| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Lee, S-Y Choi, B-H Bin, N-H Kim, K H Kim, D-H Choi, J Han, H Choi, A-Y Lee, T R Lee, E-G Ch. Interferon-inducible T-cell alpha chemoattractant (ITAC) induces the melanocytic migration and hypopigmentation through destabilizing p53 via histone deacetylase 5: a possible role of ITAC in pigment-related disorders. The British journal of dermatology. vol 176. issue 1. 2017-10-03. PMID:27436825. |
interferon-inducible t-cell alpha chemoattractant (itac) induces the melanocytic migration and hypopigmentation through destabilizing p53 via histone deacetylase 5: a possible role of itac in pigment-related disorders. |
2017-10-03 |
2023-08-13 |
Not clear |
| Carmen Rios, Gianluca D'Ippolito, Kevin M Curtis, Gaëtan J-R Delcroix, Lourdes A Gomez, Jimmy El Hokayem, Megan Rieger, Ricardo Parrondo, Alicia de Las Pozas, Carlos Perez-Stable, Guy A Howard, Paul C Schille. Low Oxygen Modulates Multiple Signaling Pathways, Increasing Self-Renewal, While Decreasing Differentiation, Senescence, and Apoptosis in Stromal MIAMI Cells. Stem cells and development. vol 25. issue 11. 2017-09-11. PMID:27059084. |
low oxygen tension, the physiological environment in progenitor cell-rich regions of the bone marrow microarchitecture, stimulates the self-renewal of marrow-isolated adult multilineage inducible (miami) cells and expression of sox2, nanog, oct4a nuclear accumulation, notch intracellular domain, notch target genes, neuronal transcriptional repressor element 1 (re1)-silencing transcription factor (rest), and hypoxia-inducible factor-1 alpha (hif-1α), and additionally, by decreasing the expression of (i) the proapoptotic proteins, apoptosis-inducing factor (aif) and bak, and (ii) senescence-associated p53 expression and β-galactosidase activity. |
2017-09-11 |
2023-08-13 |
human |
| Matthias B Stope, Dominique Koensgen, Jörg Weimer, Madeleine Paditz, Martin Burchardt, Dirk Bauerschlag, Alexander Muste. The future therapy of endometrial cancer: microRNA's functionality, capability, and putative clinical application. Archives of gynecology and obstetrics. vol 294. issue 5. 2017-08-09. PMID:27637583. |
the available biomarkers, such as cellular tumor antigen p53 (tp53), phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase (pten), and phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) genes alone might not be sufficient, and thus, new predictive and prognostic biomarkers are urgently required. |
2017-08-09 |
2023-08-13 |
Not clear |
| Sapan J Patel, Gaurang L Trivedi, Costel C Darie, Bayard D Clarkso. The possible roles of B-cell novel protein-1 (BCNP1) in cellular signalling pathways and in cancer. Journal of cellular and molecular medicine. vol 21. issue 3. 2017-07-17. PMID:27680505. |
we found that bcnp1 is highly altered in some types of cancers and that bcnp1 copy-number changes and mutations co-occur with other molecular alteration events for tp53 (tumour protein p53), pik3ca (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha), mapk1 (mitogen-activated protein kinase-1; erk: extracellular signal regulated kinase), kras (kirsten rat sarcoma viral oncogene homolog) and akt2 (v-akt murine thymoma viral oncogene homolog 2). |
2017-07-17 |
2023-08-13 |
rat |
| José L Neira, Ana Cámara-Artiga. Trifluoroethanol-induced conformational transition of the C-terminal sterile alpha motif (SAM) of human p73. Archives of biochemistry and biophysics. vol 619. 2017-05-15. PMID:28235466. |
the alpha splice variant of p73 (p73α), a homologue of the tumour suppressor p53, has at its c terminus a sterile alpha motif (sam); this domain, samp73, is involved in lipid binding and it is thought to mediate in protein-protein interactions. |
2017-05-15 |
2023-08-13 |
human |
| L Manta, N Suciu, O Toader, R M Purcărea, A Constantin, F Pop. The etiopathogenesis of uterine fibromatosis. Journal of medicine and life. vol 9. issue 1. 2017-04-07. PMID:27974911. |
proliferative effects of estrogen and progesterone may be exercised through proinflammatory factors (tnf alpha), growth factors (igf1, igf2, tgfbeta3 and betafgf) or inhibitors of apoptosis (p53 suppression). |
2017-04-07 |
2023-08-13 |
Not clear |
| Wei Chang, Wei He, Pei-Pei Li, Sha-Sha Song, Ping-Fan Yuan, Jing-Tao Lu, Wei We. Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms. European journal of pharmacology. vol 784. 2017-03-02. PMID:27181068. |
the levels of serum alanine aminotransferase (alt), glutamic oxalacetic transaminase (ast), alkaline phosphatase (alp) and alpha fetoprotein (afp) were analyzed by elisa kits, and the protein levels of p53, murine double minute (mdm) 2, bax, bcl-2, bcl-xl, cytochrome c, caspase-3, caspase-9 and poly (adp-ribose) polymerase (parp) were analyzed by western blot. |
2017-03-02 |
2023-08-13 |
rat |
| Takeharu Kanazawa, Kozue Kodama, Mitsuhiro Nokubi, Kazuo Gotsu, Akihiro Shinnabe, Masayo Hasegawa, Gen Kusaka, Yukiko Iin. A case of solitary fibrous tumor arising from the palatine tonsil. Ear, nose, & throat journal. vol 94. issue 3. 2016-11-07. PMID:25738718. |
immunohistochemical studies were strongly positive for cd34 and bcl-2, mildly positive for phosphorylated protein kinase b and phosphorylated extracellular signal-regulated kinase 1/2, and negative for platelet-derived growth factor receptor alpha and p53. |
2016-11-07 |
2023-08-13 |
Not clear |
| Xiaodu Wang, Chunyan Shao, Luyan Wang, Qunjing Li, Houhui Song, Weihuan Fan. The viral non-structural protein 1 alpha (Nsp1α) inhibits p53 apoptosis activity by increasing murine double minute 2 (mdm2) expression in porcine reproductive and respiratory syndrome virus (PRRSV) early-infected cells. Veterinary microbiology. vol 184. 2016-10-11. PMID:26854347. |
the viral non-structural protein 1 alpha (nsp1α) inhibits p53 apoptosis activity by increasing murine double minute 2 (mdm2) expression in porcine reproductive and respiratory syndrome virus (prrsv) early-infected cells. |
2016-10-11 |
2023-08-13 |
Not clear |
| Xiaodu Wang, Chunyan Shao, Luyan Wang, Qunjing Li, Houhui Song, Weihuan Fan. The viral non-structural protein 1 alpha (Nsp1α) inhibits p53 apoptosis activity by increasing murine double minute 2 (mdm2) expression in porcine reproductive and respiratory syndrome virus (PRRSV) early-infected cells. Veterinary microbiology. vol 184. 2016-10-11. PMID:26854347. |
we show for the first time that the non-structural protein 1 alpha (nsp1α) of prrsv is a negative regulator of p53 activity through increasing mdm2 expression and p53 ubiquitination, while p53 is inhibitory to prrsv replication at the early stage of infection. |
2016-10-11 |
2023-08-13 |
Not clear |
| Hee Jeong Kong, Il Kyu Lee, Julan Kim, Woo-Jin Kim, Hyung Soo Kim, Wang Sik Cho, Dong-Wook Kim, Jung Youn Park, Cheul Min A. RNA-Seq-based transcriptome analysis of Korean rose bitterling (Rhodeus uyekii) exposed to synthetic estrogen 17-α-ethinylestradiol (EE2). Marine genomics. vol 24 Pt 3. 2016-09-26. PMID:26112897. |
the analysis revealed that ee2 induced the expression of various genes, including sex hormone genes, anti-mullerian hormone, vitellogenin, and estrogen receptor alpha; cancer genes, breast cancer anti-estrogen resistance protein 3, caveolin 2, and smad2; and apoptotic genes, p53, bcl-2, tnf-α, and wdr36. |
2016-09-26 |
2023-08-13 |
human |
| Netta Mäkinen, Mervi Aavikko, Tuomas Heikkinen, Minna Taipale, Jussi Taipale, Riitta Koivisto-Korander, Ralf Bützow, Pia Vahterist. Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12. PLoS genetics. vol 12. issue 2. 2016-07-12. PMID:26891131. |
most frequently mutated genes included tumor protein p53 (tp53; 6/19; 33%), alpha thalassemia/mental retardation syndrome x-linked (atrx; 5/19; 26%), and mediator complex subunit 12 (med12; 4/19; 21%). |
2016-07-12 |
2023-08-13 |
Not clear |
| Denada Dibra, Xueqing Xia, Abhisek Mitra, Jeffry J Cutrera, Guillermina Lozano, Shulin L. Mutant p53 in concert with an interleukin-27 receptor alpha deficiency causes spontaneous liver inflammation, fibrosis, and steatosis in mice. Hepatology (Baltimore, Md.). vol 63. issue 3. 2016-07-04. PMID:26637970. |
mutant p53 in concert with an interleukin-27 receptor alpha deficiency causes spontaneous liver inflammation, fibrosis, and steatosis in mice. |
2016-07-04 |
2023-08-13 |
mouse |
| Yan Gu, Yaping He, Xuan Zhang, Yan Shi, Qian Yang, Lin Yu, Zhaogui Sun, Huiqing Zhang, Jianmei Wang, Xiang Gao, Jian Wan. Deficiency of monoclonal non-specific suppressor factor beta (MNSFB) promotes pregnancy loss in mice. Molecular reproduction and development. vol 82. issue 6. 2016-03-21. PMID:26031240. |
the uterine day-5 abundance of p53, bax, and bcl-g in pregnant mnsfb(+/-) mice was significantly decreased compared to that of wild-type mice, whereas the expression of p27 and tumor necrosis factor alpha (tnfa) was elevated. |
2016-03-21 |
2023-08-13 |
mouse |
| Seong-Jun Cho, I-Fang Teng, Min Zhang, Tiffany Yin, Yong-Sam Jung, Jin Zhang, Xinbin Che. Hypoxia-inducible factor 1 alpha is regulated by RBM38, a RNA-binding protein and a p53 family target, via mRNA translation. Oncotarget. vol 6. issue 1. 2016-01-19. PMID:25622105. |
hypoxia-inducible factor 1 alpha is regulated by rbm38, a rna-binding protein and a p53 family target, via mrna translation. |
2016-01-19 |
2023-08-13 |
Not clear |
| Simona Gurzu, Ioan Jung, Anca Otilia Contac, Mihai Turcu, Adrian Tudo. Atypical Hepatocellular Neoplasm With Peliosis in Cirrhotic Liver Versus Hepatocellular Carcinoma: A Diagnostic Trap. Medicine. vol 94. issue 29. 2015-10-20. PMID:26200629. |
during laparoscopic surgery for cholecystectomy, hemoperitoneum was installed and laparotomy was necessary to remove a 70-mm nodular encapsulated hepatic tumor that was microscopically composed by hepatocyte-like cells with clear cytoplasm, arranged in 1- to 2-cell-thick plates and intermingled with areas of peliosis, negative for alpha fetoprotein (αfp), p53, and keratin 7, with low ki67 index and intact reticulin framework. |
2015-10-20 |
2023-08-13 |
Not clear |
| Jason You, Hushan Yang, Yinzhi Lai, Lindsay Simon, Jen Au, Ashlie L Burkar. AT-rich interactive domain 2, p110α, p53, and β-catenin protein expression in hepatocellular carcinoma and clinicopathologic implications. Human pathology. vol 46. issue 4. 2015-06-08. PMID:25701229. |
at-rich interactive domain 2 (arid2), catenin (cadherin-associated protein), beta 1, 88kda (β-catenin), tumor protein 53 (p53), and phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (p110α) mutations are implicated in hepatocellular carcinoma (hcc); and previous work has contributed to thorough molecular characterization of these events. |
2015-06-08 |
2023-08-13 |
Not clear |
| Tingting Xu, Lingli Zheng, Lina Xu, Lianhong Yin, Yan Qi, Youwei Xu, Xu Han, Jinyong Pen. Protective effects of dioscin against alcohol-induced liver injury. Archives of toxicology. vol 88. issue 3. 2015-05-12. PMID:24146112. |
in addition, dioscin significantly inhibited ethanol-induced cytochrome p450 2e1 activation, down-regulated the levels of mitogen-activated protein kinases phosphorylation, inhibited the expressions of nuclear factor kappa b, glucose regulated protein 78, activating transcription factor 6 and alpha subunit of translation initiation factor 2 to attenuate oxidative damage, decreased the expressions of tumor necrosis factor alpha and interleukin-6, and down-regulated the expressions of apoptosis-related proteins including p53, caspase-3, caspase-9, poly (adp-ribose)-polymerase and cytokeratin-18. |
2015-05-12 |
2023-08-12 |
rat |
| Soumaya Ben Abdelkrim, Soumaya Rammeh, Sonia Ziadi, Taghrid Tlili, Mahdi Jaidane, Moncef Mokn. Expression of topoisomerase II alpha, ki67, and p53 in primary non-muscle-invasive urothelial bladder carcinoma. Journal of immunoassay & immunochemistry. vol 35. issue 4. 2015-03-06. PMID:24624938. |
in each case, one tissue block was chosen for immunohistochemical expression of ki67, topoisomerase ii alpha and p53. |
2015-03-06 |
2023-08-12 |
Not clear |
| Peng Chen, Haibin Wang, Zhijian Duan, June X Zou, Hongwu Chen, Wei He, Junjian Wan. Estrogen-related receptor alpha confers methotrexate resistance via attenuation of reactive oxygen species production and P53 mediated apoptosis in osteosarcoma cells. BioMed research international. vol 2014. 2015-02-12. PMID:24967384. |
estrogen-related receptor alpha confers methotrexate resistance via attenuation of reactive oxygen species production and p53 mediated apoptosis in osteosarcoma cells. |
2015-02-12 |
2023-08-13 |
Not clear |