| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E N Pothos, L Hernandez, B G Hoebe. Chronic food deprivation decreases extracellular dopamine in the nucleus accumbens: implications for a possible neurochemical link between weight loss and drug abuse. Obesity research. vol 3 Suppl 4. 1996-09-05. PMID:8697053. |
no changes were observed in nac serotonin after weight reduction. |
1996-09-05 |
2023-08-12 |
rat |
| M E Benwell, P E Holtom, R J Moran, D J Balfou. Neurochemical and behavioural interactions between ibogaine and nicotine in the rat. British journal of pharmacology. vol 117. issue 4. 1996-07-24. PMID:8646423. |
administration of ibogaine was associated with reductions in the tissue levels of 5-hydroxyindoleacetic acid (5-hiaa) in the nac (p < 0.01) and striatum (p < 0.05) and an increase in the level of this metabolite in the medial prefrontal cortex (mpfc) (p < 0.01) while the levels of dopamine and 5-hydroxytryptamine (5-ht) in the mpfc were reduced (p < 0.05). |
1996-07-24 |
2023-08-12 |
rat |
| F Weiss, L H Parsons, G Schulteis, P Hyytiä, M T Lorang, F E Bloom, G F Koo. Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 10. 1996-06-21. PMID:8627380. |
in nondependent rats, operant ethanol self-administration increased both da and 5-ht release in the nac. |
1996-06-21 |
2023-08-12 |
human |
| L H Parsons, G F Koob, F Weis. Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine. The Journal of pharmacology and experimental therapeutics. vol 274. issue 3. 1995-10-25. PMID:7562486. |
to test the hypothesis that cocaine withdrawal is associated with abnormalities in serotonin (5-ht) neurotransmission, 5-ht concentrations in the nucleus accumbens (nac) of rats were analyzed with microdialysis both during and after 12 h of unlimited-access intravenous cocaine self-administration. |
1995-10-25 |
2023-08-12 |
rat |
| P V Rada, G P Mark, B G Hoebe. In vivo modulation of acetylcholine in the nucleus accumbens of freely moving rats: I. Inhibition by serotonin. Brain research. vol 619. issue 1-2. 1993-10-20. PMID:8374797. |
local infusion of 5-hydroxytryptamine (5-ht) or the serotonin reuptake blocker fluoxetine significantly decreased extracellular acetylcholine (ach) in the nac. |
1993-10-20 |
2023-08-12 |
rat |
| P V Rada, G P Mark, B G Hoebe. In vivo modulation of acetylcholine in the nucleus accumbens of freely moving rats: II. Inhibition by gamma-aminobutyric acid. Brain research. vol 619. issue 1-2. 1993-10-20. PMID:8397051. |
our earlier studies suggest dopamine and serotonin interact with acetylcholine (ach) in the nucleus accumbens (nac) as part of a system for motivation and reinforcement. |
1993-10-20 |
2023-08-12 |
rat |
| F J White, X T Hu, D J Henr. Electrophysiological effects of cocaine in the rat nucleus accumbens: microiontophoretic studies. The Journal of pharmacology and experimental therapeutics. vol 266. issue 2. 1993-09-17. PMID:8355182. |
cocaine inhibits the firing of most nac cells due to its ability to prevent the reuptake of dopamine (da) and 5-hydroxytryptamine (5-ht), both of which predominantly inhibit nac cell discharge in vivo. |
1993-09-17 |
2023-08-12 |
rat |
| F J White, X T Hu, D J Henr. Electrophysiological effects of cocaine in the rat nucleus accumbens: microiontophoretic studies. The Journal of pharmacology and experimental therapeutics. vol 266. issue 2. 1993-09-17. PMID:8355182. |
combined administration of selective da (gbr 12909) and 5-ht (fluoxetine) uptake inhibitors was required to mimic the effects of cocaine on type i and type ii nac cells. |
1993-09-17 |
2023-08-12 |
rat |
| R Sala, E Moriggi, G Corvasce, D Morell. Protection by N-acetylcysteine against pulmonary endothelial cell damage induced by oxidant injury. The European respiratory journal. vol 6. issue 3. 1993-05-20. PMID:8472835. |
the oral administration of a single dose of nac (2 mmol.kg-1) 60 min before antigen/antibody (ag/ab) treatment was effective in preventing pulmonary endothelial cell [14c]5ht uptake loss induced by immune complex deposition. |
1993-05-20 |
2023-08-12 |
rat |
| G H Jones, T D Hernandez, D A Kendall, C A Marsden, T W Robbin. Dopaminergic and serotonergic function following isolation rearing in rats: study of behavioural responses and postmortem and in vivo neurochemistry. Pharmacology, biochemistry, and behavior. vol 43. issue 1. 1992-11-02. PMID:1384071. |
isolated rats also had a lower 5-hydroxyindoleacetic acid (5-hiaa)/5-hydroxytryptamine (5-ht) ratio in the nac (but not in the pfc or cpu) compared to controls. |
1992-11-02 |
2023-08-11 |
rat |
| D Nakahara, N Ozaki, Y Miura, H Miura, T Nagats. Increased dopamine and serotonin metabolism in rat nucleus accumbens produced by intracranial self-stimulation of medial forebrain bundle as measured by in vivo microdialysis. Brain research. vol 495. issue 1. 1989-10-19. PMID:2476201. |
these findings indicate that self-stimulation of the mfb in rats induces increases in both da and serotonin activities in the nac. |
1989-10-19 |
2023-08-11 |
rat |
| R Morgenstern, T Mende, R Gold, P Lemme, W Oelssne. Drug-induced modulation of locomotor hyperactivity induced by picrotoxin in nucleus accumbens. Pharmacology, biochemistry, and behavior. vol 21. issue 4. 1984-12-26. PMID:6504948. |
locomotor hyperactivity was induced in rats by bilateral injection of picrotoxin (pic) into the nucleus accumbens (nac) followed by intraperitoneal (ip) or intra-accumbens (ia) injection of agents affecting dopamine (da), acetylcholine, serotonin, or gaba receptors. |
1984-12-26 |
2023-08-12 |
rat |
| R Morgenstern, T Mende, R Gold, P Lemme, W Oelssne. Drug-induced modulation of locomotor hyperactivity induced by picrotoxin in nucleus accumbens. Pharmacology, biochemistry, and behavior. vol 21. issue 4. 1984-12-26. PMID:6504948. |
the results suggest that there is a complex involvement of gaba, da and serotonin functions in the effectuation of pic-induced hypermotility and that pic-induced hypermotility may be affected by da-sensitive structures situated outside the nac. |
1984-12-26 |
2023-08-12 |
rat |
| P Redgrav. Modulation of intracranial self-stimulation behaviour by local perfusions of dopamine, noradrenaline and serotonin within the caudate nucleus and nucleus accumbens. Brain research. vol 155. issue 2. 1978-12-02. PMID:688018. |
in order to examine the possible role of dopamine (da), noradrenaline (na) and 5-hydroxytryptamine (5-ht) in the control of intracranial self-stimulation behaviour (icss) a push-pull perfusion system was used to administer different consecutive doses of da, na and 5-ht to discrete regions within the caudate nucleus (cn) and nucleus accumbens (nac) of rats during icss. |
1978-12-02 |
2023-08-11 |
human |
| P Redgrav. Modulation of intracranial self-stimulation behaviour by local perfusions of dopamine, noradrenaline and serotonin within the caudate nucleus and nucleus accumbens. Brain research. vol 155. issue 2. 1978-12-02. PMID:688018. |
it is suggested that the central control of icss behaviour might depend, in part, upon a relative balance between da and 5-ht systems within the cn and nac. |
1978-12-02 |
2023-08-11 |
human |