| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Nair, F Traganos, Y C Tse-Din. Differential effect of camptothecin treatment on topoisomerase II alpha expression in ML-1 and HL-60 leukemia cell lines. Anticancer research. vol 20. issue 6B. 2001-03-01. PMID:11205246. |
binding of p53 has been shown to inhibit transcription of top2 alpha. |
2001-03-01 |
2023-08-12 |
human |
| J Nair, F Traganos, Y C Tse-Din. Differential effect of camptothecin treatment on topoisomerase II alpha expression in ML-1 and HL-60 leukemia cell lines. Anticancer research. vol 20. issue 6B. 2001-03-01. PMID:11205246. |
western blot analysis indicated rapid induction of p53 in ml-1 followed by significant decrease of top2 alpha mrna and protein levels. |
2001-03-01 |
2023-08-12 |
human |
| J Nair, F Traganos, Y C Tse-Din. Differential effect of camptothecin treatment on topoisomerase II alpha expression in ML-1 and HL-60 leukemia cell lines. Anticancer research. vol 20. issue 6B. 2001-03-01. PMID:11205246. |
these results demonstrated that induction of p53 by camptothecin treatment can lead to a decreased level of top2 alpha and should be considered in design of combination therapy. |
2001-03-01 |
2023-08-12 |
human |
| E P Gallagher, K M Sheeh. Effects of phenytoin on glutathione status and oxidative stress biomarker gene mRNA levels in cultured precision human liver slices. Toxicological sciences : an official journal of the Society of Toxicology. vol 59. issue 1. 2001-02-22. PMID:11134551. |
the biomarker genes analyzed were p53, bcl-2, alpha class glutathione s-transferases isozymes a1 and a4 (hgsta1 and hgsta4), and the catalytic subunit of gamma-glutamylcysteine synthetase (gammagcs-hs). |
2001-02-22 |
2023-08-12 |
human |
| T Shinohara, T Miki, N Nishimura, H Nokihara, H Hamada, N Mukaida, S Son. Nuclear factor-kappaB-dependent expression of metastasis suppressor KAI1/CD82 gene in lung cancer cell lines expressing mutant p53. Cancer research. vol 61. issue 2. 2001-02-22. PMID:11212267. |
our results demonstrated that expression of kai1/cd82 in pc-14 cells expressing mutant p53 could be augmented by tnf-alpha, and that transfer of the gene for a specific inhibitor of nf-kappab, ikappab alphasr (mutant ikappab alpha; nf-kappab super-repressor), into pc-14 cells could inhibit this augmentation. |
2001-02-22 |
2023-08-12 |
human |
| X S Cui, L A Donehowe. Differential gene expression in mouse mammary adenocarcinomas in the presence and absence of wild type p53. Oncogene. vol 19. issue 52. 2001-02-01. PMID:11146550. |
most of the differentially expressed genes are increased in p53+/+ tumors and many of these represent known target genes of p53 (p21waf/c1p1, cyclin g1, alpha smooth muscle actin, and cytokeratin 19). |
2001-02-01 |
2023-08-12 |
mouse |
| X J Wang, D A Greenhalgh, L A Donehower, D R Roo. Cooperation between Ha-ras and fos or transforming growth factor alpha overcomes a paradoxic tumor-inhibitory effect of p53 loss in transgenic mouse epidermis. Molecular carcinogenesis. vol 29. issue 2. 2000-11-30. PMID:11074603. |
cooperation between ha-ras and fos or transforming growth factor alpha overcomes a paradoxic tumor-inhibitory effect of p53 loss in transgenic mouse epidermis. |
2000-11-30 |
2023-08-12 |
mouse |
| X J Wang, D A Greenhalgh, L A Donehower, D R Roo. Cooperation between Ha-ras and fos or transforming growth factor alpha overcomes a paradoxic tumor-inhibitory effect of p53 loss in transgenic mouse epidermis. Molecular carcinogenesis. vol 29. issue 2. 2000-11-30. PMID:11074603. |
to investigate the role of loss of the p53 tumor suppressor gene in skin carcinogenesis, p53 knockout (p53(-/-)) mice were mated with transgenic mice coexpressing v-ha-ras, v-fos, or human transforming growth factor alpha (tgfalpha) exclusively in the epidermis by using human keratin 1 (hk1)-based vectors (hk1.ras/fos, hk1.ras/alpha, and hk1.fos/alpha). |
2000-11-30 |
2023-08-12 |
mouse |
| H Langendijk, E Thunnissen, J W Arends, J de Jong, G ten Velde, R Lamers, D Guinee, J Holden, M Wouter. Cell proliferation and apoptosis in stage III inoperable non-small cell lung carcinoma treated by radiotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. vol 56. issue 2. 2000-11-03. PMID:10927139. |
the purpose of this study was to assess the prognostic value of the expression of p53 and bcl-2, the apoptotic index and the expression of topoisomerase ii alpha in patients with inoperable non-small cell lung cancer (nsclc) treated with high dose radiotherapy. |
2000-11-03 |
2023-08-12 |
Not clear |
| W Dempke, W Voigt, A Grothey, B T Hill, H J Schmol. Cisplatin resistance and oncogenes--a review. Anti-cancer drugs. vol 11. issue 4. 2000-10-31. PMID:10898536. |
mismatch repair, bcl-2, high mobility group proteins, dna polymerases alpha and beta, pcna, and insulin-like growth factor) are known to be regulated by the p53 oncoprotein. |
2000-10-31 |
2023-08-12 |
Not clear |
| K Nylander, P J Coates, P A Hal. Characterization of the expression pattern of p63 alpha and delta Np63 alpha in benign and malignant oral epithelial lesions. International journal of cancer. vol 87. issue 3. 2000-09-28. PMID:10897041. |
here we characterize the expression of p63 alpha/delta np63 alpha in benign and malignant lesions of the oral epithelium, using a specific antibody raised against a peptide derived from the c-terminus of p63 alpha, which does not cross-react with p53 or the other p53 homologue, p73. |
2000-09-28 |
2023-08-12 |
mouse |
| G R Star. Genetic analysis of interferon and other mammalian signaling pathways. Harvey lectures. vol 93. 2000-09-18. PMID:10941415. |
more recently, mutant cells unresponsive to double-stranded rna, tumor necrosis factor alpha (tnf-alpha), or interleukin-1 (il-1) have been isolated and characterized and a mutant line defective in expressing the tumor suppressor protein p53 has also been obtained. |
2000-09-18 |
2023-08-12 |
Not clear |
| I S Kim, D H Kim, S M Han, M U Chin, H J Nam, H P Cho, S Y Choi, B J Song, E R Kim, Y S Bae, Y H Moo. Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53. The Journal of biological chemistry. vol 275. issue 30. 2000-08-31. PMID:10930427. |
truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53. |
2000-08-31 |
2023-08-12 |
Not clear |
| I S Kim, D H Kim, S M Han, M U Chin, H J Nam, H P Cho, S Y Choi, B J Song, E R Kim, Y S Bae, Y H Moo. Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53. The Journal of biological chemistry. vol 275. issue 30. 2000-08-31. PMID:10930427. |
p53 contains putative nuclear localization signals (nlss) which would interact with a nuclear transport factor, importin alpha. |
2000-08-31 |
2023-08-12 |
Not clear |
| I S Kim, D H Kim, S M Han, M U Chin, H J Nam, H P Cho, S Y Choi, B J Song, E R Kim, Y S Bae, Y H Moo. Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53. The Journal of biological chemistry. vol 275. issue 30. 2000-08-31. PMID:10930427. |
in this report we demonstrate that importin alpha binds to nlsi in p53 and mediates the nuclear import of p53. |
2000-08-31 |
2023-08-12 |
Not clear |
| I S Kim, D H Kim, S M Han, M U Chin, H J Nam, H P Cho, S Y Choi, B J Song, E R Kim, Y S Bae, Y H Moo. Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53. The Journal of biological chemistry. vol 275. issue 30. 2000-08-31. PMID:10930427. |
reverse transcriptase-polymerase chain reaction and sequencing analyses showed that a truncated importin alpha deleted the region encoding the putative nls-binding domain of p53, suggesting that it could not bind to nlss of p53 proteins. |
2000-08-31 |
2023-08-12 |
Not clear |
| I S Kim, D H Kim, S M Han, M U Chin, H J Nam, H P Cho, S Y Choi, B J Song, E R Kim, Y S Bae, Y H Moo. Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53. The Journal of biological chemistry. vol 275. issue 30. 2000-08-31. PMID:10930427. |
binding of importin alpha to p53 was confirmed by using yeast two-hybrid assay. |
2000-08-31 |
2023-08-12 |
Not clear |
| I S Kim, D H Kim, S M Han, M U Chin, H J Nam, H P Cho, S Y Choi, B J Song, E R Kim, Y S Bae, Y H Moo. Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53. The Journal of biological chemistry. vol 275. issue 30. 2000-08-31. PMID:10930427. |
in truncated importin alpha expressing cells, p53 preferentially localized to cytoplasmic sites as well. |
2000-08-31 |
2023-08-12 |
Not clear |
| I S Kim, D H Kim, S M Han, M U Chin, H J Nam, H P Cho, S Y Choi, B J Song, E R Kim, Y S Bae, Y H Moo. Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53. The Journal of biological chemistry. vol 275. issue 30. 2000-08-31. PMID:10930427. |
these results strongly suggest that importin alpha functions as a component of the nls receptor for p53 and mediates nuclear import of p53. |
2000-08-31 |
2023-08-12 |
Not clear |
| P Perjési, Z Gyöngyi, Z Baye. Effect of E-2-(4'-methoxybenzylidene)-1-benzosuberone on the 7,12-dimethylbenz[alpha]anthracene-induced onco/suppressor gene action in vivo II: A 48-hour experiment. Anticancer research. vol 20. issue 3A. 2000-08-17. PMID:10928116. |
in order to determine whether this promising antineoplastic activity would extend to anticarcinogenic properties, the effect of mbb on the 7,12-dimethylbenz [alpha]anthracene (dmba)-induced expression of the c-myc, ha-ras and p53 genes in isolated rna from the liver, lung, kidney, spleen, thymus, lymph nodes and bone marrow of cba/ca inbred mice was investigated. |
2000-08-17 |
2023-08-12 |
mouse |