| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J J Reinartz, E George, B R Lindgren, G A Niehan. Expression of p53, transforming growth factor alpha, epidermal growth factor receptor, and c-erbB-2 in endometrial carcinoma and correlation with survival and known predictors of survival. Human pathology. vol 25. issue 10. 1994-11-07. PMID:7927313. |
in the multivariate analysis p53 and tgf alpha staining were not independent predictors of survival when other variables were taken into account, including grade, stage, tumor type, presence of vascular invasion, and depth of invasion. |
1994-11-07 |
2023-08-12 |
Not clear |
| C Prive. How loops, beta sheets, and alpha helices help us to understand p53. Cell. vol 78. issue 4. 1994-09-29. PMID:8069906. |
how loops, beta sheets, and alpha helices help us to understand p53. |
1994-09-29 |
2023-08-12 |
Not clear |
| E R Sauter, L R Coia, B L Eisenberg, J A Ridg. Radiation treatment decreases transforming growth factor alpha expression in squamous carcinoma of the tongue. Cancer letters. vol 78. issue 1-3. 1994-06-14. PMID:8180957. |
the effect of xrt on p53, epidermal growth factor receptor (egfr), and transforming growth factor alpha (tgf alpha) tumor marker expression was evaluated using immunohistochemical analysis in 79 patients with scct. |
1994-06-14 |
2023-08-12 |
Not clear |
| A Dutta, J M Ruppert, J C Aster, E Wincheste. Inhibition of DNA replication factor RPA by p53. Nature. vol 365. issue 6441. 1993-09-30. PMID:8361542. |
the major evidence for this hypothesis is that p53 interacts with the simian virus 40 (sv40)-encoded protein t antigen and interferes with the ability of t antigen to unwind the sv40 origin of dna replication, and recruit dna polymerase alpha to the replication initiation complex. |
1993-09-30 |
2023-08-12 |
Not clear |
| D Fruci, P Rovero, R H Butler, R Sorrentino, R Tosi, N Tanigak. HLA class I binding of synthetic nonamer peptides carrying major anchor residue motifs of HLA-B27 (B*2705)-binding peptides. Immunogenetics. vol 38. issue 1. 1993-04-30. PMID:8462993. |
one was a known b27 (b*2705)-binding heat shock protein peptide, hsp89 alpha (201-209), and the other seven were derived from the sequence of wild-type p53, a human tumor suppressor protein. |
1993-04-30 |
2023-08-12 |
human |
| D Fruci, P Rovero, R H Butler, R Sorrentino, R Tosi, N Tanigak. HLA class I binding of synthetic nonamer peptides carrying major anchor residue motifs of HLA-B27 (B*2705)-binding peptides. Immunogenetics. vol 38. issue 1. 1993-04-30. PMID:8462993. |
hsp89 alpha (201-209) and two p53 peptides, p53 (362-370) and p53 (378-386), all possessing the motif r - k, bound strongly to b27 (b*2705) alpha chains. |
1993-04-30 |
2023-08-12 |
human |
| D Fruci, P Rovero, R H Butler, R Sorrentino, R Tosi, N Tanigak. HLA class I binding of synthetic nonamer peptides carrying major anchor residue motifs of HLA-B27 (B*2705)-binding peptides. Immunogenetics. vol 38. issue 1. 1993-04-30. PMID:8462993. |
a weak binding was seen for p53 (272-280) and p53 (334-342), both showing the motif r - r. most of these b27-binding peptides were found to bind to a3 alpha chains as well. |
1993-04-30 |
2023-08-12 |
human |
| D Fruci, P Rovero, R H Butler, R Sorrentino, R Tosi, N Tanigak. HLA class I binding of synthetic nonamer peptides carrying major anchor residue motifs of HLA-B27 (B*2705)-binding peptides. Immunogenetics. vol 38. issue 1. 1993-04-30. PMID:8462993. |
in addition, p53 (173-181) and p53 (334-342), both with the r - r motif, showed substantial binding with a31 alpha chains. |
1993-04-30 |
2023-08-12 |
human |
| D Fruci, P Rovero, R H Butler, R Sorrentino, R Tosi, N Tanigak. HLA class I binding of synthetic nonamer peptides carrying major anchor residue motifs of HLA-B27 (B*2705)-binding peptides. Immunogenetics. vol 38. issue 1. 1993-04-30. PMID:8462993. |
the remaining two peptides, p53 (201-209) and p53 (282-290), with the motif r - r, did not show significant binding with any of the alpha chains tested. |
1993-04-30 |
2023-08-12 |
human |
| E R Sauter, J A Ridge, J Gordon, B L Eisenber. p53 overexpression correlates with increased survival in patients with squamous carcinoma of the tongue base. American journal of surgery. vol 164. issue 6. 1993-01-08. PMID:1463117. |
epidermal growth factor receptor (egfr), transforming growth factor alpha (tgfa), and p53 are frequently overexpressed in squamous cell carcinomas (scc) of the upper aerodigestive tract. |
1993-01-08 |
2023-08-11 |
Not clear |
| A Yamaguchi, S Fushida, Y Kurosaka, M Kanno, Y Yonemura, I Miyazak. [Immunohistochemical detection of p53 in colorectal cancer and its relationship to prognosis]. Nihon Geka Gakkai zasshi. vol 93. issue 10. 1992-12-15. PMID:1435694. |
dna polymerase alpha positive cells rate in p53 positive tumors was significantly higher than in p53 negative tumors. |
1992-12-15 |
2023-08-11 |
Not clear |
| J A Rot. Molecular surgery for cancer. Archives of surgery (Chicago, Ill. : 1960). vol 127. issue 11. 1992-12-08. PMID:1444790. |
studies in our laboratory show that growth factors (transforming growth factor alpha), dominant oncogenes (her-2/erb b2 and k-ras), and tumor suppressor genes (p53) are functionally important in the maintenance of the malignant phenotype of human non-small-cell lung cancer cells. |
1992-12-08 |
2023-08-11 |
human |
| O Filhol, J Baudier, C Delphin, P Loue-Mackenbach, E M Chambaz, C Coche. Casein kinase II and the tumor suppressor protein P53 associate in a molecular complex that is negatively regulated upon P53 phosphorylation. The Journal of biological chemistry. vol 267. issue 29. 1992-11-18. PMID:1400378. |
studies with isolated recombinant casein kinase ii subunits disclosed that although the alpha (catalytic) subunit could phosphorylate p53, the formation of a stable p53-casein kinase ii association required the presence of the beta subunit of the kinase. |
1992-11-18 |
2023-08-11 |
Not clear |
| F M Richards, J Milner, S Metcalf. Inhibition of the serine/threonine protein phosphatases PP1 and PP2A in lymphocytes: effect on mRNA levels for interleukin-2, IL-2R alpha, krox-24, p53, hsc70 and cyclophilin. Immunology. vol 76. issue 4. 1992-11-13. PMID:1328040. |
here we have furthered these observations to the level of gene induction by measuring messenger rna (mrna) levels for the following proteins: interleukin-2 (il-2) and il-2r alpha; p53, a tumour suppressor protein; the transcription factor krox-24; and two mediators of protein folding, namely cyclophilin and the heat-shock protein hsc70. |
1992-11-13 |
2023-08-11 |
Not clear |
| D Lin, M T Shields, S J Ullrich, E Appella, W E Merce. Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 19. 1992-11-10. PMID:1409626. |
the effect of wt p53 protein on the expression of four immediate-early genes (c-fos, c-jun, jun-b, and c-myc), one delayed-early gene (ornithine decarboxylase), and two late-g1/s-phase genes (b-myb and dna polymerase alpha) was also examined. |
1992-11-10 |
2023-08-11 |
Not clear |
| R Godbout, J Miyakoshi, K D Dobler, R Andison, K Matsuo, M J Allalunis-Turner, H Takebe, R S Da. Lack of expression of tumor-suppressor genes in human malignant glioma cell lines. Oncogene. vol 7. issue 9. 1992-09-15. PMID:1501894. |
human malignant gliomas (glioblastomas and anaplastic astrocytomas) are the most frequent brain tumors and are associated with a variety of genetic alterations including retinoblastoma (rb) and p53 gene mutations, loss of interferon alpha and beta (ifna, ifnb) genes and lack of o6-methylguanine-dna methyltransferase (mgmt) expression. |
1992-09-15 |
2023-08-11 |
human |
| M Treier, W Seufert, S Jentsc. Drosophila UbcD1 encodes a highly conserved ubiquitin-conjugating enzyme involved in selective protein degradation. The EMBO journal. vol 11. issue 1. 1992-03-25. PMID:1310935. |
ubiquitin-dependent selective protein degradation serves to eliminate abnormal proteins and provides controlled short half-lives to certain cellular proteins, including proteins of regulatory function such as phytochrome, yeast mat alpha 2 repressor, p53 and cyclin. |
1992-03-25 |
2023-08-11 |
drosophila_melanogaster |
| J Zezula, K Fuchs, W Sieghar. Separation of alpha 1, alpha 2 and alpha 3 subunits of the GABAA-benzodiazepine receptor complex by immunoaffinity chromatography. Brain research. vol 563. issue 1-2. 1992-03-23. PMID:1664775. |
polyclonal antibodies raised to synthetic amino acid sequences of the rat gamma-aminobutyric acid (gabaa) receptor alpha 1-, alpha 2- and alpha 3-subunits selectively recognized single proteins with apparent molecular weight 51 kda (p51), 53 kda (p53) and 59 kda (p59), respectively, in gabaa receptor preparations affinity purified from the brains of 5-10-day-old rats. |
1992-03-23 |
2023-08-11 |
rat |
| O Eizenberg, M Ore. Reduced levels of alpha 1 (I) collagen mRNA in cells immortalized by mutant p53 or transformed by ras. Biochimica et biophysica acta. vol 1129. issue 1. 1992-02-05. PMID:1756178. |
reduced levels of alpha 1 (i) collagen mrna in cells immortalized by mutant p53 or transformed by ras. |
1992-02-05 |
2023-08-11 |
Not clear |
| O Eizenberg, M Ore. Reduced levels of alpha 1 (I) collagen mRNA in cells immortalized by mutant p53 or transformed by ras. Biochimica et biophysica acta. vol 1129. issue 1. 1992-02-05. PMID:1756178. |
levels of alpha 1 (i) collagen mrna were reduced in the majority of immortalized cell lines which greatly overproduced the transfected mutant p53. |
1992-02-05 |
2023-08-11 |
Not clear |