| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Feldman. [Apoptosis]. Annales pharmaceutiques francaises. vol 57. issue 4. 1999-10-07. PMID:10472702. |
cell integration of these new findings with regard to apoptosis is illustrated by the description of the apoptotic fas pathway, the mode of action of the proapoptotic cytokine tnf alpha and the analysis of the apoptosis mechanism when dna is damaged and when the p53 gene is overexpressed. |
1999-10-07 |
2023-08-12 |
human |
| K Ohmi, H Shinoura, Y Nakayama, N Goda, G Tsujimot. Characterization of alpha 1-adrenoceptors expressed in a novel vascular smooth muscle cell line cloned from p53 knockout mice, P53LMAC01 (AC01) cells. British journal of pharmacology. vol 127. issue 3. 1999-09-01. PMID:10401567. |
characterization of alpha 1-adrenoceptors expressed in a novel vascular smooth muscle cell line cloned from p53 knockout mice, p53lmac01 (ac01) cells. |
1999-09-01 |
2023-08-12 |
mouse |
| K Ohmi, H Shinoura, Y Nakayama, N Goda, G Tsujimot. Characterization of alpha 1-adrenoceptors expressed in a novel vascular smooth muscle cell line cloned from p53 knockout mice, P53LMAC01 (AC01) cells. British journal of pharmacology. vol 127. issue 3. 1999-09-01. PMID:10401567. |
we pharmacologically studied the alpha 1-adrenoceptor (ar) subtype(s) involved in receptor-mediated signalling in a novel vascular smooth muscle cell line cloned from p53 knockout mice, p53lmac01 (ac01) cells. |
1999-09-01 |
2023-08-12 |
mouse |
| E Bálint, S Bates, K H Vousde. Mdm2 binds p73 alpha without targeting degradation. Oncogene. vol 18. issue 27. 1999-08-17. PMID:10435614. |
we show here that like p53, p73 alpha forms an interaction with mdm2, both in vitro and in cells, but this does not result in the degradation of the p73 alpha protein. |
1999-08-17 |
2023-08-12 |
human |
| E Bálint, S Bates, K H Vousde. Mdm2 binds p73 alpha without targeting degradation. Oncogene. vol 18. issue 27. 1999-08-17. PMID:10435614. |
the human papillomavirus e6 protein also fails to degrade p73 alpha, suggesting that the mechanisms governing p73 alpha stability are distinct from those known to regulate p53 stability. |
1999-08-17 |
2023-08-12 |
human |
| R Kinscherf, M Wagner, H Kamencic, G A Bonaterra, D Hou, R A Schiele, H P Deigner, J Met. Characterization of apoptotic macrophages in atheromatous tissue of humans and heritable hyperlipidemic rabbits. Atherosclerosis. vol 144. issue 1. 1999-08-11. PMID:10381275. |
macrophages were immunohistochemically analyzed using antibodies directed against alphambeta2-integrins (cd11b/cd18), cd44, major histocompatibility complex (mhc) class i and ii, inducible nitric oxide synthase (inos), manganese superoxide dismutase (mnsod), tumor necrosis factor alpha (tnfalpha), p53, c-jun/ap-1 and rabbit macrophages (ram-11) and the tunel (tdt-mediated dutp nick end labeling) technique. |
1999-08-11 |
2023-08-12 |
human |
| P Rudolph, H Olsson, G Bonatz, V Ratjen, H Bolte, B Baldetorp, M Fernö, R Parwaresch, P Al. Correlation between p53, c-erbB-2, and topoisomerase II alpha expression, DNA ploidy, hormonal receptor status and proliferation in 356 node-negative breast carcinomas: prognostic implications. The Journal of pathology. vol 187. issue 2. 1999-06-23. PMID:10365096. |
correlation between p53, c-erbb-2, and topoisomerase ii alpha expression, dna ploidy, hormonal receptor status and proliferation in 356 node-negative breast carcinomas: prognostic implications. |
1999-06-23 |
2023-08-12 |
Not clear |
| P Rudolph, H Olsson, G Bonatz, V Ratjen, H Bolte, B Baldetorp, M Fernö, R Parwaresch, P Al. Correlation between p53, c-erbB-2, and topoisomerase II alpha expression, DNA ploidy, hormonal receptor status and proliferation in 356 node-negative breast carcinomas: prognostic implications. The Journal of pathology. vol 187. issue 2. 1999-06-23. PMID:10365096. |
the prognostic impact of p53, c-erbb-2, and topoisomerase ii alpha expression was investigated in relation to standard prognostic factors for carcinomas of the breast and to the tumour cell growth fraction. |
1999-06-23 |
2023-08-12 |
Not clear |
| P Rudolph, H Olsson, G Bonatz, V Ratjen, H Bolte, B Baldetorp, M Fernö, R Parwaresch, P Al. Correlation between p53, c-erbB-2, and topoisomerase II alpha expression, DNA ploidy, hormonal receptor status and proliferation in 356 node-negative breast carcinomas: prognostic implications. The Journal of pathology. vol 187. issue 2. 1999-06-23. PMID:10365096. |
paraffin-embedded specimens of 356 node-negative infiltrating ductal carcinomas were stained immunohistochemically using a polyclonal antiserum to c-erbb-2, and the monoclonal antibodies do-1 (p53), ki-s4 (topoisomerase ii alpha), and ki-s5 (ki-67). |
1999-06-23 |
2023-08-12 |
Not clear |
| P Rudolph, H Olsson, G Bonatz, V Ratjen, H Bolte, B Baldetorp, M Fernö, R Parwaresch, P Al. Correlation between p53, c-erbB-2, and topoisomerase II alpha expression, DNA ploidy, hormonal receptor status and proliferation in 356 node-negative breast carcinomas: prognostic implications. The Journal of pathology. vol 187. issue 2. 1999-06-23. PMID:10365096. |
both p53 and c-erbb-2 were significantly associated with high tumour grade, large tumour size, dna aneuploidy, lack of steroid hormone receptors, young age, and increased topoisomerase ii alpha and ki-67 expression levels. |
1999-06-23 |
2023-08-12 |
Not clear |
| M V Kat. The mechanisms of death of an erythroleukemic cell line by p53: involvement of the microtubule and mitochondria. Leukemia & lymphoma. vol 33. issue 1-2. 1999-06-16. PMID:10194136. |
the microtubule-severing associated with up-regulation of ef-1 alpha by p53 may be a cause of the cell death. |
1999-06-16 |
2023-08-12 |
human |
| R Dahiya, G Den. Molecular prognostic markers in breast cancer. Breast cancer research and treatment. vol 52. issue 1-3. 1999-04-29. PMID:10066082. |
possible molecular prognostic markers are: brca-1, brca-2, p53, erbb oncogenes, loss of heterozygosity (loh), chromosomal aberrations, microsatellite instability, transforming growth factor alpha (tgfalpha), and the multiple drug resistance (mdr) gene. |
1999-04-29 |
2023-08-12 |
Not clear |
| C Kühn, F Müller, C Melle, H P Nasheuer, F Janus, W Deppert, F Gross. Surface plasmon resonance measurements reveal stable complex formation between p53 and DNA polymerase alpha. Oncogene. vol 18. issue 3. 1999-03-16. PMID:9989827. |
surface plasmon resonance measurements reveal stable complex formation between p53 and dna polymerase alpha. |
1999-03-16 |
2023-08-12 |
human |
| A Saxena, L M Shriml, M Dean, I U Al. Comparative molecular genetic profiles of anaplastic astrocytomas/glioblastomas multiforme and their subsequent recurrences. Oncogene. vol 18. issue 6. 1999-03-03. PMID:10022821. |
these included loss of genes on chromosomes 17 and 10, mutations in the p53 gene, homozygous deletion of the dmbta1 and p16 and/ or p15 genes and amplification and/or overexpression of cdk4 and alpha form of the pdgf receptor. |
1999-03-03 |
2023-08-12 |
Not clear |
| P Tagliaferri, G Tortora, R Guarrasi, V Damiano, A Ruggiero, D Morelli, M Caraglia, R Bianco, G di Isernia, S Pepe, C L Arteaga, B C Langton-Webster, A R Bianco, F Ciardiell. Differential sensitivity to non-major histocompatibility complex-restricted recombinant interleukin 2-activated lymphocyte killing of human mammary epithelial MCF-10A cells overexpressing oncogenes or protein kinase A subunits. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 2. issue 1. 1999-02-10. PMID:9816108. |
therefore, the lysability of mcf-10a cells overexpressing activated oncogenes (ha-ras, erbb-2, and a mutated p53), growth factors [transforming growth factor alpha (tgfalpha)], or camp-dependent protein kinase a subunits (rialpha, riibeta, and calpha) was evaluated comparatively at different effector:target ratios by a 51cr release assay. |
1999-02-10 |
2023-08-12 |
mouse |
| M Dobbelstein, J Rot. The large T antigen of simian virus 40 binds and inactivates p53 but not p73. The Journal of general virology. vol 79 ( Pt 12). 1999-01-29. PMID:9880025. |
the p73 proteins alpha and beta were identified based on their similarity to the tumour suppressor gene product p53. |
1999-01-29 |
2023-08-12 |
Not clear |
| R H Wenger, G Camenisch, I Desbaillets, D Chilov, M Gassman. Up-regulation of hypoxia-inducible factor-1alpha is not sufficient for hypoxic/anoxic p53 induction. Cancer research. vol 58. issue 24. 1999-01-25. PMID:9865721. |
it has been proposed that the hypoxia-inducible factor-1 (hif-1) alpha subunit binds to p53 and protects it from proteasomal degradation. |
1999-01-25 |
2023-08-12 |
Not clear |
| K P De Jong, R Stellema, A Karrenbeld, J Koudstaal, A S Gouw, W J Sluiter, P M Peeters, M J Slooff, E G De Vrie. Clinical relevance of transforming growth factor alpha, epidermal growth factor receptor, p53, and Ki67 in colorectal liver metastases and corresponding primary tumors. Hepatology (Baltimore, Md.). vol 28. issue 4. 1998-11-05. PMID:9755233. |
to determine whether the expression of transforming growth factor alpha (tgf-alpha), its receptor (epidermal growth factor receptor [egfr]), p53 nuclear protein, and proliferation influences prognosis of patients with liver metastases, a study was performed in 45 liver metastases and 33 corresponding primary colorectal carcinomas in patients referred for liver surgery. |
1998-11-05 |
2023-08-12 |
Not clear |
| J L Cook, V Marcheselli, J Alam, P L Deininger, N G Baza. Temporal changes in gene expression following cryogenic rat brain injury. Brain research. Molecular brain research. vol 55. issue 1. 1998-10-09. PMID:9645955. |
the genes include thymidine kinase (tk), p53 tumor suppressor, c-fos, renin, myelin basic protein (mbp), proteolipid protein (plp), transferrin, transferrin receptor, platelet-derived growth factor a (pdgf a), platelet-derived growth factor b (pdgf b), platelet-derived growth factor receptor alpha (pdgf alpha receptor), platelet-derived growth factor receptor beta (pdgf beta receptor), glial fibrillary acidic protein (gfap), transforming growth factor-beta 1 (tgf-beta 1), basic fibroblast growth factor (bfgf), fibroblast growth factor receptor-1 (fgf-r1), insulin-like growth factor-1 (igf-1), and somatostatin. |
1998-10-09 |
2023-08-12 |
rat |
| M van Lookeren Campagne, R Gil. Tumor-suppressor p53 is expressed in proliferating and newly formed neurons of the embryonic and postnatal rat brain: comparison with expression of the cell cycle regulators p21Waf1/Cip1, p27Kip1, p57Kip2, p16Ink4a, cyclin G1, and the proto-oncogene Bax. The Journal of comparative neurology. vol 397. issue 2. 1998-09-25. PMID:9658283. |
p53, p27kip1, p16ink4a, and bax alpha mrna colocalized in the ventricular and subventricular zones at embryonic and early postnatal stages, but the distribution of p53 differed from that of its transcriptional targets cyclin g1 and p21waf1 and from that of the cyclin-dependent kinase inhibitor p57kip2, which were predominantly expressed in fully differentiated neurons. |
1998-09-25 |
2023-08-12 |
rat |