| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Thuróczy, N Oppe, E Scheuermann, E Perge, A Tibold, L Balog. Expression pattern of markers in the canine ovarian cycle. Reproduction in domestic animals = Zuchthygiene. vol 44 Suppl 2. 2010-03-15. PMID:19754539. |
serum progesterone, lh, fsh and 17beta-estradiol (e(2)) -levels were determined and immunhistochemistry was performed for a variety of receptor antigens; ki-67, vimentin, pan cytokeratin antibody, p53 and oestrogen receptor (er) alpha antigens. |
2010-03-15 |
2023-08-12 |
human |
| Karen Fernandez, Yelda Serinagaoglu, Sue Hammond, Laura T Martin, Paul T Marti. Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts. The American journal of pathology. vol 176. issue 1. 2010-03-15. PMID:20019182. |
mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant mdm2 transcripts. |
2010-03-15 |
2023-08-12 |
mouse |
| Jorge L Ruas, Utta Berchner-Pfannschmidt, Sohail Malik, Katarina Gradin, Joachim Fandrey, Robert G Roeder, Teresa Pereira, Lorenz Poellinge. Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300. The Journal of biological chemistry. vol 285. issue 4. 2010-02-22. PMID:19880525. |
our results show that interaction of hif-1 alpha n-tad with cbp/p300 is mediated by the ch3 region of cbp known to interact with, among other factors, p53. |
2010-02-22 |
2023-08-12 |
Not clear |
| Jorge L Ruas, Utta Berchner-Pfannschmidt, Sohail Malik, Katarina Gradin, Joachim Fandrey, Robert G Roeder, Teresa Pereira, Lorenz Poellinge. Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300. The Journal of biological chemistry. vol 285. issue 4. 2010-02-22. PMID:19880525. |
coimmunoprecipitation assays using endogenous proteins showed that immunoprecipitation of cbp in hypoxia results in the recovery of a larger fraction of hif-1 alpha than of p53. |
2010-02-22 |
2023-08-12 |
Not clear |
| Jorge L Ruas, Utta Berchner-Pfannschmidt, Sohail Malik, Katarina Gradin, Joachim Fandrey, Robert G Roeder, Teresa Pereira, Lorenz Poellinge. Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300. The Journal of biological chemistry. vol 285. issue 4. 2010-02-22. PMID:19880525. |
chromatin immunoprecipitation demonstrated that at 1% o(2) cbp is recruited to a hif-1 alpha but not to a p53 target gene. |
2010-02-22 |
2023-08-12 |
Not clear |
| Jorge L Ruas, Utta Berchner-Pfannschmidt, Sohail Malik, Katarina Gradin, Joachim Fandrey, Robert G Roeder, Teresa Pereira, Lorenz Poellinge. Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300. The Journal of biological chemistry. vol 285. issue 4. 2010-02-22. PMID:19880525. |
thus, we suggest that in hypoxia hif-1 alpha is a major cbp-interacting transcription factor that may compete with other cbp-dependent factors, including p53, for limiting amounts of this coactivator, underscoring the complexity in the regulation of gene expression by hif-1 alpha. |
2010-02-22 |
2023-08-12 |
Not clear |
| Christopher M Davenport, Ioanna G Sevastou, Claudie Hooper, Jennifer M Pococ. Inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to Alzheimer peptides. Journal of neurochemistry. vol 112. issue 2. 2010-02-05. PMID:19895660. |
regulating p53 pathways modulated microglial inducible nitric oxide synthase expression and tumour necrosis factor alpha secretion. |
2010-02-05 |
2023-08-12 |
Not clear |
| Rintaro Okoshi, Kiyohiro Ando, Yusuke Suenaga, Meixiang Sang, Natsumi Kubo, Harutoshi Kizaki, Akira Nakagawara, Toshinori Ozak. Transcriptional regulation of tumor suppressor p53 by cAMP-responsive element-binding protein/AMP-activated protein kinase complex in response to glucose deprivation. Genes to cells : devoted to molecular & cellular mechanisms. vol 14. issue 12. 2010-02-04. PMID:19930465. |
in this study, we found that camp-responsive element-binding protein (creb) collaborates with amp-activated protein kinase alpha (ampkalpha) to regulate the transcription of p53. |
2010-02-04 |
2023-08-12 |
human |
| Adeboye O Osunkoya, Andrew N Young, Wenle Wang, George J Netto, Jonathan I Epstei. Comparison of gene expression profiles in tubulocystic carcinoma and collecting duct carcinoma of the kidney. The American journal of surgical pathology. vol 33. issue 7. 2010-02-02. PMID:19390420. |
relative expression levels of vimentin, alpha methylacyl coa racemase, e-cadherin, p53, cd10 antigen, parvalbumin, cytokeratin 7, and cytokeratin 19 were assessed by quantitative reverse transcription polymerase chain reaction. |
2010-02-02 |
2023-08-12 |
Not clear |
| Adeboye O Osunkoya, Andrew N Young, Wenle Wang, George J Netto, Jonathan I Epstei. Comparison of gene expression profiles in tubulocystic carcinoma and collecting duct carcinoma of the kidney. The American journal of surgical pathology. vol 33. issue 7. 2010-02-02. PMID:19390420. |
tubulocystic carcinoma was characterized by relative overexpression of vimentin, p53, and alpha methylacyl coa racemase, compared with collecting duct carcinoma (p<0.05 for each gene, t test). |
2010-02-02 |
2023-08-12 |
Not clear |
| Adeboye O Osunkoya, Andrew N Young, Wenle Wang, George J Netto, Jonathan I Epstei. Comparison of gene expression profiles in tubulocystic carcinoma and collecting duct carcinoma of the kidney. The American journal of surgical pathology. vol 33. issue 7. 2010-02-02. PMID:19390420. |
our study demonstrates that tubulocystic carcinoma and collecting duct carcinoma have different expression profiles of selected genes, including vimentin, p53, and alpha methylacyl coa racemase. |
2010-02-02 |
2023-08-12 |
Not clear |
| Jing Liu, Zhenzhou Jiang, Jingwei Xiao, Yun Zhang, Sensen Lin, Weigang Duan, Jincheng Yao, Chunhui Liu, Xin Huang, Tao Wang, Zhongliang Liang, Rongrong Wang, Shuang Zhang, Luyong Zhan. Effects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell lines. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 16. issue 11. 2010-01-27. PMID:19524422. |
considering that mcf-7 cells express functional estrogen receptor alpha (eralpha) and wild-type p53, whereas mda-mb-231 cells which are eralpha-negative express mutant p53, the anti-proliferation effect of triptolide on mcf-7 and mda-mb-231 cells were examined, the apoptotic effect and cell cycle arrest caused by triptolide were investigated, eralpha and p53 expression were also observed in this paper. |
2010-01-27 |
2023-08-12 |
human |
| Akinori Morita, Shinichi Yamamoto, Bing Wang, Kaoru Tanaka, Norio Suzuki, Shin Aoki, Azusa Ito, Tomohisa Nanao, Soichiro Ohya, Minako Yoshino, Jin Zhu, Atsushi Enomoto, Yoshihisa Matsumoto, Osamu Funatsu, Yoshio Hosoi, Masahiko Ikekit. Sodium orthovanadate inhibits p53-mediated apoptosis. Cancer research. vol 70. issue 1. 2010-01-26. PMID:20048077. |
here, we show that vanadate exerts a potent antiapoptotic activity through both transcription-dependent and transcription-independent mechanisms relative to other p53 inhibitors, including pifithrin (pft) alpha. |
2010-01-26 |
2023-08-12 |
mouse |
| Swayamjot Kaur, Hilary A Kenny, Sujatha Jagadeeswaran, Marion R Zillhardt, Anthony G Montag, Emily Kistner, S Diane Yamada, Anirban K Mitra, Ernst Lengye. {beta}3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer. The American journal of pathology. vol 175. issue 5. 2010-01-11. PMID:19808644. |
the alpha(v)beta(3)-integrin-overexpressing cells had a decreased proliferation rate mediated by inhibition of cyclin b1 and induction of phospho-cdc2 and p53 expression, consistent with a g(2)m cell cycle arrest. |
2010-01-11 |
2023-08-12 |
mouse |
| Nabil A Gadelhak, Seham A Gadelhak, Doaa A El-Wahab El-Morsi, Mohamed M Abdelaziz, Ayman T Abbas, Hoda M El-Emshat. Prognostic significance of three hepatitis markers (p53 antibodies, vascular endothelial growth factors and alpha fetoprotein) in patients with hepatocellular carcinoma. Hepato-gastroenterology. vol 56. issue 94-95. 2009-12-15. PMID:19950803. |
prognostic significance of three hepatitis markers (p53 antibodies, vascular endothelial growth factors and alpha fetoprotein) in patients with hepatocellular carcinoma. |
2009-12-15 |
2023-08-12 |
Not clear |
| Pramod C Rath, Tapas Mukhopadhya. p53 gene expression and 2-methoxyestradiol treatment differentially induce nuclear factor kappa B activation in human lung cancer cells with different p53 phenotypes. DNA and cell biology. vol 28. issue 12. 2009-12-14. PMID:19715480. |
we show that expression of wt-p53 from a recombinant adenovirus-p53 followed by treatment with 2-methoxyestradiol (2-me), an endogenous, nontoxic, estrogenic metabolite, resulted in differential nf-kappab activation and inhibitor kappab alpha (ikappab-alpha) degradation in three different human lung cancer cell lines with different p53 phenotypes. |
2009-12-14 |
2023-08-12 |
human |
| Ida Autiero, Susan Costantini, Giovanni Colonn. Human sirt-1: molecular modeling and structure-function relationships of an unordered protein. PloS one. vol 4. issue 10. 2009-11-03. PMID:19806227. |
sirt-1 down-regulates p53 activity, rising lifespan, and cell survival; it also deacetylases peroxisome proliferator-activated receptor-gamma (ppar-gamma) and its coactivator 1 alpha (pgc-1alpha), promoting lipid mobilization, positively regulating insulin secretion, and increasing mitochondrial dimension and number. |
2009-11-03 |
2023-08-12 |
human |
| K M Colegrove, F M D Gulland, D K Naydan, L J Lowenstin. Tumor morphology and immunohistochemical expression of estrogen receptor, progesterone receptor, p53, and Ki67 in urogenital carcinomas of California sea lions (Zalophus californianus). Veterinary pathology. vol 46. issue 4. 2009-10-30. PMID:19276047. |
in this study, expression of estrogen receptor alpha (er alpha), progesterone receptor (pr), p53, and ki67 were evaluated by immunohistochemistry in 12 sea lions with metastatic carcinoma, genital epithelial dysplasia, and intraepithelial neoplasia; 4 with genital epithelial dysplasia and intraepithelial neoplasia without metastases; and 6 control animals. |
2009-10-30 |
2023-08-12 |
Not clear |
| Wensheng Liu, Margot M Ip, Matthew B Podgorsak, Gokul M Da. Disruption of estrogen receptor alpha-p53 interaction in breast tumors: a novel mechanism underlying the anti-tumor effect of radiation therapy. Breast cancer research and treatment. vol 115. issue 1. 2009-09-30. PMID:18481172. |
we recently reported that in mcf-7 breast cancer cells, estrogen receptor alpha (eralpha) directly binds to p53 and represses its function. |
2009-09-30 |
2023-08-12 |
mouse |
| Joanna S Morris, Colin Nixon, Oliver J A King, Iain M Morgan, Adrian W Philbe. Expression of TopBP1 in canine mammary neoplasia in relation to histological type, Ki67, ERalpha and p53. Veterinary journal (London, England : 1997). vol 179. issue 3. 2009-09-21. PMID:18314357. |
in this study, 132 canine mammary tumours (46 benign, 86 carcinomas) were examined immunohistochemically for expression of topbp1, oestrogen receptor alpha (eralpha), ki67 and p53. |
2009-09-21 |
2023-08-12 |
human |