| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Watanabe, Yukari Nishimura, Shinpei Tsunoda, Miwa Kawaguchi, Isao Okayasu, Hiroyuki Kuramot. Liquid-based preparation for endometrial cytology--usefulness for predicting the prognosis of endometrial carcinoma preoperatively. Cancer. vol 117. issue 4. 2009-09-08. PMID:19562745. |
the authors evaluated the applicability and usefulness of immunocytochemical staining for cyclin a, p53, estrogen receptor alpha (er-alpha), and progesterone receptor b (pr-b) as a preoperative prognostic indicators for endometrial carcinoma using endometrial cytology with the liquid-based cytology (lbc) method. |
2009-09-08 |
2023-08-12 |
Not clear |
| Anja Seifert, Helge Taubert, Sabine Hombach-Klonisch, Bernd Fischer, Anne Navarrete Santo. TCDD mediates inhibition of p53 and activation of ERalpha signaling in MCF-7 cells at moderate hypoxic conditions. International journal of oncology. vol 35. issue 2. 2009-09-01. PMID:19578757. |
in addition, the transcription factors p53 and the estrogen receptor alpha (eralpha) are important key players in breast cancer progression. |
2009-09-01 |
2023-08-12 |
human |
| Ricardo Sánchez, David Pantoja-Uceda, Daniel Torres, Jesús Prieto, Ramón Campos-Olivas, Francisco J Blanc. NMR assignment and secondary structure of human growth arrest and DNA damage alpha protein (Gadd45 alpha). Biomolecular NMR assignments. vol 2. issue 2. 2009-08-19. PMID:19636889. |
gadd45 alpha is a predominantly nuclear protein encoded by a dna-damage-inducible gene which is transcriptionally regulated by the tumor suppressor p53. |
2009-08-19 |
2023-08-12 |
human |
| Stephanie Harkey Shirley, Joyce E Rundhaug, Jie Tian, Noirin Cullinan-Ammann, Isabel Lambertz, Claudio J Conti, Robin Fuchs-Youn. Transcriptional regulation of estrogen receptor-alpha by p53 in human breast cancer cells. Cancer research. vol 69. issue 8. 2009-06-19. PMID:19351845. |
estrogen receptor alpha (er) and p53 are critical prognostic indicators in breast cancer. |
2009-06-19 |
2023-08-12 |
mouse |
| S Ya Proskuryakov, A G Konoplyannikov, O A Konoplyannikova, L I Shevchenko, Yu G Verkhovskii, A F Tsy. Possible involvement of NO in the stimulating effect of pifithrins on survival of hemopoietic clonogenic cells. Biochemistry. Biokhimiia. vol 74. issue 2. 2009-05-15. PMID:19267667. |
pifithrin alpha (pftalpha), one of the first known low molecular weight modulators of activity of tumor suppressor p53, increases survival of hemopoietic clonogenic cells (evaluated by the criterion of formation of endogenous spleen cfu-c8 colonies in irradiated animals). |
2009-05-15 |
2023-08-12 |
Not clear |
| Hanqiao Feng, Lisa M Miller Jenkins, Stewart R Durell, Ryo Hayashi, Sharlyn J Mazur, Scott Cherry, Joseph E Tropea, Maria Miller, Alexander Wlodawer, Ettore Appella, Yawen Ba. Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation. Structure (London, England : 1993). vol 17. issue 2. 2009-04-27. PMID:19217391. |
in the complex, p53 forms a short alpha helix and interacts with the taz2 domain through an extended surface. |
2009-04-27 |
2023-08-12 |
Not clear |
| Jun Yang, Afshan Ahmed, Evon Poon, Nina Perusinghe, Alexis de Haven Brandon, Gary Box, Melanie Valenti, Suzanne Eccles, Kasper Rouschop, Brad Wouters, Margaret Ashcrof. Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia. Molecular and cellular biology. vol 29. issue 8. 2009-04-22. PMID:19223463. |
unlike other dna damage response-inducing agents, rita treatment of cells induced a p53-dependent increase in phosphorylation of the alpha subunit of eukaryotic initiation factor 2, requiring pkr-like endoplasmic reticulum kinase activity, and led to the subsequent downregulation of hif-1alpha and p53 target proteins, including hdm2 and p21. |
2009-04-22 |
2023-08-12 |
Not clear |
| Timothy A Sutton, Jared Wilkinson, Henry E Mang, Nicole L Knipe, Zoya Plotkin, Maya Hosein, Katelyn Zak, Jeremy Wittenborn, Pierre C Daghe. p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury. American journal of physiology. Renal physiology. vol 295. issue 6. 2009-03-12. PMID:18815219. |
p53 regulates renal expression of hif-1{alpha} and pvhl under physiological conditions and after ischemia-reperfusion injury. |
2009-03-12 |
2023-08-12 |
Not clear |
| Freda H Passam, Michael G Alexandrakis, Maria Kafousi, Marianthi Fotinou, Katerina Darivianaki, George Tsirakis, Paraskevi A Roussou, Efstathios N Stathopoulos, Nikolaos M Siafaka. Histological expression of angiogenic factors: VEGF, PDGFRalpha, and HIF-1alpha in Hodgkin lymphoma. Pathology, research and practice. vol 205. issue 1. 2009-03-12. PMID:18950958. |
immunostaining was performed on 65 hodgkin biopsies with vascular endothelial growth factor (vegf), hypoxia inducible factor-1 alpha (hif-1alpha), platelet-derived growth factor receptor alpha (pdgfralpha), ki-67, and p53. |
2009-03-12 |
2023-08-12 |
Not clear |
| Ferenc Budán, Tímea Varjas, Ghodratollah Nowrasteh, Zsuzsa Varga, Imre Boncz, József Cseh, Ida Prantner, Tibold Antal, Emese Pázsit, Gyula Gobel, Miklós Bauer, Tünde Gracza, Pál Perjési, István Ember, Zoltán Gyöngy. Early modification of c-myc, Ha-ras and p53 expressions by N-methyl-N-nitrosourea. In vivo (Athens, Greece). vol 22. issue 6. 2009-02-25. PMID:19181008. |
previously, an animal model was developed by our research group to investigate the expression of three genes c-myc, ha-ras and p53 as early molecular epidemiological biomarkers of carcinogenic exposure or carcinogenesis caused by dmba (dimethylbenz[alpha]anthracene). |
2009-02-25 |
2023-08-12 |
Not clear |
| Seong-Yeon Park, Jung Hyun Lee, Minju Ha, Jin-Wu Nam, V Narry Ki. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nature structural & molecular biology. vol 16. issue 1. 2009-01-29. PMID:19079265. |
mir-29 mirnas activate p53 by targeting p85 alpha and cdc42. |
2009-01-29 |
2023-08-12 |
Not clear |
| Seong-Yeon Park, Jung Hyun Lee, Minju Ha, Jin-Wu Nam, V Narry Ki. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nature structural & molecular biology. vol 16. issue 1. 2009-01-29. PMID:19079265. |
we further find that mir-29 family members directly suppress p85 alpha (the regulatory subunit of pi3 kinase) and cdc42 (a rho family gtpase), both of which negatively regulate p53. |
2009-01-29 |
2023-08-12 |
Not clear |
| Sepideh Arbabi Bidgoli, Ebrahim Azizi, Mansour Djamali Zavarhe. Association between p53 expression and Bcl-2, P-glycoprotein, topoisomerase II alpha, thymidylate synthase and thymidine phosphorylase as potential therapeutic targets in colorectal cancer patients. Pakistan journal of biological sciences : PJBS. vol 10. issue 19. 2009-01-23. PMID:19090149. |
these were analyzed by immunohistochemical techniques using primary antibodies for p53, bcl-2, p-gp, topoisomerase ii alpha and thymidylate synthase (ts), thymidine phosphorylase/pd- ecgf (tp) and lsab detection kit. |
2009-01-23 |
2023-08-12 |
Not clear |
| Ian R Radford, Pavel N Lobachevsk. Clustered DNA lesion sites as a source of mutations during human colorectal tumourigenesis. Mutation research. vol 646. issue 1-2. 2009-01-06. PMID:18824008. |
we used statistical analyses to search for sets of dinucleotide sequences (designated target sequences) that are present at and in close proximity to mutation sites in four genes associated with human colorectal tumourigenesis (adenomatosis polyposis coli (apc), v-ki-ras2 kirsten rat sarcoma viral oncogene homolog (kras), phosphoinositide-3-kinase, catalytic, alpha polypeptide (pik3ca), and tumour protein p53 (tp53)). |
2009-01-06 |
2023-08-12 |
human |
| N I Zakharova, V V Sokolov, V V Rud'ko, S V Mel'nikov, A B Vartapetian, A G Evstaf'ev. [Influence of prothymosin alpha and its mutants on activity of the p53 tumor suppressor]. Molekuliarnaia biologiia. vol 42. issue 4. 2008-11-04. PMID:18856068. |
[influence of prothymosin alpha and its mutants on activity of the p53 tumor suppressor]. |
2008-11-04 |
2023-08-12 |
Not clear |
| N I Zakharova, V V Sokolov, V V Rud'ko, S V Mel'nikov, A B Vartapetian, A G Evstaf'ev. [Influence of prothymosin alpha and its mutants on activity of the p53 tumor suppressor]. Molekuliarnaia biologiia. vol 42. issue 4. 2008-11-04. PMID:18856068. |
overexpression of the nuclear oncoprotein prothymosin a enhanced and, in a reciprocal experiment, down-regulation of endogenous prothymosin alpha by rna interference approach inhibited transcriptional activity of the p53 tumor suppressor in the reporter gene assay. |
2008-11-04 |
2023-08-12 |
Not clear |
| N I Zakharova, V V Sokolov, V V Rud'ko, S V Mel'nikov, A B Vartapetian, A G Evstaf'ev. [Influence of prothymosin alpha and its mutants on activity of the p53 tumor suppressor]. Molekuliarnaia biologiia. vol 42. issue 4. 2008-11-04. PMID:18856068. |
ectopic expression of prothymosin alpha enhanced not only p53-dependent transcription, but also intracellular level of p53 in hela (but not hct116) cells. |
2008-11-04 |
2023-08-12 |
Not clear |
| N I Zakharova, V V Sokolov, V V Rud'ko, S V Mel'nikov, A B Vartapetian, A G Evstaf'ev. [Influence of prothymosin alpha and its mutants on activity of the p53 tumor suppressor]. Molekuliarnaia biologiia. vol 42. issue 4. 2008-11-04. PMID:18856068. |
ability to stimulate p53-dependent transcription was lost by c-terminal mutants of prothymosin alpha with impaired nuclear accumulation, but not by n-terminal deletion mutants and by the double mutant of prothymosin alpha with impaired ability to bind keap1, suggesting that prothymosinalpha-keap1 interaction is dispensable for p53 response. |
2008-11-04 |
2023-08-12 |
Not clear |
| Yiping Huang, Tanusree Sen, Jatin Nagpal, Sunil Upadhyay, Barry Trink, Edward Ratovitski, David Sidransk. ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. Cell cycle (Georgetown, Tex.). vol 7. issue 18. 2008-11-03. PMID:18769144. |
since delta np63 alpha usually plays an opposite role to p53 and tap63 in human cancers, we tested the notion that phosphorylation events induced by dna damage would affect the protein degradation of delta np63 alpha in hnscc cells upon cisplatin exposure. |
2008-11-03 |
2023-08-12 |
human |
| Katarzyna Kokoszynska, Jerzy Ostrowski, Leszek Rychlewski, Lucjan S Wyrwic. The fold recognition of CP2 transcription factors gives new insights into the function and evolution of tumor suppressor protein p53. Cell cycle (Georgetown, Tex.). vol 7. issue 18. 2008-11-03. PMID:18787404. |
the employed procedure clearly shows that the family adopts a dna binding immunoglobulin fold homologous to the p53 (tp53) core domain, and a novel type of ubiquitin-like domain and a sterile alpha motif (sam) form oligomerization modules. |
2008-11-03 |
2023-08-12 |
human |