| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Efstathios T Pavlidis, Konstantinos G Sapalidis, Theodoros E Pavlidi. Modern aspects of the management of pancreatic intraductal papillary mucinous neoplasms: a narrative review. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 63. issue 3. 2023-01-02. PMID:36588487. |
the genes most frequently altered include kirsten rat sarcoma viral proto-oncogene (kras), tumor protein p53 (tp53), cyclin-dependent kinase inhibitor 2a (cdkn2a), smad family member 4 (smad4), and guanine nucleotide-binding protein, alpha stimulating (gnas). |
2023-01-02 |
2023-08-14 |
rat |
| Charlotte Van Der Stukken, Tim S Nawrot, Congrong Wang, Wouter Lefebvre, Charlotte Vanpoucke, Michelle Plusquin, Harry A Roels, Bram G Janssen, Dries S Marten. The association between ambient particulate matter exposure and the telomere-mitochondrial axis of aging in newborns. Environment international. vol 171. 2022-12-27. PMID:36574746. |
tumor suppressor p53 (p53) and peroxisome proliferator-activated receptor gamma co-activator 1 alpha (pgc-1α), are associated with prenatal air pollution and whether there are underlying mechanisms. |
2022-12-27 |
2023-08-14 |
Not clear |
| Li Xu, Zhijie Chen, Yu Zhang, Lu Cui, Zheyi Liu, Xuefeng Li, Shengwang Liu, Hai L. P53 maintains gallid alpha herpesvirus 1 replication by direct regulation of nucleotide metabolism and ATP synthesis through its target genes. Frontiers in microbiology. vol 13. 2022-12-12. PMID:36504811. |
p53 maintains gallid alpha herpesvirus 1 replication by direct regulation of nucleotide metabolism and atp synthesis through its target genes. |
2022-12-12 |
2023-08-14 |
chicken |
| Ruipeng Wang, Xiaoye Qiao, Xiaobin Wan. Exploring the mechanisms of Gui Zhi Fu Ling Wan on varicocele via network pharmacology and molecular docking. Andrologia. 2022-11-13. PMID:36372090. |
the main targets of the active components on vc were tumour protein p53 (tp53), tumour necrosis factor (tnf), hypoxia inducible factor 1 subunit alpha (hif1a), interleukin-6 (il-6), caspase 3 (casp3), catalase (cat), prostaglandin-endoperoxide synthase 2 (ptgs2), vascular endothelial growth factor a (vegfa). |
2022-11-13 |
2023-08-14 |
cat |
| Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Set. The role of p53 in the alternation of vascular functions. Frontiers in pharmacology. vol 13. 2022-09-23. PMID:36147350. |
p53 also crosstalk with other key transcription factors like hypoxia-inducible factor 1 alpha that contribute to the progression of cardiovascular diseases. |
2022-09-23 |
2023-08-14 |
Not clear |
| Zuoxiang Wang, Zhisong He, Qinkao Xuan, Yue Zhang, Jialiang Xu, Jia Lin, Hongxia Li, Weixiang Chen, Tingbo Jian. Analysis of the potential ferroptosis mechanism and multitemporal expression change of central ferroptosis-related genes in cardiac ischemia-reperfusion injury. Frontiers in physiology. vol 13. 2022-09-12. PMID:36091399. |
a total of 43 defrgs and 7 hub genes (tumor protein p53 [tp53], tumor necrosis factor [tnf], hypoxia-inducible factor 1 subunit alpha [hif1a], interleukin 6 [il6], heme oxygenase 1 [hmox1], x-box binding protein 1 [xbp1], and caspase 8 [casp8]) were screened based on bioinformatics analysis. |
2022-09-12 |
2023-08-14 |
rat |
| Shih-Yao Chen, I-Ming Jou, Po-Yen Ko, Kai-Lan Hsu, Wei-Ren Su, Li-Chieh Kuo, Pei-Yuan Lee, Chao-Liang Wu, Po-Ting W. Amelioration of experimental tendinopathy by lentiviral CD44 gene therapy targeting senescence-associated secretory phenotypes. Molecular therapy. Methods & clinical development. vol 26. 2022-07-18. PMID:35846572. |
cd44 overexpressed tenocyte transfectants exhibited reduced levels of il-6, matrix metalloproteinases (mmps), cyclooxygenase (cox)-2, p53, p21, p16, sa-β-gal, and phospho-nuclear factor (nf)-κb, whereas their collagen type i alpha 1 (col1a1) and tenomodulin (tnmd) levels were increased when compared with control transfectants under il-1β-stimulated conditions. |
2022-07-18 |
2023-08-14 |
human |
| R Dumke, C Dumke, F Eberle, Ch Nimsky, U Keber, R Engenhart-Cabillic, S Lautenschläge. Monocentric evaluation of Ki-67 labeling index in combination with a modified RPA score as a prognostic factor for survival in IDH-wildtype glioblastoma patients treated with radiochemotherapy. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]. 2022-05-25. PMID:35612598. |
other markers implicated in tumor formation and/or malignancy are p53, alpha thalassemia/mental retardation syndrome x-linked (atrx), epidermal growth factor receptor splice variant iii (egfrviii), and ki-67, with loss of nuclear atrx expression and lower ki-67 index being associated with prolonged survival. |
2022-05-25 |
2023-08-13 |
Not clear |
| Ruizhong Wang, Brijesh Kumar, Emma H Doud, Amber L Mosley, Matthew S Alexander, Louis M Kunkel, Harikrishna Nakshatr. Skeletal muscle-specific overexpression of miR-486 limits mammary tumor-induced skeletal muscle functional limitations. Molecular therapy. Nucleic acids. vol 28. 2022-04-11. PMID:35402076. |
in this model, mir-486 reversed cancer-induced skeletal muscle changes, including loss of p53, phospho-akt, and phospho-laminin alpha 2 (lama2) and gain of hnrnpa0 and srsf10 phosphorylation. |
2022-04-11 |
2023-08-13 |
mouse |
| Mohammed W Al-Rabia, Nabil A Alhakamy, Waleed Y Rizg, Adel F Alghaith, Osama A A Ahmed, Usama A Fahm. Boosting curcumin activity against human prostatic cancer PC3 cells by utilizing scorpion venom conjugated phytosomes as promising functionalized nanovesicles. Drug delivery. vol 29. issue 1. 2022-03-10. PMID:35266425. |
the anticancer effect of the fabricated formulation was determined by performing a tetrazolium (mtt) assay, cell cycle analysis, annexin v staining, and examining the expression levels of bcl-associated x-protein (bax), p53, caspase-3, b-cell lymphoma 2 (bcl-2), nuclear factor kappa beta (nf-kb), and tumor necrosis factor alpha (tnf-α). |
2022-03-10 |
2023-08-13 |
human |
| John O Olanlokun, Wisdom Oshireku Abiodun, Oluwakemi Ebenezer, Neil A Koorbanally, Olufunso Olabode Olorunsog. Curcumin modulates multiple cell death, matrix metalloproteinase activation and cardiac protein release in susceptible and resistant Plasmodium berghei-infected mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 146. 2021-12-11. PMID:34894518. |
serum tumour necrosis factor alpha (tnf-α), c-reactive protein (crp), interleukins-1 beta (il-1β) and interleukins-6 (il-6) as well as caspases-3, 9 (c3 and c9), p53, serum troponin i (ti) and creatine kinase (ck), were assayed using elisa techniques. |
2021-12-11 |
2023-08-13 |
mouse |
| Paula Pierozan, Daiane Cattani, Oskar Karlsso. Tumorigenic activity of alternative per- and polyfluoroalkyl substances (PFAS): Mechanistic in vitro studies. The Science of the total environment. 2021-11-29. PMID:34843762. |
exposure to 100 μm pfhxs on the other hand was shown to affect important regulatory cell-cycle proteins (cyclin d1, cdk6, p27, p53 and erk) and induced cell proliferation, at least in part through activation of the constitutive androstane receptor (car) and the peroxisome proliferator-activated receptor alpha (pparα). |
2021-11-29 |
2023-08-13 |
human |
| Soo Fern Lee, Jayshree L Hirpara, Jianhua Qu, Sanjiv K Yadav, Karishma Sashaphibulkij, Shazib Pervai. Identification of a novel catalytic inhibitor of topoisomerase II alpha that engages distinct mechanisms in p53 Cancer letters. 2021-11-29. PMID:34843865. |
identification of a novel catalytic inhibitor of topoisomerase ii alpha that engages distinct mechanisms in p53 we report a novel topoisomerase iiα inhibitor, mercaptopyridine oxide (mpo), which induces g2/m arrest and senescence with distinctly different cell cycle regulators (p21 or p14 |
2021-11-29 |
2023-08-13 |
Not clear |
| Cihan Gur, Fatih Mehmet Kandemir, Ekrem Darendelioglu, Cuneyt Caglayan, Sefa Kucukler, Ozge Kandemir, Mustafa Ileritur. Morin protects against acrylamide-induced neurotoxicity in rats: an investigation into different signal pathways. Environmental science and pollution research international. vol 28. issue 36. 2021-09-20. PMID:33939091. |
biochemical and western blot analyses showed that acr increased malondialdehyde (mda), p38α mitogen-activated protein kinase (p38α mapk), nuclear factor kappa-b (nf-κb), tumor necrosis factor alpha (tnf-α), interleukin-1 beta (il-1β), interleukin-6 (il-6), cyclooxygenase-2 (cox-2), p53, caspase-3, bcl-2 associated x protein (bax), beclin-1, light chain 3a (lc3a), and light chain 3b (lc3b) levels and decreased those of superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), glutathione (gsh), b-cell lymphoma-2 (bcl-2), mammalian target of rapamycin (mtor), phosphoinositide 3-kinase (pi3k), and protein kinase b (akt) in brain tissue and therefore induced neurotoxicity by causing oxidative stress, inflammation, apoptosis, and autophagy. |
2021-09-20 |
2023-08-13 |
rat |
| Huiying Wan, Dingding Zhang, Weimin Hu, Zhen Xie, Qiu Du, Qiongrong Xia, Taishen Wen, Haiping Ji. Aberrant PTEN, PIK3CA, pMAPK, and TP53 expression in human scalp and face angiosarcoma. Medicine. vol 100. issue 30. 2021-08-20. PMID:34397726. |
this study aimed to investigate the expression of phosphatase and tensin homolog (pten), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca), phosphorylated mitogen-activated kinase-like protein (pmapk), and tumor protein p53 (tp53) in scalp and face angiosarcoma and to assess tumor tissue apoptosis.the expression and intracellular distribution of pten, pik3ca, pmapk, and tp53 proteins in 21 specimens of human scalp and face angiosarcoma and 16 specimens of human benign hemangioma were evaluated using immunohistochemistry. |
2021-08-20 |
2023-08-13 |
human |
| Mabrouk Attia Abd Eldaim, Ehab Tousson, Mohamed Mohamed Soliman, Ibrahim El Tantawy El Sayed, Abdel Aleem H Abdel Aleem, Hebatalla Nashaat Elsharkaw. Grape seed extract ameliorated Ehrlich solid tumor-induced hepatic tissue and DNA damage with reduction of PCNA and P53 protein expression in mice. Environmental science and pollution research international. vol 28. issue 32. 2021-08-13. PMID:33851294. |
the ehrlich solid tumor significantly raised the activities of alt, ast, and alp; the level of alpha fetoprotein (afp) in serum; and the protein expressions of hepatic proliferating cell nuclear antigen (pcna) and tumor suppressor protein (p53), as well as induced dna damage and pathological alterations in liver tissue. |
2021-08-13 |
2023-08-13 |
mouse |
| Israa F Mosa, Haitham H Abd, Abdelsalam Abuzreda, Amenh B Yousif, Nadhom Assa. Chitosan and Curcumin Nanoformulations against Potential Cardiac Risks Associated with Hydroxyapatite Nanoparticles in Wistar Male Rats. International journal of biomaterials. vol 2021. 2021-08-11. PMID:34373695. |
in this study, the cardiac toxicity of rats orally exposed to hydroxyapatite nanoparticles (hapnps) has been observed through an increase in myocardial infarction serum markers including ck-mb and alterations in routine blood factors, expression of apoptosis-related protein p53, and increased levels of serum inflammatory markers represented by the tumor necrosis factor alpha and interleukin-6, as well as a decline in heart antioxidant enzymes and reduced glutathione level, while an induction in lipid peroxidation and nitric oxide has been observed, as well as notable histological and histochemical alterations in the heart of these animals. |
2021-08-11 |
2023-08-13 |
rat |
| Shyam Sundar P, Podila Naresh, Justin A, Ashish Wadhwani, Suresh Kumar M, Selvaraj Jubi. Dual Modulators of p53 and Cyclin D in ER Alpha Signaling by Albumin Nanovectors Bearing Zinc Chaperones for ER-positive Breast Cancer Therapy. Mini reviews in medicinal chemistry. vol 21. issue 7. 2021-08-03. PMID:33238842. |
dual modulators of p53 and cyclin d in er alpha signaling by albumin nanovectors bearing zinc chaperones for er-positive breast cancer therapy. |
2021-08-03 |
2023-08-13 |
Not clear |
| Michael L Rossetti, Robert J Tomko, Bradley S Gordo. Androgen depletion alters the diurnal patterns to signals that regulate autophagy in the limb skeletal muscle. Molecular and cellular biochemistry. vol 476. issue 2. 2021-07-20. PMID:33128669. |
moreover, we observed an increase in the protein expression pattern of p53 and the mrna of the p53 target genes cyclin-dependent kinase inhibitor 1a (p21) and growth arrest and dna damage alpha (gadd45a), which are known to increase autophagy and induce muscle atrophy. |
2021-07-20 |
2023-08-13 |
mouse |
| Yasmeen M Attia, Rasha A Tawfiq, Abdullah A Gibriel, Aya A Ali, Dina H Kassem, Olfat A Hammam, Mohamed M Elmaza. Activation of FXR modulates SOCS3/Jak2/STAT3 signaling axis in a NASH-dependent hepatocellular carcinoma animal model. Biochemical pharmacology. vol 186. 2021-06-30. PMID:33675775. |
this was paralleled with noticeable downregulation of alpha fetoprotein along with reduction in interferon gamma and transforming growth factor beta-1 hepatic levels besides caspase-3 and p53 upregulation. |
2021-06-30 |
2023-08-13 |
Not clear |