| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manjun Shen, Yi Yang, Ying Wu, Beibei Zhang, Haishan Wu, Lu Wang, Hui Tang, Jindong Che. L-theanine ameliorate depressive-like behavior in a chronic unpredictable mild stress rat model via modulating the monoamine levels in limbic-cortical-striatal-pallidal-thalamic-circuit related brain regions. Phytotherapy research : PTR. vol 33. issue 2. 2019-05-21. PMID:30474152. |
in the pfc, nac, and hip, l-theanine administration significantly increased the levels of 5-ht, ne, and da. |
2019-05-21 |
2023-08-13 |
rat |
| Darakhshan Jabeen Haleem, Shazia Nawaz, Tabinda Salma. Dopamine and serotonin metabolism associated with morphine reward and its inhibition with buspirone: A study in the rat striatum. Pharmacology, biochemistry, and behavior. vol 170. 2019-03-22. PMID:29782941. |
to understand the neurochemical mechanism involved in morphine addiction and its inhibition with buspirone, present study determines the effects of buspirone, morphine and their co-administration on the metabolism of serotonin and dopamine in the nac and cn. |
2019-03-22 |
2023-08-13 |
rat |
| Darakhshan Jabeen Haleem, Shazia Nawaz, Tabinda Salma. Dopamine and serotonin metabolism associated with morphine reward and its inhibition with buspirone: A study in the rat striatum. Pharmacology, biochemistry, and behavior. vol 170. 2019-03-22. PMID:29782941. |
co-administration of buspirone not only prevents rewarding effects of morphine, but its effects on the metabolism of dopamine and serotonin in the nac and cn are also reversed. |
2019-03-22 |
2023-08-13 |
rat |
| Amy R Johnson, Matthew L Banks, Dana E Selley, S Stevens Negu. Amphetamine maintenance differentially modulates effects of cocaine, methylenedioxypyrovalerone (MDPV), and methamphetamine on intracranial self-stimulation and nucleus accumbens dopamine in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 8. 2019-02-14. PMID:29703999. |
in neurochemical studies, nucleus accumbens (nac) levels of dopamine (da) and serotonin (5-ht) were monitored by in vivo microdialysis. |
2019-02-14 |
2023-08-13 |
rat |
| Amy R Johnson, Matthew L Banks, Dana E Selley, S Stevens Negu. Amphetamine maintenance differentially modulates effects of cocaine, methylenedioxypyrovalerone (MDPV), and methamphetamine on intracranial self-stimulation and nucleus accumbens dopamine in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 8. 2019-02-14. PMID:29703999. |
cocaine, methamphetamine, and mdpv each produced dose-dependent icss facilitation and increases in nac da; cocaine and methamphetamine also increased nac 5-ht. |
2019-02-14 |
2023-08-13 |
rat |
| Amy R Johnson, Matthew L Banks, Dana E Selley, S Stevens Negu. Amphetamine maintenance differentially modulates effects of cocaine, methylenedioxypyrovalerone (MDPV), and methamphetamine on intracranial self-stimulation and nucleus accumbens dopamine in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 8. 2019-02-14. PMID:29703999. |
amphetamine maintenance (0.32 mg/kg/h × 7 days) produced (1) sustained increases in basal icss and nac da with no change in nac 5-ht, (2) blockade of cocaine but not methamphetamine effects on icss and nac da, and (3) no blockade of cocaine- or methamphetamine-induced increases in nac 5-ht. |
2019-02-14 |
2023-08-13 |
rat |
| Amy R Johnson, Matthew L Banks, Dana E Selley, S Stevens Negu. Amphetamine maintenance differentially modulates effects of cocaine, methylenedioxypyrovalerone (MDPV), and methamphetamine on intracranial self-stimulation and nucleus accumbens dopamine in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 8. 2019-02-14. PMID:29703999. |
the selective effectiveness of amphetamine maintenance to treat cocaine abuse may reflect attenuation of cocaine-induced increases in nac da while preserving cocaine-induced increases in nac 5-ht. |
2019-02-14 |
2023-08-13 |
rat |
| J J Dimatelis, A Mtintsilana, V Naidoo, D J Stein, V A Russel. Chronic light exposure alters serotonergic and orexinergic systems in the rat brain and reverses maternal separation-induced increase in orexin receptors in the prefrontal cortex. Metabolic brain disease. vol 33. issue 2. 2019-01-31. PMID:29039077. |
the present results suggest that ccl treatment affects 5-ht and orexinergic systems in the ms model while not affecting the ms-induced decrease in dopamine release in the nac. |
2019-01-31 |
2023-08-13 |
rat |
| Raúl López-Arnau, Mario Buenrostro-Jáuregui, Jorge Camarasa, David Pubill, Elena Escubed. Effect of the combination of mephedrone plus ethanol on serotonin and dopamine release in the nucleus accumbens and medial prefrontal cortex of awake rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 391. issue 3. 2018-11-26. PMID:29349706. |
etoh combined with meph increased the 5-ht release compared with the rats receiving meph alone (85% in nac, 65% in mpfc), although the overall change in the area under the curve only reached statistical significance in the nac. |
2018-11-26 |
2023-08-13 |
rat |
| Christine Winter, Dana M Greene, Paraskevi Mavrogiorgou, Helge Schaper, Reinhard Sohr, Abel Bult-Ito, Georg Jucke. Altered serotonergic and GABAergic neurotransmission in a mice model of obsessive-compulsive disorder. Behavioural brain research. vol 337. 2018-06-08. PMID:28916503. |
the neurochemical investigation of several brain regions of the corticostriato-thalamocortical circuity, i.e., nucleus caudatus (cpu), nucleus accumbens (nac), globus pallidus (gp), hippocampus (hpc), amygdala (am), ventral tegmental area (vta) and substantia nigra (sn) was performed by electrochemical (serotonin and dopamine) and fluorescence (glutamate and gaba) hplc detection. |
2018-06-08 |
2023-08-13 |
mouse |
| Ji-Chun Zhang, Wei Yao, Qian Ren, Chun Yang, Chao Dong, Min Ma, Jin Wu, Kenji Hashimot. Depression-like phenotype by deletion of α7 nicotinic acetylcholine receptor: Role of BDNF-TrkB in nucleus accumbens. Scientific reports. vol 6. 2018-05-14. PMID:27821848. |
systemic administration of the trkb antagonist ana-12, but not the trkb agonist 7,8-dihydroxyflavone and the selective serotonin reuptake inhibitor fluoxetine, showed a rapid antidepressant effect in ko mice by normalizing increased synaptogenesis in the nac. |
2018-05-14 |
2023-08-13 |
mouse |
| Marie-Line Reynaert, Jordan Marrocco, Jérôme Mairesse, Luana Lionetto, Maurizio Simmaco, Lucie Deruyter, Delphine Allorge, Anna Moles, Anna Pittaluga, Stefania Maccari, Sara Morley-Fletcher, Gilles Van Camp, Ferdinando Nicolett. Hedonic sensitivity to natural rewards is affected by prenatal stress in a sex-dependent manner. Addiction biology. vol 21. issue 6. 2018-01-16. PMID:26011513. |
male prs rats also show increases in plasma dihydrotestosterone (dht) levels and dopamine (da) levels in the nucleus accumbens (nac), and reductions in 5-hydroxytryptamine (5-ht) levels in the nac and prefrontal cortex (pfc). |
2018-01-16 |
2023-08-13 |
rat |
| Matthew Brodsky, Alec W Gibson, Denis Smirnov, Sunila G Nair, John F Neumaie. Striatal 5-HT6 Receptors Regulate Cocaine Reinforcement in a Pathway-Selective Manner. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 9. 2018-01-09. PMID:27032690. |
the nucleus accumbens (nac) in the ventral striatum integrates many neurochemical inputs including dopamine and serotonin projections from midbrain nuclei to modulate drug reward. |
2018-01-09 |
2023-08-13 |
rat |
| Iku Tsutsui-Kimura, Yu Ohmura, Takayuki Yoshida, Mitsuhiro Yoshiok. Milnacipran affects mouse impulsive, aggressive, and depressive-like behaviors in a distinct dose-dependent manner. Journal of pharmacological sciences. vol 134. issue 3. 2018-01-03. PMID:28694090. |
a milnacipran dose of 10 mg/kg suppressed all behaviors, which was accompanied by increased dopamine and serotonin levels in the medial prefrontal cortex (mpfc) but not in the nucleus accumbens (nac). |
2018-01-03 |
2023-08-13 |
mouse |
| Iku Tsutsui-Kimura, Yu Ohmura, Takayuki Yoshida, Mitsuhiro Yoshiok. Milnacipran affects mouse impulsive, aggressive, and depressive-like behaviors in a distinct dose-dependent manner. Journal of pharmacological sciences. vol 134. issue 3. 2018-01-03. PMID:28694090. |
finding drugs that increase serotonin and dopamine levels in the mpfc without affecting dopamine levels in the nac is a potential strategy for developing novel antidepressants. |
2018-01-03 |
2023-08-13 |
mouse |
| Miku Aoki, Yoshihisa Watanabe, Kanji Yoshimoto, Atsushi Tsujimura, Toshiro Yamamoto, Narisato Kanamura, Masaki Tanak. Involvement of serotonin 2C receptor RNA editing in accumbal neuropeptide Y expression and behavioural despair. The European journal of neuroscience. vol 43. issue 9. 2017-12-22. PMID:26950265. |
ini mice showed an enhanced behavioural despair in the forced swimming test, elevated sensitivity to the tricyclic antidepressant desipramine, and significantly decreased serotonin in the nucleus accumbens (nac), amygdala, and striatum. |
2017-12-22 |
2023-08-13 |
mouse |
| L Recinella, S Leone, C Ferrante, A Chiavaroli, C Di Nisio, S Martinotti, M Vacca, L Brunetti, G Orland. Effects of central fibroblast growth factor 21 (FGF21) in energy balance. Journal of biological regulators and homeostatic agents. vol 31. issue 3. 2017-12-14. PMID:28889722. |
in addition, we evaluated the effects of fgf21 on orexigenic [agouti-related peptide (agrp) and neuropeptide y (npy)] and anorexigenic [cocaine and amphetamine-regulated transcript (cart) and proopiomelanocortin (pomc)] peptides, in the hypothalamus, and dopamine (da) and serotonin (5-hydroxytriptamine, 5-ht) levels in nucleus accumbens (nac). |
2017-12-14 |
2023-08-13 |
rat |
| Daniel L C Costa, Juliana B Diniz, Guaraci Requena, Marinês A Joaquim, Christopher Pittenger, Michael H Bloch, Euripedes C Miguel, Roseli G Shavit. Randomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder. The Journal of clinical psychiatry. vol 78. issue 7. 2017-09-21. PMID:28617566. |
to evaluate the efficacy of serotonin reuptake inhibitor (sri) augmentation with n-acetylcysteine (nac), a glutamate modulator and antioxidant medication, for treatment-resistant obsessive-compulsive disorder (ocd). |
2017-09-21 |
2023-08-13 |
Not clear |
| Yusuf S Althobaiti, Atiah H Almalki, Sujan C Das, Fahad S Alshehri, Youssef Sar. Effects of repeated high-dose methamphetamine and ceftriaxone post-treatments on tissue content of dopamine and serotonin as well as glutamate and glutamine. Neuroscience letters. vol 634. 2017-08-21. PMID:27702628. |
meth induced a significant depletion of dopamine and 5-ht in the nac and pfc. |
2017-08-21 |
2023-08-13 |
rat |
| M F Lazenka, J A Suyama, C T Bauer, M L Banks, S S Negu. Sex differences in abuse-related neurochemical and behavioral effects of 3,4-methylenedioxymethamphetamine (MDMA) in rats. Pharmacology, biochemistry, and behavior. vol 152. 2017-06-01. PMID:27566288. |
to evaluate potential for sex differences in abuse-related mdma effects, the present study compared mdma effects on intracranial self-stimulation (icss) and on in vivo microdialysis measurements of da or 5ht in the nucleus accumbens (nac) in female and male sprague-dawley rats. |
2017-06-01 |
2023-08-13 |
rat |