| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mei Huang, Wenqi He, Lakshmi Rajagopal, Andrea Kudwa, Dimitri E Grigoriadis, Herbert Y Meltze. Effects of NBI-98782, a selective vesicular monoamine transporter 2 (VMAT2) inhibitor, on neurotransmitter efflux and phencyclidine-induced locomotor activity: Relevance to tardive dyskinesia and antipsychotic action. Pharmacology, biochemistry, and behavior. vol 190. 2021-01-07. PMID:32084491. |
acute nbi-98782 and tetrabenazine decreased mpfc, dstr, hippocampus, and nac da, 5-ht, and ne efflux, while increasing that of dopac, hva, and 5-hiaa. |
2021-01-07 |
2023-08-13 |
mouse |
| Emma J Mitchell, David M Thomson, Rebecca L Openshaw, Greg C Bristow, Neil Dawson, Judith A Pratt, Brian J Morri. Drug-responsive autism phenotypes in the 16p11.2 deletion mouse model: a central role for gene-environment interactions. Scientific reports. vol 10. issue 1. 2020-12-10. PMID:32704009. |
the ability of the excitation/inhibition modulator n-acetyl cysteine (nac) and the 5-ht |
2020-12-10 |
2023-08-13 |
mouse |
| Gerdien A H Korte-Bouws, Floor van Heesch, Koen G C Westphal, Lisa M J Ankersmit, Edwin M van Oosten, Onur Güntürkün, S Mechiel Kort. Bacterial Lipopolysaccharide Increases Serotonin Metabolism in Both Medial Prefrontal Cortex and Nucleus Accumbens in Male Wild Type Rats, but Not in Serotonin Transporter Knockout Rats. Pharmaceuticals (Basel, Switzerland). vol 11. issue 3. 2020-10-01. PMID:29976854. |
administered lps increased extracellular monoamine metabolite levels in the nucleus accumbens (nac) and medial prefrontal cortex (mpfc), which was completely, or at least partly, prevented by pretreatment with a triple reuptake inhibitor that also blocks the serotonin (5-ht) transporter (sert). |
2020-10-01 |
2023-08-13 |
rat |
| Gerdien A H Korte-Bouws, Floor van Heesch, Koen G C Westphal, Lisa M J Ankersmit, Edwin M van Oosten, Onur Güntürkün, S Mechiel Kort. Bacterial Lipopolysaccharide Increases Serotonin Metabolism in Both Medial Prefrontal Cortex and Nucleus Accumbens in Male Wild Type Rats, but Not in Serotonin Transporter Knockout Rats. Pharmaceuticals (Basel, Switzerland). vol 11. issue 3. 2020-10-01. PMID:29976854. |
therefore, the effects of an intraperitoneal lps injection on extracellular concentrations of 5-ht and its metabolite 5-hydroxyindoleacetic acid (5-hiaa) were investigated by in vivo microdialysis in the nac and mpfc of wild type (sert |
2020-10-01 |
2023-08-13 |
rat |
| Takahira Shirahase, Yoshihisa Watanabe, Atsushi Tsujimura, Shin Kwak, Toshiro Yamamoto, Narisato Kanamura, Masaki Tanak. Ethanol Preference and Drinking Behavior Are Controlled by RNA Editing in the Nucleus Accumbens. Frontiers in behavioral neuroscience. vol 12. 2020-10-01. PMID:30697154. |
we previously found that chronic consumption of ethanol was associated with increased levels of rna editing of serotonin 2c receptor in the nucleus accumbens (nac). |
2020-10-01 |
2023-08-13 |
mouse |
| Arnauld Belmer, Kate Beecher, Angela Jacques, Omkar L Patkar, Florian Sicherre, Selena E Bartlet. Axonal Non-segregation of the Vesicular Glutamate Transporter VGLUT3 Within Serotonergic Projections in the Mouse Forebrain. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31133811. |
however, in the posterior part of the nac shell, we confirmed the presence of a subtype of 5-ht immunoreactive axons that lack the sert. |
2020-10-01 |
2023-08-13 |
mouse |
| Yan Hua, Ce Li, Jian Hu, Yu-Yuan Wang, Pei-Le Liu, Bei-Yao Gao, Chan Chen, Dong-Sheng Xu, Bei Zhang, Yu-Long Ba. Fluoxetine adjunct to therapeutic exercise promotes motor recovery in rats with cerebral ischemia: Roles of nucleus accumbens. Brain research bulletin. vol 153. 2020-09-24. PMID:31369829. |
we hypothesized that the nucleus accumbens (nac) may be one of the responding areas to fluoxetine where relevant elevations in 5-hydroxytryptamine (5-ht) and Δfosb were associated with motor behavioral recovery. |
2020-09-24 |
2023-08-13 |
rat |
| Yan Hua, Ce Li, Jian Hu, Yu-Yuan Wang, Pei-Le Liu, Bei-Yao Gao, Chan Chen, Dong-Sheng Xu, Bei Zhang, Yu-Long Ba. Fluoxetine adjunct to therapeutic exercise promotes motor recovery in rats with cerebral ischemia: Roles of nucleus accumbens. Brain research bulletin. vol 153. 2020-09-24. PMID:31369829. |
5-ht level in the bilateral nac and the expression of 5-ht |
2020-09-24 |
2023-08-13 |
rat |
| Liubov S Kalinichenko, Lara Hammad, Martin Reichel, Zacharias Kohl, Erich Gulbins, Johannes Kornhuber, Christian P Mülle. Acid sphingomyelinase controls dopamine activity and responses to appetitive stimuli in mice. Brain research bulletin. vol 146. 2020-03-10. PMID:30716394. |
we found reduced basal extracellular da levels in the nucleus accumbens (nac) and dorsal hippocampus (dh) of tgasm mice with little effect on 5-ht and ne levels. |
2020-03-10 |
2023-08-13 |
mouse |
| Liubov S Kalinichenko, Lara Hammad, Martin Reichel, Zacharias Kohl, Erich Gulbins, Johannes Kornhuber, Christian P Mülle. Acid sphingomyelinase controls dopamine activity and responses to appetitive stimuli in mice. Brain research bulletin. vol 146. 2020-03-10. PMID:30716394. |
da and ne responses to a food stimulus were not altered in tgasm mice, but the nac 5-ht response was enhanced. |
2020-03-10 |
2023-08-13 |
mouse |
| Joneth Fernandes, Girdhari Lal Gupt. N-acetylcysteine attenuates neuroinflammation associated depressive behavior induced by chronic unpredictable mild stress in rat. Behavioural brain research. vol 364. 2020-02-13. PMID:30772427. |
moreover, the levels of pro-inflammatory cytokines in the hippocampus as well as pre-frontal cortex were suppressed, and remarkably restored the serotonin levels by nac (50 and 100 mg/kg, p.o.) |
2020-02-13 |
2023-08-13 |
rat |
| Caleb J Browne, Andrew R Abela, Duong Chu, Zhaoxia Li, Xiaodong Ji, Evelyn K Lambe, Paul J Fletche. Dorsal raphe serotonin neurons inhibit operant responding for reward via inputs to the ventral tegmental area but not the nucleus accumbens: evidence from studies combining optogenetic stimulation and serotonin reuptake inhibition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 4. 2019-11-25. PMID:30420603. |
we then examined whether these effects could be recapitulated if optogenetic stimulation specifically targeted 5-ht terminals in the ventral tegmental area (vta) or nucleus accumbens (nac) of the mesolimbic da system. |
2019-11-25 |
2023-08-13 |
mouse |
| Caleb J Browne, Andrew R Abela, Duong Chu, Zhaoxia Li, Xiaodong Ji, Evelyn K Lambe, Paul J Fletche. Dorsal raphe serotonin neurons inhibit operant responding for reward via inputs to the ventral tegmental area but not the nucleus accumbens: evidence from studies combining optogenetic stimulation and serotonin reuptake inhibition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 4. 2019-11-25. PMID:30420603. |
however, this effect was not observed when optogenetic stimulation targeted 5-ht terminals in the nac. |
2019-11-25 |
2023-08-13 |
mouse |
| Megan J Moerke, Subramaniam Ananthan, Matthew L Banks, Jose M Eltit, Kelen C Freitas, Amy R Johnson, Surendra K Saini, Tyler W E Steele, S Stevens Negu. Interactions between Cocaine and the Putative Allosteric Dopamine Transporter Ligand SRI-31142. The Journal of pharmacology and experimental therapeutics. vol 367. issue 2. 2019-10-08. PMID:30150482. |
in neurochemical studies, in vivo microdialysis was used to compare the effects of sri-31142 and cocaine on levels of da and serotonin in nucleus accumbens (nac). |
2019-10-08 |
2023-08-13 |
rat |
| Francisco J Pavon, Antonia Serrano, Nimish Sidhpura, Ilham Polis, David Stouffer, Fernando Rodriguez de Fonseca, Benjamin F Cravatt, Rémi Martin-Fardon, Loren H Parson. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addiction biology. vol 23. issue 2. 2019-09-17. PMID:28660730. |
we conducted a microdialysis study to characterize nicotine-induced changes in da and serotonin (5-ht) levels in the nac of faah knockout (ko) mice using a conditioned place preference-like paradigm with three nicotine doses (0.1, 1 and 10 mg/kg, s.c.). |
2019-09-17 |
2023-08-13 |
mouse |
| Francisco J Pavon, Antonia Serrano, Nimish Sidhpura, Ilham Polis, David Stouffer, Fernando Rodriguez de Fonseca, Benjamin F Cravatt, Rémi Martin-Fardon, Loren H Parson. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addiction biology. vol 23. issue 2. 2019-09-17. PMID:28660730. |
furthermore, faah ko mice displayed a moderate enhancement of the effect of low-dose nicotine on nac 5-ht release (p < 0.05), with no differences between the genotypes at higher doses. |
2019-09-17 |
2023-08-13 |
mouse |
| Francisco J Pavon, Antonia Serrano, Nimish Sidhpura, Ilham Polis, David Stouffer, Fernando Rodriguez de Fonseca, Benjamin F Cravatt, Rémi Martin-Fardon, Loren H Parson. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addiction biology. vol 23. issue 2. 2019-09-17. PMID:28660730. |
similar to faah ko mice, pf-3845-pretreated mice displayed a moderate enhancement of the effect of low-dose nicotine on nac 5-ht release (p < 0.01). |
2019-09-17 |
2023-08-13 |
mouse |
| Rutuja Yawalkar, Harish Changotra, Girdhari Lal Gupt. Protective influences of N-acetylcysteine against alcohol abstinence-induced depression by regulating biochemical and GRIN2A, GRIN2B gene expression of NMDA receptor signaling pathway in rats. Neurochemistry international. vol 118. 2019-09-16. PMID:29704590. |
the significant reversal effect of nac on the serotonin level following alcohol abstinence was greater in the hippocampus as compared to the third-day alcohol withdrawal group. |
2019-09-16 |
2023-08-13 |
rat |
| Rutuja Yawalkar, Harish Changotra, Girdhari Lal Gupt. Protective influences of N-acetylcysteine against alcohol abstinence-induced depression by regulating biochemical and GRIN2A, GRIN2B gene expression of NMDA receptor signaling pathway in rats. Neurochemistry international. vol 118. 2019-09-16. PMID:29704590. |
in conclusion, the results of the study reveal that nac has remarkable protective effects in the alcohol abstinence-induced depression by modulating alcohol markers, serotonin levels and grin2a, grin2b gene expression of nmdar signaling pathway in rats. |
2019-09-16 |
2023-08-13 |
rat |
| Manjun Shen, Yi Yang, Ying Wu, Beibei Zhang, Haishan Wu, Lu Wang, Hui Tang, Jindong Che. L-theanine ameliorate depressive-like behavior in a chronic unpredictable mild stress rat model via modulating the monoamine levels in limbic-cortical-striatal-pallidal-thalamic-circuit related brain regions. Phytotherapy research : PTR. vol 33. issue 2. 2019-05-21. PMID:30474152. |
the monoamine neurotransmitters that involve serotonin (5-ht), norepinephrine (ne), and dopamine (da) were measured in the limbic-cortical-striatal-pallidal-thalamic (lcspt)-circuit related brain regions, including the prefrontal cortex (pfc), nucleus accumbens (nac), striatum (st), amygdala, and hippocampus (hip). |
2019-05-21 |
2023-08-13 |
rat |