| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Duan, Ricardo E Perez, Carl G Mak. Alpha ketoglutarate levels, regulated by p53 and OGDH, determine autophagy and cell fate/apoptosis in response to Nutlin-3a. Cancer biology & therapy. vol 20. issue 3. 2020-05-19. PMID:30289354. |
alpha ketoglutarate levels, regulated by p53 and ogdh, determine autophagy and cell fate/apoptosis in response to nutlin-3a. |
2020-05-19 |
2023-08-13 |
Not clear |
| Otília Porubiaková, Natália Bohálová, Alberto Inga, Natália Vadovičová, Jan Coufal, Miroslav Fojta, Václav Brázd. The Influence of Quadruplex Structure in Proximity to P53 Target Sequences on the Transactivation Potential of P53 Alpha Isoforms. International journal of molecular sciences. vol 21. issue 1. 2020-05-18. PMID:31878115. |
the influence of quadruplex structure in proximity to p53 target sequences on the transactivation potential of p53 alpha isoforms. |
2020-05-18 |
2023-08-13 |
human |
| Prerana Jha, Niveditha Manjunath, Jyotsna Singh, Kalaivani Mani, Ajay Garg, Kavneet Kaur, Mehar C Sharma, Amol Raheja, Ashish Suri, Chitra Sarkar, Vaishali Sur. Analysis of PD-L1 expression and T cell infiltration in different molecular subgroups of diffuse midline gliomas. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 39. issue 6. 2020-04-28. PMID:31625205. |
one hundred and twenty-six dmgs (89 adult and 37 pediatric) were assessed for immune profile (pd-l1, cluster of differentiation (cd3, cd8) and genetic markers (mutation in 27th amino acid of histone h3 (h3k27m), alpha thalassemia/mental retardation syndrome x-linked (atrx), isocitrate dehydrogenase 1 (idh1), p53) by immunohistochemistry. |
2020-04-28 |
2023-08-13 |
Not clear |
| Changlong Shi, Li Sun, Shaozhuang Liu, Enchong Zhang, Yongsheng Son. Overexpression of Karyopherin Subunit alpha 2 (KPNA2) Predicts Unfavorable Prognosis and Promotes Bladder Cancer Tumorigenicity via the P53 Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-03-16. PMID:32147666. |
overexpression of karyopherin subunit alpha 2 (kpna2) predicts unfavorable prognosis and promotes bladder cancer tumorigenicity via the p53 pathway. |
2020-03-16 |
2023-08-13 |
human |
| Ssu-Yu Chen, Shu-Ting Liu, Wun-Rong Lin, Chi-Kang Lin, Shih-Ming Huan. The Mechanisms Underlying the Cytotoxic Effects of Copper Via Differentiated Embryonic Chondrocyte Gene 1. International journal of molecular sciences. vol 20. issue 20. 2020-03-03. PMID:31652494. |
copper sulfate also increased the levels of apoptosis, senescence, mitochondrial dysfunction, autophagy, ros, and the expression of several stress proteins, including atf3, c-fos, dec1 (differentiated embryonic chondrocyte gene 1), p21, p53, and hif-1α (hypoxia-inducible factor 1 alpha). |
2020-03-03 |
2023-08-13 |
Not clear |
| Zelin Tian, Jianing Tang, Qian Yang, Xin Li, Jian Zhu, Gaosong W. Atypical ubiquitin-binding protein SHARPIN promotes breast cancer progression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 119. 2020-02-25. PMID:31518875. |
abnormal oncogenic signaling has important effects on the development of breast cancer, such as erα/ esr1 (estrogen receptor alpha), pten (gene of phosphate and tension homology deleted on chromsome ten), nfκb(nuclear factor κb), and tumor protein p53 (p53 / tp53). |
2020-02-25 |
2023-08-13 |
Not clear |
| Hai Xiao, Xinyue Qin, Jinping Wan, Rong L. Pharmacological Targets and the Biological Mechanisms of Formononetin for Alzheimer's Disease: A Network Analysis. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-01-16. PMID:31175839. |
results seven key target genes for formononetin in the treatment of patients with ad were identified, including estrogen receptor alpha (esr1), peroxisome proliferator-activated receptor gamma (pparg), tumor protein p53 (tp53), sirtuin 1 (sirt1), tumor necrosis factor (tnf), cytochrome p450 19a1 (cyp19a1), and nuclear factor (erythroid-derived 2)-like 2 (nfe2l2). |
2020-01-16 |
2023-08-13 |
Not clear |
| Kumaraswamy Naidu Chitrala, Mitzi Nagarkatti, Prakash Nagarkatti, Suneetha Yeguvapall. Analysis of the International journal of molecular sciences. vol 20. issue 12. 2019-11-27. PMID:31216622. |
among the estrogen receptors, estrogen receptor alpha (erα) is known to interact with tumor suppressor protein p53 directly thereby repressing its function. |
2019-11-27 |
2023-08-13 |
Not clear |
| T. Hachisuga, K. Fukuda, M. Uchiyama, N. Matsuo, T. Iwasaka, H. Sugimor. Immunohistochemical study of p53 expression in endometrial carcinomas: correlation with markers of proliferating cells and clinicopathologic features. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 3. issue 6. 2019-11-20. PMID:11578370. |
using anti-p53 (pab1801 and pab240), anti-dna polymerase alpha and ki-67 monoclonal antibodies, the expression of p53 was studied in 11 normal endometria, 14 endometrial hyperplasias and 27 endometrial carcinomas and its relationship to the proliferative activity of the tumors was examined. |
2019-11-20 |
2023-08-12 |
Not clear |
| T. Hachisuga, K. Fukuda, M. Uchiyama, N. Matsuo, T. Iwasaka, H. Sugimor. Immunohistochemical study of p53 expression in endometrial carcinomas: correlation with markers of proliferating cells and clinicopathologic features. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 3. issue 6. 2019-11-20. PMID:11578370. |
a significant correlation between p53 expression and labeling indices of ki-67 and dna polymerase alpha was observed in endometrial carcinomas. |
2019-11-20 |
2023-08-12 |
Not clear |
| Shotaro Kamata, Junya Yamamoto, Haruka Ohtani, Yuka Tosaka, Sayumi Yoshikawa, Noriyuki Akahoshi, Isao Ishi. 2D DIGE proteomic analysis reveals fasting-induced protein remodeling through organ-specific transcription factor(s) in mice. FEBS open bio. vol 8. issue 9. 2019-11-20. PMID:30186752. |
upstream regulator analysis highlighted transcriptional regulation by peroxisome proliferator-activated receptor alpha (pparα) in the liver and kidney and by tumor protein/suppressor p53 (tp53) in the thymus, spleen, and liver. |
2019-11-20 |
2023-08-13 |
mouse |
| Anne H S Martinelli, Fernanda C Lopes, Elisa B O John, Célia R Carlini, Rodrigo Ligabue-Brau. Modulation of Disordered Proteins with a Focus on Neurodegenerative Diseases and Other Pathologies. International journal of molecular sciences. vol 20. issue 6. 2019-07-03. PMID:30875980. |
in this review, we discuss some idps that are involved in neurodegenerative diseases (such as beta amyloid, alpha synuclein, tau, and the "idp-like" prp), cancer (p53, c-myc), and diabetes (amylin), focusing on the structural changes of these idps that are linked to such pathologies. |
2019-07-03 |
2023-08-13 |
Not clear |
| Homa Rahnamoun, Juyeong Hong, Zhengxi Sun, Jihoon Lee, Hanbin Lu, Shannon M Laubert. Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4. The Journal of biological chemistry. vol 293. issue 34. 2019-02-28. PMID:29954944. |
using chip-seq in human colon cancer cells, we demonstrate that mutant p53 depletion results in decreased h3k4me1 levels at active enhancers that reveal a striking colocalization of mutant p53 and the h3k4 monomethyltransferase mll4 following chronic tumor necrosis factor alpha (tnfα) signaling. |
2019-02-28 |
2023-08-13 |
human |
| Jinhua Jiang, Gaojie Hu, Changpeng Zhang, Xueping Zhao, Qiang Wang, Liezhong Che. Toxicological analysis of triadimefon on endocrine disruption and oxidative stress during rare minnow (Gobiocypris rarus) larvae development. Environmental science and pollution research international. vol 24. issue 34. 2018-10-31. PMID:28956230. |
furthermore, tdf induced the accumulation of reactive oxygen species (ros) and the activity of antioxidant proteins glutathione peroxidase (gpx), superoxide dismutase (sod), and catalase (cat), and significantly increased the transcriptions of stress response genes p53, growth arrest and dna damage-inducible 45 alpha (gadd45α), and cox1, suggested that tdf might cause oxidative stress during larvae development. |
2018-10-31 |
2023-08-13 |
cat |
| Sandra Lee, Vikrant V Sahasrabuddhe, Diana Mendoza-Cervantes, Rachel Zhao, Máire A Dugga. Tissue-based Immunohistochemical Biomarker Expression in Malignant Glandular Lesions of the Uterine Cervix: A Systematic Review. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. vol 37. issue 2. 2018-08-20. PMID:28582347. |
ais case-comparator biomarkers were hik1083, alpha sma, pax8, vil1, cea, p53, p16, and cd10, and only alpha sma had a difference of 100%. |
2018-08-20 |
2023-08-13 |
Not clear |
| Dalia Medhat, Jihan Hussein, Mehrez E El-Naggar, Mohamed F Attia, Mona Anwar, Yasmine Abdel Latif, Hoda F Booles, Safaa Morsy, Abdel Razik Farrag, Wagdy K B Khalil, Zakaria El-Khaya. Effect of Au-dextran NPs as anti-tumor agent against EAC and solid tumor in mice by biochemical evaluations and histopathological investigations. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 91. 2018-03-22. PMID:28525943. |
the obtained results revealed that eac and solid tumors caused significant increase in liver and kidney functions, liver oxidant parameters, alpha feto protein levels and diminished liver antioxidant accompanied by positive expression of tumor protein p53 of liver while the treatment with au-dextran nps for both types caused improvement in liver and kidney functions, increased liver antioxidant, increased the expression level of b-cell lymphoma 2 gene and subsequently suppressed the apoptotic pathway. |
2018-03-22 |
2023-08-13 |
mouse |
| Natalia Quiroz-Casian, David Lozano-Giral, Antonio Miranda-Duarte, Ivan Garcia-Montalvo, Jose L Rodriguez-Loaiza, Juan C Zenten. ASSOCIATION STUDY BETWEEN POLYMORPHISMS OF THE p53 AND LYMPHOTOXIN ALPHA (LTA) GENES AND THE RISK OF PROLIFERATIVE VITREORETINOPATHY/RETINAL DETACHMENT IN A MEXICAN POPULATION. Retina (Philadelphia, Pa.). vol 38. issue 1. 2018-02-19. PMID:28106707. |
association study between polymorphisms of the p53 and lymphotoxin alpha (lta) genes and the risk of proliferative vitreoretinopathy/retinal detachment in a mexican population. |
2018-02-19 |
2023-08-13 |
Not clear |
| Alfredo Lagunas-Martínez, Enrique García-Villa, Magaly Arellano-Gaytán, Carla O Contreras-Ochoa, Jisela Dimas-González, María E López-Arellano, Vicente Madrid-Marina, Patricio Garigli. MG132 plus apoptosis antigen-1 (APO-1) antibody cooperate to restore p53 activity inducing autophagy and p53-dependent apoptosis in HPV16 E6-expressing keratinocytes. Apoptosis : an international journal on programmed cell death. vol 22. issue 1. 2018-02-12. PMID:27766434. |
finally, using pifithrin alpha we observed a decrease in apoptosis induced by mg132, and by apo-1 plus mg132, suggesting that restoration of apo-1 sensitivity occurs in part through an increase in both the levels and the activity of p53. |
2018-02-12 |
2023-08-13 |
Not clear |
| Tsunehito Nakao, Yasuo Sasagawa, Sumihito Nobusawa, Yasushi Takabatake, Hemragul Sabit, Masashi Kinoshita, Katsuyoshi Miyashita, Yasuhiko Hayashi, Hideaki Yokoo, Mitsutoshi Nakad. Radiation-induced gliomas: a report of four cases and analysis of molecular biomarkers. Brain tumor pathology. vol 34. issue 4. 2018-01-23. PMID:28795231. |
immunohistochemical (ihc) staining for isocitrate dehydrogenase 1 (idh1), p53, alpha thalassemia/mental retardation syndrome x-linked (atrx), and h3k27m, and direct dna sequencing of idh1/2, telomerase reverse transcriptase (tert) promoter, histone h3.3 (h3f3a) and b-raf (braf) genes was performed. |
2018-01-23 |
2023-08-13 |
Not clear |
| Joan J Castellano, Alfons Navarro, Nuria Viñolas, Ramon M Marrades, Jorge Moises, Anna Cordeiro, Adela Saco, Carmen Muñoz, Dolors Fuster, Laureano Molins, Josep Ramirez, Mariano Monz. LincRNA-p21 Impacts Prognosis in Resected Non-Small Cell Lung Cancer Patients through Angiogenesis Regulation. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. vol 11. issue 12. 2017-11-13. PMID:27496652. |
long intergenic noncoding rna-p21 (lincrna-p21) is a long noncoding rna transcriptionally activated by tumor protein p53 (tp53) and hypoxia inducible factor 1 alpha subunit (hif1a). |
2017-11-13 |
2023-08-13 |
Not clear |