| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L R Hendricks-Taylor, G J Darlingto. Inhibition of cell proliferation by C/EBP alpha occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen. Nucleic acids research. vol 23. issue 22. 1996-01-25. PMID:8524667. |
furthermore, it appears that the effects of c/ebp alpha are not mediated through p53 or rb and are not altered by t-antigen. |
1996-01-25 |
2023-08-12 |
human |
| R Partanen, H Koskinen, P Oksa, K Hemminki, W Carney, S Smith, P Brandt-Rau. Serum oncoproteins in asbestosis patients. Clinical chemistry. vol 41. issue 12 Pt 2. 1996-01-16. PMID:7497643. |
using elisas, we determined the concentrations of transforming growth factor alpha (tgf-alpha), the extracellular domain of the erbb-2 receptor (erbb-2 ecd), and mutant p53 protein in stored serum samples of asbestosis patients with and without cancer and control subjects (without asbestosis or cancer). |
1996-01-16 |
2023-08-12 |
human |
| C T Quang, M Pironin, M von Lindern, H Beug, J Ghysdae. Spi-1 and mutant p53 regulate different aspects of the proliferation and differentiation control of primary erythroid progenitors. Oncogene. vol 11. issue 7. 1995-11-28. PMID:7478542. |
however, expression of p53(v135a) in erythroid progenitors obtained from bone marrow cells in the presence of scf, tgf alpha and estradiol, was found to relieve these cells from their absolute tgf alpha requirement for long term proliferation. |
1995-11-28 |
2023-08-12 |
Not clear |
| L Wang, R J Rayanade, D Garcia, K Patel, H Pan, P B Sehga. Modulation of interleukin-6-induced plasma protein secretion in hepatoma cells by p53 species. The Journal of biological chemistry. vol 270. issue 39. 1995-11-06. PMID:7559462. |
hepatoma cell lines stably expressing the val-135 temperature-sensitive mutant of murine p53 (wt-like at 32.5 degrees c and mutant-like at 37 degrees c) were derived from hep3b cells and tested for the temperature-sensitive phenotype of their ability to synthesize and secrete fibrinogen and alpha 1-antichymotrypsin in response to il-6. |
1995-11-06 |
2023-08-12 |
human |
| G V Scagliotti, P Masiero, E Pozz. Biological prognostic factors in non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands). vol 12 Suppl 1. 1995-10-30. PMID:7551921. |
the major categories of biological events implicated in non-small cell lung cancer include growth factor receptors expression (epidermal growth receptor, p185c-neu), autocrine growth factor production (transforming growth factor alpha), dominant oncogenes activation (ras genes) and deletion of tumour suppressor genes (p53 gene, retinoblastoma gene) and these are some of the abnormalities associated with specific histological types and with poor prognosis. |
1995-10-30 |
2023-08-12 |
Not clear |
| Y Shintani, K Yoshimoto, H Horie, T Sano, Y Kanesaki, E Hosoi, Y Yokogoshi, H Bando, H Iwahana, S Kannuk. Two different pituitary adenomas in a patient with multiple endocrine neoplasia type 1 associated with growth hormone-releasing hormone-producing pancreatic tumor: clinical and genetic features. Endocrine journal. vol 42. issue 3. 1995-10-19. PMID:7670561. |
on the other hand, mutations of ras, p53, gs alpha, and gi2 alpha genes were not found in these tumors. |
1995-10-19 |
2023-08-12 |
Not clear |
| T H Shin, A J Paterson, J E Kudlo. p53 stimulates transcription from the human transforming growth factor alpha promoter: a potential growth-stimulatory role for p53. Molecular and cellular biology. vol 15. issue 9. 1995-09-22. PMID:7651386. |
p53 stimulates transcription from the human transforming growth factor alpha promoter: a potential growth-stimulatory role for p53. |
1995-09-22 |
2023-08-12 |
human |
| A Facchian. Investigating hypothetical products from noncoding frames (HyPNoFs). Journal of molecular evolution. vol 40. issue 6. 1995-09-19. PMID:7543950. |
hypnofs of cd4, pkc, oncostatin, bcl-2 proto-oncogene, tumor suppressor p53, cystic fibrosis transmembrane regulator (cftr), and tumor necrosis factors alpha and beta were searched as query sequences vs the swiss-prot data bank. |
1995-09-19 |
2023-08-12 |
Not clear |
| X Sun, H Shimizu, K Yamamot. Identification of a novel p53 promoter element involved in genotoxic stress-inducible p53 gene expression. Molecular and cellular biology. vol 15. issue 8. 1995-08-29. PMID:7623839. |
although a kappa b motif partially overlaps with this element and those genotoxic agents activate nf-kappa b, it does not play a major role in p53 genotoxic stress response: nf-kappa b p65 expression did not induce significant p53 promoter activation, and nf-kappa b inhibitors (n-acetyl cysteine and i kappa b alpha) did not inhibit genotoxic stress-inducible p53 promoter activation. |
1995-08-29 |
2023-08-12 |
Not clear |
| J M Dubuis, C L Deal, R T Drews, C G Goodyer, G Lagacé, S L Asa, G Van Vliet, R Coll. Mammosomatotroph adenoma causing gigantism in an 8-year old boy: a possible pathogenetic mechanism. Clinical endocrinology. vol 42. issue 5. 1995-08-28. PMID:7621575. |
screening of tumour dna after amplification by polymerase chain reaction followed by single-strand conformational polymorphism analysis did not reveal any mutations in the hot spots of g protein alpha subunits (alpha s, alpha i2, alpha o2 and alpha 11) genes or in the h-ras and p53 genes. |
1995-08-28 |
2023-08-12 |
Not clear |
| S Yoshida, T Todoroki, Y Ichikawa, S Hanai, H Suzuki, M Hori, K Fukao, M Miwa, K Uchid. Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers. Cancer research. vol 55. issue 13. 1995-08-01. PMID:7796400. |
in contrast, no mutation in the p15ink4b/mts2 gene, one base change in the k-ras gene, and one loss of heterozygosity at the ifn alpha locus in 25 cancers and one base change in the p53 gene in 19 cancers were observed. |
1995-08-01 |
2023-08-12 |
Not clear |
| G Packham, C Bello-Fernandez, J L Clevelan. Position and orientation independent transactivation by c-Myc. Cellular & molecular biology research. vol 40. issue 7-8. 1995-07-25. PMID:7787888. |
the ornithine decarboxylase (odc), p53, prothymosin alpha and eca39 promoters are transactivated by c-myc, and are considered direct targets, as activation is mediated by cacgtg sequences. |
1995-07-25 |
2023-08-12 |
Not clear |
| J Chen, T Liu, Q Cu. [Gene expression of growth factors, growth factor receptor and oncogenes in human lung cancer cell lines]. Zhonghua bing li xue za zhi = Chinese journal of pathology. vol 24. issue 1. 1995-07-19. PMID:7781111. |
gene expression of growth factors including epidermal growth factor (egf), transforming growth factor alpha (tgf alpha), epidermal growth factor receptor (egfr), oncogenes such as c-myc, n-ras, c-erbb2 and tumor suppressor gene p53 were studied in 4 human lung cancer cell lines using northern blot technique. |
1995-07-19 |
2023-08-12 |
human |
| V Rusch, D Klimstra, I Linkov, E Dmitrovsk. Aberrant expression of p53 or the epidermal growth factor receptor is frequent in early bronchial neoplasia and coexpression precedes squamous cell carcinoma development. Cancer research. vol 55. issue 6. 1995-04-12. PMID:7882337. |
we conclude that: (a) transforming growth factor alpha is variably expressed in normal respiratory epithelium as well as reactive and preneoplastic bronchial lesions; (b) p53 expression is seen in preneoplastic bronchial lesions but is not present in reactive or metaplastic epithelium; (c) aberrant egfr expression occurs in both reactive and preinvasive bronchial lesions and may be an early marker of neoplastic transformation; and (d) the simultaneous aberrant expression of egfr and p53 occurs predominantly in scc and their associated bronchial lesions. |
1995-04-12 |
2023-08-12 |
Not clear |
| L R Coia, E R Saute. Esophageal cancer. Current problems in cancer. vol 18. issue 4. 1995-04-06. PMID:7533069. |
a variety of tumor-suppressor genes (including p53, apc, dcc and rb) and proto-oncogenes (including prad1, egfr, c-erb-2 and tgf alpha) may be involved in the development and progression of esophageal cancer. |
1995-04-06 |
2023-08-12 |
Not clear |
| T Nakajima, N Ohi, T Arai, N Nozaki, A Kikuchi, K Od. Adenovirus E1A-induced apoptosis elicits a steep decrease in the topoisomerase II alpha level during the latent phase. Oncogene. vol 10. issue 4. 1995-03-22. PMID:7862442. |
these results strongly suggest that e1a or e1a stabilized p53 induces apoptosis by targeting topoisomerase ii alpha to the ubiquitination pathway and e1b 19k alleviates its action. |
1995-03-22 |
2023-08-12 |
human |
| K Jaskiewicz, J E Krige, J Thomso. Expression of p53 tumor suppressor gene, oncoprotein c-erbB-2, cellular proliferation and differentiation in malignant and benign pancreatic lesions. Anticancer research. vol 14. issue 5A. 1995-03-09. PMID:7847827. |
tumor suppressor gene p53 and transforming growth factor alpha were overexpressed in the majority of malignant tumors. |
1995-03-09 |
2023-08-12 |
Not clear |
| A W Hickman, R J Jaramillo, J F Lechner, N F Johnso. Alpha-particle-induced p53 protein expression in a rat lung epithelial cell strain. Cancer research. vol 54. issue 22. 1994-12-02. PMID:7954402. |
in addition, more cells exposed to low doses of alpha radiation had increased p53 protein levels than would be predicted based on the number of nuclei expected to be traversed by an alpha-particle, suggesting that alpha-particles cause genetic damage by mechanisms in addition to direct interactions with dna. |
1994-12-02 |
2023-08-12 |
rat |
| J J Reinartz, E George, B R Lindgren, G A Niehan. Expression of p53, transforming growth factor alpha, epidermal growth factor receptor, and c-erbB-2 in endometrial carcinoma and correlation with survival and known predictors of survival. Human pathology. vol 25. issue 10. 1994-11-07. PMID:7927313. |
abnormal expression of p53, transforming growth factor alpha (tgf alpha), epidermal growth factor receptor (egfr), and c-erbb-2 occurs in a variety of cancers and in some cases is associated with poor prognosis. |
1994-11-07 |
2023-08-12 |
Not clear |
| J J Reinartz, E George, B R Lindgren, G A Niehan. Expression of p53, transforming growth factor alpha, epidermal growth factor receptor, and c-erbB-2 in endometrial carcinoma and correlation with survival and known predictors of survival. Human pathology. vol 25. issue 10. 1994-11-07. PMID:7927313. |
p53 and tgf alpha staining showed statistically significant correlations with decreased length of survival (p < .0017 and p < .0013, respectively, generalized savage [mantel cox]). |
1994-11-07 |
2023-08-12 |
Not clear |