| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pankaj K Singh, Michael A Hollingswort. Cell surface-associated mucins in signal transduction. Trends in cell biology. vol 16. issue 9. 2006-11-03. PMID:16904320. |
the cytoplasmic tail of muc1 (muc1ct), the best characterized of the transmembrane mucins, is involved in several signaling pathways, including those involving ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. |
2006-11-03 |
2023-08-12 |
Not clear |
| Ghazaleh Tabatabai, Brigitte Frank, Robert Möhle, Michael Weller, Wolfgang Wic. Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-beta-dependent HIF-1alpha-mediated induction of CXCL12. Brain : a journal of neurology. vol 129. issue Pt 9. 2006-10-04. PMID:16835250. |
reporter assays reveal that the cxcl12 promoter activity is enhanced in lnt-229 cells at 24 h after irradiation at 8 gy or after exposure to 1% oxygen for 12 h. the irradiation- and hypoxia-induced release of cxcl12 depends on hypoxia inducible factor-1 alpha (hif-1alpha), but not on p53. |
2006-10-04 |
2023-08-12 |
mouse |
| Toru Yamada, Muneharu Maruyama, Tadashi Fujita, Koutarou Miyabayashi, Chie Shinoda, Yukio Kawagishi, Takashi Fujishita, Ryuji Hayashi, Toshiro Miwa, Nobuki Arai, Shoko Matsui, Eiji Sugiyama, Masashi Kobayash. Ionizing radiation suppresses FAP-1 mRNA level in A549 cells via p53 activation. FEBS letters. vol 580. issue 18. 2006-09-19. PMID:16844116. |
pretreatment with p53 inhibitor pifithrin alpha cancelled the ir-induced downregulation of fap-1 mrna. |
2006-09-19 |
2023-08-12 |
Not clear |
| Giuseppina Bianchi, Camillo Di Giulio, Cinzia Rapino, Monica Rapino, Adriano Antonucci, Amelia Catald. p53 and p66 proteins compete for hypoxia-inducible factor 1 alpha stabilization in young and old rat hearts exposed to intermittent hypoxia. Gerontology. vol 52. issue 1. 2006-09-07. PMID:16439820. |
p53 and p66 proteins compete for hypoxia-inducible factor 1 alpha stabilization in young and old rat hearts exposed to intermittent hypoxia. |
2006-09-07 |
2023-08-12 |
rat |
| Paola Di Lello, Lisa M Miller Jenkins, Tamara N Jones, Bao D Nguyen, Toshiaki Hara, Hiroshi Yamaguchi, Jimmy D Dikeakos, Ettore Appella, Pascale Legault, James G Omichinsk. Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53. Molecular cell. vol 22. issue 6. 2006-08-28. PMID:16793543. |
our structure reveals that p53 forms a nine residue amphipathic alpha helix (residues 47-55) upon binding to tfb1. |
2006-08-28 |
2023-08-12 |
human |
| Jose G Teodoro, Albert E Parker, Xiaochun Zhu, Michael R Gree. p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase. Science (New York, N.Y.). vol 313. issue 5789. 2006-08-28. PMID:16917063. |
here we show that p53 transcriptionally activates the alpha(ii) collagen prolyl-4-hydroxylase [alpha(ii)ph] gene, resulting in the extracellular release of antiangiogenic fragments of collagen type 4 and 18. |
2006-08-28 |
2023-08-12 |
mouse |
| Jose G Teodoro, Albert E Parker, Xiaochun Zhu, Michael R Gree. p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase. Science (New York, N.Y.). vol 313. issue 5789. 2006-08-28. PMID:16917063. |
conditioned media from cells ectopically expressing either p53 or alpha(ii)ph selectively inhibited growth of primary human endothelial cells. |
2006-08-28 |
2023-08-12 |
mouse |
| D Marot, P Opolon, S Brailly-Tabard, N Elie, V Randrianarison, E Connault, N Foray, J Feunteun, M Perricaude. The tumor suppressor activity induced by adenovirus-mediated BRCA1 overexpression is not restricted to breast cancers. Gene therapy. vol 13. issue 3. 2006-06-29. PMID:16208422. |
we also observed a significant antitumor effect in these pre-established subcutaneous tumors after in situ delivery of adbrca1, although these two tumors do not express wt p53, and also estrogen alpha and beta, progesterone and androgen receptors. |
2006-06-29 |
2023-08-12 |
Not clear |
| Ariane Scoumanne, Kelly Lynn Harms, Xinbin Che. Structural basis for gene activation by p53 family members. Cancer biology & therapy. vol 4. issue 11. 2006-06-22. PMID:16294021. |
indeed, the p53 c-terminus contains a basic domain (bd) whereas p63/p73 have a sterile alpha motif (sam) domain and an inhibitory domain (id). |
2006-06-22 |
2023-08-12 |
Not clear |
| Takahiko Kobayashi, Ting Wang, Masaji Maezawa, Masanobu Kobayashi, Shunsuke Ohnishi, Kazuteru Hatanaka, Shuhei Hige, Yuichi Shimizu, Mototsugu Kato, Masahiro Asaka, Junji Tanaka, Masahiro Imamura, Kiminori Hasegawa, Yoshiyuki Tanaka, Rainer K Brachman. Overexpression of the oncoprotein prothymosin alpha triggers a p53 response that involves p53 acetylation. Cancer research. vol 66. issue 6. 2006-05-03. PMID:16540664. |
overexpression of the oncoprotein prothymosin alpha triggers a p53 response that involves p53 acetylation. |
2006-05-03 |
2023-08-12 |
human |
| Takahiko Kobayashi, Ting Wang, Masaji Maezawa, Masanobu Kobayashi, Shunsuke Ohnishi, Kazuteru Hatanaka, Shuhei Hige, Yuichi Shimizu, Mototsugu Kato, Masahiro Asaka, Junji Tanaka, Masahiro Imamura, Kiminori Hasegawa, Yoshiyuki Tanaka, Rainer K Brachman. Overexpression of the oncoprotein prothymosin alpha triggers a p53 response that involves p53 acetylation. Cancer research. vol 66. issue 6. 2006-05-03. PMID:16540664. |
here, we show that inappropriate activity of prothymosin alpha (ptma), an oncoprotein overexpressed in human cancers, triggers a p53 response. |
2006-05-03 |
2023-08-12 |
human |
| Naozumi Ishimaru, Rieko Arakaki, Fumie Omotehara, Koichi Yamada, Kenji Mishima, Ichiro Saito, Yoshio Hayash. Novel role for RbAp48 in tissue-specific, estrogen deficiency-dependent apoptosis in the exocrine glands. Molecular and cellular biology. vol 26. issue 8. 2006-05-03. PMID:16581768. |
prominent rbap48 expression with apoptosis was observed in the exocrine glands of c57bl/6 ovariectomized (ovx) mice but not in ovx estrogen receptor alpha(-/-), p53(-/-), and e2f-1(-/-) mice. |
2006-05-03 |
2023-08-12 |
mouse |
| Lydie Sparfel, Julien Van Grevenynghe, Marc Le Vee, Caroline Aninat, Olivier Farde. Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha. Carcinogenesis. vol 27. issue 3. 2006-04-04. PMID:16258175. |
potent inhibition of carcinogen-bioactivating cytochrome p450 1b1 by the p53 inhibitor pifithrin alpha. |
2006-04-04 |
2023-08-12 |
human |
| Brandon D Jeffy, Jennifer K Hockings, Michael Q Kemp, Sherif S Morgan, Jill A Hager, Jason Beliakoff, Luke J Whitesell, G Timothy Bowden, Donato F Romagnol. An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription. Neoplasia (New York, N.Y.). vol 7. issue 9. 2006-02-23. PMID:16229810. |
conversely, we document that overexpression of wild-type p53 prevents the recruitment of er alpha to the ap-1 site and represses brca-1 promoter activity. |
2006-02-23 |
2023-08-12 |
Not clear |
| Kai Uwe Chow, Daniel Nowak, Soo-Zin Kim, Bernd Schneider, Martina Komor, Simone Boehrer, Paris S Mitrou, Dieter Hoelzer, Eckhart Weidmann, Wolf-Karsten Hofman. In vivo drug-response in patients with leukemic non-Hodgkin's lymphomas is associated with in vitro chemosensitivity and gene expression profiling. Pharmacological research. vol 53. issue 1. 2006-02-09. PMID:16213748. |
among these 30 genes we found a high proportion of genes associated with apoptotic cell death, cell proliferation and cell cycle signalling including complement lysis inhibitor (clusterin/clu), beta-catenin interacting protein (icat), peroxisome proliferator activated receptor alpha (pparalpha), tnf alpha converting enzyme (adam17/tace), homeo box a3 (hox1), inositol polyphosphatase 5-phosphatase type iv (ppi5piv) and inhibitor of p53 induced apoptosis alpha (ipia-alpha/nm23-h6). |
2006-02-09 |
2023-08-12 |
Not clear |
| Grace Guzman, Victoria Alagiozian-Angelova, Jennifer E Layden-Almer, Thomas J Layden, Guiliano Testa, Enrico Benedetti, André Kajdacsy-Balla, Scott J Cotle. p53, Ki-67, and serum alpha feto-protein as predictors of hepatocellular carcinoma recurrence in liver transplant patients. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 18. issue 11. 2006-01-11. PMID:16007066. |
p53, ki-67, and serum alpha feto-protein as predictors of hepatocellular carcinoma recurrence in liver transplant patients. |
2006-01-11 |
2023-08-12 |
human |
| Karin Fehsel, Stefan Loeffler, Klaus Krieger, Uwe Henning, Markus Agelink, Victoria Kolb-Bachofen, Ansgar Klimk. Clozapine induces oxidative stress and proapoptotic gene expression in neutrophils of schizophrenic patients. Journal of clinical psychopharmacology. vol 25. issue 5. 2005-11-30. PMID:16160616. |
we observed dramatically increased numbers of native neutrophils stained for superoxide anion production (p < or = 0.005, n = 10) and significantly elevated expression levels of the proapoptotic genes p53 (p < or = 0.020), bax alpha (p < or = 0.001), and bik (p < or = 0.002) in all tested non-ca patients (n = 19) and ca patients (n = 4). |
2005-11-30 |
2023-08-12 |
human |
| Susan W P Wijnhoven, Edwin Zwart, Ewoud N Speksnijder, Rudolf B Beems, Kenneth P Olive, David A Tuveson, Jos Jonkers, Mirjam M Schaap, Jolanda van den Berg, Tyler Jacks, Harry van Steeg, Annemieke de Vrie. Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development. Cancer research. vol 65. issue 18. 2005-11-25. PMID:16166291. |
the majority of spontaneous and dmba-induced carcinomas and sarcomas from p53(r270h/+)wapcre mice is estrogen receptor alpha positive, and expression profiles of genes also implicated in human breast cancer appear similarly altered. |
2005-11-25 |
2023-08-12 |
mouse |
| Anatol Panasiuk, Danuta Prokopowicz, Janusz Dziecioł, Maciej Adamsk. [The apoptosis of hepatic tissues in hepatitis C]. Przeglad epidemiologiczny. vol 59. issue 2. 2005-11-21. PMID:16190549. |
the purpose of the study was the evaluation of p53 and bcl2 protein expression on intrahepatic hepatocytes in chronic hepatitis c before and after the treatment with interferon alpha 2b (ifna2b) combined with ribavirin (rbv). |
2005-11-21 |
2023-08-12 |
Not clear |
| Sebastian A Lewandowski, Jerome Thiery, Abdelali Jalil, Guy Leclercq, Cezary Szczylik, Salem Chouai. Opposite effects of estrogen receptors alpha and beta on MCF-7 sensitivity to the cytotoxic action of TNF and p53 activity. Oncogene. vol 24. issue 30. 2005-08-08. PMID:15870704. |
opposite effects of estrogen receptors alpha and beta on mcf-7 sensitivity to the cytotoxic action of tnf and p53 activity. |
2005-08-08 |
2023-08-12 |
human |