| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming Liang, Lu-Gang Zhao, Ben-Kang Shi, Jing-Qin L. [Expressions of hypoxia inducible factor 1 alpha and P53 in the epididymis of varicocele rats]. Zhonghua nan ke xue = National journal of andrology. vol 20. issue 7. 2015-01-22. PMID:25095617. |
[expressions of hypoxia inducible factor 1 alpha and p53 in the epididymis of varicocele rats]. |
2015-01-22 |
2023-08-13 |
rat |
| Ming Liang, Lu-Gang Zhao, Ben-Kang Shi, Jing-Qin L. [Expressions of hypoxia inducible factor 1 alpha and P53 in the epididymis of varicocele rats]. Zhonghua nan ke xue = National journal of andrology. vol 20. issue 7. 2015-01-22. PMID:25095617. |
to investigate the mechanism of epididymal hypofunction of rats with varicocele (vc) by observing the changes in the epididymal index, motility of epididymal sperm, expressions of hypoxia-inducible factor 1 alpha (hif-1 alpha) and the tumor suppressor protein p53, and epididymal epithelial cells. |
2015-01-22 |
2023-08-13 |
rat |
| Anna Supernat, Sylwia Lapińska-Szumczyk, Hanna Majewska, Jacek Gulczyński, Wojciech Biernat, Dariusz Wydra, Anna J Zacze. Tumor heterogeneity at protein level as an independent prognostic factor in endometrial cancer. Translational oncology. vol 7. issue 5. 2014-12-02. PMID:25048628. |
the following proteins were examined: estrogen receptor 1 (esr1), progesterone receptor, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, receptor tyrosine-protein kinase erbb-3, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4, phosphatidylinositol-4,5-bisphosphate 3-kinase, phosphorylated v-akt murine thymoma viral oncogene homolog 1, v-myc avian myelocytomatosis viral oncogene homolog, dna topoisomerase ii alpha 170 kda (top2a), cyclin-dependent kinase inhibitor 2a (cdkn2a), tumor protein p53, rad21 homolog, s. pombe, and runt-related transcription factor 1. |
2014-12-02 |
2023-08-13 |
Not clear |
| Parviz Deyhimi, Zahra Hashemzade. Study of the biologic behavior of odontogenic keratocyst and orthokeratinaized odontogenic cyst using TGF-alpha and P53 markers. Pathology, research and practice. vol 210. issue 4. 2014-10-21. PMID:24462551. |
the difference between the expression of p53 and tgf alpha in the basal layer of okc and ooc was not statistically significant (p-value>0.05), but the expression of p53 and tgf-alpha in the parabasal layer in okc was statistically higher compared to ooc (p<0.05). |
2014-10-21 |
2023-08-12 |
Not clear |
| José L Neir. Structural dissection of the C-terminal sterile alpha motif (SAM) of human p73. Archives of biochemistry and biophysics. vol 558. 2014-10-10. PMID:25034213. |
the alpha splice variant of p73 (p73α), a homologue of the tumour suppressor p53, has at its c terminus a sterile alpha motif (sam); this domain, samp73, is involved in lipid binding and it is thought to mediate in protein-protein interactions. |
2014-10-10 |
2023-08-13 |
human |
| Wei Ma, Wen Tia. [The function of transcription factor P63 and its signaling pathway during limb development]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 31. issue 4. 2014-10-06. PMID:25119911. |
transcription factor p63, one member of the p53 family, is characterized by a similar amino acid domain, plays a crucial role in the development of limb and ectoderm differentiation, especially with its dna binding domain, and sterile alpha motif domains. |
2014-10-06 |
2023-08-13 |
human |
| Elizabeth A White, Johanna Walther, Hassan Javanbakht, Peter M Howle. Genus beta human papillomavirus E6 proteins vary in their effects on the transactivation of p53 target genes. Journal of virology. vol 88. issue 15. 2014-10-01. PMID:24850740. |
this is in contrast to a well-characterized ability of the e6 proteins of cancer-associated hpvs of genus alpha hpv, which inactivate p53 by targeting its ubiquitin-mediated proteolysis. |
2014-10-01 |
2023-08-13 |
human |
| Elizabeth A White, Johanna Walther, Hassan Javanbakht, Peter M Howle. Genus beta human papillomavirus E6 proteins vary in their effects on the transactivation of p53 target genes. Journal of virology. vol 88. issue 15. 2014-10-01. PMID:24850740. |
we conclude that some genus beta hpv e6 proteins inhibit at least some p53 target genes, although perhaps not by the same mechanism or to the same degree as the high-risk genus alpha hpv e6 proteins. |
2014-10-01 |
2023-08-13 |
human |
| German Reyes-Botero, Marine Giry, Karima Mokhtari, Marianne Labussière, Ahmed Idbaih, Jean-Yves Delattre, Florence Laigle-Donadey, Marc Sanso. Molecular analysis of diffuse intrinsic brainstem gliomas in adults. Journal of neuro-oncology. vol 116. issue 2. 2014-09-02. PMID:24242757. |
we analyzed 17 dibg samples for idh1 r132h, alpha internexin, p53, and ki67 expression, and, in a subset with sufficient dna amount, for idh1 and histone h3 mutational status, genomic profiling and mgmt promoter methylation status. |
2014-09-02 |
2023-08-12 |
Not clear |
| Srijayaprakash B Uppada, Terrianne Erickson, Luke Wojdyla, David N Moravec, Ziyuan Song, Jianjun Cheng, Neelu Pur. Novel delivery system for T-oligo using a nanocomplex formed with an alpha helical peptide for melanoma therapy. International journal of nanomedicine. vol 9. 2014-08-18. PMID:24391441. |
to develop t-oligo as an innovative, effective therapeutic drug and to understand its mechanism of action, we investigated the antitumor effects of t-oligo or t-oligo complexed with a novel cationic alpha helical peptide, pvblg-8 (pvblg), in a p53 null melanoma cell line both in vitro and in vivo. |
2014-08-18 |
2023-08-12 |
mouse |
| Cheng Luo, Yan Li, Liang Yang, Zhihui Feng, Yuan Li, Jiangang Long, Jiankang Li. A cigarette component acrolein induces accelerated senescence in human diploid fibroblast IMR-90 cells. Biogerontology. vol 14. issue 5. 2014-05-16. PMID:24026667. |
the results showed that subacute treatment with low dose of acrolein induces the following events compared to the control cells: cell senescence demonstrated by increases in the activity of β-galactosidase, the higher expression of p53 and p21, decreases in dna synthesis, sirt1 expression, and telomere length; oxidative stress occurred as the increases in the production of reactive oxygen species, dna damage, and protein oxidation; and mitochondrial dysfunction shown as decreases in the mitochondrial membrane potential, mitochondrial biogenesis regulator pgc-1 alpha and mitochondria complex i, ii, iii, and v. these results suggest that acrolein may accelerate aging through the mechanism of increasing oxidative stress and mitochondrial dysfunction. |
2014-05-16 |
2023-08-12 |
human |
| Sun-Ju Byeon, Hwa Jin Cho, Hae Woon Baek, Chul-Kee Park, Seung-Hong Choi, Se-Hoon Kim, Hee Kyung Kim, Sung-Hye Par. Rhabdoid glioblastoma is distinguishable from classical glioblastoma by cytogenetics and molecular genetics. Human pathology. vol 45. issue 3. 2014-05-01. PMID:24457079. |
all 5 cases had supratentorial tumors that immunohistochemical analysis revealed to be robustly positive for epithelial membrane antigen, vimentin, p53, and pdgfrα (platelet-derived growth factor receptor, alpha polypeptide) but only focally positive for glial fibrillary acidic protein. |
2014-05-01 |
2023-08-12 |
Not clear |
| Vijaya Galic, Robert L Coleman, Thomas J Herzo. Unmet needs in ovarian cancer: dividing histologic subtypes to exploit novel targets and pathways. Current cancer drug targets. vol 13. issue 6. 2014-03-18. PMID:23675882. |
areas specifically addressed include hormonal pathways, tumor protein p53 (tp53) and at rich interactive domain 1a (swi-like; arid1a) mutation, and the breast cancer 1/2, early onset (brca1/2) mutation/poly (adp-ribose) polymerase 1 (parp1), phosphatidylinositol-4,5-bisphosphate 3- kinase, catalytic subunit alpha (pi3kca)/v-akt murine thymoma viral oncogene homolog 1 (akt1)/mechanistic target of rapamycin (mtor), and mitogen-activated protein kinase kinase 1 and 2 (map2k1/2) pathways. |
2014-03-18 |
2023-08-12 |
Not clear |
| Swei Sunny Hann, Fang Zheng, Shunyu Zha. Targeting 3-phosphoinositide-dependent protein kinase 1 by N-acetyl-cysteine through activation of peroxisome proliferators activated receptor alpha in human lung cancer cells, the role of p53 and p65. Journal of experimental & clinical cancer research : CR. vol 32. 2013-12-19. PMID:23867003. |
targeting 3-phosphoinositide-dependent protein kinase 1 by n-acetyl-cysteine through activation of peroxisome proliferators activated receptor alpha in human lung cancer cells, the role of p53 and p65. |
2013-12-19 |
2023-08-12 |
human |
| S Jin, A P Mutvei, I V Chivukula, E R Andersson, D Ramsköld, R Sandberg, K L Lee, P Kronqvist, V Mamaeva, P Ostling, J-P Mpindi, O Kallioniemi, I Screpanti, L Poellinger, C Sahlgren, U Lendah. Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ. Oncogene. vol 32. issue 41. 2013-12-04. PMID:23178494. |
instead, notch-mediated il-6 upregulation was controlled by two proteins in the nuclear factor (nf)-κb signaling cascade, ikkα and ikkβ (inhibitor of nuclear factor kappa-b kinase subunit alpha and beta, respectively), as well as by p53. |
2013-12-04 |
2023-08-12 |
Not clear |
| Finny Monickaraj, Sankaramoorthy Aravind, Pichamoorthy Nandhini, Paramasivam Prabu, Chandrakumar Sathishkumar, Viswanathan Mohan, Muthuswamy Balasubramanya. Accelerated fat cell aging links oxidative stress and insulin resistance in adipocytes. Journal of biosciences. vol 38. issue 1. 2013-07-23. PMID:23385819. |
adipocytes subjected to oxidative stress also showed shortened telomeres and increased mrna and protein expression of p53, p21, tnf alpha and il-6. |
2013-07-23 |
2023-08-12 |
Not clear |
| Marie Maynadier, Jingxue Shi, Ophélie Vaillant, Magali Gary-Bobo, Ilaria Basile, Michel Gleizes, Anne-Marie Cathiard, Jonathan Lee Tin Wah, M Saeed Sheikh, Marcel Garci. Roles of estrogen receptor and p21(Waf1) in bortezomib-induced growth inhibition in human breast cancer cells. Molecular cancer research : MCR. vol 10. issue 11. 2013-07-05. PMID:22964432. |
p21(waf1) expression can be modulated by p53, a tumor suppressor, and especially in breast cancer cells, by estrogen receptor alpha (erα), which is highly relevant to cancer growth. |
2013-07-05 |
2023-08-12 |
human |
| Parviz Deyhimi, Zahra Hashemzad. Comparative study of TGF-alpha and P53 markers' expression in odontogenic keratocyst and orthokeratinaized odontogenic cyst. Dental research journal. vol 9. issue Suppl 1. 2013-07-02. PMID:23814560. |
the present study aims to evaluate the quantity and intensity of the expression of p53 protein and transforming growth factor alpha (tgf-alpha) in okc and ooc in order to compare the biologic behavior of these two cysts. |
2013-07-02 |
2023-08-12 |
Not clear |
| Dinka Sundov, Ana Caric, Ivana Mrklic, Dijana Gugic, Vesna Capkun, Irena Drmic Hofman, Branka Petric Mise, Snjezana Tomi. P53, MAPK, topoisomerase II alpha and Ki67 immunohistochemical expression and KRAS/BRAF mutation in ovarian serous carcinomas. Diagnostic pathology. vol 8. 2013-06-27. PMID:23388101. |
p53, mapk, topoisomerase ii alpha and ki67 immunohistochemical expression and kras/braf mutation in ovarian serous carcinomas. |
2013-06-27 |
2023-08-12 |
Not clear |
| Dinka Sundov, Ana Caric, Ivana Mrklic, Dijana Gugic, Vesna Capkun, Irena Drmic Hofman, Branka Petric Mise, Snjezana Tomi. P53, MAPK, topoisomerase II alpha and Ki67 immunohistochemical expression and KRAS/BRAF mutation in ovarian serous carcinomas. Diagnostic pathology. vol 8. 2013-06-27. PMID:23388101. |
we investigated the immunohistochemical expression of p53, mapk, topoisomerase ii alpha (topoii alpha) and ki67 in ovarian serous carcinomas (oscs) along with mutational analysis for kras and braf. |
2013-06-27 |
2023-08-12 |
Not clear |