| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V M Pickel, J Cha. Ultrastructural localization of the serotonin transporter in limbic and motor compartments of the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 17. 1999-09-23. PMID:10460242. |
extracellular levels of serotonin [5-hydroxytryptamine (5-ht)] in the nucleus accumbens (nac) can influence both cognitive and motor functions involving extensive connections with the frontal cortex. |
1999-09-23 |
2023-08-12 |
rat |
| V M Pickel, J Cha. Ultrastructural localization of the serotonin transporter in limbic and motor compartments of the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 17. 1999-09-23. PMID:10460242. |
our results suggest that in the nac (1) reuptake into serotonergic axons is most efficient after exocytotic release from dcvs, and (2) increased 5-ht release without concomitant increase in sert expression in individual axons may contribute to higher extracellular levels of serotonin in the shell versus the core. |
1999-09-23 |
2023-08-12 |
rat |
| V M Pickel, J Cha. Ultrastructural localization of the serotonin transporter in limbic and motor compartments of the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 17. 1999-09-23. PMID:10460242. |
these findings also indicate that sert may play a minor substrate-dependent role in serotonin uptake or channel activity in selective nonserotonergic neurons and glia in the nac. |
1999-09-23 |
2023-08-12 |
rat |
| P De Deurwaerdère, U Spampinat. Role of serotonin(2A) and serotonin(2B/2C) receptor subtypes in the control of accumbal and striatal dopamine release elicited in vivo by dorsal raphe nucleus electrical stimulation. Journal of neurochemistry. vol 73. issue 3. 1999-09-14. PMID:10461892. |
this study investigates, using in vivo microdialysis, the role of serotonin2a (5-ht2a) and 5-ht(2b/2c) receptors in the effect of dorsal raphe nucleus (drn) electrical stimulation on dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac), and 5-hydroxyindoleacetic acid (5-hiaa) extracellular levels monitored in the nucleus accumbens (nac) and the striatum of halothane-anesthetized rats. |
1999-09-14 |
2023-08-12 |
rat |
| P De Deurwaerdère, U Spampinat. Role of serotonin(2A) and serotonin(2B/2C) receptor subtypes in the control of accumbal and striatal dopamine release elicited in vivo by dorsal raphe nucleus electrical stimulation. Journal of neurochemistry. vol 73. issue 3. 1999-09-14. PMID:10461892. |
the 5-ht2a antagonist sr 46349b (0.5 mg/kg) and the mixed 5-ht(2a/2b/2c) antagonist ritanserin (0.63 mg/kg) significantly reduced the effect of drn stimulation on da release in the nac but not in the striatum. |
1999-09-14 |
2023-08-12 |
rat |
| R D Myers, D E Robinso. Tetrahydropapaveroline injected in the ventral tegmental area shifts dopamine efflux differentially in the shell and core of nucleus accumbens in high-ethanol-preferring (HEP) rats. Alcohol (Fayetteville, N.Y.). vol 18. issue 1. 1999-08-17. PMID:10386670. |
sequential samples of the nac perfusate were assayed by an hplc coulometric system to quantitate the concentrations of dopamine and its metabolites, dopac and hva, as well as the 5-ht metabolite, 5-hiaa. |
1999-08-17 |
2023-08-12 |
rat |
| S ThyagaRajan, S Y Stevens, D L Felte. Region-specific alterations in the concentrations of catecholamines and indoleamines in the brains of young and old F344 rats after L-deprenyl treatment. Brain research bulletin. vol 48. issue 5. 1999-07-28. PMID:10372512. |
the effects of l-deprenyl, a monoamine oxidase-b (mao-b) inhibitor, on the concentrations of norepinephrine (ne), dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac), homovanillic acid (hva), serotonin (5-hydroxytryptamine), and 5-hydroxyindoleacetic acid (5-hiaa) in medial basal hypothalamus (mbh), substantia nigra (sn), striatum (str), and nucleus accumbens (nac) of young (3 month) and old (21 month) male f344 rats were examined after a 7-day wash-out period following 1, 15, or 30 days of deprenyl treatment in young rats and a 9-day wash-out period after a 10-week deprenyl treatment in old rats. |
1999-07-28 |
2023-08-12 |
rat |
| F I Tarazi, E C Tomasini, R J Baldessarin. Postnatal development of dopamine and serotonin transporters in rat caudate-putamen and nucleus accumbens septi. Neuroscience letters. vol 254. issue 1. 1999-06-07. PMID:9780082. |
density of dopamine transporter (dat) and serotonin transporter (5-htt) membrane proteins in the caudate-putamen (cpu) and nucleus accumbens (nac) of rat brain was assessed at seven ages at postnatal days (pd) 7-60, by in vitro quantitative autoradiography. |
1999-06-07 |
2023-08-12 |
rat |
| T Kuroki, H Y Meltzer, J Ichikaw. Effects of antipsychotic drugs on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 288. issue 2. 1999-02-22. PMID:9918588. |
the effects of the six antipsychotic drugs to increase extracellular da levels in the mpfc relative to those in the nac was positively correlated with the difference between their pki values for serotonin (5-hydroxytryptamine, 5-ht2a) and da-d2 receptors and was inversely correlated to their pki values for d2 or d3 receptors, but was not for 5-ht2a receptors alone. |
1999-02-22 |
2023-08-12 |
rat |
| C Heidbreder, J Feldo. Amphetamine-induced neurochemical and locomotor responses are expressed differentially across the anteroposterior axis of the core and shell subterritories of the nucleus accumbens. Synapse (New York, N.Y.). vol 29. issue 4. 1998-09-24. PMID:9661249. |
in the present study, we sought to investigate if (1) the direct infusion of d-amphetamine (amph) by reverse microdialysis into either the core or shell of the nac across its anteroposterior axis differentially affects dialysate da and 5-ht levels, and (2) these subterritories also subserve different behavioral functions. |
1998-09-24 |
2023-08-12 |
Not clear |
| C Heidbreder, J Feldo. Amphetamine-induced neurochemical and locomotor responses are expressed differentially across the anteroposterior axis of the core and shell subterritories of the nucleus accumbens. Synapse (New York, N.Y.). vol 29. issue 4. 1998-09-24. PMID:9661249. |
the highest dose of amph significantly increased dialysate 5-ht levels over baseline only in the caudal shell of the nac. |
1998-09-24 |
2023-08-12 |
Not clear |
| C Heidbreder, J Feldo. Amphetamine-induced neurochemical and locomotor responses are expressed differentially across the anteroposterior axis of the core and shell subterritories of the nucleus accumbens. Synapse (New York, N.Y.). vol 29. issue 4. 1998-09-24. PMID:9661249. |
the basal dialysate 5-ht levels did not significantly differ between the three subterritories of the nac. |
1998-09-24 |
2023-08-12 |
Not clear |
| D Wei, I M Maisonneuve, M E Kuehne, S D Glic. Acute iboga alkaloid effects on extracellular serotonin (5-HT) levels in nucleus accumbens and striatum in rats. Brain research. vol 800. issue 2. 1998-09-04. PMID:9685673. |
in vivo microdialysis and hplc (microbore) were used to determine acute changes in extracellular serotonin levels in nucleus accumbens (nac) and striatum (str) after both i.p. |
1998-09-04 |
2023-08-12 |
rat |
| D Wei, I M Maisonneuve, M E Kuehne, S D Glic. Acute iboga alkaloid effects on extracellular serotonin (5-HT) levels in nucleus accumbens and striatum in rats. Brain research. vol 800. issue 2. 1998-09-04. PMID:9685673. |
administration, ibogaine, noribogaine and 18-mc had very different effects on extracellular serotonin levels in both nac and str: ibogaine elicited large increases (up to 25-fold in nac and 10- fold in str), noribogaine produced moderate increases (up to 8-fold in nac and 5-fold in str), and 18-mc had no effect in either brain region. |
1998-09-04 |
2023-08-12 |
rat |
| D L Willins, H Y Meltze. Serotonin 5-HT2C agonists selectively inhibit morphine-induced dopamine efflux in the nucleus accumbens. Brain research. vol 781. issue 1-2. 1998-04-29. PMID:9507167. |
these results suggest that the activation of 5-ht2c receptors selectively inhibits morphine-induced da release in the nac in a manner which is independent of the inhibition of 5-ht neurons. |
1998-04-29 |
2023-08-12 |
rat |
| K Ikemoto, K Kitahama, T Maeda, K Sato. The distribution of noradrenaline, serotonin and gamma-aminobutyric acid in the monkey nucleus accumbens. Progress in neuro-psychopharmacology & biological psychiatry. vol 20. issue 8. 1997-06-05. PMID:9004346. |
in order to further investigate the neurochemical characteristics of the primate nac, the distribution of structures that contain noradrenaline (na), serotonin (5-ht) and gamma-aminobutyric acid (gaba) were examined in the macaque monkey by using transmitter-immunohistochemical methods. |
1997-06-05 |
2023-08-12 |
monkey |
| I Panocka, R Ciccocioppo, C Polidori, S Romagnoli, R Froldi, M Mass. Possible mechanism of action for the attenuation of ethanol intake induced by ritanserin in rats. Psychopharmacology. vol 128. issue 2. 1997-04-10. PMID:8956379. |
recent microdialysis studies have shown that acute subcutaneous (sc) administration of ritanserin increases extracellular 5-ht levels in the nac. |
1997-04-10 |
2023-08-12 |
rat |
| I Panocka, R Ciccocioppo, C Polidori, S Romagnoli, R Froldi, M Mass. Possible mechanism of action for the attenuation of ethanol intake induced by ritanserin in rats. Psychopharmacology. vol 128. issue 2. 1997-04-10. PMID:8956379. |
the present study evaluated, in genetically heterogeneous rats with developed preference for 3% ethanol, whether the attenuation of ethanol intake induced by ritanserin might be related to its effect on the synaptic availability of 5-ht in the nac. |
1997-04-10 |
2023-08-12 |
rat |
| I Panocka, R Ciccocioppo, C Polidori, S Romagnoli, R Froldi, M Mass. Possible mechanism of action for the attenuation of ethanol intake induced by ritanserin in rats. Psychopharmacology. vol 128. issue 2. 1997-04-10. PMID:8956379. |
the present findings, together with those of previous experiments showing that the tryptophan hydroxylase inhibitor p-chlorophenylalanine abolishes the effect of ritanserin, support the hypothesis that its effect on ethanol intake may be due to increased synaptic availability of 5-ht into the nac. |
1997-04-10 |
2023-08-12 |
rat |
| R N Clark, C R Ashby, S L Dewey, P V Ramachandran, R E Strecke. Effect of acute and chronic fluoxetine on extracellular dopamine levels in the caudate-putamen and nucleus accumbens of rat. Synapse (New York, N.Y.). vol 23. issue 3. 1997-03-24. PMID:8807740. |
recent studies indicate that an increase in serotonergic (5-ht) activity in the nucleus accumbens (nac) produces an increase in dopamine (da) release, providing a possible mechanism for the involvement of da in the therapeutic action of selective serotonin reuptake inhibitor (ssri) antidepressants. |
1997-03-24 |
2023-08-12 |
rat |