| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Drané, V Leblanc, F Miro-Mur, R Saffroy, B Debuire, E Ma. Accumulation of an inactive form of p53 protein in cells treated with TNF alpha. Cell death and differentiation. vol 9. issue 5. 2002-08-28. PMID:11973611. |
this assumption was further supported by the following observations: (i) the p53 dna-binding activity to its consensus sequence was not stimulated following tnf alpha treatment, (ii) phosphorylation at ser-15, -20 or -392 was not detected in response to tnf alpha, (iii) the transcription rate of ddb2, another p53 target gene, was not stimulated by tnf alpha. |
2002-08-28 |
2023-08-12 |
Not clear |
| Len Necker. Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends in molecular medicine. vol 8. issue 4 Suppl. 2002-08-19. PMID:11927289. |
hsp90 client proteins include mutated p53, bcr-abl, raf-1, akt, erbb2 and hypoxia-inducible factor 1 alpha (hif-1 alpha). |
2002-08-19 |
2023-08-12 |
Not clear |
| Kalpana Ballal, Wei Zhang, Tapas Mukhopadyay, Peng Huan. Suppression of mismatched mutation by p53: a mechanism for guarding genomic integrity. Journal of molecular medicine (Berlin, Germany). vol 80. issue 1. 2002-08-07. PMID:11862321. |
the 3'-->5' exonuclease activity of p53 has recently been recognized as a novel biochemical function of this molecule, and has been shown to preferentially excise mismatched nucleotides from dna and enhance the dna replication fidelity of polymerase alpha in vitro. |
2002-08-07 |
2023-08-12 |
Not clear |
| Ravid Sasson, Neomi Winder, Salem Kees, Abraham Amsterda. Induction of apoptosis in granulosa cells by TNF alpha and its attenuation by glucocorticoids involve modulation of Bcl-2. Biochemical and biophysical research communications. vol 294. issue 1. 2002-07-22. PMID:12054739. |
induction of apoptosis and suppression of steroidogenesis by tnf alpha in primary preovulatory rat and human granulosa cells, as well as, in human granulosa cells immortalized by mutated p53, were characterized in the present work. |
2002-07-22 |
2023-08-12 |
human |
| Tahsin Yakut, Ahmet Bekar, Muammer Doygun, Hasan Acar, Unal Egeli, Erhan Ogu. Evaluation of relationship between chromosome 22 and p53 gene alterations and the subtype of meningiomas by the interphase-FISH technique. Teratogenesis, carcinogenesis, and mutagenesis. vol 22. issue 3. 2002-06-10. PMID:11948632. |
thirty-four meningiomas (23 typical and 11 aggressive) were examined by application of fluorescence in situ hybridization (fish) with chromosome 22 specific alpha satellite probe and a combination of p53 locus specific and chromosome 17 centromere specific alpha satellite probes, to evaluate the chromosome 22 aneuploidy and gain or loss of p53 gene along with chromosome 17. |
2002-06-10 |
2023-08-12 |
Not clear |
| Staffan Strömblad, Arun Fotedar, Howard Brickner, Chandra Theesfeld, Edith Aguilar de Diaz, Martin Friedlander, David A Cheres. Loss of p53 compensates for alpha v-integrin function in retinal neovascularization. The Journal of biological chemistry. vol 277. issue 16. 2002-06-07. PMID:11856728. |
loss of p53 compensates for alpha v-integrin function in retinal neovascularization. |
2002-06-07 |
2023-08-12 |
mouse |
| Staffan Strömblad, Arun Fotedar, Howard Brickner, Chandra Theesfeld, Edith Aguilar de Diaz, Martin Friedlander, David A Cheres. Loss of p53 compensates for alpha v-integrin function in retinal neovascularization. The Journal of biological chemistry. vol 277. issue 16. 2002-06-07. PMID:11856728. |
given that blockade of alpha(v)-integrins during angiogenesis induces p53 activity, we utilized p53 null mice to elucidate whether loss of p53 can compensate for alpha(v)-integrin function in neovascularization of the retina. |
2002-06-07 |
2023-08-12 |
mouse |
| Staffan Strömblad, Arun Fotedar, Howard Brickner, Chandra Theesfeld, Edith Aguilar de Diaz, Martin Friedlander, David A Cheres. Loss of p53 compensates for alpha v-integrin function in retinal neovascularization. The Journal of biological chemistry. vol 277. issue 16. 2002-06-07. PMID:11856728. |
in contrast, mice lacking p53 were refractory to this treatment, indicating that neovascularization in normal mice depends on alpha(v)-integrin-mediated suppression of p53. |
2002-06-07 |
2023-08-12 |
mouse |
| Staffan Strömblad, Arun Fotedar, Howard Brickner, Chandra Theesfeld, Edith Aguilar de Diaz, Martin Friedlander, David A Cheres. Loss of p53 compensates for alpha v-integrin function in retinal neovascularization. The Journal of biological chemistry. vol 277. issue 16. 2002-06-07. PMID:11856728. |
blockade of alpha(v)-integrins during neovascularization resulted in an induction of p21(cip1) in wild type and, surprisingly, in p53 null retinas, indicating that alpha(v)-integrin ligation regulates p21(cip1) levels in a p53-independent manner. |
2002-06-07 |
2023-08-12 |
mouse |
| Staffan Strömblad, Arun Fotedar, Howard Brickner, Chandra Theesfeld, Edith Aguilar de Diaz, Martin Friedlander, David A Cheres. Loss of p53 compensates for alpha v-integrin function in retinal neovascularization. The Journal of biological chemistry. vol 277. issue 16. 2002-06-07. PMID:11856728. |
in conclusion, we demonstrate for the first time an in vivo intracellular mechanism for compensation of integrin function and that p53 and alpha(v)-integrins act in concert during retinal neovascularization. |
2002-06-07 |
2023-08-12 |
mouse |
| Chitra Subramanian, Sameez Hasan, Martin Rowe, Michael Hottiger, Rama Orre, Erle S Robertso. Epstein-Barr virus nuclear antigen 3C and prothymosin alpha interact with the p300 transcriptional coactivator at the CH1 and CH3/HAT domains and cooperate in regulation of transcription and histone acetylation. Journal of virology. vol 76. issue 10. 2002-06-07. PMID:11967287. |
in this report we show that prot(alpha) interacts with p300 similarly to p53 and other known oncoproteins at the ch1 amino-terminal domain as well as at a second domain downstream of the bromodomain which includes the ch3 region and hat domain. |
2002-06-07 |
2023-08-12 |
human |
| Francisco N Barrera, María T Garzón, Javier Gómez, José L Neir. Equilibrium unfolding of the C-terminal SAM domain of p73. Biochemistry. vol 41. issue 18. 2002-05-23. PMID:11980478. |
the alpha splice variant of p73 (p73 alpha), a homologue of the tumor suppressor p53, has close to its c-terminus a sam motif. |
2002-05-23 |
2023-08-12 |
Not clear |
| Kathryn Jessen-Eller, Jill A Kreiling, Gail S Begley, Marjorie E Steele, Charles W Walker, Raymond E Stephens, Carol L Reinisc. A new invertebrate member of the p53 gene family is developmentally expressed and responds to polychlorinated biphenyls. Environmental health perspectives. vol 110. issue 4. 2002-05-14. PMID:11940455. |
the predicted protein, p120, resembles p53 across all evolutionarily conserved regions and contains a c-terminal extension with a sterile alpha motif (sam) as in p63 and p73. |
2002-05-14 |
2023-08-12 |
Not clear |
| Kiyoko Kato, Shinji Horiuchi, Akira Takahashi, Yousuke Ueoka, Takahiro Arima, Takao Matsuda, Hidenori Kato, Jun-ichi Nishida Ji, Yusaku Nakabeppu, Norio Wak. Contribution of estrogen receptor alpha to oncogenic K-Ras-mediated NIH3T3 cell transformation and its implication for escape from senescence by modulating the p53 pathway. The Journal of biological chemistry. vol 277. issue 13. 2002-05-10. PMID:11781307. |
contribution of estrogen receptor alpha to oncogenic k-ras-mediated nih3t3 cell transformation and its implication for escape from senescence by modulating the p53 pathway. |
2002-05-10 |
2023-08-12 |
Not clear |
| T Sawai, A Nanashima, T Tsuji, H Yamaguchi, T Yasutake, T Nakagoe, H Ayabe, Y Tagaw. Instability of chromosome 17 and the p53 locus in non-familial colorectal cancer with multiple primary malignancies. Journal of experimental & clinical cancer research : CR. vol 20. issue 3. 2002-05-02. PMID:11718221. |
to examine the association among chromosomal instability and multiple primary malignancies (mpm) in colorectal cancer, fluorescence in situ hybridization using a chromosome 17-specific probe, p53 cosmid probe, and/or an alpha satellite dna probe was performed in 184 patients with colorectal cancer. |
2002-05-02 |
2023-08-12 |
Not clear |
| D Gupta, V Shidham, J Holden, L Layfiel. Value of topoisomerase II alpha, MIB-1, p53, E-cadherin, retinoblastoma gene protein product, and HER-2/neu immunohistochemical expression for the prediction of biologic behavior in adrenocortical neoplasms. Applied immunohistochemistry & molecular morphology : AIMM. vol 9. issue 3. 2002-02-13. PMID:11556748. |
in the current article, the authors evaluated a set of molecular markers (topoisomerase ii alpha (topo ii alpha), mib-1, p53, human epithelial cadherin (e-cadherin), retinoblastoma gene protein product, and her-2/neu) and correlated their expression with histologic diagnosis and clinical outcome. |
2002-02-13 |
2023-08-12 |
human |
| Y Yasuoka, Y Naomoto, T Yamatsuji, M Takaoka, M Kimura, H Uetsuka, N Matsubara, T Fujiwara, M Gunduz, N Tanaka, M Hais. Combination of tumor necrosis factor alpha and interferon alpha induces apoptotic cell death through a c-myc-dependent pathway in p53 mutant H226br non-small-cell lung cancer cell line. Experimental cell research. vol 271. issue 2. 2002-01-11. PMID:11716533. |
combination of tumor necrosis factor alpha and interferon alpha induces apoptotic cell death through a c-myc-dependent pathway in p53 mutant h226br non-small-cell lung cancer cell line. |
2002-01-11 |
2023-08-12 |
human |
| Y Yasuoka, Y Naomoto, T Yamatsuji, M Takaoka, M Kimura, H Uetsuka, N Matsubara, T Fujiwara, M Gunduz, N Tanaka, M Hais. Combination of tumor necrosis factor alpha and interferon alpha induces apoptotic cell death through a c-myc-dependent pathway in p53 mutant H226br non-small-cell lung cancer cell line. Experimental cell research. vol 271. issue 2. 2002-01-11. PMID:11716533. |
we investigated the role of wild-type p53 and c-myc activity in apoptosis induced by a combination of natural human tumor necrosis factor alpha (tnf-alpha) and natural human interferon alpha (ifn-alpha). |
2002-01-11 |
2023-08-12 |
human |
| A L Scovassi, N S Pellegata, L Di Stefano, L Padovan, C Negri, E Prosperi, F Riva, M Ciomei, G N Ranzan. Effects of topoisomerase II inhibitors on gastric cancer cells characterized by different genetic lesions. Anticancer research. vol 21. issue 4A. 2001-12-07. PMID:11724358. |
we characterised mkn74 and mkn28 cells for p53 gene status and for the expression of p53 and p21 proteins, as well as of topoisomerase ii alpha and beta isoforms. |
2001-12-07 |
2023-08-12 |
Not clear |
| P Lindgren, T Bäckström, C G Mählck, M Ridderheim, S Cajande. Steroid receptors and hormones in relation to cell proliferation and apoptosis in poorly differentiated epithelial ovarian tumors. International journal of oncology. vol 19. issue 1. 2001-08-23. PMID:11408919. |
serum progesterone concentration, the immunohistochemical expression of estrogen receptor alpha (er), progesterone receptor a/b (pr), ki-67, bcl-2, p53, apoptosis and morphology were determined in 33 patients, all with poorly differentiated surface epithelial ovarian tumors of different types. |
2001-08-23 |
2023-08-12 |
Not clear |