| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christian P Müller, Robert J Carey, Maria A De Souza Silva, Gerhard Jocham, Joseph P Husto. Cocaine increases serotonergic activity in the hippocampus and nucleus accumbens in vivo: 5-HT1a-receptor antagonism blocks behavioral but potentiates serotonergic activation. Synapse (New York, N.Y.). vol 45. issue 2. 2002-08-08. PMID:12112399. |
here we describe for the first time a cocaine-induced increase in 5-ht concentration in the hippocampus and the nac parallel to behavioral activation. |
2002-08-08 |
2023-08-12 |
rat |
| Christian P Müller, Robert J Carey, Maria A De Souza Silva, Gerhard Jocham, Joseph P Husto. Cocaine increases serotonergic activity in the hippocampus and nucleus accumbens in vivo: 5-HT1a-receptor antagonism blocks behavioral but potentiates serotonergic activation. Synapse (New York, N.Y.). vol 45. issue 2. 2002-08-08. PMID:12112399. |
in addition, pretreatment with the 5-ht(1a)-receptor antagonist way 100635 blocked the behavioral activation after cocaine while potentiating the 5-ht increase in the hippocampus and the nac. |
2002-08-08 |
2023-08-12 |
rat |
| Christian P Müller, Robert J Carey, Maria A De Souza Silva, Gerhard Jocham, Joseph P Husto. Cocaine increases serotonergic activity in the hippocampus and nucleus accumbens in vivo: 5-HT1a-receptor antagonism blocks behavioral but potentiates serotonergic activation. Synapse (New York, N.Y.). vol 45. issue 2. 2002-08-08. PMID:12112399. |
in vivo microdialysis was used in behaving rats to measure extracellular concentration of 5-ht in the hippocampus and the nac. |
2002-08-08 |
2023-08-12 |
rat |
| Christian P Müller, Robert J Carey, Maria A De Souza Silva, Gerhard Jocham, Joseph P Husto. Cocaine increases serotonergic activity in the hippocampus and nucleus accumbens in vivo: 5-HT1a-receptor antagonism blocks behavioral but potentiates serotonergic activation. Synapse (New York, N.Y.). vol 45. issue 2. 2002-08-08. PMID:12112399. |
cocaine, at a dose that activates behavior, increases 5-ht levels in the hippocampus and in the nac, and 2.) |
2002-08-08 |
2023-08-12 |
rat |
| Christian P Müller, Robert J Carey, Maria A De Souza Silva, Gerhard Jocham, Joseph P Husto. Cocaine increases serotonergic activity in the hippocampus and nucleus accumbens in vivo: 5-HT1a-receptor antagonism blocks behavioral but potentiates serotonergic activation. Synapse (New York, N.Y.). vol 45. issue 2. 2002-08-08. PMID:12112399. |
5-ht(1a)-receptor antagonism can cause a dissociation of the hippocampal and nac 5-ht activity from behavioral activation after cocaine. |
2002-08-08 |
2023-08-12 |
rat |
| M D Lapiz, A Fulford, S Muchimapura, R Mason, T Parker, C A Marsde. Influence of postweaning social isolation in the rat on brain development, conditioned behaviour and neurotransmission. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 87. issue 6. 2001-12-04. PMID:11534200. |
isolation-reared rats have enhanced presynaptic dopamine (da) and 5-ht function in the nucleus accimbens (nac) associated with decreased presynaptic 5-ht function in the frontal cortex and hippocampus. |
2001-12-04 |
2023-08-12 |
human |
| L R McMahon, M Filip, K A Cunningha. Differential regulation of the mesoaccumbens circuit by serotonin 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 19. 2001-10-11. PMID:11567068. |
to test this hypothesis, the present study measured cocaine-evoked locomotor activity after bilateral microinjection of selective 5-ht(2a)r and 5-ht(2c)r antagonists into the ventral tegmental area (vta) or the nucleus accumbens (nac) shell. |
2001-10-11 |
2023-08-12 |
Not clear |
| L R McMahon, M Filip, K A Cunningha. Differential regulation of the mesoaccumbens circuit by serotonin 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 19. 2001-10-11. PMID:11567068. |
these findings are the first to demonstrate that the behavioral effects of cocaine are generated in part by activation of 5-ht(2a)rs in the vta and by activation of 5-ht(2c)rs in the nac shell. |
2001-10-11 |
2023-08-12 |
Not clear |
| A Mayerhofer, K A Kovar, W J Schmid. Changes in serotonin, dopamine and noradrenaline levels in striatum and nucleus accumbens after repeated administration of the abused drug MDMA in rats. Neuroscience letters. vol 308. issue 2. 2001-09-13. PMID:11457569. |
decreased noradrenaline and/or serotonin may subsequently cause the augmentation of dopamine in nac, a structure crucially involved in motivation circuits. |
2001-09-13 |
2023-08-12 |
rat |
| S Herges, D A Taylo. Involvement of 5-HT(3) receptors in the nucleus accumbens in the potentiation of cocaine-induced behaviours in the rat. British journal of pharmacology. vol 131. issue 7. 2001-02-01. PMID:11090100. |
the present study investigated the central effects of the selective serotonin reuptake inhibitor (ssri) fluoxetine and the role of 5-hydroxytryptamine(3) (5-ht(3)) receptors in the core of the nucleus accumbens (nac) on cocaine-induced behavioural changes in rats. |
2001-02-01 |
2023-08-12 |
rat |
| S Herges, D A Taylo. Involvement of 5-HT(3) receptors in the nucleus accumbens in the potentiation of cocaine-induced behaviours in the rat. British journal of pharmacology. vol 131. issue 7. 2001-02-01. PMID:11090100. |
the 5-ht(3) receptor antagonist ondansetron (1 or 10 ng) was microinjected bilaterally into the core of the nac 60 min prior to peripheral cocaine (15 mg kg(-1), i.p.) |
2001-02-01 |
2023-08-12 |
rat |
| S Herges, D A Taylo. Involvement of 5-HT(3) receptors in the nucleus accumbens in the potentiation of cocaine-induced behaviours in the rat. British journal of pharmacology. vol 131. issue 7. 2001-02-01. PMID:11090100. |
thus, 5-ht(3) receptors in the core of the nac appear to mediate stimulatory effects on cocaine-induced locomotor activity, rears and head bobs, whereas the attenuation of cocaine-induced behaviours by fluoxetine at the higher dose, suggests the involvement of a different 5-ht receptor subtype. |
2001-02-01 |
2023-08-12 |
rat |
| M M Marcus, G G Nomikos, T H Svensso. Effects of atypical antipsychotic drugs on dopamine output in the shell and core of the nucleus accumbens: role of 5-HT(2A) and alpha(1)-adrenoceptor antagonism. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 4. 2000-09-14. PMID:10871706. |
the effects of acute intravenous administration of several new, atypical antipsychotic drugs (apds): olanzapine (0.05 and 1.0 mg/kg), sertindole (0.1 and 1.0 mg/kg) and quetiapine (0.25 and 2.5 mg/kg), a selective 5-ht(2a) receptor antagonist, m100907 (0.03 and 0.3 mg/kg), and an alpha(1)-adrenoceptor antagonist, prazosin (0.3 mg/kg), on regional dopamine output were examined in the two subdivisions of the nucleus accumbens (nac), the core and shell, which seem associated with motor control and limbic functions, respectively, by using in vivo differential normal pulse voltammetry in anaesthetised, pargyline-pretreated rats. |
2000-09-14 |
2023-08-12 |
rat |
| M M Marcus, G G Nomikos, T H Svensso. Effects of atypical antipsychotic drugs on dopamine output in the shell and core of the nucleus accumbens: role of 5-HT(2A) and alpha(1)-adrenoceptor antagonism. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 4. 2000-09-14. PMID:10871706. |
the results indicate that both 5-ht(2a) and alpha(1)-adrenoceptor antagonism may play an important role in the preferential effect of atypical apds on dopamine output in the shell versus the core of the nac. |
2000-09-14 |
2023-08-12 |
rat |
| S Puglisi-Allegra, S Cabib, T Pascucci, R Ventura, F Cali, V Roman. Dramatic brain aminergic deficit in a genetic mouse model of phenylketonuria. Neuroreport. vol 11. issue 6. 2000-07-17. PMID:10817622. |
results indicated a significant reduction of 5-ht levels and metabolism in prefrontal cortex (pfc), cingulate cortex (cg), nucleus accumbens (nac), caudate putamen (cp), hippocampus (hip) and amygdala (amy). |
2000-07-17 |
2023-08-12 |
mouse |
| M M Iravani, D Asari, J Patel, W J Wieczorek, Z L Kru. Direct effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin or dopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulata, and the dorsal raphé nucleus slices. Synapse (New York, N.Y.). vol 36. issue 4. 2000-06-06. PMID:10819905. |
we examined the effects of pressure ejected 3, 4-methylenedioxymethamphetamine (mdma) from a micropipette on direct chemically stimulated release, and on electrically stimulated serotonin (5-ht) or dopamine (da) release in the caudate putamen (cpu), nucleus accumbens (nac), substantia nigra pars reticulata (snr), and the dorsal raphé nucleus (drn) brain slices of rat, using fast cyclic voltammetry (fcv). |
2000-06-06 |
2023-08-12 |
rat |
| M M Iravani, D Asari, J Patel, W J Wieczorek, Z L Kru. Direct effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin or dopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulata, and the dorsal raphé nucleus slices. Synapse (New York, N.Y.). vol 36. issue 4. 2000-06-06. PMID:10819905. |
in the drn or in the nac, mdma was without effect on peak electrically stimulated 5-ht or da release. |
2000-06-06 |
2023-08-12 |
rat |
| J Ichikawa, H Y Meltze. The effect of serotonin(1A) receptor agonism on antipsychotic drug-induced dopamine release in rat striatum and nucleus accumbens. Brain research. vol 858. issue 2. 2000-04-24. PMID:10708676. |
serotonin (5-ht)(1a) receptor agonism may be of interest in regard to both the antipsychotic action and extrapyramidal symptoms (eps) of antipsychotic drugs (apd) based, in part, on the effect of 5-ht(1a) receptor stimulation on the release of dopamine (da) in the nucleus accumbens (nac) and striatum (str), respectively. |
2000-04-24 |
2023-08-12 |
rat |
| J Ichikawa, H Y Meltze. The effect of serotonin(1A) receptor agonism on antipsychotic drug-induced dopamine release in rat striatum and nucleus accumbens. Brain research. vol 858. issue 2. 2000-04-24. PMID:10708676. |
in both str and nac, r(+)-8-oh-dpat (0.2 mg/kg) decreased basal da release; r(+)-8-oh-dpat (0.05 mg/kg) inhibited da release produced by the 5-ht(2a)/d(2) receptor antagonists clozapine (20 mg/kg), low dose risperidone (0.01 and 0. |
2000-04-24 |
2023-08-12 |
rat |
| J Ichikawa, H Y Meltze. The effect of serotonin(1A) receptor agonism on antipsychotic drug-induced dopamine release in rat striatum and nucleus accumbens. Brain research. vol 858. issue 2. 2000-04-24. PMID:10708676. |
these results suggest that 5-ht(1a) receptor stimulation inhibits basal and some apd-induced da release in the str and nac, and that this effect is unlikely to be mediated by an interaction with 5-ht(2a) receptors. |
2000-04-24 |
2023-08-12 |
rat |