| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anatol Panasiuk, Danuta Prokopowicz, Janusz Dziecio. p53 protein expression in chronic hepatitis C; effect of interferon alpha 2b therapy. Hepato-gastroenterology. vol 52. issue 64. 2005-08-04. PMID:16001656. |
p53 protein expression in chronic hepatitis c; effect of interferon alpha 2b therapy. |
2005-08-04 |
2023-08-12 |
Not clear |
| Anatol Panasiuk, Danuta Prokopowicz, Janusz Dziecio. p53 protein expression in chronic hepatitis C; effect of interferon alpha 2b therapy. Hepato-gastroenterology. vol 52. issue 64. 2005-08-04. PMID:16001656. |
the aim of the study was the evaluation of protein p53 expression on hepatocytes in chronic hepatitis c regarding inflammatory activity and fibrosis as well as the influence of interferon alpha 2b (ifnalpha2b) on gene p53 activity. |
2005-08-04 |
2023-08-12 |
Not clear |
| Mary Jo Atten, Ernesto Godoy-Romero, Bashar M Attar, Thomas Milson, Matthew Zopel, Oksana Holia. Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells. Investigational new drugs. vol 23. issue 2. 2005-06-14. PMID:15744586. |
here we demonstrate that treatment of gastric adenocarcinoma snu-1 cells with resveratrol results in time and concentration dependent accumulation of tumor suppressors p21(cip1/waf-1) and p53 and is preceded by loss of membrane-associated pkc delta protein and a concomitant increase in cytosolic pkc alpha. |
2005-06-14 |
2023-08-12 |
Not clear |
| Caroline A Lamb, Victoria Fabris, María Alicia Gorostiaga, Luisa A Helguero, Alejo Efeyan, María Cecilia Bottino, Marina Simian, Rocío Soldati, Norberto Sanjuan, Alfredo Molinolo, Claudia Lanar. Isolation of a stromal cell line from an early passage of a mouse mammary tumor line: a model for stromal parenchymal interactions. Journal of cellular physiology. vol 202. issue 3. 2005-04-07. PMID:15389583. |
they expressed mutated p53 and estrogen receptors alpha; progesterone receptors were undetectable. |
2005-04-07 |
2023-08-12 |
mouse |
| Dalit May, Ahuva Itin, Oded Gal, Hagar Kalinski, Elena Feinstein, Eli Keshe. Ero1-L alpha plays a key role in a HIF-1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancer. Oncogene. vol 24. issue 6. 2005-03-02. PMID:15592500. |
further, we provide genetic evidence that induction of ero1-l alpha by hypoxia and hypoglycemia is mediated by the transcription factor hypoxia-inducible factor 1 (hif-1) but is independent of p53. |
2005-03-02 |
2023-08-12 |
human |
| Kwang S Suh, Michihiro Mutoh, Michael Gerdes, John M Crutchley, Tomoko Mutoh, Lindsay E Edwards, Rebecca A Dumont, Pooja Sodha, Christina Cheng, Adam Glick, Stuart H Yusp. Antisense suppression of the chloride intracellular channel family induces apoptosis, enhances tumor necrosis factor {alpha}-induced apoptosis, and inhibits tumor growth. Cancer research. vol 65. issue 2. 2005-03-02. PMID:15695400. |
mtclic/clic4 is a p53 and tumor necrosis factor alpha (tnfalpha) regulated intracellular chloride channel protein that localizes to cytoplasm and organelles and induces apoptosis when overexpressed in several cell types of mouse and human origin. |
2005-03-02 |
2023-08-12 |
mouse |
| W G McCluggage, E Oliva, L E Connolly, H A McBride, R H Youn. An immunohistochemical analysis of ovarian small cell carcinoma of hypercalcemic type. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. vol 23. issue 4. 2005-02-22. PMID:15381902. |
cases were stained with ae1/3, ema, berep4, ck5/6, calretinin, wt1, chromogranin, cd56, synaptophysin, cd99, nb84, desmin, s100, cd10, alpha inhibin, ttfi, and p53. |
2005-02-22 |
2023-08-12 |
Not clear |
| Yentram Huyen, Philip D Jeffrey, W Brent Derry, Joel H Rothman, Nikola P Pavletich, Elena S Stavridi, Thanos D Halazoneti. Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1. Structure (London, England : 1993). vol 12. issue 7. 2005-02-09. PMID:15242600. |
however, three loops, involved in dna and zn binding in human p53, contain small alpha helices in cep-1. |
2005-02-09 |
2023-08-12 |
human |
| Yentram Huyen, Philip D Jeffrey, W Brent Derry, Joel H Rothman, Nikola P Pavletich, Elena S Stavridi, Thanos D Halazoneti. Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1. Structure (London, England : 1993). vol 12. issue 7. 2005-02-09. PMID:15242600. |
the alpha helix in loop l3 of cep-1 orients the side chains of two conserved arginines toward dna; in human p53, both arginines are mutation hotspots, but only one contacts dna. |
2005-02-09 |
2023-08-12 |
human |
| Yentram Huyen, Philip D Jeffrey, W Brent Derry, Joel H Rothman, Nikola P Pavletich, Elena S Stavridi, Thanos D Halazoneti. Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1. Structure (London, England : 1993). vol 12. issue 7. 2005-02-09. PMID:15242600. |
the alpha helix in loop l1 of cep-1 repositions the entire loop, making it unlikely for residues of this loop to contact bases in the major groove of dna, as occurs in human p53. |
2005-02-09 |
2023-08-12 |
human |
| Nobuyasu Komazawa, Morihiro Matsuda, Gen Kondoh, Wataru Mizunoya, Masanori Iwaki, Toshiyuki Takagi, Yasuyuki Sumikawa, Kazuo Inoue, Akira Suzuki, Tak Wah Mak, Toru Nakano, Tohru Fushiki, Junji Takeda, Iichiro Shimomur. Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice. Nature medicine. vol 10. issue 11. 2005-02-04. PMID:15489860. |
adipopten-ko mice also showed marked hyperthermia and increased energy expenditure with induced mitochondriagenesis in adipose tissue, associated with marked reduction of p53, inactivation of rb, phosphorylation of cyclic amp response element binding protein (creb) and increased expression of ppargc1a, the gene that encodes peroxisome proliferative activated receptor gamma coactivator 1 alpha. |
2005-02-04 |
2023-08-12 |
mouse |
| Hanako Simooka, Tetsunari Oyama, Takaaki Sano, Jun Horiguchi, Takashi Nakajim. Immunohistochemical analysis of 14-3-3 sigma and related proteins in hyperplastic and neoplastic breast lesions, with particular reference to early carcinogenesis. Pathology international. vol 54. issue 8. 2005-01-25. PMID:15260850. |
immunostaining for estrogen receptor alpha (eralpha), p53 and estrogen-responsive ring finger protein (efp) was also carried out. |
2005-01-25 |
2023-08-12 |
Not clear |
| John M Routes, Kristin Morris, Misoo C Ellison, Sharon Rya. Macrophages kill human papillomavirus type 16 E6-expressing tumor cells by tumor necrosis factor alpha- and nitric oxide-dependent mechanisms. Journal of virology. vol 79. issue 1. 2005-01-14. PMID:15596807. |
the lysis of cells that expressed e6 by macrophages was p53 independent but dependent on the production of tumor necrosis factor alpha (tnf-alpha) or nitric oxide (no) by macrophages. |
2005-01-14 |
2023-08-12 |
human |
| Elayne Pereira, Márcia Cristina Tamia-Ferreira, Renato Sousa Cardoso, Stephano Spanó Mello, Elza Tiemi Sakamoto-Hojo, Geraldo A S Passos, Eduardo Antonio Donad. Immunosuppressive therapy modulates T lymphocyte gene expression in patients with systemic lupus erythematosus. Immunology. vol 113. issue 1. 2004-10-12. PMID:15312140. |
a total of 10 genes were repressed in untreated patients and induced in treated ones, among them tumour necrosis factor (ligand) superfamily member 9, tumour protein p53, mannosidase alpha class ia, and cd22. |
2004-10-12 |
2023-08-12 |
Not clear |
| H Akca, O N Oze. Epidermal growth factor suppresses interferon-induced accumulation of p53 and p21 by using protein kinase C. Scandinavian journal of clinical and laboratory investigation. vol 63. issue 7-8. 2004-08-31. PMID:14743960. |
in this study it is shown that treatment of me180s cells with interferon alpha (ifn-alpha) and interferon gamma (ifn-gamma) result in time-dependent accumulation of p53 and its transcriptional target, p21. |
2004-08-31 |
2023-08-12 |
human |
| Daniel E B Swinson, J Louise Jones, Giles Cox, Donna Richardson, Adrian L Harris, Kenneth J O'Byrn. Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways. International journal of cancer. vol 111. issue 1. 2004-07-20. PMID:15185341. |
in conclusion, the associations with egfr, mmp-9, p53 and ca ix suggest that these factors may either regulate or be regulated by hif-1 alpha. |
2004-07-20 |
2023-08-12 |
Not clear |
| Slavica Tudzarova-Trajkovska, Józefa Wesierska-Gade. Strong induction of p73 protein in vivo coincides with the onset of apoptosis in rat liver after treatment with the hepatocarcinogen N-nitrosomorpholine (NNM). Journal of cellular biochemistry. vol 90. issue 4. 2004-07-09. PMID:14587038. |
the increase of p73 alpha and beta occurred already 6 h after nnm administration and preceded the onset of apoptosis by 6 h. very strong p73 signals appeared 20 and 40 h post-treatment and persisted for a few days, whereas p53 was induced only transiently at 20 and 40 h post-treatment. |
2004-07-09 |
2023-08-12 |
rat |
| Ronen R Leker, Michal Aharonowiz, Nigel H Greig, Haim Ovadi. The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. Experimental neurology. vol 187. issue 2. 2004-06-30. PMID:15144874. |
the role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. |
2004-06-30 |
2023-08-12 |
Not clear |
| Ronen R Leker, Michal Aharonowiz, Nigel H Greig, Haim Ovadi. The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. Experimental neurology. vol 187. issue 2. 2004-06-30. PMID:15144874. |
pifithrin alpha reduced the number of apoptotic cells in the ischemic brain by inhibiting the binding of p53 to its dna sites as it reduced the expression of the p53-related gene p21(waf) without changing the amount of p53 protein itself. |
2004-06-30 |
2023-08-12 |
Not clear |
| Tao-Xiang Chen, Yong-Yan Xiong, Lin Li. [Expression and significance of telomerase reverse transcriptase and its regulators in non-small cell lung carcinoma]. Ai zheng = Aizheng = Chinese journal of cancer. vol 23. issue 3. 2004-06-15. PMID:15025956. |
this study was designed to investigate the relationship of expression of human telomerase reverse transcriptase mrna (htert mrna) and its regulators including c-myc, mutant p53, protein kinase c alpha (pkcalpha) with clinicopathological significance of expression of the four markers in non-small cell lung carcinoma (nsclc). |
2004-06-15 |
2023-08-12 |
human |