| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M R Kelley, L Cheng, R Foster, R Tritt, J Jiang, J Broshears, M Koc. Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 7. issue 4. 2001-06-14. PMID:11309329. |
a crucial step in the ber pathway involves the cleavage of baseless sites in dna by an apurinic/apyrimidinic or baseless (ap) endonuclease (ape1/ref-1), which is a multifunctional enzyme that acts not only as an ap endonuclease but also as a redox-modifying factor for a variety of transcription factors including fos, jun, paired box containing genes (pax), nuclear factor-kappab, hypoxia-inducible factor alpha (hif-1alpha), hif-like factor (hlf), p53, and others. |
2001-06-14 |
2023-08-12 |
Not clear |
| U Seitz, M Wagner, A T Vogg, G Glatting, B Neumaier, F R Greten, R M Schmid, S N Resk. In vivo evaluation of 5-[(18)F]fluoro-2'-deoxyuridine as tracer for positron emission tomography in a murine pancreatic cancer model. Cancer research. vol 61. issue 10. 2001-06-14. PMID:11358795. |
5-[(18)f]-2'-deoxyuridine ([(18)f]fdurd) was synthesized with >98% radiochemical purity and investigated in a pancreatic cancer model, transforming growth factor alpha transgenic mice crossbred to p53 deficient mice. |
2001-06-14 |
2023-08-12 |
mouse |
| D Deb, A Lanyi, M Scian, J Keiger, D R Brown, D Le Roith, S P Deb, S De. Differential modulation of cellular and viral promoters by p73 and p53. International journal of oncology. vol 18. issue 2. 2001-05-24. PMID:11172610. |
however, wild-type p53, p73 alpha and p73 beta differ in their ability to inhibit transcriptional activity of different promoters. |
2001-05-24 |
2023-08-12 |
human |
| D Deb, A Lanyi, M Scian, J Keiger, D R Brown, D Le Roith, S P Deb, S De. Differential modulation of cellular and viral promoters by p73 and p53. International journal of oncology. vol 18. issue 2. 2001-05-24. PMID:11172610. |
while wild-type p53 inhibits the promoters of the human cytomegalovirus (cmv) immediate-early gene, the long terminal repeat of human immunodeficiency virus type 1 (hiv ltr), human cyclin a (cyc a) gene, and insulin-like growth factor receptor i (igf-i-r), p73 alpha only inhibits the hiv ltr and cyc a promoters significantly; and p73 beta inhibits the cmv, hiv ltr and cyc a promoters. |
2001-05-24 |
2023-08-12 |
human |
| D Deb, A Lanyi, M Scian, J Keiger, D R Brown, D Le Roith, S P Deb, S De. Differential modulation of cellular and viral promoters by p73 and p53. International journal of oncology. vol 18. issue 2. 2001-05-24. PMID:11172610. |
interestingly, p73 alpha transactivates the igf-i-r promoter, which is inhibited by wild-type p53; p73 beta has no significant effect on this promoter. |
2001-05-24 |
2023-08-12 |
human |
| D Deb, A Lanyi, M Scian, J Keiger, D R Brown, D Le Roith, S P Deb, S De. Differential modulation of cellular and viral promoters by p73 and p53. International journal of oncology. vol 18. issue 2. 2001-05-24. PMID:11172610. |
this is a unique situation where p73 alpha differs from p73 beta as well as p53. |
2001-05-24 |
2023-08-12 |
human |
| J Gil, M Esteba. Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action. Apoptosis : an international journal on programmed cell death. vol 5. issue 2. 2001-05-03. PMID:11232238. |
pkr inhibits translation initiation through the phosphorylation of the alpha subunit of the initiation factor eif-2 (eif-2 alpha) and also controls the activation of several transcription factors such as nf-kappa b, p53, or stats. |
2001-05-03 |
2023-08-12 |
Not clear |
| E A Ratovitski, M Patturajan, K Hibi, B Trink, K Yamaguchi, D Sidransk. p53 associates with and targets Delta Np63 into a protein degradation pathway. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172034. |
overexpression of wild type but not mutant (r175h) p53 results in the caspase-dependent degradation of certain delta np63 proteins (p40 and delta np63 alpha). |
2001-04-19 |
2023-08-12 |
mouse |
| J Shou, Y Zhang, D W. Molecular alteration of alpha-induced transformed Syrian hamster embryo cells. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih. vol 12. issue 1. 2001-04-19. PMID:11243103. |
these results imply that activation of h-ras and c-myc genes coupled with inactivation of p53 tumor suppressor gene play important role in alpha particle-induced cell transformation. |
2001-04-19 |
2023-08-12 |
Not clear |
| D Gupta, J Holden, L Layfiel. Topoisomerase alpha II, retinoblastoma gene product, and p53: potential relationships with aggressive behavior and malignant transformation in recurrent respiratory papillomatosis. Applied immunohistochemistry & molecular morphology : AIMM. vol 9. issue 1. 2001-04-19. PMID:11277421. |
topoisomerase alpha ii, retinoblastoma gene product, and p53: potential relationships with aggressive behavior and malignant transformation in recurrent respiratory papillomatosis. |
2001-04-19 |
2023-08-12 |
Not clear |
| D Gupta, J Holden, L Layfiel. Topoisomerase alpha II, retinoblastoma gene product, and p53: potential relationships with aggressive behavior and malignant transformation in recurrent respiratory papillomatosis. Applied immunohistochemistry & molecular morphology : AIMM. vol 9. issue 1. 2001-04-19. PMID:11277421. |
we investigated by immunohistochemistry expressions of topoisomerase alpha ii, mib-1, p53, p21, e-cadherin, retinoblastoma (rb) gene protein product, her-2/neu, and steroid hormone receptors in a case of juvenile respiratory papillomatosis with malignant transformation to determine whether these markers are associated with malignant transformation. |
2001-04-19 |
2023-08-12 |
Not clear |
| D Gupta, J Holden, L Layfiel. Topoisomerase alpha II, retinoblastoma gene product, and p53: potential relationships with aggressive behavior and malignant transformation in recurrent respiratory papillomatosis. Applied immunohistochemistry & molecular morphology : AIMM. vol 9. issue 1. 2001-04-19. PMID:11277421. |
increased staining was found in areas of invasive papillomatosis for topoisomerase alpha ii, p53, and mib-1, with highest labeling indices in areas of squamous carcinoma. |
2001-04-19 |
2023-08-12 |
Not clear |
| D Gupta, J Holden, L Layfiel. Topoisomerase alpha II, retinoblastoma gene product, and p53: potential relationships with aggressive behavior and malignant transformation in recurrent respiratory papillomatosis. Applied immunohistochemistry & molecular morphology : AIMM. vol 9. issue 1. 2001-04-19. PMID:11277421. |
increased topoisomerase alpha ii and p53 expression along with reduced rb gene protein product and p21 expression may serve as markers of transformation to invasive papillomatosis and squamous carcinoma. |
2001-04-19 |
2023-08-12 |
Not clear |
| C Gaiddon, M Lokshin, J Ahn, T Zhang, C Prive. A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Molecular and cellular biology. vol 21. issue 5. 2001-04-12. PMID:11238924. |
we and others have discovered previously that certain tumor-derived mutants of p53 can associate and inhibit transcriptional activation by the alpha and beta isoforms of p73. |
2001-04-12 |
2023-08-12 |
Not clear |
| C Gaiddon, M Lokshin, J Ahn, T Zhang, C Prive. A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Molecular and cellular biology. vol 21. issue 5. 2001-04-12. PMID:11238924. |
in this study we have extended these observations to show that in transfected cells a number of mutant p53 proteins could bind and down-regulate several isoforms not only of p73 (p73 alpha, -beta, -gamma, and -delta) but also of p63 (p63 alpha and -gamma; delta np63 alpha and -gamma). |
2001-04-12 |
2023-08-12 |
Not clear |
| S Saji, N Okumura, H Eguchi, S Nakashima, A Suzuki, M Toi, Y Nozawa, S Saji, S Hayash. MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells. Biochemical and biophysical research communications. vol 281. issue 1. 2001-04-05. PMID:11178989. |
overexpression of the oncoprotein mdm2, a negative feedback regulator of p53, is often observed in breast cancer tissue and cell lines, particularly in those which express estrogen receptor alpha (eralpha). |
2001-04-05 |
2023-08-12 |
human |
| B Bode-Lesniewska, J Zhao, E J Speel, A M Biraima, M Turina, P Komminoth, P U Heit. Gains of 12q13-14 and overexpression of mdm2 are frequent findings in intimal sarcomas of the pulmonary artery. Virchows Archiv : an international journal of pathology. vol 438. issue 1. 2001-03-15. PMID:11213836. |
focal positivity was observed for alpha smooth muscle actin, cd117, cd68, p53, and bcl2. |
2001-03-15 |
2023-08-12 |
Not clear |
| F A Mulder, A Ayed, D Yang, C H Arrowsmith, L E Ka. Assignment of 1H(N), 15N, 13C(alpha), 13CO and 13C(beta) resonances in a 67 kDa p53 dimer using 4D-TROSY NMR spectroscopy. Journal of biomolecular NMR. vol 18. issue 2. 2001-03-08. PMID:11101222. |
assignment of 1h(n), 15n, 13c(alpha), 13co and 13c(beta) resonances in a 67 kda p53 dimer using 4d-trosy nmr spectroscopy. |
2001-03-08 |
2023-08-12 |
Not clear |
| D Gupta, V Shidham, J Holden, L Layfiel. Prognostic value of immunohistochemical expression of topoisomerase alpha II, MIB-1, p53, E-cadherin, retinoblastoma gene protein product, and HER-2/neu in adrenal and extra-adrenal pheochromocytomas. Applied immunohistochemistry & molecular morphology : AIMM. vol 8. issue 4. 2001-03-01. PMID:11127918. |
prognostic value of immunohistochemical expression of topoisomerase alpha ii, mib-1, p53, e-cadherin, retinoblastoma gene protein product, and her-2/neu in adrenal and extra-adrenal pheochromocytomas. |
2001-03-01 |
2023-08-12 |
Not clear |
| D Gupta, V Shidham, J Holden, L Layfiel. Prognostic value of immunohistochemical expression of topoisomerase alpha II, MIB-1, p53, E-cadherin, retinoblastoma gene protein product, and HER-2/neu in adrenal and extra-adrenal pheochromocytomas. Applied immunohistochemistry & molecular morphology : AIMM. vol 8. issue 4. 2001-03-01. PMID:11127918. |
overexpression of topoisomerase ii alpha and mib-1 and loss of rb protein product were more common in malignant lesions, whereas p53, e-cadherin, and her-2/neu do not seem to have diagnostic utility in the prediction of biologic behavior in these neoplasms. |
2001-03-01 |
2023-08-12 |
Not clear |