| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M F Lazenka, J A Suyama, C T Bauer, M L Banks, S S Negu. Sex differences in abuse-related neurochemical and behavioral effects of 3,4-methylenedioxymethamphetamine (MDMA) in rats. Pharmacology, biochemistry, and behavior. vol 152. 2017-06-01. PMID:27566288. |
for in vivo microdialysis, rats were implanted with bilateral guide cannulae targeting the nac, and the time course of mdma effects (1.0-3.2mg/kg, 0-180min) on da and 5ht was determined. |
2017-06-01 |
2023-08-13 |
rat |
| Nesrin F Basaran, R Levent Buyukuysal, M Sertac Yilmaz, Sami Aydin, Sinan Cavun, William R Millingto. The effect of Gly-Gln [ß-endorphin30-31] on morphine-evoked serotonin and GABA efflux in the nucleus accumbens of conscious rats. Neuropeptides. vol 58. 2017-02-13. PMID:26861257. |
gly-gln administration influences the rise in extracellular serotonin and gaba concentrations evoked by morphine in the nac. |
2017-02-13 |
2023-08-13 |
rat |
| Nesrin F Basaran, R Levent Buyukuysal, M Sertac Yilmaz, Sami Aydin, Sinan Cavun, William R Millingto. The effect of Gly-Gln [ß-endorphin30-31] on morphine-evoked serotonin and GABA efflux in the nucleus accumbens of conscious rats. Neuropeptides. vol 58. 2017-02-13. PMID:26861257. |
these data show that gly-gln stimulates nac serotonin efflux and, together with earlier studies, support the hypothesis that gly-gln inhibits the rewarding effects of morphine by modulating morphine induced dopamine, gaba and serotonin efflux in the nac. |
2017-02-13 |
2023-08-13 |
rat |
| Sujan C Das, Yusuf S Althobaiti, Fahad S Alshehri, Youssef Sar. Binge ethanol withdrawal: Effects on post-withdrawal ethanol intake, glutamate-glutamine cycle and monoamine tissue content in P rat model. Behavioural brain research. vol 303. 2016-12-13. PMID:26821293. |
we also measured glutamine synthetase (gs) activity, and the tissue content of glutamate, glutamine, dopamine and serotonin in both mpfc and nac. |
2016-12-13 |
2023-08-13 |
rat |
| Sujan C Das, Yusuf S Althobaiti, Fahad S Alshehri, Youssef Sar. Binge ethanol withdrawal: Effects on post-withdrawal ethanol intake, glutamate-glutamine cycle and monoamine tissue content in P rat model. Behavioural brain research. vol 303. 2016-12-13. PMID:26821293. |
the tissue content of da was significantly lower in both mpfc and nac, whereas tissue content of serotonin was unchanged in both mpfc and nac. |
2016-12-13 |
2023-08-13 |
rat |
| Mohammed Abul Kashem, Selina Ahmed, Nilufa Sultana, Eakhlas U Ahmed, Russell Pickford, Caroline Rae, Omar Šerý, Iain S McGregor, Vladimir J Balca. Metabolomics of Neurotransmitters and Related Metabolites in Post-Mortem Tissue from the Dorsal and Ventral Striatum of Alcoholic Human Brain. Neurochemical research. vol 41. issue 1-2. 2016-11-02. PMID:26801172. |
there were no differences in the levels of dopamine (da), 3,4-dihydrophenylacetic acid (dopac), serotonin (5ht), homovanillic acid (hva), 5-hydroxyindoleacetic acid (hiaa), histamine, l-glutamate (glu), γ-aminobutyric acid (gaba), tyrosine (tyr) and tryptophan (tryp) between the ds (cn and p) and vs (nac) in control brains. |
2016-11-02 |
2023-08-13 |
human |
| Justin R Yates, Mahesh Darna, Cassandra D Gipson, Linda P Dwoskin, Michael T Bard. Dissociable roles of dopamine and serotonin transporter function in a rat model of negative urgency. Behavioural brain research. vol 291. 2016-03-28. PMID:26005123. |
upon completion of behavioral training, vmax and km were obtained from kinetic analysis of [(3)h]da and [(3)h]5-ht uptake using synaptosomes prepared from nucleus accumbens (nac), dorsal striatum (str), medial prefrontal cortex (mpfc), and orbitofrontal cortex (ofc) isolated from individual rats. |
2016-03-28 |
2023-08-13 |
rat |
| Julie A Suyama, Farhana Sakloth, Renata Kolanos, Richard A Glennon, Matthew F Lazenka, S Stevens Negus, Matthew L Bank. Abuse-Related Neurochemical Effects of Para-Substituted Methcathinone Analogs in Rats: Microdialysis Studies of Nucleus Accumbens Dopamine and Serotonin. The Journal of pharmacology and experimental therapeutics. vol 356. issue 1. 2016-03-15. PMID:26645638. |
the present study used in vivo microdialysis to determine the relationship between these previous measures and the in vivo neurochemical selectivity of these compounds to alter nucleus accumbens (nac) da and 5-ht levels. |
2016-03-15 |
2023-08-13 |
rat |
| Julie A Suyama, Farhana Sakloth, Renata Kolanos, Richard A Glennon, Matthew F Lazenka, S Stevens Negus, Matthew L Bank. Abuse-Related Neurochemical Effects of Para-Substituted Methcathinone Analogs in Rats: Microdialysis Studies of Nucleus Accumbens Dopamine and Serotonin. The Journal of pharmacology and experimental therapeutics. vol 356. issue 1. 2016-03-15. PMID:26645638. |
mcat and five para-substituted analogs (4-f, 4-cl, 4-br, 4-ch3, and 4-och3) produced dose- and time-dependent increases in nac da and/or 5-ht levels. |
2016-03-15 |
2023-08-13 |
rat |
| Laurence L Miller, Michael D Leitl, Matthew L Banks, Bruce E Blough, S Stevens Negu. Effects of the triple monoamine uptake inhibitor amitifadine on pain-related depression of behavior and mesolimbic dopamine release in rats. Pain. vol 156. issue 1. 2015-09-30. PMID:25599313. |
in the absence of the noxious stimulus, amitifadine increased nac levels of both da and serotonin, and behaviorally, amitifadine produced significant but weak abuse-related icss facilitation. |
2015-09-30 |
2023-08-13 |
rat |
| Jiamei Lian, Xu-Feng Huang, Nagesh Pai, Chao Den. Chronic betahistine co-treatment reverses olanzapine's effects on dopamine D₂ but not 5-HT2A/2C bindings in rat brains. Progress in neuro-psychopharmacology & biological psychiatry. vol 56. 2015-07-31. PMID:25149912. |
this study investigated the effects of chronic treatment of olanzapine and/or betahistine on the binding density of the serotonergic 5-ht2a (5-ht2ar) and 5-ht2c (5-ht2cr) receptors, 5-ht transporter (5-htt), and dopaminergic d₂ receptors (d₂r) in the brain regions involved in antipsychotic efficacy, including the prefrontal cortex (pfc), cingulate cortex (cg), nucleus accumbens (nac), and caudate putamen (cpu). |
2015-07-31 |
2023-08-13 |
rat |
| Céline Devroye, Adeline Cathala, Marlène Maitre, Pier Vincenzo Piazza, Djoher Nora Abrous, Jean-Michel Revest, Umberto Spampinat. Serotonin2C receptor stimulation inhibits cocaine-induced Fos expression and DARPP-32 phosphorylation in the rat striatum independently of dopamine outflow. Neuropharmacology. vol 89. 2015-07-15. PMID:25446572. |
recent studies assessing the influence of 5-ht(2c)rs on cocaine-induced neurochemical and behavioral responses have shown that 5-ht2crs can also modulate mesoaccumbens da pathway activity at post-synaptic level, by controlling da transmission in the nucleus accumbens (nac), independently of da release itself. |
2015-07-15 |
2023-08-13 |
rat |
| Kimberly Kirkpatrick, Andrew T Marshall, Aaron P Smith, Juraj Koci, Yoonseong Par. Individual differences in impulsive and risky choice: effects of environmental rearing conditions. Behavioural brain research. vol 269. 2015-01-15. PMID:24769268. |
furthermore, serotonin and norepinephrine concentrations in the nac significantly correlated with incentive motivation and the timing of the reward delays within the choice tasks. |
2015-01-15 |
2023-08-13 |
rat |
| Mei-Yi Lee, Chun-Cheng Chiang, Hong-Yi Chiu, Ming-Huan Chan, Hwei-Hsien Che. N-acetylcysteine modulates hallucinogenic 5-HT(2A) receptor agonist-mediated responses: behavioral, molecular, and electrophysiological studies. Neuropharmacology. vol 81. 2014-12-15. PMID:24534112. |
the present study determined the effects of nac on hallucinogenic 5-ht(2a)r agonist (±)1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi)-elicited behavioral and molecular responses in mice and doi-evoked field potentials in the mouse cortical slices. |
2014-12-15 |
2023-08-12 |
mouse |
| Mei-Yi Lee, Chun-Cheng Chiang, Hong-Yi Chiu, Ming-Huan Chan, Hwei-Hsien Che. N-acetylcysteine modulates hallucinogenic 5-HT(2A) receptor agonist-mediated responses: behavioral, molecular, and electrophysiological studies. Neuropharmacology. vol 81. 2014-12-15. PMID:24534112. |
in addition, the cystine-glutamate antiporter inhibitor (s)-4-carboxyphenylglycine (cpg) and the mglur2 antagonist ly341495 reversed the suppressing effects of nac on doi-induced head twitch and molecular responses and increased frequency of excitatory field potentials, supporting that nac attenuates the 5-ht(2a)r-mediated hallucinogenic effects via increased activity of cystine-glutamate antiporter followed by activation of mglur2 receptors. |
2014-12-15 |
2023-08-12 |
mouse |
| Giuseppe Mocci, Laura Jiménez-Sánchez, Albert Adell, Roser Cortés, Francesc Artiga. Expression of 5-HT2A receptors in prefrontal cortex pyramidal neurons projecting to nucleus accumbens. Potential relevance for atypical antipsychotic action. Neuropharmacology. vol 79. 2014-12-03. PMID:24211653. |
classical antipsychotic drugs modulate information processing in cortico-limbic circuits via dopamine d2 receptor blockade in nucleus accumbens (nac) whereas atypical antipsychotic drugs preferentially target cortical serotonin (5-ht) receptors. |
2014-12-03 |
2023-08-12 |
rat |
| Costanza Burattini, Giulia Battistini, Francesco Tamagnini, Giorgio Aicard. Low-frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid. Journal of neurophysiology. vol 111. issue 5. 2014-10-30. PMID:24335217. |
recent evidences demonstrate cross talk between ecb signaling pathways and those of other receptor systems, including serotonin (5-ht); the extensive colocalization of cb1 and 5-ht receptors within the nac suggests the potential for interplay between them. |
2014-10-30 |
2023-08-12 |
rat |
| Costanza Burattini, Giulia Battistini, Francesco Tamagnini, Giorgio Aicard. Low-frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid. Journal of neurophysiology. vol 111. issue 5. 2014-10-30. PMID:24335217. |
these observations might be helpful to understand the neurophysiological mechanisms underlying drug addiction, major depression, and other psychiatric disorders characterized by dysfunction of 5-ht neurotransmission in the nac. |
2014-10-30 |
2023-08-12 |
rat |
| Marisa Möller, Jan L Du Preez, Francois P Viljoen, Michael Berk, Brian H Harve. N-Acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats. Metabolic brain disease. vol 28. issue 4. 2014-06-20. PMID:24000072. |
this study evaluated the dose-dependent effects of nac (50, 150 and 250 mg/kg/day × 14 days) on sir- vs. socially reared induced changes in cortico-striatal levels of dopamine (da), serotonin (5-ht) noradrenaline (na) and their associated metabolites. |
2014-06-20 |
2023-08-12 |
rat |
| Marisa Möller, Jan L Du Preez, Francois P Viljoen, Michael Berk, Brian H Harve. N-Acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats. Metabolic brain disease. vol 28. issue 4. 2014-06-20. PMID:24000072. |
nac at 150 and 250 mg/kg reversed all cortico-striatal da, dopac, hva, 5-ht, 5-hiaa and striatal na alterations in sir animals, with 250 mg/kg of nac also reversing alterations in cortico-striatal mhpg. |
2014-06-20 |
2023-08-12 |
rat |