| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Figarella-Branger, A Maues de Paula, C Colin, C Bouvie. Histomolecular classification of adult diffuse gliomas: the diagnostic value of immunohistochemical markers. Revue neurologique. vol 167. issue 10. 2012-01-26. PMID:21889777. |
interestingly, p53 expression and internexin alpha (ina) expression can replace to some extent tp53 mutation and 1p19 codeletion, respectively. |
2012-01-26 |
2023-08-12 |
Not clear |
| N I Zakharova, V V Sokolov, A A Suvorova, A I Shiau, C L Wu, A G Efstaf'ev. [Prothymosin alpha interacts with C-terminal domain of histone H1 and dissociates p53-histone H1 complex]. Molekuliarnaia biologiia. vol 45. issue 4. 2011-10-25. PMID:21954601. |
previously, a histone-binding nuclear protein prothymosin alpha (prota) was shown to trigger a p53 response. |
2011-10-25 |
2023-08-12 |
Not clear |
| I Dolka, T Motyl, R Malicka, E Sapierzyński, M Fabisia. Relationship between receptors for insulin-like growth factor- I, steroid hormones and apoptosis-associated proteins in canine mammary tumors. Polish journal of veterinary sciences. vol 14. issue 2. 2011-08-02. PMID:21721409. |
the aim of the present study was the evaluation of igf-ir expression and its correlation to the expression of estrogen receptor alpha (eralpha) and progesterone receptor (pr), proteins: bcl-2, bax, p53 in canine mammary gland tumors, and also a correlation with other features: bitch's age, tumor diameter, histologic type of tumor, degree of histologic malignancy, proliferate activity. |
2011-08-02 |
2023-08-12 |
Not clear |
| Nabanita Patra, Umasankar De, Jin-Ah Kang, Ji Mim Kim, Mee Young Ahn, Jaewon Lee, Jee H Jung, Hae Young Chung, Hyung Ryong Moon, Hyung Sik Ki. A novel epoxypropoxy flavonoid derivative and topoisomerase II inhibitor, MHY336, induces apoptosis in prostate cancer cells. European journal of pharmacology. vol 658. issue 2-3. 2011-07-25. PMID:21376033. |
also, mhy336 significantly down-regulated topoisomerase ii alpha expression and up-regulated p53 expression in lncap cells (wild-type p53), whereas it up-regulated the topoisomerase ii alpha protein in both du145 and pc3 cells (p53 mutated or deleted). |
2011-07-25 |
2023-08-12 |
human |
| Marc R Del Bigi. Cell proliferation in human ganglionic eminence and suppression after prematurity-associated haemorrhage. Brain : a journal of neurology. vol 134. issue Pt 5. 2011-07-22. PMID:21478186. |
the cell cycle arrest transcription factor p53 was transiently increased and the oligodendroglial lineage markers olig2 and platelet-derived growth factor receptor alpha were decreased. |
2011-07-22 |
2023-08-12 |
human |
| A O Ivantsov, E N Imianitov, V M Moiseenko, D E Matsko, A S Artem'ev. [Expression of Ki-67, p53, bcl-2, estrogen receptors alpha in patients with clear cell renal carcinoma and epidermal growth factor receptor mutation]. Arkhiv patologii. vol 73. issue 2. 2011-07-20. PMID:21695979. |
[expression of ki-67, p53, bcl-2, estrogen receptors alpha in patients with clear cell renal carcinoma and epidermal growth factor receptor mutation]. |
2011-07-20 |
2023-08-12 |
Not clear |
| A O Ivantsov, E N Imianitov, V M Moiseenko, D E Matsko, A S Artem'ev. [Expression of Ki-67, p53, bcl-2, estrogen receptors alpha in patients with clear cell renal carcinoma and epidermal growth factor receptor mutation]. Arkhiv patologii. vol 73. issue 2. 2011-07-20. PMID:21695979. |
the expression of ki-67, bcl-2, p53, and estrogen receptors alpha was studied in ccrc with egfr mutation. |
2011-07-20 |
2023-08-12 |
Not clear |
| Ettie Piura, Benjamin Piur. Autoantibodies to tumor-associated antigens in breast carcinoma. Journal of oncology. vol 2010. 2011-07-14. PMID:21113302. |
so far, the following taas have been identified to elicit circulating aabs in breast carcinoma: p53, muc-1, heat shock proteins (hsp-27, hsp-60, and hsp-90), her2/neu/c-erb b2, gipc-1, c-myc, c-myb, cancer-testis antigens (ny-eso-1), brca1, brca2, endostatin, lipophilin b, cyclin b1, cyclin d1, fibulin, insulin-like growth factor binding protein 2 (igfbp-2), topoisomerase ii alpha (topo2α), and cathepsin d. measurement of serum aabs to one specific taa only is of little value for screening and early diagnosis of breast carcinoma; however, assessment of aabs to a panel of taas may have promising diagnostic potential. |
2011-07-14 |
2023-08-12 |
Not clear |
| Hetian Lei, Gisela Velez, Andrius Kazlauska. Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. Molecular and cellular biology. vol 31. issue 9. 2011-06-16. PMID:21357737. |
pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of akt and suppression of p53. |
2011-06-16 |
2023-08-12 |
Not clear |
| Weili Liu, Xiaoxing Li, Eagle S H Chu, Minnie Y Y Go, Lixia Xu, Guijun Zhao, Lili Li, Ning Dai, Jianmin Si, Qian Tao, Joseph J Y Sung, Jun Y. Paired box gene 5 is a novel tumor suppressor in hepatocellular carcinoma through interaction with p53 signaling pathway. Hepatology (Baltimore, Md.). vol 53. issue 3. 2011-05-12. PMID:21319196. |
the antitumorigenic function of pax5 was at least up-regulated by p53 and its downstream targets including tumor necrosis factor, fas ligand, leucine-rich repeats, and death domain-containing, poly(rc) binding protein 4, p21, and growth arrest and dna-damage-inducible alpha. |
2011-05-12 |
2023-08-12 |
mouse |
| P Manikandan, G Vinothini, R Vidya Priyadarsini, D Prathiba, S Nagin. Eugenol inhibits cell proliferation via NF-κB suppression in a rat model of gastric carcinogenesis induced by MNNG. Investigational new drugs. vol 29. issue 1. 2011-04-11. PMID:19851710. |
in the present study, we investigated the modulatory effects of eugenol on nf-κb signaling in a rat model of gastric carcinogenesis induced by n-methyl-n(')-nitro-n-nitrosoguanidine (mnng) by analysing the expression of nuclear factor-kappab (nf-κb) family members ((nf-κb (p50 and p65), inhibitor of kappab alpha (iκbα), phosphorylated iκbα (p-iκbα), iκb kinase β (ikkβ)) and the nf-κb target genes that promote (e.g., cyclin d1, cyclin b and pcna) or inhibit (e.g., p53, p21, and gadd45) cell proliferation and cell survival. |
2011-04-11 |
2023-08-12 |
rat |
| Pinelopi Argyriou, Sotirios G Papageorgiou, Varvara Panteleon, Amanda Psyrri, Vassiliki Bakou, Vassiliki Pappa, Aris Spathis, Panagiota Economopoulou, Efstathios Papageorgiou, Theofanis Economopoulos, Dimitra Rontogiann. Hypoxia-inducible factors in mantle cell lymphoma: implication for an activated mTORC1→HIF-1α pathway. Annals of hematology. vol 90. issue 3. 2011-03-30. PMID:20838824. |
in this study, we investigated downstream the immunohistochemical expression of (ser2448)pmtor [indicative of mtor complex 1 (mtorc1) activation status] as well as of hypoxia-inducible factor 1 alpha (hif-1α), hypoxia-inducible factor 2 alpha (hif-2α), p53, and p21 in the same series of mcl patients. |
2011-03-30 |
2023-08-12 |
Not clear |
| Aydin Sedat, Oguztuzun Serpil, Gurbuz Nurdan, Gul Aylin, Sanli Arif, Ozhavzali Muzeyyen, Satar Bulent, Ozan Sezen, Karadayi Nime. Immunohistochemical localization of glutathione s-transferase isoenzymes (gsta, Gstp, Gstm4, And Gstt1) and tumour marker p53 in matched tissue from normal larynx and laryngeal carcinoma: correlations with prognostic factors. Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale. vol 39. issue 5. 2011-02-01. PMID:20828517. |
the immunohistochemical staining characteristics of glutathione s-transferase (gst) alpha (gsta), pi (gstp), mu (gstm4), and theta (gstt1) and p53 were investigated in laryngeal squamous cell carcinoma (lscc) cases and normal laryngeal tissue from 46 patients. |
2011-02-01 |
2023-08-12 |
Not clear |
| Caigang Liu, Hao Zhang, Chen Shuang, Yang Lu, Feng Jin, Huimian Xu, Ping L. Alterations of ER, PR, HER-2/neu, and P53 protein expression in ductal breast carcinomas and clinical implications. Medical oncology (Northwood, London, England). vol 27. issue 3. 2010-12-30. PMID:19657752. |
the aim of the study is to investigate the alterations in expression of estrogen receptor alpha (er), progesterone receptor (pgr), c-erbb2 gene (her-2/neu), and p53 protein in the progression from ductal carcinoma in situ (dcis) to invasive ductal carcinomas (idc), and the association between their expression and clinicopathologic findings. |
2010-12-30 |
2023-08-12 |
Not clear |
| Xiao-yun Mao, Chui-feng Fan, Hua-chuan Zheng, Jing Wei, Fan Yao, Feng Ji. p53 nuclear accumulation and ERalpha expression in ductal hyperplasia of breast in a cohort of 215 Chinese women. Journal of experimental & clinical cancer research : CR. vol 29. 2010-12-28. PMID:20712900. |
the importance of several molecular markers in breast cancer has been of considerable interest during recent years such as p53 and estrogen receptor alpha (eralpha). |
2010-12-28 |
2023-08-12 |
Not clear |
| Hyuk-Chan Kwon, Sung Hyun Kim, Sung Yong Oh, Suee Lee, Kyung A Kwon, Hong-Jo Choi, Ki-Jae Park, Hyo-Jin Kim, Mee Sook Ro. Clinicopathological significance of p53, hypoxia-inducible factor 1alpha, and vascular endothelial growth factor expression in colorectal cancer. Anticancer research. vol 30. issue 10. 2010-12-10. PMID:21036736. |
the principal objective of this study was to evaluate the prognostic significances of p53, hypoxia inducible factor-1 alpha (hif-1α), and vascular endothelial growth factor (vegf) expression in colorectal cancer. |
2010-12-10 |
2023-08-12 |
Not clear |
| Benjamin Berger, David Capper, Dieter Lemke, Philipp-Niclas Pfenning, Michael Platten, Michael Weller, Andreas von Deimling, Wolfgang Wick, Markus Weile. Defective p53 antiangiogenic signaling in glioblastoma. Neuro-oncology. vol 12. issue 9. 2010-12-02. PMID:20504876. |
p53 responsiveness of the angiogenesis-related target genes, such as vascular endothelial growth factor (vegf), basic fibroblast growth factor (bfgf), thrombospondin 1 (tsp-1), brain-specific angiogenesis inhibitor 1 (bai1), and collagen prolyl-4-hydroxylase alpha 2 (p4ha2), was evaluated by (i) overexpression of wild-type p53 in homozygously tp53-deleted ln-308 cells; (ii) shrna-mediated p53 knockdown in the tp53 wild-type lnt-229 cells; and (iii) chemical induction of wild-type p53 expression in lnt-229 cells by camptothecin. |
2010-12-02 |
2023-08-12 |
Not clear |
| Hirotaka Tomiyasu, Yuko Goto-Koshino, Masashi Takahashi, Yasuhito Fujino, Koichi Ohno, Hajime Tsujimot. Quantitative analysis of mRNA for 10 different drug resistance factors in dogs with lymphoma. The Journal of veterinary medical science. vol 72. issue 9. 2010-11-16. PMID:20431255. |
expression levels of abcb1, abcc1, lung resistance-associated protein (lrp), abcg2, p53, p21(waf1), bcl-2, cd40l, glutathione s-transferase alpha (gstα), and o⁶-methylguanine-dna-methyltransferase (mgmt) genes, and mutation of p53 gene were examined in 23 dogs with multicentric high-grade lymphoma to explore their association with drug resistance of the tumor cells. |
2010-11-16 |
2023-08-12 |
Not clear |
| Lusheng Xu, Yeon-Jin Kwon, Natalya Frolova, Adam D Steg, Kun Yuan, Martin R Johnson, William E Grizzle, Renee A Desmond, Andra R Fros. Gli1 promotes cell survival and is predictive of a poor outcome in ERalpha-negative breast cancer. Breast cancer research and treatment. vol 123. issue 1. 2010-11-09. PMID:19902354. |
in these cancers, the association of gli1 with expression of estrogen receptor alpha (eralpha) and progesterone receptor (pr), erbb2, p53, the rate of proliferation, and clinicopathologic parameters and outcome was assessed. |
2010-11-09 |
2023-08-12 |
Not clear |
| Amanda P Struckhoff, Bhumi Patel, Barbara S Beckma. Inhibition of p53 sensitizes MCF-7 cells to ceramide treatment. International journal of oncology. vol 37. issue 1. 2010-09-27. PMID:20514393. |
interestingly, inhibition of p53 using pifithrin alpha or rnai sensitized mcf-7 cells to ceramide-induced cell death. |
2010-09-27 |
2023-08-12 |
Not clear |