| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J S Lanni, S W Lowe, E J Licitra, J O Liu, T Jack. p53-independent apoptosis induced by paclitaxel through an indirect mechanism. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 18. 1997-10-01. PMID:9275183. |
in an attempt to reconcile this apparent discrepancy, we examined the requirement for p53 in the cytotoxic effects of tumor necrosis factor alpha (tnf-alpha), a cytokine released from murine macrophages upon paclitaxel treatment. |
1997-10-01 |
2023-08-12 |
mouse |
| N F Johnson, T R Carpenter, R J Jaramillo, T A Liberat. DNA damage-inducible genes as biomarkers for exposures to environmental agents. Environmental health perspectives. vol 105 Suppl 4. 1997-09-11. PMID:9255580. |
exposure of cultures of a549 cells to alpha particles resulted in an increase in the protein levels of the dna damage-inducible genes, p53, cip1, and gadd45. |
1997-09-11 |
2023-08-12 |
rat |
| P Komminot. The RET proto-oncogene in medullary and papillary thyroid carcinoma. Molecular features, pathophysiology and clinical implications. Virchows Archiv : an international journal of pathology. vol 431. issue 1. 1997-08-25. PMID:9247627. |
several early events have been implicated in the neoplastic transformation of thyrocytes, and recent reports have described the involvement of specific genetic alterations in different types of thyroid neoplasms: ras point mutations are frequently observed in tumours with follicular histology, gsp-the mutated form of the alpha subunit of the gs-protein-is encountered in up to 73% of papillary or follicular thyroid carcinomas, and a high prevalence of p53 point mutations has been found in anaplastic thyroid carcinomas but not in differentiated follicular tumours. |
1997-08-25 |
2023-08-12 |
Not clear |
| H Wang, L Chen, L Li. [Expression of transforming growth factor alpha and p53 in non-small cell lung cancer by immunohistochemical study]. Zhonghua zhong liu za zhi [Chinese journal of oncology]. vol 18. issue 2. 1997-08-04. PMID:9206035. |
[expression of transforming growth factor alpha and p53 in non-small cell lung cancer by immunohistochemical study]. |
1997-08-04 |
2023-08-12 |
Not clear |
| H Wang, L Chen, L Li. [Expression of transforming growth factor alpha and p53 in non-small cell lung cancer by immunohistochemical study]. Zhonghua zhong liu za zhi [Chinese journal of oncology]. vol 18. issue 2. 1997-08-04. PMID:9206035. |
primary non-small cell lung cancer samples were examined for the expression of p53, transforming growth factor alpha (tgf-alpha) and its receptor egf-r by immunohistochemistry. |
1997-08-04 |
2023-08-12 |
Not clear |
| L Sompayra. SV40 and adenovirus may act as cocarcinogens by downregulating glutathione S-transferase expression. Virology. vol 233. issue 1. 1997-07-24. PMID:9201222. |
this gst alpha downregulation does not require expression of sv40 small t antigen or complex formation between large t antigen and p53, p300, or the prb family of proteins. |
1997-07-24 |
2023-08-12 |
human |
| L Sompayra. SV40 and adenovirus may act as cocarcinogens by downregulating glutathione S-transferase expression. Virology. vol 233. issue 1. 1997-07-24. PMID:9201222. |
we propose that by downregulating gst alpha expression and inactivating p53 function, sv40 and adenovirus may contribute to the initiation of, or the progression toward, malignancy. |
1997-07-24 |
2023-08-12 |
human |
| R B Myers, W E Grizzl. Changes in biomarker expression in the development of prostatic adenocarcinoma. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 72. issue 2. 1997-07-22. PMID:9152521. |
mutations of the p53 tumor suppressor gene, as well as strong expression of transforming growth factor alpha and bcl-2 typically occur in advanced stage prostatic adenocarcinomas and therefore likely represent late events in the development of prostatic adenocarcinoma. |
1997-07-22 |
2023-08-12 |
Not clear |
| T Kinoshita, H Shirasawa, Y Shino, H Moriya, L Desbarats, M Eilers, B Simiz. Transactivation of prothymosin alpha and c-myc promoters by human papillomavirus type 16 E6 protein. Virology. vol 232. issue 1. 1997-07-08. PMID:9185588. |
e6 was able to transactivate the prothymosin alpha promoter in h358 cells lacking p53 and in c33a cells harboring a mutant p53 allele. |
1997-07-08 |
2023-08-12 |
human |
| T Kinoshita, H Shirasawa, Y Shino, H Moriya, L Desbarats, M Eilers, B Simiz. Transactivation of prothymosin alpha and c-myc promoters by human papillomavirus type 16 E6 protein. Virology. vol 232. issue 1. 1997-07-08. PMID:9185588. |
these results suggest that e6 is able to transactivate the c-myc promoter independently of p53, and that the prothymosin alpha promoter is subsequently transactivated by myc. |
1997-07-08 |
2023-08-12 |
human |
| A C Hobeika, P S Subramaniam, H M Johnso. IFNalpha induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells. Oncogene. vol 14. issue 10. 1997-04-24. PMID:9121765. |
we report here on the inhibitory effects of interferon alpha (ifn alpha) on the cell cycle of prostate cancer cells, using the human prostate carcinoma cell line du145 that has mutations in the tumor suppressor genes prb, p53 and kai1. |
1997-04-24 |
2023-08-12 |
human |
| Y Kitahori, H Naitoh, N Konishi, T Ohnishi, Y Hias. Genetic alterations in N-bis(2-hydroxypropyl)nitrosamine-induced rat transplantable thyroid carcinoma lines: analysis of the TSH-R, G(alpha)s, ras and p53 genes. Carcinogenesis. vol 18. issue 2. 1997-03-24. PMID:9054617. |
genetic alterations in n-bis(2-hydroxypropyl)nitrosamine-induced rat transplantable thyroid carcinoma lines: analysis of the tsh-r, g(alpha)s, ras and p53 genes. |
1997-03-24 |
2023-08-12 |
rat |
| Y Kitahori, H Naitoh, N Konishi, T Ohnishi, Y Hias. Genetic alterations in N-bis(2-hydroxypropyl)nitrosamine-induced rat transplantable thyroid carcinoma lines: analysis of the TSH-R, G(alpha)s, ras and p53 genes. Carcinogenesis. vol 18. issue 2. 1997-03-24. PMID:9054617. |
we therefore screened for mutations in the tsh-r, g(alpha)s, ras and p53 genes in nine rat transplantable thyroid carcinoma lines derived from tumors induced by dhpn as a chemical carcinogen. |
1997-03-24 |
2023-08-12 |
rat |
| B A Goff, K Shy, B E Greer, H G Muntz, M Skelly, A M Gow. Overexpression and relationships of HER-2/neu, epidermal growth factor receptor, p53, Ki-67, and tumor necrosis factor alpha in epithelial ovarian cancer. European journal of gynaecological oncology. vol 17. issue 6. 1997-03-20. PMID:8971524. |
overexpression and relationships of her-2/neu, epidermal growth factor receptor, p53, ki-67, and tumor necrosis factor alpha in epithelial ovarian cancer. |
1997-03-20 |
2023-08-12 |
Not clear |
| M M Arnold, S Srivastava, J Fredenburgh, C R Stockard, R B Myers, W E Grizzl. Effects of fixation and tissue processing on immunohistochemical demonstration of specific antigens. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 71. issue 5. 1997-02-06. PMID:8896794. |
the dehydrating (coagulant) fixatives (e.g., ethanol and methanol) preserved immunorecognition of p53 and broad spectrum keratins best while the slow cross-linking fixatives (e.g., unbuffered zinc formalin) were best for demonstrating tgf alpha and p185erbb-2. |
1997-02-06 |
2023-08-12 |
Not clear |
| Q Wang, G P Zambetti, D P Suttl. Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor. Molecular and cellular biology. vol 17. issue 1. 1997-01-22. PMID:8972219. |
inhibition of dna topoisomerase ii alpha gene expression by the p53 tumor suppressor. |
1997-01-22 |
2023-08-12 |
human |
| Q Wang, G P Zambetti, D P Suttl. Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor. Molecular and cellular biology. vol 17. issue 1. 1997-01-22. PMID:8972219. |
while an elevated level of topo ii alpha is associated with cell proliferation, wild-type (wt) p53 inhibits the expression of various growth-stimulatory genes. |
1997-01-22 |
2023-08-12 |
human |
| Q Wang, G P Zambetti, D P Suttl. Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor. Molecular and cellular biology. vol 17. issue 1. 1997-01-22. PMID:8972219. |
to determine if p53 downregulates topo ii alpha gene expression, a murine cell line, (10)1val, that expresses a temperature-sensitive p53 was utilized. |
1997-01-22 |
2023-08-12 |
human |
| Q Wang, G P Zambetti, D P Suttl. Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor. Molecular and cellular biology. vol 17. issue 1. 1997-01-22. PMID:8972219. |
the (10)1val cells had significantly lower levels of topo ii alpha mrna and protein following incubation for 24 h at 32 degrees c (p53 with wt conformation) than at 39 degrees c (p53 with mutant conformation). |
1997-01-22 |
2023-08-12 |
human |
| Q Wang, G P Zambetti, D P Suttl. Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor. Molecular and cellular biology. vol 17. issue 1. 1997-01-22. PMID:8972219. |
the effect of p53 on the human topo ii alpha gene promoter was determined by using luciferase reporter plasmids containing varying lengths of the topo ii alpha promoter transiently cotransfected into p53-deficient (10)1 cells together with wt or mutant p53 expression plasmids. |
1997-01-22 |
2023-08-12 |
human |