| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Goldschneider, Etienne Blanc, Gilda Raguénez, Michel Barrois, Agnès Legrand, Gwenaëlle Le Roux, Hedi Haddada, Jean Bénard, Sétha Douc-Ras. Differential response of p53 target genes to p73 overexpression in SH-SY5Y neuroblastoma cell line. Journal of cell science. vol 117. issue Pt 2. 2004-06-10. PMID:14676279. |
p73, the first p53 gene homologue, encodes an array of p73 proteins including p73 alpha full-length (tap73 alpha) and amino-truncated isoforms (delta np73 alpha), two proteins with opposite biological functions. |
2004-06-10 |
2023-08-12 |
human |
| David Goldschneider, Etienne Blanc, Gilda Raguénez, Michel Barrois, Agnès Legrand, Gwenaëlle Le Roux, Hedi Haddada, Jean Bénard, Sétha Douc-Ras. Differential response of p53 target genes to p73 overexpression in SH-SY5Y neuroblastoma cell line. Journal of cell science. vol 117. issue Pt 2. 2004-06-10. PMID:14676279. |
tap73 alpha can induce tumor suppressive properties, while delta np73 alpha antagonizes p53 as well as tap73 in a dominant-negative manner. |
2004-06-10 |
2023-08-12 |
human |
| David Goldschneider, Etienne Blanc, Gilda Raguénez, Michel Barrois, Agnès Legrand, Gwenaëlle Le Roux, Hedi Haddada, Jean Bénard, Sétha Douc-Ras. Differential response of p53 target genes to p73 overexpression in SH-SY5Y neuroblastoma cell line. Journal of cell science. vol 117. issue Pt 2. 2004-06-10. PMID:14676279. |
data indicate that (i) both ta- and delta n-p73 alpha enhance p53 protein level in sh-sy5y cells, whereas level remains unchanged in igr-n-91 cells; (ii) only in sh-sy5y cells does forced tap73 alpha overexpression markedly induce nuclear accumulation of p53 protein; (iii) p21 protein expression is increased in both cell lines infected with tap73, suggesting that, in igr-n-91 cells, p21 is induced by p73 through a p53-independent pathway; (iv) in the shsy5y cell line, btg2 expression is strongly enhanced in cells overexpressing ta, and to a lesser extent in cells overexpressing delta n. taken together our results suggest that tap73 may restore p53 function in nb with wild-type nonfunctional p53, but not in nb with mutated p53. |
2004-06-10 |
2023-08-12 |
human |
| M B Martin, S V Angeloni, P Garcia-Morales, P F Sholler, M D Castro-Galache, J A Ferragut, M Saced. Regulation of estrogen receptor-alpha expression in MCF-7 cells by taxol. The Journal of endocrinology. vol 180. issue 3. 2004-05-27. PMID:15012603. |
evidence is presented that the effects of taxol on er alpha gene transcription may be mediated through the induction of p53. |
2004-05-27 |
2023-08-12 |
human |
| S V Angeloni, M B Martin, P Garcia-Morales, M D Castro-Galache, J A Ferragut, M Saced. Regulation of estrogen receptor-alpha expression by the tumor suppressor gene p53 in MCF-7 cells. The Journal of endocrinology. vol 180. issue 3. 2004-05-27. PMID:15012604. |
the results presented here demonstrate that p53 upregulates estrogen receptor-alpha (er alpha) expression in the human breast cancer cell line mcf-7. |
2004-05-27 |
2023-08-12 |
human |
| S V Angeloni, M B Martin, P Garcia-Morales, M D Castro-Galache, J A Ferragut, M Saced. Regulation of estrogen receptor-alpha expression by the tumor suppressor gene p53 in MCF-7 cells. The Journal of endocrinology. vol 180. issue 3. 2004-05-27. PMID:15012604. |
in the stable clones, expression of antisense p53 resulted in a decrease in the expression of er alpha protein. |
2004-05-27 |
2023-08-12 |
human |
| S V Angeloni, M B Martin, P Garcia-Morales, M D Castro-Galache, J A Ferragut, M Saced. Regulation of estrogen receptor-alpha expression by the tumor suppressor gene p53 in MCF-7 cells. The Journal of endocrinology. vol 180. issue 3. 2004-05-27. PMID:15012604. |
overexpression of p53 increased the amount of er alpha. |
2004-05-27 |
2023-08-12 |
human |
| S V Angeloni, M B Martin, P Garcia-Morales, M D Castro-Galache, J A Ferragut, M Saced. Regulation of estrogen receptor-alpha expression by the tumor suppressor gene p53 in MCF-7 cells. The Journal of endocrinology. vol 180. issue 3. 2004-05-27. PMID:15012604. |
to determine whether the effects of p53 on the expression of er alpha were due to changes in transcription, deletion mutants of the er alpha promoter were used. |
2004-05-27 |
2023-08-12 |
human |
| S V Angeloni, M B Martin, P Garcia-Morales, M D Castro-Galache, J A Ferragut, M Saced. Regulation of estrogen receptor-alpha expression by the tumor suppressor gene p53 in MCF-7 cells. The Journal of endocrinology. vol 180. issue 3. 2004-05-27. PMID:15012604. |
this experimental approach demonstrated that p53 up-regulates er alpha gene expression by increasing transcription of the gene through elements located upstream of promoter a. transfection assays using p53 mutants further demonstrated that the p53-induced increase in er alpha gene transcription was not dependent on the ability of p53 to bind to dna but on its ability to interact with other proteins. |
2004-05-27 |
2023-08-12 |
human |
| Michael J Clemen. Targets and mechanisms for the regulation of translation in malignant transformation. Oncogene. vol 23. issue 18. 2004-05-06. PMID:15094767. |
this review will describe recent aspects of the mechanisms involved, with particular emphasis on the regulation of the eif2 alpha kinase pkr and the control of 4e-bp phosphorylation by viral gene products, growth-inhibitory cytokines and the tumour-suppressor protein p53. |
2004-05-06 |
2023-08-12 |
Not clear |
| Young Ik Lee, Yoo Jung Han, Soo Young Lee, Yoon Ik Lee, Sook Kyung Park, Youn Jung Park, Hyung Bae Moon, Jeh Hoon Shin, Je Ho Le. Activation of insulin-like growth factor II signaling by mutant type p53: physiological implications for potentiation of IGF-II signaling by p53 mutant 249. Molecular and cellular endocrinology. vol 203. issue 1-2. 2004-04-30. PMID:12782403. |
p53mt249 enhanced igf-ii dependent igf-ir signaling in p53 negative hep3b hepatoma cells which were specifically prevented by igf-ir antibody, alpha ir3 and lovastin. |
2004-04-30 |
2023-08-12 |
Not clear |
| Anirban Maitra, N Volkan Adsay, Pedram Argani, Christine Iacobuzio-Donahue, Angelo De Marzo, John L Cameron, Charles J Yeo, Ralph H Hruba. Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 16. issue 9. 2004-04-29. PMID:13679454. |
the protein products of 14 genes encompassing a variety of functional classes, such as tumor suppressor genes (p53, smad4/dpc4), oncogenes (beta-catenin), cell cycle antigens (p16, cyclin d1), proliferation antigens (ki-67, topoisomerase ii alpha), and epithelial apomucins (muc1, muc2, muc5), as well as "novel" genes described as differentially up-regulated in invasive pancreas cancer by global microarray expression analysis (mesothelin, prostate stem cell antigen, fascin, and 14-3-3varsigma), were analyzed by immunohistochemistry on the panin tissue microarray. |
2004-04-29 |
2023-08-12 |
Not clear |
| Takamune Shibaji, Mitsuo Nagao, Naoya Ikeda, Hiromichi Kanehiro, Michiyoshi Hisanaga, Saiho Ko, Akihisa Fukumoto, Yoshiyuki Nakajim. Prognostic significance of HIF-1 alpha overexpression in human pancreatic cancer. Anticancer research. vol 23. issue 6C. 2004-04-01. PMID:14981919. |
the aim of this study was to investigate the impact of hif-1 alpha expression on clinicopathological factors and to clarify whether or not hif-1 alpha is correlated with angiogenesis and mutation of p53 in pancreatic cancer. |
2004-04-01 |
2023-08-12 |
human |
| Yasushi Sasaki, Hiroaki Mita, Minoru Toyota, Setsuko Ishida, Ichiro Morimoto, Toshiharu Yamashita, Toshihiro Tanaka, Kohzoh Imai, Yusuke Nakamura, Takashi Tokin. Identification of the interleukin 4 receptor alpha gene as a direct target for p73. Cancer research. vol 63. issue 23. 2004-02-27. PMID:14678968. |
here, we found that the interleukin 4 receptor alpha (il-4ralpha) gene is up-regulated by p73 but not significantly by p53 in several human cancer cell lines. |
2004-02-27 |
2023-08-12 |
mouse |
| Francisco N Barrera, José A Poveda, José M González-Ros, José L Neir. Binding of the C-terminal sterile alpha motif (SAM) domain of human p73 to lipid membranes. The Journal of biological chemistry. vol 278. issue 47. 2004-02-03. PMID:12954612. |
the alpha splice variant of p73 (p73alpha), a homologue of the tumor suppressor p53, has close to its c terminus a sterile alpha motif (sam), samp73, that is thought to be involved in protein-protein interactions. |
2004-02-03 |
2023-08-12 |
human |
| Mihaela M Mocanu, Derek M Yello. p53 down-regulation: a new molecular mechanism involved in ischaemic preconditioning. FEBS letters. vol 555. issue 2. 2004-01-13. PMID:14644432. |
furthermore, pifithrin alpha (a p53 inhibitor), administered to isolated perfused hearts prior to ischaemia, significantly attenuated the infarction. |
2004-01-13 |
2023-08-12 |
Not clear |
| S A Maxwell, S A Acosta, G E Davi. Induction and alternative splicing of the Bax gene mediated by p53 in a transformed endothelial cell line. Apoptosis : an international journal on programmed cell death. vol 4. issue 2. 2003-12-23. PMID:14634288. |
surprisingly, bax alpha expression was reduced several-fold in ecv-304 endothelial cells overproducing p53 and no change in bax alpha was detected in huvec cells after induction of p53. |
2003-12-23 |
2023-08-12 |
human |
| S A Maxwell, S A Acosta, G E Davi. Induction and alternative splicing of the Bax gene mediated by p53 in a transformed endothelial cell line. Apoptosis : an international journal on programmed cell death. vol 4. issue 2. 2003-12-23. PMID:14634288. |
bax alpha was the predominant species expressed in normal human endothelial cells but, in contrast to the immortalized ecv-304 endothelial cell line, induction of p53 failed to alter the expression of bax alpha or to induce any other bax transcripts. |
2003-12-23 |
2023-08-12 |
human |
| T Arnould, L Mercy, A Houbion, S Vankoningsloo, P Renard, T Pascal, N Ninane, C Demazy, M Rae. mtCLIC is up-regulated and maintains a mitochondrial membrane potential in mtDNA-depleted L929 cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 14. 2003-12-09. PMID:12958156. |
we showed that its expression is dependent on creb and p53 and is sensitive to calcium and tumor necrosis factor alpha. |
2003-12-09 |
2023-08-12 |
Not clear |
| A Amsterdam, R Sasson, I Keren-Tal, D Aharoni, A Dantes, E Rimon, A Land, T Cohen, Y Dor, L Hirs. Alternative pathways of ovarian apoptosis: death for life. Biochemical pharmacology. vol 66. issue 8. 2003-11-20. PMID:14555209. |
in contrast, we found that it is elevated for up to 24hr following the onset of the apoptotic stimuli exerted by starvation, camp, p53 or tumor necrosis factor alpha stimulation, before total cell collapse. |
2003-11-20 |
2023-08-12 |
human |