| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Perjési, Z Bayer, I Embe. Effect of E-2-(4'-methoxybenzylidene)-1-benzosuberone on the 7,12-dimethylbenz[alpha]anthracene-induced onco/suppressor gene action in vivo. I: A 24-hour experiment. Anticancer research. vol 20. issue 1A. 2000-05-11. PMID:10769699. |
in order to determine whether this promising antineoplastic activity would extend to anticarcinogenic properties, the effects of mbb on the 7,12-dimethylbenz[alpha] anthracene (dmba)-induced expression of c-myc, ha-ras and p53 genes in isolated rna from liver, lung, kidney, spleen, thymus, lymph nodes and bone marrow of cba/ca inbred mice was investigated. |
2000-05-11 |
2023-08-12 |
mouse |
| J Liu, X Shen, V A Nguyen, G Kunos, B Ga. Alpha(1) adrenergic agonist induction of p21(waf1/cip1) mRNA stability in transfected HepG2 cells correlates with the increased binding of an AU-rich element binding factor. The Journal of biological chemistry. vol 275. issue 16. 2000-05-10. PMID:10766810. |
stimulation of transfected hepg2 cells (tfg2) with the alpha(1)-adrenergic agonist phenylephrine (pe) significantly activated p21(waf1/cip1) gene expression without affecting p53 gene expression. |
2000-05-10 |
2023-08-12 |
cat |
| G Liu, J A Schwartz, S C Brook. Estrogen receptor protects p53 from deactivation by human double minute-2. Cancer research. vol 60. issue 7. 2000-05-04. PMID:10766163. |
we and others have demonstrated that estrogen receptor alpha (eralpha) and p53, two important regulatory proteins in breast cancer, bind to each other. |
2000-05-04 |
2023-08-12 |
human |
| C C Wong, W H Poon, T Y Tsim, E Y Wong, M S Leun. Gene expressions during the development and sexual differentiation of the olfactory bulb in rats. Brain research. Developmental brain research. vol 119. issue 2. 2000-04-11. PMID:10675768. |
in this study, expressions of cell-cycle-related genes: p53, retinoblastoma (rb), p21, bcl-2(alpha), bcl-2(beta); protooncogene c-ski; glial cell marker protein gene s100beta; neurotransmitter gene, substance p and sexual-differentiation-related genes, androgen receptor (ar) and estrogen receptor beta (er(beta)), are studied in the olfactory bulb of groups of both six female and six male rats at the ages of 3, 10, 20 and 40 days. |
2000-04-11 |
2023-08-12 |
rat |
| C C Wong, W H Poon, T Y Tsim, E Y Wong, M S Leun. Gene expressions during the development and sexual differentiation of the olfactory bulb in rats. Brain research. Developmental brain research. vol 119. issue 2. 2000-04-11. PMID:10675768. |
conclusively, developmental changes of the p53, rb, ar, er(beta), substance p and s100beta genes expressions are quite evidenced while only the bcl-2(alpha) gene seems to change significantly during the sexual differentiation of olfactory bulb in rats. |
2000-04-11 |
2023-08-12 |
rat |
| A D'Errico, C Barozzi, M Fiorentino, R Carella, M Di Simone, L Ferruzzi, S Mattioli, W F Grigion. Role and new perspectives of transforming growth factor-alpha (TGF-alpha) in adenocarcinoma of the gastro-oesophageal junction. British journal of cancer. vol 82. issue 4. 2000-04-05. PMID:10732760. |
we examined samples from 87 resected type ii gej adenocarcinomas, 30 of these with endoscopic diagnostic biopsy material, to evaluate transforming growth factor alpha (tgf-a) expression and p53 overexpression by immunohistochemistry and in situ hybridization (for tgf-alpha), in relation to biological and clinical behaviour. |
2000-04-05 |
2023-08-12 |
Not clear |
| G Aquilina, S Ceccotti, S Martinelli, S Soddu, M Crescenzi, P Branch, P Karran, M Bignam. Mismatch repair and p53 independently affect sensitivity to N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 6. issue 2. 2000-03-28. PMID:10690553. |
in contrast, mmr-defective a2780 variants, which had a similar hmutl alpha defect but retained a wild-type p53, did exhibit the expected ccnu sensitivity. |
2000-03-28 |
2023-08-12 |
human |
| D Adamek, M Moskała, J Kałuza, I Gościńsk. CT-guided stereotactic biopsy of brain. Three years of experience. Folia neuropathologica. vol 37. issue 3. 2000-02-08. PMID:10581847. |
different pathomorphological methods, including especially immunohistochemistry with gfap, vimentin, p53, ki-67, and topoisomerase ii alpha if applied together, may at least partially help to overcome the problems of the differentiation of reactive and neoplastic gliosis. |
2000-02-08 |
2023-08-12 |
Not clear |
| E Fernández-Salas, M Sagar, C Cheng, S H Yuspa, W C Weinber. p53 and tumor necrosis factor alpha regulate the expression of a mitochondrial chloride channel protein. The Journal of biological chemistry. vol 274. issue 51. 2000-01-27. PMID:10593946. |
p53 and tumor necrosis factor alpha regulate the expression of a mitochondrial chloride channel protein. |
2000-01-27 |
2023-08-12 |
mouse |
| E Fernández-Salas, M Sagar, C Cheng, S H Yuspa, W C Weinber. p53 and tumor necrosis factor alpha regulate the expression of a mitochondrial chloride channel protein. The Journal of biological chemistry. vol 274. issue 51. 2000-01-27. PMID:10593946. |
this represents the first report of localization of a clic type chloride channel in mitochondria and the first indication that expression of an organellular chloride channel can be regulated by p53 and tumor necrosis factor alpha. |
2000-01-27 |
2023-08-12 |
mouse |
| R R Rustandi, D M Baldisseri, A C Drohat, D J Webe. Structural changes in the C-terminus of Ca2+-bound rat S100B (beta beta) upon binding to a peptide derived from the C-terminal regulatory domain of p53. Protein science : a publication of the Protein Society. vol 8. issue 9. 2000-01-13. PMID:10493575. |
analysis of nuclear overhauser effect (noe) correlations, amide proton exchange rates, 3j(nh-h alpha) coupling constants, and chemical shift index data show that, like apo- and ca2+-bound s100b(beta beta), s100b remains a dimer in the p53 peptide complex, and each subunit has four helices (helix 1, glu2-arg20; helix 2, lys29-asn38; helix 3, gln50-asp61; helix 4, phe70-phe87), four loops (loop 1, glu21-his25; loop 2, glu39-glu49; loop 3, glu62-gly66; loop 4, phe88-glu91), and two beta-strands (beta-strand 1, lys26-lys28; beta-strand 2, glu67-asp69), which forms a short antiparallel beta-sheet. |
2000-01-13 |
2023-08-12 |
rat |
| K Tamura, R L Rice, P Wipf, J S Laz. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597298. |
sc-alpha alpha delta 9 did not alter p53, p21 or p16 levels. |
2000-01-04 |
2023-08-12 |
Not clear |
| N Veldhoen, S Metcalfe, J Milne. A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597303. |
expression of exon alpha disrupts in vitro translation of the p53 binding domain of mdm2. |
2000-01-04 |
2023-08-12 |
Not clear |
| N Veldhoen, S Metcalfe, J Milne. A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597303. |
the putative mdm2 alpha protein lacks the n-terminus of mdm2 and shows little, if any, binding capacity for p53. |
2000-01-04 |
2023-08-12 |
Not clear |
| S H Liang, M F Clark. A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domain. The Journal of biological chemistry. vol 274. issue 46. 2000-01-03. PMID:10551826. |
these results indicate that the csd can regulate p53 nuclear import by controlling access of the nls to importin alpha binding. |
2000-01-03 |
2023-08-12 |
Not clear |
| R E Bachelder, M J Ribick, A Marchetti, R Falcioni, S Soddu, K R Davis, A M Mercuri. p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB. The Journal of cell biology. vol 147. issue 5. 1999-12-30. PMID:10579725. |
p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of akt/pkb. |
1999-12-30 |
2023-08-12 |
Not clear |
| D M Jacobs, A S Lipton, N G Isern, G W Daughdrill, D F Lowry, X Gomes, M S Wol. Human replication protein A: global fold of the N-terminal RPA-70 domain reveals a basic cleft and flexible C-terminal linker. Journal of biomolecular NMR. vol 14. issue 4. 1999-11-02. PMID:10526407. |
the n-terminal 168 residues of rpa70 form a structurally distinct domain that stimulates dna polymerase alpha activity, interacts with several transcriptional activators including tumor suppressor p53, and during the cell cycle it signals escape from the dna damage induced g2/m checkpoint. |
1999-11-02 |
2023-08-12 |
human |
| J L Cook, B A Routes, C Y Leu, T A Walker, K L Colvi. E1A oncogene-induced cellular sensitization to immune-mediated apoptosis is independent of p53 and resistant to blockade by E1B 19 kDa protein. Experimental cell research. vol 252. issue 1. 1999-11-01. PMID:10502412. |
in this study, the roles of p53 and e1b 19 kda were tested for e1a sensitization to cl-induced apoptosis in contrast with apoptosis triggered by tnf alpha or chemical injuries. |
1999-11-01 |
2023-08-12 |
mouse |
| R K Srivastava, A R Srivastava, P Seth, S Agrawal, Y S Cho-Chun. Growth arrest and induction of apoptosis in breast cancer cells by antisense depletion of protein kinase A-RI alpha subunit: p53-independent mechanism of action. Molecular and cellular biochemistry. vol 195. issue 1-2. 1999-10-28. PMID:10395066. |
interestingly, ri alpha antisense inhibited cell viability and induced apoptosis in the absence of p53, suggesting that these actions of ri alpha antisense are exerted independent of p53. |
1999-10-28 |
2023-08-12 |
human |
| K Rittinger, J Budman, J Xu, S Volinia, L C Cantley, S J Smerdon, S J Gamblin, M B Yaff. Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. Molecular cell. vol 4. issue 2. 1999-10-12. PMID:10488331. |
structural homology between the 14-3-3 nes structure and those within i kappa b alpha and p53 reveals a conserved topology recognized by the crm1 nuclear export machinery. |
1999-10-12 |
2023-08-12 |
Not clear |