| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas Naves, Soha Jawhari, Marie-Odile Jauberteau, Marie-Hélène Ratinaud, Mireille Verdie. Autophagy takes place in mutated p53 neuroblastoma cells in response to hypoxia mimetic CoCl(2). Biochemical pharmacology. vol 85. issue 8. 2013-05-16. PMID:23380477. |
to delineate the eventual implication of the p53(mut) in the autophagic process in response to hypoxia, we monitored signaling in p53(wt)shsy5y cells, after either shrna-p53 down-regulation or transcriptional activity inhibition by pifithrin alpha. |
2013-05-16 |
2023-08-12 |
Not clear |
| Simonetta Piana, Moira Ragazzi, Giovanni Tallini, Dario de Biase, Alessia Ciarrocchi, Andrea Frasoldati, Juan Rosa. Papillary thyroid microcarcinoma with fatal outcome: evidence of tumor progression in lymph node metastases: report of 3 cases, with morphological and molecular analysis. Human pathology. vol 44. issue 4. 2013-05-07. PMID:23079204. |
in addition to morphology, immunohistochemical (cyclin d1 and p53) and molecular analyses (braf [v-raf murine sarcoma viral oncogene homolog b1], kras [v-ki-ras2 kirsten rat sarcoma viral oncogene homolog], hras [v-ha-ras harvey rat sarcoma viral oncogene homolog], nras [neuroblastoma ras viral oncogene homolog], and pik3ca [phosphoinositide-3-kinase, catalytic, alpha polypeptide]) were performed. |
2013-05-07 |
2023-08-12 |
rat |
| Alexander Kirilyuk, Mika Shimoji, Jason Catania, Geetaram Sahu, Nagarajan Pattabiraman, Antonio Giordano, Christopher Albanese, Italo Mocchetti, Jeffrey A Toretsky, Vladimir N Uversky, Maria Laura Avantaggiat. An intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation. PloS one. vol 7. issue 11. 2013-05-07. PMID:23133622. |
proteins with high tendency to aggregate include the p53 gene product, tau and alpha synuclein. |
2013-05-07 |
2023-08-12 |
human |
| Jason G Glanzer, Katie A Carnes, Patricia Soto, Shengqin Liu, Lawrence J Parkhurst, Gregory G Oakle. A small molecule directly inhibits the p53 transactivation domain from binding to replication protein A. Nucleic acids research. vol 41. issue 3. 2013-04-17. PMID:23267009. |
this domain functions as a binding site for p53 and other dna damage and repair proteins that contain amphipathic alpha helical domains. |
2013-04-17 |
2023-08-12 |
human |
| Antoine Italiano, Chun-Liang Chen, Rachael Thomas, Matthew Breen, Françoise Bonnet, Nicolas Sevenet, Michel Longy, Robert G Maki, Jean-Michel Coindre, Cristina R Antonesc. Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: a pattern distinct from other sarcomas with complex genomics. Cancer. vol 118. issue 23. 2013-03-06. PMID:22648906. |
the p53 and phosphoinositide-3-kinase, catalytic, alpha polypeptide/v-akt murine thymoma viral oncogene homolog/mechanistic target of rapamycin (pik3ca/akt/mtor) pathways frequently are altered in sarcoma with complex genomics, such as leiomyosarcoma (lms) or undifferentiated pleomorphic sarcoma (ups). |
2013-03-06 |
2023-08-12 |
Not clear |
| José L Neira, Paz Sevilla, Francisco García-Blanc. The C-terminal sterile alpha motif (SAM) domain of human p73 is a highly dynamic protein, which acquires high thermal stability through a decrease in backbone flexibility. Physical chemistry chemical physics : PCCP. vol 14. issue 29. 2013-01-18. PMID:22728462. |
the α-splice variant of p73 (p73α), a homologue of the tumour suppressor p53, has close to its c terminus a sterile alpha motif (sam), samp73, that is involved in protein-biomolecule interactions. |
2013-01-18 |
2023-08-12 |
human |
| Mairead A Murphy, David J O'Connell, Sara L O'Kane, John K O'Brien, Sharon O'Toole, Cara Martin, Orla Sheils, John J O'Leary, Dolores J Cahil. Epitope presentation is an important determinant of the utility of antigens identified from protein arrays in the development of autoantibody diagnostic assays. Journal of proteomics. vol 75. issue 15. 2012-12-04. PMID:22415278. |
we analyse the performance of autoantibodies to the tumour suppressor protein p53 and the novel autoantigens alpha adducin and endosulfine alpha identified in our array screen. |
2012-12-04 |
2023-08-12 |
human |
| J Soares, L Filipe C Castro, M A Reis-Henriques, N M Monteiro, M M Santo. Zebrafish (Danio rerio) life-cycle exposure to chronic low doses of ethinylestradiol modulates p53 gene transcription within the gonads, but not NER pathways. Ecotoxicology (London, England). vol 21. issue 5. 2012-11-08. PMID:22543959. |
real time pcr was used to analyse the expression levels of nucleotide excision repair genes (ner) as well as the tumor suppressor p53 and downstream selected effectors, i.e., p21 (cyclin-dependent kinase inhibitor), gadd45α (growth arrest and dna damage induced 45, alpha), bax (bcl2-associated x protein) and p53 key regulator mdm2 (murine double minute 2 protein). |
2012-11-08 |
2023-08-12 |
zebrafish |
| Christian Liedtke, Christian Trautwei. The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer. European journal of cell biology. vol 91. issue 6-7. 2012-11-07. PMID:22153863. |
targeted stimulation of the caspase-8 promoter by interferons alpha and gamma, cytotoxic drugs or p53 can substantially sensitize hepatoma cells for apoptosis, whereas hepatocellular carcinoma frequently present an inactive caspase-8 gene promoter. |
2012-11-07 |
2023-08-12 |
mouse |
| V Damiano, G Diisernia, F Ciardiello, S Pepe, A Bianco, C Bianco, A Ruggiero, G Baldassarre, G Merlo, G Tortor. Overexpression of wild-type p53 overrides the mitogenic effect of ri-alpha subunit of protein-kinase-a in human breast cells. International journal of oncology. vol 7. issue 2. 2012-10-02. PMID:21552843. |
in this study we evaluated the interaction of p53 and ri alpha on cell cycle progression and cell proliferation of mcf-10a cells. |
2012-10-02 |
2023-08-12 |
human |
| V Damiano, G Diisernia, F Ciardiello, S Pepe, A Bianco, C Bianco, A Ruggiero, G Baldassarre, G Merlo, G Tortor. Overexpression of wild-type p53 overrides the mitogenic effect of ri-alpha subunit of protein-kinase-a in human breast cells. International journal of oncology. vol 7. issue 2. 2012-10-02. PMID:21552843. |
retroviral vector-mediated overexpression of wild-type p53 in the mcf-10a neo and mcf-10a ri alpha cells determined a marked inhibition of ri alpha protein expression in mcf-10a-p53 cells and induced g0/g1 accumulation, cell gowth arrest and changes in cell morphology not due to apoptosis in both mcf-10a-p53 and mcf-10a ri alpha-p53 cells. |
2012-10-02 |
2023-08-12 |
human |
| V Damiano, G Diisernia, F Ciardiello, S Pepe, A Bianco, C Bianco, A Ruggiero, G Baldassarre, G Merlo, G Tortor. Overexpression of wild-type p53 overrides the mitogenic effect of ri-alpha subunit of protein-kinase-a in human breast cells. International journal of oncology. vol 7. issue 2. 2012-10-02. PMID:21552843. |
on the other hand, in the mcf-10a ri alpha cells we observed an increased expression of the endogenous p53, although these cells were still able to proliferate. |
2012-10-02 |
2023-08-12 |
human |
| V Damiano, G Diisernia, F Ciardiello, S Pepe, A Bianco, C Bianco, A Ruggiero, G Baldassarre, G Merlo, G Tortor. Overexpression of wild-type p53 overrides the mitogenic effect of ri-alpha subunit of protein-kinase-a in human breast cells. International journal of oncology. vol 7. issue 2. 2012-10-02. PMID:21552843. |
these results suggest that overexpression of wildtype p53 acts in a dominant fashion to abrogate the ri alpha induction of g1>s transition and cell proliferation. |
2012-10-02 |
2023-08-12 |
human |
| V Damiano, G Diisernia, F Ciardiello, S Pepe, A Bianco, C Bianco, A Ruggiero, G Baldassarre, G Merlo, G Tortor. Overexpression of wild-type p53 overrides the mitogenic effect of ri-alpha subunit of protein-kinase-a in human breast cells. International journal of oncology. vol 7. issue 2. 2012-10-02. PMID:21552843. |
moreover, overexpression of ri alpha leads to increased synthesis of endogenous p53 which, however, is unable to interfere with the ri alpha-dependent mitogenic signalling. |
2012-10-02 |
2023-08-12 |
human |
| W Uckert, W Walther, O Humme. Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines. International journal of oncology. vol 6. issue 5. 2012-10-02. PMID:21556635. |
a significant decrease in the cea-specific mrna and protein was observed in tnf-transduced tumor cells ls174t and lovo while other probes (c-myc, k-ras, c-jun, p53, tgf alpha) as well as anti-k-ras- and anti-p53-antibodies failed to detect differences between cytokine-transduced and parental tumor cells. |
2012-10-02 |
2023-08-12 |
human |
| E Castelli, U Wollin. Mediterranean and immunodeficiency associated Kaposi's sarcoma - Does micromorphology reflect clinical patterns? Oncology reports. vol 4. issue 2. 2012-10-02. PMID:21590045. |
immunohistochemistry was performed on deparaffinated sections using the microwave technique with avidin-peroxidase and 3-amino-ethyl-carbazole for alpha smooth muscle actin, cd34, phosphotyrosine, p53, and bcl-2. |
2012-10-02 |
2023-08-12 |
Not clear |
| E Castelli, U Wollin. Mediterranean and immunodeficiency associated Kaposi's sarcoma - Does micromorphology reflect clinical patterns? Oncology reports. vol 4. issue 2. 2012-10-02. PMID:21590045. |
both types could further be characterized by presence of alpha smooth muscle actin and cd34 expressing cells, high levels of phosphotyrosinase in plump spindle cells and variable expression of p53, sometimes coexpressed with phosphotyrosinase indicating cellular activation. |
2012-10-02 |
2023-08-12 |
Not clear |
| Mary T Sylvia, Surendra Kumar, Papa Dasar. The expression of immunohistochemical markers estrogen receptor, progesterone receptor, Her-2-neu, p53 and Ki-67 in epithelial ovarian tumors and its correlation with clinicopathologic variables. Indian journal of pathology & microbiology. vol 55. issue 1. 2012-08-06. PMID:22499297. |
this study aims to evaluate the expression of estrogen receptor alpha (er α), progesterone receptor a (pra), her-2-neu, p53, and ki-67 in epithelial ovarian tumors and their correlation with various clinicopathologic variables. |
2012-08-06 |
2023-08-12 |
Not clear |
| Dina Fomina-Yadlin, Stefan Kubicek, Amedeo Vetere, Kai Hui Hu He, Kaihui Hu He, Stuart L Schreiber, Bridget K Wagne. GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity. PloS one. vol 7. issue 1. 2012-05-08. PMID:22242153. |
gw8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity. |
2012-05-08 |
2023-08-12 |
Not clear |
| Rebecca Tuttle, Kelly R Miller, J Nicholas Maiorano, Paula M Termuhlen, Yongping Gao, Steven J Berberic. Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence. International journal of cancer. vol 130. issue 10. 2012-05-04. PMID:21671470. |
estrogen repression of ypel3 expression was found to be independent of p53 but dependent on estrogen receptor alpha expression. |
2012-05-04 |
2023-08-12 |
Not clear |