| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marisa Möller, Jan L Du Preez, Francois P Viljoen, Michael Berk, Brian H Harve. N-Acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats. Metabolic brain disease. vol 28. issue 4. 2014-06-20. PMID:24000072. |
in conclusion, sir profoundly alters cortico-striatal da, 5-ht and na pathways that parallel observations in schizophrenia, while these changes are dose-dependently reversed or abrogated by sub-chronic nac treatment. |
2014-06-20 |
2023-08-12 |
rat |
| Alan L Pehrson, Thomas Cremers, Cecile Bétry, Marieke G C van der Hart, Laerke Jørgensen, Mathias Madsen, Nasser Haddjeri, Bjarke Ebert, Connie Sanche. Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters--a rat microdialysis and electrophysiology study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 2. 2014-04-21. PMID:22612991. |
extracellular 5-ht, ne and da levels were evaluated in the ventral hippocampus (vhc), medial prefrontal cortex (mpfc) and nucleus accumbens (nac) after acute and subchronic treatment with lu aa21004 or escitalopram. |
2014-04-21 |
2023-08-12 |
rat |
| Alan L Pehrson, Thomas Cremers, Cecile Bétry, Marieke G C van der Hart, Laerke Jørgensen, Mathias Madsen, Nasser Haddjeri, Bjarke Ebert, Connie Sanche. Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters--a rat microdialysis and electrophysiology study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 2. 2014-04-21. PMID:22612991. |
acute lu aa21004 dose-dependently increased 5-ht in the vhc, mpfc and nac. |
2014-04-21 |
2023-08-12 |
rat |
| Floor van Heesch, Jolanda Prins, Gerdien A H Korte-Bouws, Koen G C Westphal, Suzanne Lemstra, Berend Olivier, Aletta D Kraneveld, S Mechiel Kort. Systemic tumor necrosis factor-alpha decreases brain stimulation reward and increases metabolites of serotonin and dopamine in the nucleus accumbens of mice. Behavioural brain research. vol 253. 2014-03-18. PMID:23896053. |
tnf-α did not affect serotonin levels, but increased its metabolite 5-hiaa in the nac. |
2014-03-18 |
2023-08-12 |
mouse |
| Xiaofang Xue, Shuang Shao, Man Li, Feng Shao, Weiwen Wan. Maternal separation induces alterations of serotonergic system in different aged rats. Brain research bulletin. vol 95. 2014-02-10. PMID:23523983. |
we found that ms increased 5-ht levels in the pfc of juvenile rats, and although ms increased 5-ht and 5-hiaa levels in the nac of adolescent rats, the ratio between 5-hiaa and 5-ht decreased in the pfc. |
2014-02-10 |
2023-08-12 |
rat |
| Xiaofang Xue, Shuang Shao, Man Li, Feng Shao, Weiwen Wan. Maternal separation induces alterations of serotonergic system in different aged rats. Brain research bulletin. vol 95. 2014-02-10. PMID:23523983. |
in addition, ms-treated adult rats showed increased levels of 5-ht in the pfc as well as 5-ht and 5-hiaa in the nac. |
2014-02-10 |
2023-08-12 |
rat |
| Mary Kay Lobo, Samir Zaman, Diane M Damez-Werno, Ja Wook Koo, Rosemary C Bagot, Jennifer A DiNieri, Alexandria Nugent, Eric Finkel, Dipesh Chaudhury, Ramesh Chandra, Efrain Riberio, Jacqui Rabkin, Ezekiell Mouzon, Roger Cachope, Joseph F Cheer, Ming-Hu Han, David M Dietz, David W Self, Yasmin L Hurd, Vincent Vialou, Eric J Nestle. ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 47. 2014-01-21. PMID:24259563. |
we make use of fluorescent reporter bac transgenic mice to evaluate induction of Δfosb in dopamine receptor 1 (d1) enriched and dopamine receptor 2 (d2) enriched msns in ventral striatum, nucleus accumbens (nac) shell and core, and in dorsal striatum (dstr) after chronic exposure to several drugs of abuse including cocaine, ethanol, Δ(9)-tetrahydrocannabinol, and opiates; the antipsychotic drug, haloperidol; juvenile enrichment; sucrose drinking; calorie restriction; the serotonin selective reuptake inhibitor antidepressant, fluoxetine; and social defeat stress. |
2014-01-21 |
2023-08-12 |
mouse |
| Qian Bu, Lei Lv, Guangyan Yan, Pengchi Deng, Yanli Wang, Jiaqing Zhou, Yanzhu Yang, Yan Li, Xiaobo Ce. NMR-based metabonomic in hippocampus, nucleus accumbens and prefrontal cortex of methamphetamine-sensitized rats. Neurotoxicology. vol 36. 2014-01-13. PMID:23462569. |
additionally, decreased serotonin was observed in both nac and pfc, whereas decreased dopamine was only observed in nac after repeated map treatment. |
2014-01-13 |
2023-08-12 |
rat |
| Tatiana V Lipina, Paul J Fletcher, Frankie H Lee, Albert H C Wong, John C Rode. Disrupted-in-schizophrenia-1 Gln31Leu polymorphism results in social anhedonia associated with monoaminergic imbalance and reduction of CREB and β-arrestin-1,2 in the nucleus accumbens in a mouse model of depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 3. 2013-10-17. PMID:23011268. |
first, we found reduced levels of dopamine, serotonin and norepinephrine in the nucleus accumbens (nac) of disc1-q31l mutants. |
2013-10-17 |
2023-08-12 |
mouse |
| Chiung-Chun Huang, Che-Ming Yeh, Mei-Ying Wu, Kuei-Sen Hs. A single in vivo cocaine administration impairs 5-HT(1B) receptor-induced long-term depression in the nucleus accumbens. Journal of neurochemistry. vol 125. issue 6. 2013-08-06. PMID:23452061. |
while nac neurons are richly innervated by serotonergic fibers, information on the functional role of serotonin 5-hydroxytryptamine (5-ht) in the nac is still sparse. |
2013-08-06 |
2023-08-12 |
mouse |
| Chiung-Chun Huang, Che-Ming Yeh, Mei-Ying Wu, Kuei-Sen Hs. A single in vivo cocaine administration impairs 5-HT(1B) receptor-induced long-term depression in the nucleus accumbens. Journal of neurochemistry. vol 125. issue 6. 2013-08-06. PMID:23452061. |
here, we demonstrate that brief application of 5-ht or 5-ht1b receptor agonist cp 93129 induced a long-term depression (ltd) of glutamatergic transmission in nac neurons. |
2013-08-06 |
2023-08-12 |
mouse |
| Chiung-Chun Huang, Che-Ming Yeh, Mei-Ying Wu, Kuei-Sen Hs. A single in vivo cocaine administration impairs 5-HT(1B) receptor-induced long-term depression in the nucleus accumbens. Journal of neurochemistry. vol 125. issue 6. 2013-08-06. PMID:23452061. |
our results reveal a novel 5-ht1b receptor-mediated ltd in the nac and suggest that cocaine exposure may result in elevated phosphorylation of presynaptic proteins involved in regulating glutamate release, which counteracts the presynaptic depressant effects of 5-ht1b receptors and thereby impairs the induction of ltd by 5-ht. |
2013-08-06 |
2023-08-12 |
mouse |
| Maria Stratinaki, Artemis Varidaki, Vasiliki Mitsi, Subroto Ghose, Jane Magida, Caroline Dias, Scott J Russo, Vincent Vialou, Barbara J Caldarone, Carol A Tamminga, Eric J Nestler, Venetia Zachario. Regulator of G protein signaling 4 [corrected] is a crucial modulator of antidepressant drug action in depression and neuropathic pain models. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 20. 2013-07-25. PMID:23630294. |
behavioral studies of mice lacking rgs4, including specific knockdowns in nac, demonstrate that rgs4 in this brain region acts as a positive modulator of the antidepressant-like and antiallodynic-like actions of several monoamine-directed antidepressant drugs, including tricyclic antidepressants, selective serotonin reuptake inhibitors, and norepinephrine reuptake inhibitors. |
2013-07-25 |
2023-08-12 |
mouse |
| A Jean, L Laurent, J Bockaert, Y Charnay, N Dusticier, A Nieoullon, M Barrot, R Neve, V Compa. The nucleus accumbens 5-HTR₄-CART pathway ties anorexia to hyperactivity. Translational psychiatry. vol 2. 2013-05-17. PMID:23233022. |
we previously discovered an addictive molecular facet of anorexia, involving production, in the nucleus accumbens (nac), of the same transcripts stimulated in response to cocaine and amphetamine (cart) upon stimulation of the 5-ht(4) receptors (5-htr(4)) or mdma (ecstasy). |
2013-05-17 |
2023-08-12 |
mouse |
| Yoji Kato, Alexander V Peskin, Nina Dickerhof, D Tim Harwood, Anthony J Kettl. Myeloperoxidase catalyzes the conjugation of serotonin to thiols via free radicals and tryptamine-4,5-dione. Chemical research in toxicology. vol 25. issue 11. 2013-05-07. PMID:23009681. |
5ht formed three adducts with n-acetylcysteine (nac) when it was incubated with myeloperoxidase, xanthine oxidase, and acetaldehyde. |
2013-05-07 |
2023-08-12 |
human |
| Andrey Sequeira-Cordero, Marianela Masís-Calvo, Andrea Mora-Gallegos, Jaime Fornaguera-Tría. Maternal behavior as an early modulator of neurobehavioral offspring responses by Sprague-Dawley rats. Behavioural brain research. vol 237. 2013-04-26. PMID:23018125. |
this effect seems to be associated with the serotonergic systems in both nucleus accumbens (nac) and hippocampus (hpc), since offspring of low lg mothers showed decreased 5-ht neurotransmission in those brain regions compared with animals of high lg mothers. |
2013-04-26 |
2023-08-12 |
rat |
| Addy van Dijk, Andre A Klompmakers, Matthijs G P Feenstra, Damiaan Deny. Deep brain stimulation of the accumbens increases dopamine, serotonin, and noradrenaline in the prefrontal cortex. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:23061486. |
freely moving rats were bilaterally stimulated in the nac core for 2 h while dopamine, serotonin, and noradrenaline were measured using in vivo microdialysis in the mpfc and the ofc. |
2013-02-14 |
2023-08-12 |
rat |
| Addy van Dijk, Andre A Klompmakers, Matthijs G P Feenstra, Damiaan Deny. Deep brain stimulation of the accumbens increases dopamine, serotonin, and noradrenaline in the prefrontal cortex. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:23061486. |
we report rapid increases in the release of dopamine and serotonin to a maximum of 177% and 127% in the mpfc and an increase up to 171% and 166% for dopamine and noradrenaline in the ofc after onset of stimulation in the nac core. |
2013-02-14 |
2023-08-12 |
rat |
| Iván Gómez-Milanés, Pilar Almela, Juan-Antonio García-Carmona, M Salud García-Gutiérrez, Auxiliadora Aracil-Fernández, Jorge Manzanares, María Victoria Milanés Maquilón, M Luisa Laorde. Accumbal dopamine, noradrenaline and serotonin activity after naloxone-conditioned place aversion in morphine-dependent mice. Neurochemistry international. vol 61. issue 3. 2013-01-22. PMID:22713675. |
the purpose of the present study was to evaluate: (i) the turnover of da, na and 5-ht in the nucleus accumbens (nac), one of the most important substrates for aversive states, (ii) the changes in tyrosine hydroxylase (th) gene expression in the ventral tegmental area, and (iii) total th protein levels and th phosphorylation in the nac after naloxone-induced morphine withdrawal. |
2013-01-22 |
2023-08-12 |
mouse |
| J Kleijn, J Wiskerke, T I F H Cremers, A N M Schoffelmeer, B H C Westerink, T Patti. Effects of amphetamine on dopamine release in the rat nucleus accumbens shell region depend on cannabinoid CB1 receptor activation. Neurochemistry international. vol 60. issue 8. 2012-10-12. PMID:22426202. |
results show that systemic administration of a low, clinically relevant dose of amphetamine (0.5mg/kg) robustly increased dopamine and norepinephrine release (to ∼175-350% of baseline values) in the nac shell and core subregions as well as the ventral and dorsal parts of the mpfc, while moderately enhancing extracellular serotonin levels (to ∼135% of baseline value) in the nac core only. |
2012-10-12 |
2023-08-12 |
rat |