| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Sasson, A Amsterda. Pleiotropic anti-apoptotic activity of glucocorticoids in ovarian follicular cells. Biochemical pharmacology. vol 66. issue 8. 2003-11-20. PMID:14555213. |
glucocorticoids (gc) such as hydrocortisone and dexamethasone (dex) protect steroidogenic granulosa cells against apoptosis induced by serum deprivation, camp, tumor necrosis factor alpha stimulation or p53 activation. |
2003-11-20 |
2023-08-12 |
human |
| Merav Ben-Yehoyada, Israel Ben-Dor, Yosef Shau. c-Abl tyrosine kinase selectively regulates p73 nuclear matrix association. The Journal of biological chemistry. vol 278. issue 36. 2003-10-07. PMID:12824179. |
under these conditions p73 alpha but not p53 is specifically tyrosine-phosphorylated by c-abl. |
2003-10-07 |
2023-08-12 |
Not clear |
| Amnon Zisman, Allan J Pantuck, Matthew H T Bui, Jonathan W Said, Randy R Caliliw, Nagesh Rao, Peter Shintaku, Frank Berger, Sanjiv S Gambhir, Arie S Belldegru. LABAZ1: A metastatic tumor model for renal cell carcinoma expressing the carbonic anhydrase type 9 tumor antigen. Cancer research. vol 63. issue 16. 2003-09-24. PMID:12941820. |
subsequent xenograft generations have conserved immunohistochemical and ultrastructural properties typical for malignant renal epithelium-derived neoplasia (vimentin+, ck-19+, ca ix+ with hypoxia-inducible factor (hif)-1 alpha constitutive expression) and have demonstrated extensive proliferation, lack of apoptosis, severe genetic alterations, and molecular expression alterations; transforming growth factor beta 1 (tgf-beta 1), hepatocyte growth factor (hgf), proto-oncogene (c-met), matrix metalloproteinase (mmp)-1, and vascular endothelial growth factor (vegf) c and d were overexpressed, whereas human epidermal growth factor receptor (her)-2, mmp-2 and mmp-9, vegf-r3, p53, and p27 were severely down-regulated, suggesting a proangiogenic environment, local invasiveness, and facilitated lymphatic metastasis. |
2003-09-24 |
2023-08-12 |
mouse |
| Naoki Okumura, Shigehira Saji, Hidetaka Eguchi, Shin-ichi Hayashi, Shigetoyo Saji, Shigeru Nakashim. Estradiol stabilizes p53 protein in breast cancer cell line, MCF-7. Japanese journal of cancer research : Gann. vol 93. issue 8. 2003-08-20. PMID:12716463. |
overexpression of the oncoprotein mdm2, an important regulator of the p53 tumor suppressor protein, is often observed in breast cancer tissues and cell lines, particularly in those which express estrogen receptor alpha (eralpha). |
2003-08-20 |
2023-08-12 |
Not clear |
| Bernhard Brüne, Jie Zhou, Andreas von Knethe. Nitric oxide, oxidative stress, and apoptosis. Kidney international. Supplement. issue 84. 2003-07-16. PMID:12694301. |
this is exemplified by using oxidized lipoproteins (oxldl), or no donors, in provoking the stabilization of two well recognized transcription factors, such as tumor suppressor p53 and hypoxia-inducible factor-1 alpha (hif-1 alpha). |
2003-07-16 |
2023-08-12 |
human |
| Bernhard Brüne, Jie Zhou, Andreas von Knethe. Nitric oxide, oxidative stress, and apoptosis. Kidney international. Supplement. issue 84. 2003-07-16. PMID:12694301. |
radical (i.e., superoxide) (o2-) formation in response to oxldl is associated with p53, as well as hif-1 alpha accumulation in human macrophages, a process that is antagonized by no. |
2003-07-16 |
2023-08-12 |
human |
| Elena A Komarova, Nickolay Neznanov, Pavel G Komarov, Mikhail V Chernov, Kaihua Wang, Andrei V Gudko. p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways. The Journal of biological chemistry. vol 278. issue 18. 2003-06-17. PMID:12637507. |
p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways. |
2003-06-17 |
2023-08-12 |
mouse |
| Paula Ofek, Daniella Ben-Meir, Zehavit Kariv-Inbal, Moshe Oren, Sara Lav. Cell cycle regulation and p53 activation by protein phosphatase 2C alpha. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12514180. |
cell cycle regulation and p53 activation by protein phosphatase 2c alpha. |
2003-05-22 |
2023-08-12 |
human |
| Paula Ofek, Daniella Ben-Meir, Zehavit Kariv-Inbal, Moshe Oren, Sara Lav. Cell cycle regulation and p53 activation by protein phosphatase 2C alpha. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12514180. |
furthermore, pp2c alpha induced the expression of endogenous p53 and the p53-responsive gene p21. |
2003-05-22 |
2023-08-12 |
human |
| Paula Ofek, Daniella Ben-Meir, Zehavit Kariv-Inbal, Moshe Oren, Sara Lav. Cell cycle regulation and p53 activation by protein phosphatase 2C alpha. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12514180. |
activation of the p53 pathway by pp2c alpha took place both in cells harboring endogenous p53, as well as in p53-null cells transfected with exogenous p53. |
2003-05-22 |
2023-08-12 |
human |
| Paula Ofek, Daniella Ben-Meir, Zehavit Kariv-Inbal, Moshe Oren, Sara Lav. Cell cycle regulation and p53 activation by protein phosphatase 2C alpha. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12514180. |
induction of pp2c alpha resulted in an increase in the overall levels of p53 protein as well as an augmentation of p53 transcription activity. |
2003-05-22 |
2023-08-12 |
human |
| Paula Ofek, Daniella Ben-Meir, Zehavit Kariv-Inbal, Moshe Oren, Sara Lav. Cell cycle regulation and p53 activation by protein phosphatase 2C alpha. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12514180. |
the role of pp2c alpha in p53 activation is discussed. |
2003-05-22 |
2023-08-12 |
human |
| Delin Chen, Muyang Li, Jianyuan Luo, Wei G. Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12606552. |
direct interactions between hif-1 alpha and mdm2 modulate p53 function. |
2003-05-22 |
2023-08-12 |
Not clear |
| Delin Chen, Muyang Li, Jianyuan Luo, Wei G. Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12606552. |
although hypoxia-inducible factor 1 alpha (hif-1 alpha) has been implicated to be involved in p53 stabilization, the precise mechanism by which hif-1 alpha regulates p53-mediated function remains unknown. |
2003-05-22 |
2023-08-12 |
Not clear |
| Delin Chen, Muyang Li, Jianyuan Luo, Wei G. Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12606552. |
here, we found that hif-1 alpha directly binds mdm2 both in vitro and in vivo; in contrast, p53 fails to directly interact with hif-1 alpha in vitro. |
2003-05-22 |
2023-08-12 |
Not clear |
| Delin Chen, Muyang Li, Jianyuan Luo, Wei G. Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12606552. |
interestingly, mdm2 expression can significantly enhance the in vivo association between p53 and hif-1 alpha, indicating that mdm2 may act as a bridge and mediate the indirect interaction between hif-1 alpha and p53 in cells. |
2003-05-22 |
2023-08-12 |
Not clear |
| Delin Chen, Muyang Li, Jianyuan Luo, Wei G. Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12606552. |
furthermore, hif-1 alpha protects p53 degradation mediated by mdm2, and leads to activation of p53-mediated transcription in cells. |
2003-05-22 |
2023-08-12 |
Not clear |
| Delin Chen, Muyang Li, Jianyuan Luo, Wei G. Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12606552. |
to elucidate the mechanism of hif-1 alpha-mediated effect, we also found that hif-1 alpha can significantly suppress mdm2-mediated p53 ubiquitination in vitro and blocks mdm2-mediated nuclear export of p53. |
2003-05-22 |
2023-08-12 |
Not clear |
| Delin Chen, Muyang Li, Jianyuan Luo, Wei G. Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12606552. |
these results have significant implications regarding the molecular mechanism by which p53 is activated by hif-1 alpha in response to hypoxia. |
2003-05-22 |
2023-08-12 |
Not clear |
| Fumio Ide, Munenori Kitada, Hideaki Sakashita, Kaoru Kusam. Reduction of p53 dosage renders mice hypersensitive to 7, 12-dimethylbenz(alpha) anthracene-induced salivary gland tumorigenesis. Anticancer research. vol 23. issue 1A. 2003-05-01. PMID:12680213. |
reduction of p53 dosage renders mice hypersensitive to 7, 12-dimethylbenz(alpha) anthracene-induced salivary gland tumorigenesis. |
2003-05-01 |
2023-08-12 |
mouse |