b. |
1996-10-16 |
2023-08-12 |
human |
| T Jussila, M Mäkinen, F Stenbäc. Oncogenes and growth factors as indicators of carcinogen exposure. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 48. issue 2-3. 1996-08-15. PMID:8672868. |
the expression of growth factors (transforming growth factor alpha and epidermal growth factor), growth factor receptors (epidermal growth factor receptor/c-erbb-1 and c-erbb-2/neu), cell signalling component c-myc, the nuclear transcription factor harvey-ras and the tumor suppressor gene p53, were studied in carcinogen- and uv-induced tumor formation in mouse. |
1996-08-15 |
2023-08-12 |
mouse |
| K Jaskiewicz, L Banach, E Izyck. Hepatocellular carcinoma in young patients: histology, cellular differentiation, HBV infection and oncoprotein p53. Anticancer research. vol 15. issue 6B. 1996-08-07. PMID:8669853. |
the study of 226 cases of hepatocellular carcinoma (hcc) in a homogenous rural southern african population is based on the assessment of histology, hbv infection, p53 oncoprotein and transforming growth factor alpha (tgfa) expression. |
1996-08-07 |
2023-08-12 |
Not clear |
| M Aguilar-Santelises, M E Rottenberg, N Lewin, H Mellstedt, M Jonda. Bcl-2, Bax and p53 expression in B-CLL in relation to in vitro survival and clinical progression. International journal of cancer. vol 69. issue 2. 1996-05-29. PMID:8608978. |
we have now analyzed the in vitro survival of b-cll cells in relation to bcl-2, bax alpha and p53 expression and compared this with the clinical progression of the disease. |
1996-05-29 |
2023-08-12 |
Not clear |
| M Aguilar-Santelises, M E Rottenberg, N Lewin, H Mellstedt, M Jonda. Bcl-2, Bax and p53 expression in B-CLL in relation to in vitro survival and clinical progression. International journal of cancer. vol 69. issue 2. 1996-05-29. PMID:8608978. |
our data suggest that the bcl-2/bax alpha ratio is important for the regulation of b-cll cell survival, that p53 over-expression in progressive b-cll is the result of post-transcriptional modifications and that a directed pka activation may potentiate the cytolytic effect of glucocorticoids in vivo. |
1996-05-29 |
2023-08-12 |
Not clear |
| B T Kren, C M Rodrigues, K D Setchell, C J Stee. Posttranscriptional regulation of mRNA levels in rat liver associated with deoxycholic acid feeding. The American journal of physiology. vol 269. issue 6 Pt 1. 1996-03-07. PMID:8572228. |
the 0.4% deoxycholic acid-fed animals exhibited increased mrna levels for c-jun, h-ras, p53, cyclins d1 and d3, fibronectin, and procollagens alpha 1(i) and alpha 1(iii). |
1996-03-07 |
2023-08-12 |
rat |
| A Cano, C Gamallo, C J Kemp, N Benito, J Palacios, M Quintanilla, A Balmai. Expression pattern of the cell adhesion molecules. E-cadherin, P-cadherin and alpha 6 beta 4 intergrin is altered in pre-malignant skin tumors of p53-deficient mice. International journal of cancer. vol 65. issue 2. 1996-03-01. PMID:8567126. |
the alpha 6 beta 4 integrin showed suprabasal expression in more than 70% of the papillomas derived from either wild-type, heterozygous or homozygous p53 null mice. |
1996-03-01 |
2023-08-12 |
mouse |
| A Cano, C Gamallo, C J Kemp, N Benito, J Palacios, M Quintanilla, A Balmai. Expression pattern of the cell adhesion molecules. E-cadherin, P-cadherin and alpha 6 beta 4 intergrin is altered in pre-malignant skin tumors of p53-deficient mice. International journal of cancer. vol 65. issue 2. 1996-03-01. PMID:8567126. |
surprisingly, the extent of the suprabasal localization of alpha 6 beta 4 decreased in the p53 null papillomas. |
1996-03-01 |
2023-08-12 |
mouse |
| K Pavelić, R Hrasćan, S Kapitanović, N Karapandza, Z Vranes, M Belicza, B Kruslin, T Cabrija. Multiple genetic alterations in malignant metastatic insulinomas. The Journal of pathology. vol 177. issue 4. 1996-03-01. PMID:8568594. |
patients with mutated c-k-ras oncogene had overexpression of p53 protein as well as c-myc and tgf alpha overexpression. |
1996-03-01 |
2023-08-12 |
Not clear |
| L Panico, A D'Antonio, G Salvatore, E Mezza, G Tortora, M De Laurentiis, S De Placido, T Giordano, M Merino, D S Salomon, W J Mullick, G Pettinato, S J Schnitt, A R Bianco, F Ciardiell. Differential immunohistochemical detection of transforming growth factor alpha, amphiregulin and CRIPTO in human normal and malignant breast tissues. International journal of cancer. vol 65. issue 1. 1996-02-09. PMID:8543395. |
the expression of growth factors, such as transforming growth factor alpha (tgf alpha), amphiregulin (ar) and cripto, a type-1 tyrosine-kinase growth factor receptor (erbb-2), and a tumor-suppressor gene (p53), that have been implicated in the development and/or the progression of breast cancer, was evaluated by immunohistochemistry in 100 human primary infiltrating breast carcinomas (ibc). |
1996-02-09 |
2023-08-12 |
human |
| L R Hendricks-Taylor, G J Darlingto. Inhibition of cell proliferation by C/EBP alpha occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen. Nucleic acids research. vol 23. issue 22. 1996-01-25. PMID:8524667. |
inhibition of cell proliferation by c/ebp alpha occurs in many cell types, does not require the presence of p53 or rb, and is not affected by large t-antigen. |
1996-01-25 |
2023-08-12 |
human |