| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Huan. Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein. Oncogene. vol 17. issue 3. 1998-08-14. PMID:9690508. |
the misincorporation of non-complementary deoxynucleotides into dna by pol alpha was substantially decreased by p53. |
1998-08-14 |
2023-08-12 |
human |
| P Huan. Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein. Oncogene. vol 17. issue 3. 1998-08-14. PMID:9690508. |
in contrast, wt p53 showed no significant effect on replication fidelity or the rates of dna synthesis by human pol epsilon or the bacterial enzyme pol i. inhibition of 3'-->5' exonuclease activity by guanosine monophosphate (gmp) abolished the ability of p53 to enhance the replication fidelity of pol alpha. |
1998-08-14 |
2023-08-12 |
human |
| P Huan. Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein. Oncogene. vol 17. issue 3. 1998-08-14. PMID:9690508. |
these results suggest a possibility that the 3'-->5' exonuclease of the wt p53 protein might provide the proof-reading function for dna pol alpha. |
1998-08-14 |
2023-08-12 |
human |
| G Shkla. Mechanisms of cancer inhibition by anti-oxidant nutrients. Oral oncology. vol 34. issue 1. 1998-07-23. PMID:9659516. |
these various micronutrients appear to act through a complex group of "common pathways" of anticancer activity based upon three major mechanisms: (1) tumour inhibition by immune cytokines; (2) stimulation of cancer suppressor genes, such as "wild type" p53, and diminished expression or dysregulation of oncogenes such as mutant p53 and h-ras; (3) inhibition of tumour angiogenesis through the inhibition of angiogenesis-stimulating factors such as tgf alpha. |
1998-07-23 |
2023-08-12 |
human |
| A C Hobeika, W Etienne, P E Cruz, P S Subramaniam, H M Johnso. IFNgamma induction of p21WAF1 in prostate cancer cells: role in cell cycle, alteration of phenotype and invasive potential. International journal of cancer. vol 77. issue 1. 1998-07-07. PMID:9639405. |
we have previously shown that the type i ifn ifn alpha induces the expression of the cyclin-dependent kinase inhibitor p21waf1 and inhibits the cell cycle of the human prostate adenocarcinoma cell line, du145, that carries mutations in the tumor suppressor gene products p53 and prb. |
1998-07-07 |
2023-08-12 |
human |
| L Shen, R I Glaze. Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3. Biochemical pharmacology. vol 55. issue 10. 1998-07-02. PMID:9634008. |
these results suggest that pkc(alpha) suppresses apoptosis in glioblastoma cells primarily by restricting the accumulation of p53 and the expression of insulin-like growth factor-1-binding protein, as well as by maintaining rb in an inactive hyperphosphorylated state. |
1998-07-02 |
2023-08-12 |
Not clear |
| C Huang, T Taki, M Adachi, T Konishi, M Higashiyama, M Miyak. Mutations in exon 7 and 8 of p53 as poor prognostic factors in patients with non-small cell lung cancer. Oncogene. vol 16. issue 19. 1998-07-01. PMID:9627113. |
worse overall survival of the patients with mutations in exon 8 of p53 was suggested to be associated with codon 273 mutations as well as mutations between codon 280 and 285 included into the h2 alpha helix corresponding to residues 278-286. |
1998-07-01 |
2023-08-12 |
Not clear |
| M Youmell, S J Park, S Basu, B D Pric. Regulation of the p53 protein by protein kinase C alpha and protein kinase C zeta. Biochemical and biophysical research communications. vol 245. issue 2. 1998-06-02. PMID:9571186. |
regulation of the p53 protein by protein kinase c alpha and protein kinase c zeta. |
1998-06-02 |
2023-08-12 |
Not clear |
| M Youmell, S J Park, S Basu, B D Pric. Regulation of the p53 protein by protein kinase C alpha and protein kinase C zeta. Biochemical and biophysical research communications. vol 245. issue 2. 1998-06-02. PMID:9571186. |
here, we demonstrate that cotransfection of p53 with either pkc alpha or pkc zeta increases p53's transcriptional activity. |
1998-06-02 |
2023-08-12 |
Not clear |
| M Youmell, S J Park, S Basu, B D Pric. Regulation of the p53 protein by protein kinase C alpha and protein kinase C zeta. Biochemical and biophysical research communications. vol 245. issue 2. 1998-06-02. PMID:9571186. |
mutagenesis of p53 indicates that serine 371 is the major site for phosphorylation by pkc alpha in vitro. |
1998-06-02 |
2023-08-12 |
Not clear |
| M Youmell, S J Park, S Basu, B D Pric. Regulation of the p53 protein by protein kinase C alpha and protein kinase C zeta. Biochemical and biophysical research communications. vol 245. issue 2. 1998-06-02. PMID:9571186. |
mutation of serine 371 caused a small decline in p53 activation by pkc alpha and pkc zeta. |
1998-06-02 |
2023-08-12 |
Not clear |
| M Youmell, S J Park, S Basu, B D Pric. Regulation of the p53 protein by protein kinase C alpha and protein kinase C zeta. Biochemical and biophysical research communications. vol 245. issue 2. 1998-06-02. PMID:9571186. |
however, the alternatively spliced murine p53, which lacks the pkc phosphorylation sites, still demonstrated increased transcriptional activation when cotransfected with either pkc alpha or pkc zeta. |
1998-06-02 |
2023-08-12 |
Not clear |
| A Bakir, F Gezen, O Yildiz, A Ayhan, S Kahraman, C A Kruse, M Varella-Garcia, F Yildiz, A Kuba. Establishment and characterization of a human glioblastoma multiforme cell line. Cancer genetics and cytogenetics. vol 103. issue 1. 1998-06-02. PMID:9595044. |
the cytoskeleton was positive for neuron-specific enolase, vimentin, and neurofilament, and it was negative for glial fibrillary acidic protein, s-100 protein, p53 protein, epidermal growth factor, and transforming growth factor alpha. |
1998-06-02 |
2023-08-12 |
human |
| R Kinscherf, R Claus, M Wagner, C Gehrke, H Kamencic, D Hou, O Nauen, W Schmiedt, G Kovacs, J Pill, J Metz, H P Deigne. Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependent. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 12. issue 6. 1998-04-17. PMID:9535218. |
we found that induction of apoptosis in mphi by oxldl, c2-ceramide, tumor necrosis factor alpha (tnf-alpha), and hydrogen peroxide (h2o2) was associated with enhanced expression of manganese superoxide dismutase (mnsod) and p53. |
1998-04-17 |
2023-08-12 |
human |
| J Shou, Y Zhang, D W. Partial deletion of p53 gene in alpha particle-induced transformant of Syrian hamster embryo cells. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih. vol 11. issue 3. 1997-12-31. PMID:9387401. |
partial deletion of p53 gene in alpha particle-induced transformant of syrian hamster embryo cells. |
1997-12-31 |
2023-08-12 |
mouse |
| J Shou, Y Zhang, D W. Partial deletion of p53 gene in alpha particle-induced transformant of Syrian hamster embryo cells. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih. vol 11. issue 3. 1997-12-31. PMID:9387401. |
the mutation of p53 gene was detected in syrian hamster embryo (she) cells neoplastically initiated with alpha particles. |
1997-12-31 |
2023-08-12 |
mouse |
| J Shou, Y Zhang, D W. Partial deletion of p53 gene in alpha particle-induced transformant of Syrian hamster embryo cells. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih. vol 11. issue 3. 1997-12-31. PMID:9387401. |
the results implied that p53 gene had been mutated by deletion, which might lead to loss of p53 protein expression but the increased expression of p53 remained in alpha particle-induced she transformant. |
1997-12-31 |
2023-08-12 |
mouse |
| N Mori, F Kashanchi, D Prage. Repression of transcription from the human T-cell leukemia virus type I long terminal repeat and cellular gene promoters by wild-type p53. Blood. vol 90. issue 12. 1997-12-29. PMID:9389710. |
we have investigated the effects of wild-type and mutant p53 on tax-mediated activation of the htlv-i long terminal repeat (ltr) and the promoters of several cellular genes including the interleukin (il)-1alpha, il-6, granulocyte-macrophage colony-stimulating factor (gm-csf ), and il-2 receptor alpha chain gene. |
1997-12-29 |
2023-08-12 |
human |
| P Srivastava, J Russo, I H Russ. Chorionic gonadotropin inhibits rat mammary carcinogenesis through activation of programmed cell death. Carcinogenesis. vol 18. issue 9. 1997-11-13. PMID:9328178. |
rna from mammary glands, adenocarcinomas and ovaries was probed for transforming growth factors (tgf) alpha and beta, and the apoptotic genes trpm2, ice, bcl2, bcl-xl, bcl-xs, p53 and c-myc. |
1997-11-13 |
2023-08-12 |
human |
| Y Ikematsu, G Liu, M A Fienhold, M Cano, T E Adrian, M A Hollingsworth, J E Williamson, W Sanger, T Tomioka, P M Pou. In vitro pancreatic ductal cell carcinogenesis. International journal of cancer. vol 72. issue 6. 1997-11-10. PMID:9378545. |
the resulting tumor from taka-1 + bop was re-cultured in vitro and designated taka-1 + bop-t. mutation of c-k-ras and p53 oncogenes, chromosomal changes, expression of transforming growth factor alpha (tgf-alpha) and epidermal growth factor (egf) receptor and several biochemical markers were examined in all cell lines. |
1997-11-10 |
2023-08-12 |
Not clear |