| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aya M Helal, Mohamed S Abdel-Latif, Mosleh Mohammed Abomughaid, Doaa A Ghareeb, Mohamed M El-Saye. Potential therapeutic effects of Ulva lactuca water fraction on monosodium glutamate-induced testicular and prostatic tissue damage in rats. Environmental science and pollution research international. vol 28. issue 23. 2021-06-28. PMID:33559824. |
in addition, relative expression of pro-inflammatory genes (inducible nitric oxide synthase (i-nos), cyclooxygenase-2 (cox-2), tumor necrosis factor-α alpha (tnf-α), and tumor protein (p53)) were assessed in testicular and prostatic tissues. |
2021-06-28 |
2023-08-13 |
rat |
| Omid Toupchian, Shima Abdollahi, Amin Salehi-Abargouei, Javad Heshmati, Cain C T Clark, Mohammad Hasan Sheikhha, Hossein Fallahzadeh, Hassan Mozaffari-Khosrav. The effects of resveratrol supplementation on PPARα, p16, p53, p21 gene expressions, and sCD163/sTWEAK ratio in patients with type 2 diabetes mellitus: A double-blind controlled randomized trial. Phytotherapy research : PTR. vol 35. issue 6. 2021-06-28. PMID:33580595. |
the present study sought to evaluate the effect of resveratrol supplementation on mrna expression levels of peroxisome proliferator-activated receptor alpha (pparα), p53, p21, p16, and serum levels of cluster of differentiation 163 (cd163) to tnf-like weak inducer of apoptosis (tweak) ratio in patients with type 2 diabetes. |
2021-06-28 |
2023-08-13 |
Not clear |
| Eman Taha Mohammed, Khalid S Hashem, Ahmed Z Abdelazem, Fatma A M A Fod. Prospective Protective Effect of Ellagic Acid as a SIRT1 Activator in Iron Oxide Nanoparticle-Induced Renal Damage in Rats. Biological trace element research. vol 198. issue 1. 2021-06-18. PMID:31933277. |
in the present study, the potent antioxidant and antiapoptotic effects of ea were indicated by the significant overexpression of sirt1 in renal tissues that leads to significant decreases in renal mda content, p53 protein level and forkhead-box transcription factor1 (foxo1) expression, and significant increases in renal gsh level, catalase activity, growth arrest and dna damage-inducible protein 45 alpha (gaddα45), and renal inhibition of apoptosis protein (kiap) gene expression levels in the ea + ionp-treated group. |
2021-06-18 |
2023-08-13 |
rat |
| Madison Schank, Juan Zhao, Ling Wang, Zhengke Li, Dechao Cao, Lam Nhat Nguyen, Xindi Dang, Sushant Khanal, Lam Ngoc Thao Nguyen, Bal Krishna Chand Thakuri, Stella C Ogbu, Zeyuan Lu, Jinyu Zhang, Xiao Y Wu, Zheng D Morrison, Mohamed El Gazzar, Shunbin Ning, Jonathan P Moorman, Zhi Q Ya. Telomeric injury by KML001 in human T cells induces mitochondrial dysfunction through the p53-PGC-1α pathway. Cell death & disease. vol 11. issue 12. 2021-04-08. PMID:33268822. |
mechanistically, we found that the kml001-induced telomeric ddr activated p53 signaling, which in turn repressed the expression of peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (pgc-1α) and nuclear respiratory factor 1 (nrf-1), leading to t cell mitochondrial dysfunction. |
2021-04-08 |
2023-08-13 |
human |
| Qingling Huang, Lihong Chen, Ernst Schonbrunn, Jiandong Che. MDMX inhibits casein kinase 1α activity and stimulates Wnt signaling. The EMBO journal. vol 39. issue 14. 2021-04-06. PMID:32511789. |
casein kinase 1 alpha (ck1α) is a serine/threonine kinase with numerous functions, including regulating the wnt/β-catenin and p53 pathways. |
2021-04-06 |
2023-08-13 |
Not clear |
| Marcel Chris Conrady, Irina Suarez, Gergö Gogl, Desiree Isabella Frecot, Anna Bonhoure, Camille Kostmann, Alexandra Cousido-Siah, André Mitschler, JiaWen Lim, Murielle Masson, Thomas Iftner, Frank Stubenrauch, Gilles Travé, Claudia Simo. Structure of High-Risk Papillomavirus 31 E6 Oncogenic Protein and Characterization of E6/E6AP/p53 Complex Formation. Journal of virology. vol 95. issue 2. 2021-03-18. PMID:33115863. |
the degradation of p53 is a hallmark of high-risk human papillomaviruses (hpvs) of the alpha genus and hpv-related carcinogenicity. |
2021-03-18 |
2023-08-13 |
human |
| Jin-Young Park, Hee Jae Lee, Yong-Soo Kwon, Wanjoo Chu. 3,4,5-Trihydroxycinnamic Acid Inhibits LPS-Induced Inflammatory Response by Increasing SIRT1 Expression in Human Umbilical Vein Endothelial Cells. Journal of vascular research. vol 57. issue 5. 2021-01-27. PMID:32564014. |
among the downstream molecular targets of sirt1, the level of lps-induced acetylated p53 was significantly decreased by thc treatment, whereas no noticeable change was observed in the levels of forkhead box o3 and peroxisome proliferator activated receptor gamma coactivator 1 alpha. |
2021-01-27 |
2023-08-13 |
mouse |
| Humberto De Vitto, Joohyun Ryu, Ali Calderon-Aparicio, Josh Monts, Raja Dey, Abhijit Chakraborty, Mee-Hyun Lee, Ann M Bode, Zigang Don. Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function. Cancer & metabolism. vol 8. issue 1. 2020-12-16. PMID:33303020. |
estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function. |
2020-12-16 |
2023-08-13 |
Not clear |
| Xinxing Wang, Yujie Zhang, Xinhong Pei, Guangcheng Guo, Bingjian Xue, Xin Duan, Dongwei Do. TRIM3 inhibits P53 signaling in breast cancer cells. Cancer cell international. vol 20. issue 1. 2020-12-12. PMID:33292295. |
among the er alpha positive breast cancer, about 80% are p53 wild type, indicating the potential tumor suppression role in er alpha positive breast cancer. |
2020-12-12 |
2023-08-13 |
Not clear |
| Qiong Man, Yi Deng, Pengjie Li, Jun Ma, Zhijun Yang, Xiujuan Yang, Yan Zhou, Xiao Ya. Licorice Ameliorates Cisplatin-Induced Hepatotoxicity Through Antiapoptosis, Antioxidative Stress, Anti-Inflammation, and Acceleration of Metabolism. Frontiers in pharmacology. vol 11. 2020-11-27. PMID:33240085. |
the experimental results indicated that gc can recover functional indices and pathological liver injury, inhibit hepatocyte apoptosis, upregulate b-cell lymphoma/leukemia 2 (bcl-2) and superoxide dismutase (sod) levels, and downregulate cellular tumor antigen p53 (p53), caspase-3, malondialdehyde high mobility group protein b1 (hmgb1), tumor necrosis factor alpha (tnf-α), and interleukin 1β (il-1β) levels. |
2020-11-27 |
2023-08-13 |
Not clear |
| Lili Wang, Shasha Hu, Fangjie Xin, Han Zhao, Guangqi Li, Wenwen Ran, Xiaoming Xing, Jigang Wan. MED12 exon 2 mutation is uncommon in intravenous leiomyomatosis: clinicopathologic features and molecular study. Human pathology. vol 99. 2020-10-26. PMID:32240666. |
the immunohistochemical expressions of p16, phosphatase and tensin homolog deleted on chromosome 10 (pten), alpha thalassemia/mental retardation syndrome x-linked (atrx), retinoblastoma 1 (rb1), fumarate hydratase (fh), and p53, were evaluated. |
2020-10-26 |
2023-08-13 |
Not clear |
| G U Deshpande, Ramji Ra. AN OVERVIEW OF PROGNOSTIC MARKERS IN BREAST CANCER. Medical journal, Armed Forces India. vol 55. issue 2. 2020-10-01. PMID:28775603. |
the parameters reviewed are er, pr, s phase fraction, dna ploidy, mib-1 antibody, p53, c-erb-2, nm23, cathepsin, topoisomerase ii alpha. |
2020-10-01 |
2023-08-13 |
Not clear |
| Mahadev Potharaju, Anugraha Mathavan, Balamurugan Mangaleswaran, Sushama Patil, Reginald John, Siddhartha Ghosh, Chandrasekhar Kalavakonda, Mitra Ghosh, Rama Shanker Verm. Clinicopathological Analysis of HIF-1alpha and TERT on Survival Outcome in Glioblastoma Patients: A Prospective, Single Institution Study. Journal of Cancer. vol 10. issue 11. 2020-10-01. PMID:31258744. |
we studied the association of immunohistochemical expression of hypoxia inducible factor-1 alpha (hif-1α), telomerase reverse transcriptase (tert), isocitrate dehydrogenase 1 (idh1) and tumor protein p53 with overall survival (os) in glioblastoma patients uniformly treated by standard of care, with adequate follow-up. |
2020-10-01 |
2023-08-13 |
Not clear |
| Victoria Lloyd, Mia Morse, Betsy Purakal, Jordan Parker, Paige Benard, Michael Crone, Samantha Pfiffner, Monica Szmyd, Sumi Dind. Hormone-Like Effects of Bisphenol A on p53 and Estrogen Receptor Alpha in Breast Cancer Cells. BioResearch open access. vol 8. issue 1. 2020-09-30. PMID:31681507. |
hormone-like effects of bisphenol a on p53 and estrogen receptor alpha in breast cancer cells. |
2020-09-30 |
2023-08-13 |
cattle |
| Shin-Mae Wang, Po-Ming Chen, Yu-Wen Sung, Wei-Chieh Huang, Hung-Sen Huang, Pei-Yi Ch. Effect of COL4A1 Expression on the Survival of Neoadjuvant Chemotherapy Breast Cancer Patients. Journal of oncology. vol 2020. 2020-09-28. PMID:32565804. |
though it has been indicated that the protein of the collagen type iv alpha 1 (col4a1) gene is induced by p53 to inhibit angiogenesis and tumorigenic activity in cancer cells, its prognostic significance in breast cancer (bc) patients has not yet been fully elucidated. |
2020-09-28 |
2023-08-13 |
Not clear |
| Maria Carmen Romero-Medina, Assunta Venuti, Giusi Melita, Alexis Robitaille, Maria Grazia Ceraolo, Laura Pacini, Cecilia Sirand, Daniele Viarisio, Valerio Taverniti, Purnima Gupta, Mariafrancesca Scalise, Cesare Indiveri, Rosita Accardi, Massimo Tommasin. Human papillomavirus type 38 alters wild-type p53 activity to promote cell proliferation via the downregulation of integrin alpha 1 expression. PLoS pathogens. vol 16. issue 8. 2020-09-18. PMID:32813746. |
human papillomavirus type 38 alters wild-type p53 activity to promote cell proliferation via the downregulation of integrin alpha 1 expression. |
2020-09-18 |
2023-08-13 |
mouse |
| Maria Carmen Romero-Medina, Assunta Venuti, Giusi Melita, Alexis Robitaille, Maria Grazia Ceraolo, Laura Pacini, Cecilia Sirand, Daniele Viarisio, Valerio Taverniti, Purnima Gupta, Mariafrancesca Scalise, Cesare Indiveri, Rosita Accardi, Massimo Tommasin. Human papillomavirus type 38 alters wild-type p53 activity to promote cell proliferation via the downregulation of integrin alpha 1 expression. PLoS pathogens. vol 16. issue 8. 2020-09-18. PMID:32813746. |
pkr-mediated s392 p53 phosphorylation promotes the formation of a p53/dnmt1 complex, which inhibits expression of integrin alpha 1 (itga1), a repressor of epidermal growth factor receptor (egfr) signaling. |
2020-09-18 |
2023-08-13 |
mouse |
| Badriyah Alotaibi, Ehab Tousson, Thanaa A El-Masry, Najla Altwaijry, Asmaa Sale. Ehrlich ascites carcinoma as model for studying the cardiac protective effects of curcumin nanoparticles against cardiac damage in female mice. Environmental toxicology. 2020-08-31. PMID:32865349. |
serum lactate dehydrogenase (ldh), phosphocreatine kinase (cpk), creatine kinase myoglobin (ck-mb), alkaline phosphatase (alp), glutamic oxaloacetic transaminase (got), cholesterol, triglycerides, potassium ions, cardiac injury, p53, vascular endothelial growth factor protein (vegf), bax, and tumor necrosis factor alpha (tnfα) expressions were significantly elevated while sodium ions levels were significantly depleted in eac when compared to control. |
2020-08-31 |
2023-08-13 |
mouse |
| Kate Packwood, Guy Martland, Matthew Sommerlad, Emily Shaw, Karwan Moutasim, Gareth Thomas, Adrian C Bateman, Louise Jones, Linda Haywood, D Gareth Evans, Jillian M Birch, Ohud A Alsalmi, Alex Henderson, Nicola Poplawski, Diana M Eccle. Breast cancer in patients with germline TP53 pathogenic variants have typical tumour characteristics: the Cohort study of TP53 carrier early onset breast cancer (COPE study). The journal of pathology. Clinical research. vol 5. issue 3. 2020-07-29. PMID:31041842. |
immunohistochemistry (ihc) for her2, er, pr, p53, integrin alpha v beta 6 (αvβ6) integrin, α-smooth muscle actin (α-sma) and psmad2/3 was performed on tissue microarrays of invasive carcinoma. |
2020-07-29 |
2023-08-13 |
Not clear |
| Gang Gao, Feng Chang, Ting Zhang, Xinhu Huang, Chen Yu, Zhaolin Hu, Mingming Ji, Yufen Dua. Naringin Protects Against Interleukin 1β (IL-1β)-Induced Human Nucleus Pulposus Cells Degeneration via Downregulation Nuclear Factor kappa B (NF-κB) Pathway and p53 Expression. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-06-15. PMID:31927560. |
the expression levels of matrix metalloproteinases (mmp-3, mmp-13, adamts-4, adamts-5, collagen ii, aggrecan), inflammatory genes (tumor necrosis factor [tnf]-alpha, interleukin [il]-6), kappa b kinase alpha (ikappabalpha), p65 and p53 were determined by quantitative real-time polymerase chain reaction (qpcr) and western blotting. |
2020-06-15 |
2023-08-13 |
human |