| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lisa Y Pang, Ted R Hup. Protein kinases coordinately regulate the p53: Delta Np63 alpha axis after DNA damage. Cell cycle (Georgetown, Tex.). vol 7. issue 18. 2008-11-03. PMID:18797190. |
protein kinases coordinately regulate the p53: delta np63 alpha axis after dna damage. |
2008-11-03 |
2023-08-12 |
Not clear |
| Jian Huang, Lijun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejim. Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways. Journal of pharmacological sciences. vol 107. issue 4. 2008-10-07. PMID:18719315. |
p53, a specific inhibitor of pifithrin alpha (pft alpha), markedly inhibited ros generation and apoptosis, showing that p53 was responsible for the cytotoxity of oridonin through mediation by ros. |
2008-10-07 |
2023-08-12 |
human |
| Ilio Vitale, Laura Senovilla, Lorenzo Galluzzi, Alfredo Criollo, Sonia Vivet, Maria Castedo, Guido Kroeme. Chk1 inhibition activates p53 through p38 MAPK in tetraploid cancer cells. Cell cycle (Georgetown, Tex.). vol 7. issue 13. 2008-09-30. PMID:18642443. |
depletion of p38 mapk by transfection with a sirna targeting the alpha isoform of p38 mapk (p38alpha mapk) abolishes the phosphorylation of p53 on serines 15 and 46 that is induced by chk1 knockdown. |
2008-09-30 |
2023-08-12 |
Not clear |
| Frances V Fuller-Pace, Simak Al. The DEAD box RNA helicases p68 (Ddx5) and p72 (Ddx17): novel transcriptional co-regulators. Biochemical Society transactions. vol 36. issue Pt 4. 2008-09-25. PMID:18631126. |
in the present paper, we shall review the literature demonstrating the action of p68 and, where data are available, p72 as transcriptional co-regulators for a range of transcription factors, namely eralpha (oestrogen receptor alpha), the tumour suppressor p53, the myogenic regulator myod and runx2, a transcription factor essential for osteoblast development. |
2008-09-25 |
2023-08-12 |
Not clear |
| Tracie L Verkler, Robert R Delongchamp, Barbara J Miller, Peggy J Webb, Paul C Howard, Barbara L Parson. Simulated solar light-induced p53 mutagenesis in SKH-1 mouse skin: a dose-response assessment. Molecular carcinogenesis. vol 47. issue 8. 2008-08-14. PMID:18314877. |
the increase in the logarithm of p53 mf was described by the linear function: log(10) mf = alpha + 0.0016 x d, where alpha is the spontaneous log(10) mf after a particular time point and d is the dose of ssl in mj x cie/cm(2). |
2008-08-14 |
2023-08-12 |
mouse |
| Marcos C Dias, Maria A M Rodrigues, Maria C H Reimberg, Luís F Barbisa. Protective effects of Ginkgo biloba against rat liver carcinogenesis. Chemico-biological interactions. vol 173. issue 1. 2008-07-31. PMID:18367157. |
liver samples were collected for the analysis of proliferating cell nuclear antigen (pcna), transforming growth factor alpha (tgf-alpha), p53, apoptosis and induction of single hepatocytes and minifoci positive for the enzyme glutathione s-transferase p-form (gst-p). |
2008-07-31 |
2023-08-12 |
rat |
| Lisa M Miller Jenkins, Sharlyn J Mazur, Matteo Rossi, Olga Gaidarenko, Yang Xu, Ettore Appell. Quantitative proteomics analysis of the effects of ionizing radiation in wild type and p53 K317R knock-in mouse thymocytes. Molecular & cellular proteomics : MCP. vol 7. issue 4. 2008-06-23. PMID:18178582. |
pathway analysis of the differently regulated proteins suggests an increase in p53 activity in the p53(k317r) thymocytes as well as a decrease in tumor necrosis factor alpha signaling. |
2008-06-23 |
2023-08-12 |
mouse |
| Quan-Sheng Zhu, Wenhong Ren, Borys Korchin, Guy Lahat, Adam Dicker, Yiling Lu, Gordon Mills, Raphael E Pollock, Dina Le. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer research. vol 68. issue 8. 2008-06-10. PMID:18413758. |
akt inhibition induced gadd45 alpha mrna and protein expression in all sts cells treated independent of p53 mutational status. |
2008-06-10 |
2023-08-12 |
mouse |
| Joanna S Morris, Colin Nixon, Alicia Bruck, Lubna Nasir, Iain M Morgan, Adrian W Philbe. Immunohistochemical expression of TopBP1 in feline mammary neoplasia in relation to histological grade, Ki67, ERalpha and p53. Veterinary journal (London, England : 1997). vol 175. issue 2. 2008-06-03. PMID:17336111. |
the immunohistochemical expression of topoisomerase iibeta binding protein 1 (topbp1) was examined in 123 feline mammary lesions (18 non-neoplastic lesions including six fibroadenomatous hyperplasia and 12 duct ectasia, 17 adenomas and 88 carcinomas) in relation to histological grade, oestrogen receptor alpha (eralpha) status, proliferation index (ki67) and p53 expression. |
2008-06-03 |
2023-08-12 |
Not clear |
| Jian-Wei Fei, Ethel-Michele de Villier. Degradation of HPV20E6 by p53: Delta Np63 alpha and mutant p53R248W protect the wild type p53 mediated caspase-degradation. International journal of cancer. vol 123. issue 1. 2008-06-02. PMID:18412244. |
degradation of hpv20e6 by p53: delta np63 alpha and mutant p53r248w protect the wild type p53 mediated caspase-degradation. |
2008-06-02 |
2023-08-12 |
human |
| Rintaro Okoshi, Toshinori Ozaki, Hideki Yamamoto, Kiyohiro Ando, Nami Koida, Sayaka Ono, Tadayuki Koda, Takehiko Kamijo, Akira Nakagawara, Harutoshi Kizak. Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress. The Journal of biological chemistry. vol 283. issue 7. 2008-05-05. PMID:18056705. |
in this study, we have found that glucose depletion promotes the phosphorylation of amp-activated protein kinase catalytic subunit alpha (ampkalpha) in association with a significant up-regulation of p53, thereby inducing p53-dependent apoptosis in vivo and in vitro. |
2008-05-05 |
2023-08-12 |
mouse |
| Aurora M Nedelcu, Christopher Ta. Early diversification and complex evolutionary history of the p53 tumor suppressor gene family. Development genes and evolution. vol 217. issue 11-12. 2008-04-30. PMID:17924139. |
although similar in sequence, gene structure, and expression potential, the three p53 members differ in domain organization (in addition to the transactivation, dna-binding, and tetramerization domains, p63 and p73 encode a sterile alpha motif, sam, domain) and functional roles (with p63 and p73 assuming additional key roles in development). |
2008-04-30 |
2023-08-12 |
Not clear |
| Roberta Malaguarnera, Veronica Vella, Giuseppe Pandini, Mariangela Sanfilippo, Vincenzo Pezzino, Riccardo Vigneri, Francesco Frasc. TAp73 alpha increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation. Molecular cancer research : MCR. vol 6. issue 1. 2008-03-27. PMID:18234963. |
tap73 alpha increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of mdm2-mediated degradation. |
2008-03-27 |
2023-08-12 |
Not clear |
| T Maekawa, Y Sano, T Shinagawa, Z Rahman, T Sakuma, S Nomura, J D Licht, S Ishi. ATF-2 controls transcription of Maspin and GADD45 alpha genes independently from p53 to suppress mammary tumors. Oncogene. vol 27. issue 8. 2008-03-03. PMID:17700520. |
atf-2 controls transcription of maspin and gadd45 alpha genes independently from p53 to suppress mammary tumors. |
2008-03-03 |
2023-08-12 |
mouse |
| Trang-Tiau Wu, Yi-Hsien Hsieh, Yih-Shou Hsieh, Jer-Yuh Li. Reduction of PKC alpha decreases cell proliferation, migration, and invasion of human malignant hepatocellular carcinoma. Journal of cellular biochemistry. vol 103. issue 1. 2008-02-29. PMID:17486587. |
when treated with pkc alpha antisense oligonucleotides (odn), both ha22t/vgh and sk-hep-1 cells lines showed the reduction of pkc alpha expression, as well as a deceleration in the growth rate and in the level of cyclin d1, but the increase in the levels of p53 and p21(waf1/cip1). |
2008-02-29 |
2023-08-12 |
human |
| Matthias Woenckhaus, Johannes Merk, Robert Stoehr, Frank Schaeper, Andreas Gaumann, Karsten Wiebe, Arndt Hartmann, Ferdinand Hofstaedter, Wolfgang Dietmaie. Prognostic value of FHIT, CTNNB1, and MUC1 expression in non-small cell lung cancer. Human pathology. vol 39. issue 1. 2008-02-14. PMID:17949785. |
to evaluate the prognostic relevance of these proteins in nsclcs, we used immunohistochemistry to investigate the expression of beta-catenin (ctnnb1), dickkopf, xenopus, homolog of 3 (dkk3 gene), fibroblast growth factor receptor 3 (fgfr3), fragile histidine triad (fhit), tumor protein p53 (tp53), mucin1 (muc1), topoisomerase ii alpha (top2a), and glutathione s-transferase-pi (gst) in a cohort of patients (n = 125). |
2008-02-14 |
2023-08-12 |
xenopus_laevis |
| Nan Li, Yuanyuan Zheng, Wei Chen, Chunmei Wang, Xingguang Liu, Weigang He, Hongmei Xu, Xuetao Ca. Adaptor protein LAPF recruits phosphorylated p53 to lysosomes and triggers lysosomal destabilization in apoptosis. Cancer research. vol 67. issue 23. 2008-01-22. PMID:18056442. |
in this study, we show that lapf specifically interacted with phosphorylated p53 (ser(15/18)) both in vitro and in vivo, which could be enhanced by apoptotic stimuli, such as tumor necrosis factor alpha (tnf-alpha) and ionizing irradiation. |
2008-01-22 |
2023-08-12 |
Not clear |
| Tomoko Yamaguchi, Yoshio Miki, Kiyotsugu Yoshid. Protein kinase C delta activates IkappaB-kinase alpha to induce the p53 tumor suppressor in response to oxidative stress. Cellular signalling. vol 19. issue 10. 2007-12-06. PMID:17644309. |
protein kinase c delta activates ikappab-kinase alpha to induce the p53 tumor suppressor in response to oxidative stress. |
2007-12-06 |
2023-08-12 |
Not clear |
| K L Schavolt, J A Pietenpo. p53 and Delta Np63 alpha differentially bind and regulate target genes involved in cell cycle arrest, DNA repair and apoptosis. Oncogene. vol 26. issue 42. 2007-10-24. PMID:17404570. |
p53 and delta np63 alpha differentially bind and regulate target genes involved in cell cycle arrest, dna repair and apoptosis. |
2007-10-24 |
2023-08-12 |
human |
| Aejaz Sayeed, Santhi D Konduri, Wensheng Liu, Sanjay Bansal, Fengzhi Li, Gokul M Da. Estrogen receptor alpha inhibits p53-mediated transcriptional repression: implications for the regulation of apoptosis. Cancer research. vol 67. issue 16. 2007-10-04. PMID:17699779. |
estrogen receptor alpha (eralpha) and tumor suppressor protein p53 exert opposing effects on cellular proliferation. |
2007-10-04 |
2023-08-12 |
human |