| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ben Rein, Kendall Raymond, Cali Boustani, Sabrena Tuy, Jie Zhang, Robyn St Laurent, Matthew B Pomrenze, Parnaz Boroon, Boris Heifets, Monique Smith, Robert C Malenk. MDMA enhances empathy-like behaviors in mice via 5-HT release in the nucleus accumbens. Science advances. vol 10. issue 17. 2024-04-24. PMID:38657057. |
last, we demonstrate that systemic mdma or optogenetic stimulation of nac 5-ht inputs restores deficits in empathy-like behaviors in the |
2024-04-24 |
2024-04-28 |
mouse |
| Ben Rein, Kendall Raymond, Cali Boustani, Sabrena Tuy, Jie Zhang, Robyn St Laurent, Matthew B Pomrenze, Parnaz Boroon, Boris Heifets, Monique Smith, Robert C Malenk. MDMA enhances empathy-like behaviors in mice via 5-HT release in the nucleus accumbens. Science advances. vol 10. issue 17. 2024-04-24. PMID:38657057. |
optogenetic stimulation of 5-ht release in the nac recapitulates the effects of mdma, implicating 5-ht signaling as a core mechanism. |
2024-04-24 |
2024-04-28 |
mouse |
| Yuki Moriya, Yoshiyuki Kasahara, Kana Ishihara, Frank Scott Hall, Yoko Hagino, René Hen, Kazutaka Ikeda, George R Uhl, Ichiro Sor. Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization. Behavioural pharmacology. 2023-09-05. PMID:37668157. |
to clarify the action of meth in 5-ht1b ko mice the effects of meth on extracellular levels of da (daec) and 5-ht (5-htec) in the caudate putamen (cpu) and the nucleus accumbens (nac) were examined. |
2023-09-05 |
2023-09-07 |
mouse |
| Adejoke Elizabeth Memud. The Efficacy of N-Acetyl-Cysteine (NAC) Supplementation in FST Model for Screening Antidepressants. Basic and clinical neuroscience. vol 13. issue 6. 2023-06-16. PMID:37323955. |
this study was aimed at potential antidepressant mechanism of n-acetyl cysteine (nac), a glutamate precursor on fst animal model for screening antidepressant drugs using fluoxetine, a selective serotonin reuptake inhibitors (ssris) as standard antidepressant drug. |
2023-06-16 |
2023-08-14 |
rat |
| Yifeng Shi, Mengqi Wang, Linglong Xiao, Luolan Gui, Wen Zheng, Lin Bai, Bo Su, Bin Li, Yangyang Xu, Wei Pan, Jie Zhang, Wei Wan. Potential therapeutic mechanism of deep brain stimulation of the nucleus accumbens in obsessive-compulsive disorder. Frontiers in cellular neuroscience. vol 16. 2023-01-23. PMID:36687525. |
furthermore, we found that the local levels of monoamines [dopamine (da) and serotonin (5-ht)] and amino acids [glutamate (glu) and gamma-aminobutyric acid (gaba)] in the nac were increased in ocd status, and that the expression of the two types of da receptors in the nac exhibited an opposite change. |
2023-01-23 |
2023-08-14 |
rat |
| Grace E Anderson, Alexandra Sharp, Wayne E Prat. Stimulation of nucleus accumbens 5-HT6 receptors increases both appetitive and consummatory motivation in an effort-based choice task. Neuroreport. vol 34. issue 2. 2023-01-06. PMID:36608167. |
stimulation of nac 5-ht receptors significantly increased both appetitive and consummatory motivation as assessed in this effort-based choice task. |
2023-01-06 |
2023-08-14 |
rat |
| Andrey Sequeira-Cordero, Juan C Brene. Time course of plasticity-related alterations following the first exposure to amphetamine in juvenile rats. Pharmacology, biochemistry, and behavior. 2022-11-14. PMID:36375621. |
high amph responders characterized by overexpressing bdnf, creb, p250gap, and crf in nac and by showing lower levels of dopamine and serotonin metabolites and turnovers in both regions. |
2022-11-14 |
2023-08-14 |
rat |
| Yan Li, Zhi Chen, Jianting Zhao, Heming Yu, Xiangyu Chen, Yong He, Yu Tian, Yue Wang, Chong Chen, Ke Cheng, Peng Xi. Neurotransmitter and Related Metabolic Profiling in the Nucleus Accumbens of Chronic Unpredictable Mild Stress-Induced Anhedonia-Like Rats. Frontiers in behavioral neuroscience. vol 16. 2022-05-16. PMID:35571281. |
anhedonia, as a core symptom, was closely associated with altered levels of 5-hydroxytryptamine (5-ht), dopamine (da), and diverse types of glutamate (glu) receptors in the nucleus accumbens (nac). |
2022-05-16 |
2023-08-13 |
rat |
| Daniel J Christoffel, Jessica J Walsh, Paul Hoerbelt, Boris D Heifets, Pierre Llorach, Ricardo C Lopez, Charu Ramakrishnan, Karl Deisseroth, Robert C Malenk. Selective filtering of excitatory inputs to nucleus accumbens by dopamine and serotonin. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 24. 2021-12-11. PMID:34103400. |
here, we examined whether da and 5-ht selectively modulate excitatory synaptic transmission in nac medium spiny neurons in an input-specific manner. |
2021-12-11 |
2023-08-13 |
Not clear |
| Daniel J Christoffel, Jessica J Walsh, Paul Hoerbelt, Boris D Heifets, Pierre Llorach, Ricardo C Lopez, Charu Ramakrishnan, Karl Deisseroth, Robert C Malenk. Selective filtering of excitatory inputs to nucleus accumbens by dopamine and serotonin. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 24. 2021-12-11. PMID:34103400. |
the detailed mechanisms by which dopamine (da) and serotonin (5-ht) act in the nucleus accumbens (nac) to influence motivated behaviors in distinct ways remain largely unknown. |
2021-12-11 |
2023-08-13 |
Not clear |
| Daniel J Christoffel, Jessica J Walsh, Paul Hoerbelt, Boris D Heifets, Pierre Llorach, Ricardo C Lopez, Charu Ramakrishnan, Karl Deisseroth, Robert C Malenk. Selective filtering of excitatory inputs to nucleus accumbens by dopamine and serotonin. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 24. 2021-12-11. PMID:34103400. |
these findings suggest that the distinct, input-specific filtering of excitatory inputs in the nac by da and 5-ht contribute to their discrete behavioral effects. |
2021-12-11 |
2023-08-13 |
Not clear |
| Marta Ielmini, Ivano Caselli, Francesca Ceccon, Marcello Diurni, Nicola Poloni, Camilla Callegar. Selective Serotonin Reuptake Inhibitors and Nutraceutical Combination in Major Depression Disorder: A Case-Control Study. Psychopharmacology bulletin. vol 51. issue 4. 2021-12-11. PMID:34887597. |
the study aims to compare the antidepressants response in the utilization of selective serotonin reuptake inhibitors (ssris) versus a combination of ssris and nutraceutical supplements based on s-adenosyl methionine (same), n-acetylcysteine (nac) and folate in terms of efficacy and tolerability. |
2021-12-11 |
2023-08-13 |
Not clear |
| Jessica J Walsh, Pierre Llorach, Daniel F Cardozo Pinto, Wendy Wenderski, Daniel J Christoffel, Juliana S Salgado, Boris D Heifets, Gerald R Crabtree, Robert C Malenk. Systemic enhancement of serotonin signaling reverses social deficits in multiple mouse models for ASD. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 11. 2021-09-16. PMID:34239048. |
we recently demonstrated that enhanced serotonin (5-ht) activity in the nucleus accumbens (nac), via optogenetic activation of 5-htergic inputs or direct infusion of a specific 5-ht1b receptor agonist, reverses social deficits in a genetic mouse model for asd based on 16p11.2 copy number variation. |
2021-09-16 |
2023-08-13 |
mouse |
| Jessica J Walsh, Pierre Llorach, Daniel F Cardozo Pinto, Wendy Wenderski, Daniel J Christoffel, Juliana S Salgado, Boris D Heifets, Gerald R Crabtree, Robert C Malenk. Systemic enhancement of serotonin signaling reverses social deficits in multiple mouse models for ASD. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 11. 2021-09-16. PMID:34239048. |
furthermore, the recreational drug mdma, which is currently being evaluated in clinical trials, promotes sociability in mice due to its 5-ht releasing properties in the nac. |
2021-09-16 |
2023-08-13 |
mouse |
| Eric Murillo-Rodríguez, Gloria Arankowsky-Sandoval, Roger G Pertwee, Linda Parker, Raphael Mechoula. Sleep and neurochemical modulation by cannabidiolic acid methyl ester in rats. Brain research bulletin. vol 155. 2021-06-03. PMID:31838151. |
hu-580 enhanced extracellular levels of dopamine, serotonin collected from nac while adenosine and acetylcholine were increased in basal forebrain. |
2021-06-03 |
2023-08-13 |
rat |
| Jesper Vestlund, Elisabet Jerlha. Glucagon-like peptide-1 receptors and sexual behaviors in male mice. Psychoneuroendocrinology. vol 117. 2021-06-01. PMID:32388229. |
in male mice tested in the sexual interaction test, nts-ex4 increased dopamine turnover and enhanced serotonin levels in the nucleus accumbens (nac). |
2021-06-01 |
2023-08-13 |
mouse |
| Katsumasa Muneoka, Yasunori Oda, Masaaki Iwata, Masaomi Iyo, Kenji Hashimoto, Yukihiko Shirayam. Monoaminergic balances predict non-depression-like phenotype in Learned Helplessness Paradigm. Neuroscience. vol 440. 2021-05-14. PMID:32222554. |
changes that occurred in lh or non-lh rats when compared with those in naïve rats suggest that suppressed da activity in the hippocampus and ofc; elevated da activity in the amygdala; and facilitated 5-ht activity in the hippocampus, mpfc, and nac are phenomena related to the expression of a non-depression-like phenotype. |
2021-05-14 |
2023-08-13 |
rat |
| Katsumasa Muneoka, Yasunori Oda, Masaaki Iwata, Masaomi Iyo, Kenji Hashimoto, Yukihiko Shirayam. Monoaminergic balances predict non-depression-like phenotype in Learned Helplessness Paradigm. Neuroscience. vol 440. 2021-05-14. PMID:32222554. |
compared with lh rats, non-lh rats showed lower 3-methoxy-4-hydroxyphenylglycol (mhpg) levels and na turnovers in the amygdala and higher 5-ht levels in the nac. |
2021-05-14 |
2023-08-13 |
rat |
| Katsumasa Muneoka, Yasunori Oda, Masaaki Iwata, Masaomi Iyo, Kenji Hashimoto, Yukihiko Shirayam. Monoaminergic balances predict non-depression-like phenotype in Learned Helplessness Paradigm. Neuroscience. vol 440. 2021-05-14. PMID:32222554. |
here, we measured the levels of monoamines, including noradrenaline (na), serotonin (5-ht), and dopamine (da), and their metabolites in the medial prefrontal cortex (mpfc), orbitofrontal cortex (ofc), hippocampus, nucleus accumbens (nac), amygdala, and striatum in lh, non-lh, and non-manipulated (naïve) rats. |
2021-05-14 |
2023-08-13 |
rat |
| Katsumasa Muneoka, Yasunori Oda, Masaaki Iwata, Masaomi Iyo, Kenji Hashimoto, Yukihiko Shirayam. Monoaminergic balances predict non-depression-like phenotype in Learned Helplessness Paradigm. Neuroscience. vol 440. 2021-05-14. PMID:32222554. |
comparison between lh and non-lh suggest that suppressed amygdaloid na activity and elevated 5-ht activity in the nac are related to stress resilience. |
2021-05-14 |
2023-08-13 |
rat |