| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L F Callado, S E Hopwood, P J Hancock, J A Stamfor. Effects of dizocilpine (MK 801) on noradrenaline, serotonin and dopamine release and uptake. Neuroreport. vol 11. issue 1. 2000-03-16. PMID:10683852. |
in the present study, we examined the actions of the nmda antagonist dizocilpine (mk801) on electrically evoked release and uptake of noradrenaline (na) in the locus coeruleus (lc), serotonin (5-ht) in the dorsal raphe nucleus (drn) and dopamine (da) in the nucleus accumbens (nac), measured by fast cyclic voltammetry (fcv) in rat brain slices. |
2000-03-16 |
2023-08-12 |
rat |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
dopamine release in the nucleus accumbens (nac) has been implicated as mediating the rewarding effects of stimulant drugs; however, recent studies suggest that 5-ht release may also contribute. |
2000-03-09 |
2023-08-12 |
rat |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
in an effort to assess the role of 5-ht in drug-mediated reward, this study analyzed the serotonergic innervation of nac using immunocytochemistry for 5-ht and the 5-ht transporter (sert). |
2000-03-09 |
2023-08-12 |
rat |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
we report that in control rats the nac receives two distinct types of 5-ht axons that differ in regional distribution, morphology, and sert expression. |
2000-03-09 |
2023-08-12 |
rat |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
most regions of the nac are innervated by thin 5-ht axons that express sert, but in the caudal nac shell nearly all 5-ht axons lack sert and have large spherical varicosities. |
2000-03-09 |
2023-08-12 |
rat |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
two weeks after methamphetamine or p-chloroamphetamine (pca) treatment, most 5-ht axons in dorsal striatum and nac have degenerated; however, the varicose axons in the shell appear intact. |
2000-03-09 |
2023-08-12 |
rat |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
moreover, 4 hr after pca, the varicose axons in the caudal shell retain prominent stores of 5-ht, whereas 5-ht axons in the rest of the nac are depleted of neurotransmitter. |
2000-03-09 |
2023-08-12 |
rat |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
the results demonstrate that two functionally different 5-ht projections innervate separate regions of the nac and that selective vulnerability to amphetamines may result from differential expression of sert. |
2000-03-09 |
2023-08-12 |
rat |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
we postulate that action potentials conducted from the raphe nuclei can release 5-ht throughout the nac, whereas transporter-mediated release induced by stimulant drugs is more restricted and unlikely to occur in the caudal nac shell. |
2000-03-09 |
2023-08-12 |
rat |
| Q S Ya. Activation of 5-HT2A/2C receptors within the nucleus accumbens increases local dopaminergic transmission. Brain research bulletin. vol 51. issue 1. 2000-02-18. PMID:10654584. |
this study was designed to assess the involvement of the 5-hydroxytryptamine (5-ht)2a/2c receptor subtypes in the regulation of in vivo dopamine release in the rat nucleus accumbens (nac). |
2000-02-18 |
2023-08-12 |
rat |
| J Ichikawa, H Y Meltze. The effect of ipsapirone and S(-)-pindolol on dopamine release in rat striatum and nucleus accumbens. Brain research. vol 842. issue 2. 1999-12-21. PMID:10526141. |
however, studies of the role of 5-ht(1a) receptor agonism in the ability of these drugs to modulate dopamine (da) release in the nucleus accumbens (nac), which may be relevant to antipsychotic action, are lacking. |
1999-12-21 |
2023-08-12 |
rat |
| J Ichikawa, H Y Meltze. The effect of ipsapirone and S(-)-pindolol on dopamine release in rat striatum and nucleus accumbens. Brain research. vol 842. issue 2. 1999-12-21. PMID:10526141. |
thus, we examined the effect of clinically available agents, ipsapirone, a 5-ht(1a) receptor partial agonist, and the mixed 5-ht(1a/1b)/beta receptor antagonist s(-)-pindolol, on da release in the nac compared to the striatum (str). |
1999-12-21 |
2023-08-12 |
rat |
| J Ichikawa, H Y Meltze. The effect of ipsapirone and S(-)-pindolol on dopamine release in rat striatum and nucleus accumbens. Brain research. vol 842. issue 2. 1999-12-21. PMID:10526141. |
these results suggest that the ability of lower dose of ipsapirone to decrease da release in the nac is more likely to be due to 5-ht(1a) receptor agonism. |
1999-12-21 |
2023-08-12 |
rat |
| J Ichikawa, H Y Meltze. R(+)-8-OH-DPAT, a serotonin(1A) receptor agonist, potentiated S(-)-sulpiride-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens but not striatum. The Journal of pharmacology and experimental therapeutics. vol 291. issue 3. 1999-12-20. PMID:10565846. |
the serotonin (5-ht)(2a/2c) receptor antagonist ritanserin has been reported to potentiate the dopamine (da) d(2/3) receptor antagonist raclopride-induced da release in medial prefrontal cortex (mpfc) and nucleus accumbens (nac) but not striatum (str). |
1999-12-20 |
2023-08-12 |
rat |
| J Ichikawa, H Y Meltze. R(+)-8-OH-DPAT, a serotonin(1A) receptor agonist, potentiated S(-)-sulpiride-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens but not striatum. The Journal of pharmacology and experimental therapeutics. vol 291. issue 3. 1999-12-20. PMID:10565846. |
these results suggest that 5-ht(1a) receptor agonism facilitates da release in mpfc and nac but not str in combination with d(2) receptor antagonism. |
1999-12-20 |
2023-08-12 |
rat |
| Q S Ya. Extracellular dopamine and serotonin after ethanol monitored with 5-minute microdialysis. Alcohol (Fayetteville, N.Y.). vol 19. issue 1. 1999-11-02. PMID:10487381. |
ethanol at the doses of 0.5, 1, and 2 g/kg was administered ip and extracellular da and 5-ht in 5-min dialysates from the nucleus accumbens (nac) of freely moving rats were determined. |
1999-11-02 |
2023-08-12 |
rat |
| Q S Ya. Extracellular dopamine and serotonin after ethanol monitored with 5-minute microdialysis. Alcohol (Fayetteville, N.Y.). vol 19. issue 1. 1999-11-02. PMID:10487381. |
based on previous reports showing that brain or blood ethanol levels peaked within 10-20 min after administration, the results indicate that peak increases in extracellular da and 5-ht in the nac occurred at approximately the same time, with the da time course more temporally correlated with the blood or brain alcohol concentration curve reported in the literature. |
1999-11-02 |
2023-08-12 |
rat |
| L R McMahon, K A Cunningha. Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell. The Journal of pharmacology and experimental therapeutics. vol 291. issue 1. 1999-10-12. PMID:10490917. |
to test the hypothesis that cocaine-elicited behaviors were modulated by 5-ht(4) receptors in the nucleus accumbens (nac) shell, two separate groups of male rats were implanted with bilateral cannulas aimed at the nac shell. |
1999-10-12 |
2023-08-12 |
rat |
| L R McMahon, K A Cunningha. Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell. The Journal of pharmacology and experimental therapeutics. vol 291. issue 1. 1999-10-12. PMID:10490917. |
these results support an involvement of 5-ht(4) receptors, particularly those in the nac shell, in the locomotor stimulatory effects of cocaine. |
1999-10-12 |
2023-08-12 |
rat |
| S L Lee, W W Wang, G A Finlay, B L Fanbur. Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion. The American journal of physiology. vol 277. issue 2. 1999-09-23. PMID:10444522. |
we presently show that 1 microm 5-ht also rapidly elevates phosphorylation and activation of the mitogen-activated protein (map) kinases extracellular signal-regulated kinase (erk) 1 and erk2 of smcs, and the enhanced phosphorylation is blocked by the antioxidants tiron, n-acetyl-l-cysteine (nac), and ginkgo biloba extract. |
1999-09-23 |
2023-08-12 |
cattle |