| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C P Müller, R J Carey, J B Salloum, J P Husto. Serotonin1A-receptor agonism attenuates the cocaine-induced increase in serotonin levels in the hippocampus and nucleus accumbens but potentiates hyperlocomotion: an in vivo microdialysis study. Neuropharmacology. vol 44. issue 5. 2003-06-23. PMID:12668045. |
in order to further investigate the relationship between extracellular 5-ht concentration and cocaine-induced behaviour, we used in vivo microdialysis to measure the effects of the 5-ht(1a)-receptor agonist 8-oh-dpat on cocaine-induced changes in the extracellular 5-ht concentration in the hippocampus and the nac and on behavioural activity. |
2003-06-23 |
2023-08-12 |
rat |
| C P Müller, R J Carey, J B Salloum, J P Husto. Serotonin1A-receptor agonism attenuates the cocaine-induced increase in serotonin levels in the hippocampus and nucleus accumbens but potentiates hyperlocomotion: an in vivo microdialysis study. Neuropharmacology. vol 44. issue 5. 2003-06-23. PMID:12668045. |
we found that the 5-ht(1a)-receptor agonist 8-oh-dpat attenuated the cocaine-induced increases in 5-ht in the hippocampus and the nac, but potentiated cocaine-induced hyperlocomotion. |
2003-06-23 |
2023-08-12 |
rat |
| C P Müller, R J Carey, J B Salloum, J P Husto. Serotonin1A-receptor agonism attenuates the cocaine-induced increase in serotonin levels in the hippocampus and nucleus accumbens but potentiates hyperlocomotion: an in vivo microdialysis study. Neuropharmacology. vol 44. issue 5. 2003-06-23. PMID:12668045. |
altogether, these observations support an important role of the 5-ht(1a)-receptor in the hippocampus and nac in the modulation of cocaine stimulant effects. |
2003-06-23 |
2023-08-12 |
rat |
| M J Bubar, L R McMahon, P De Deurwaerdère, U Spampinato, K A Cunningha. Selective serotonin reuptake inhibitors enhance cocaine-induced locomotor activity and dopamine release in the nucleus accumbens. Neuropharmacology. vol 44. issue 3. 2003-05-02. PMID:12604093. |
in the present study, the ability of the selective serotonin reuptake inhibitors (ssris) fluoxetine (10 mg/kg, ip) and fluvoxamine (10 and 20 mg/kg, ip) to alter cocaine (10 mg/kg, ip)-induced hyperactivity and da release in the nucleus accumbens (nac) was analyzed in male sprague-dawley rats. |
2003-05-02 |
2023-08-12 |
rat |
| Timothy E Koeltzow, Jennifer D Austin, Paul Vezin. Behavioral sensitization to quinpirole is not associated with increased nucleus accumbens dopamine overflow. Neuropharmacology. vol 44. issue 1. 2003-04-30. PMID:12559127. |
in addition, although acute quinpirole did not affect nac levels of the serotonin metabolite 5-hydroxyindolacetic acid (5-hiaa), quinpirole challenge produced a significant increase in 5-hiaa levels following repeated treatment. |
2003-04-30 |
2023-08-12 |
Not clear |
| Katherine A Helm, Pedro Rada, Bartley G Hoebe. Cholecystokinin combined with serotonin in the hypothalamus limits accumbens dopamine release while increasing acetylcholine: a possible satiation mechanism. Brain research. vol 963. issue 1-2. 2003-04-28. PMID:12560135. |
if so, 5-ht and/or cck in the pvn should lower extracellular da or release ach in the nac. |
2003-04-28 |
2023-08-12 |
rat |
| Junji Ichikawa, Zhu Li, Jin Dai, Herbert Y Meltze. Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism. Brain research. vol 956. issue 2. 2003-04-22. PMID:12445705. |
these results indicate that quetiapine, iloperidone and melperone preferentially increase da release in the mpfc, compared to the nac via a 5-ht(1a)-related mechanism. |
2003-04-22 |
2023-08-12 |
rat |
| M D S Lapiz, A Fulford, S Muchimapura, R Mason, T Parker, C A Marsde. Influence of postweaning social isolation in the rat on brain development, conditioned behavior, and neurotransmission. Neuroscience and behavioral physiology. vol 33. issue 1. 2003-04-14. PMID:12617300. |
isolation-reared rats have enhanced presynaptic dopamine (da) and 5-ht function in the nucleus accumbens (nac) associated with decreased presynaptic 5-ht function in the frontal cortex and hippocampus. |
2003-04-14 |
2023-08-12 |
human |
| Christian P Müller, Maria A De Souza Silva, Gail DePalma, Carlos Tomaz, Robert J Carey, Joseph P Husto. The selective serotonin(1A)-receptor antagonist WAY 100635 blocks behavioral stimulating effects of cocaine but not ventral striatal dopamine increase. Behavioural brain research. vol 134. issue 1-2. 2002-11-19. PMID:12191821. |
these results indicate that (1) the 5-ht(1a)-receptor is an important component in the mediation of cocaine locomotor stimulant effects, and (2) an increase in the extracellular da concentration in the nac might be a necessary but is not a sufficient condition for the locomotor stimulant effects of cocaine. |
2002-11-19 |
2023-08-12 |
rat |
| Stefania Bonaccorso, Herbert Y Meltzer, Zhu Li, Jin Dai, Anna R Alboszta, Junji Ichikaw. SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 3. 2002-11-15. PMID:12225700. |
the present study demonstrated that another putative apd and 5-ht(2a/2c) antagonist, sr46349-b (10 mg/kg, but not 1-3 mg/kg) alone, but not m100907 (0.1 and 3 mg/kg) alone, increased mpfc da release, whereas neither drug alone affected nucleus accumbens (nac) da release. |
2002-11-15 |
2023-08-12 |
rat |
| Stefania Bonaccorso, Herbert Y Meltzer, Zhu Li, Jin Dai, Anna R Alboszta, Junji Ichikaw. SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 3. 2002-11-15. PMID:12225700. |
way100635 (0.2 mg/kg), a 5-ht(1a) antagonist, abolished the effects of haloperidol plus m100907 as well as sr46349-b on da release in the mpfc, but did not do so in the nac. |
2002-11-15 |
2023-08-12 |
rat |
| Stefania Bonaccorso, Herbert Y Meltzer, Zhu Li, Jin Dai, Anna R Alboszta, Junji Ichikaw. SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 3. 2002-11-15. PMID:12225700. |
thus, 5-ht(2a) and 5-ht(2a/2c) antagonism together with haloperidol-induced d(2) antagonism may potentiate mpfc da release via 5-ht(1a) agonism, whereas the combined effects of these agents on nac da release is not dependent upon 5-ht(1a) receptor stimulation. |
2002-11-15 |
2023-08-12 |
rat |
| Stefania Bonaccorso, Herbert Y Meltzer, Zhu Li, Jin Dai, Anna R Alboszta, Junji Ichikaw. SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 3. 2002-11-15. PMID:12225700. |
interestingly, similar to the effect of sr46349-b, high dose m100907 (3 mg/kg), which might have antagonist activity at 5-ht(2c) receptors, potentiated 1 mg/kg haloperidol-induced da release in the mpfc and nac. |
2002-11-15 |
2023-08-12 |
rat |
| Takuya Watanabe, Rajbabu Pakala, Takashi Katagiri, Claude R Benedic. Antioxidant N-acetylcysteine inhibits vasoactive agents-potentiated mitogenic effect of mildly oxidized LDL on vascular smooth muscle cells. Hypertension research : official journal of the Japanese Society of Hypertension. vol 25. issue 2. 2002-11-13. PMID:12047048. |
growth-arrested vsmcs were incubated with different concentrations of native ldl, mox-ldl, or highly oxidized ldl (ox-ldl) with 5-ht, ang-ii, et-1, or u-ii in the absence or presence of n-acetylcysteine (nac), an intracellular free radical scavenger. |
2002-11-13 |
2023-08-12 |
Not clear |
| Takuya Watanabe, Rajbabu Pakala, Takashi Katagiri, Claude R Benedic. Antioxidant N-acetylcysteine inhibits vasoactive agents-potentiated mitogenic effect of mildly oxidized LDL on vascular smooth muscle cells. Hypertension research : official journal of the Japanese Society of Hypertension. vol 25. issue 2. 2002-11-13. PMID:12047048. |
synergistic interactions of mox-ldl with 5-ht, ang-ii, et-1, or u-ii were significantly inhibited by nac (400 micromol/l). |
2002-11-13 |
2023-08-12 |
Not clear |
| Jean-François Liégeois, Junji Ichikawa, Herbert Y Meltze. 5-HT(2A) receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner. Brain research. vol 947. issue 2. 2002-10-30. PMID:12176156. |
we provide additional support for this hypothesis by examining the effect of the selective 5-ht(2a) antagonist m100907 plus haloperidol, a potent d(2) antagonist apd, on da release in the mpfc and nucleus accumbens (nac). |
2002-10-30 |
2023-08-12 |
rat |
| Jean-François Liégeois, Junji Ichikawa, Herbert Y Meltze. 5-HT(2A) receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner. Brain research. vol 947. issue 2. 2002-10-30. PMID:12176156. |
these results suggest that the relatively higher ratio of 5-ht(2a) to d(2) antagonism may contribute to the potentiation of haloperidol-induced mpfc da release, whereas 5-ht(2a) antagonism can diminish haloperidol-induced nac da release, even when combined with extensive d(2) antagonism, which may not be synergistic with 5-ht(2a) antagonism in the mpfc. |
2002-10-30 |
2023-08-12 |
rat |
| Malgorzata Filip, Kathryn A Cunningha. Serotonin 5-HT(2C) receptors in nucleus accumbens regulate expression of the hyperlocomotive and discriminative stimulus effects of cocaine. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888566. |
the serotonin 5-ht(2c) receptor (5-ht(2c)r) is abundant in the nucleus accumbens (nac) shell and is considered an important target for 5-ht to modulate the dopamine (da) mesoaccumbens circuit, which plays a prominent role in the behavioral effects of cocaine. |
2002-09-11 |
2023-08-12 |
rat |
| Malgorzata Filip, Kathryn A Cunningha. Serotonin 5-HT(2C) receptors in nucleus accumbens regulate expression of the hyperlocomotive and discriminative stimulus effects of cocaine. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888566. |
these data reinforce the hypothesis that 5-ht(2c)r plays a role in the regulatory neurochemistry of the nac shell that is important to the full expression of the behaviors evoked by cocaine. |
2002-09-11 |
2023-08-12 |
rat |
| Christian P Müller, Robert J Carey, Maria A De Souza Silva, Gerhard Jocham, Joseph P Husto. Cocaine increases serotonergic activity in the hippocampus and nucleus accumbens in vivo: 5-HT1a-receptor antagonism blocks behavioral but potentiates serotonergic activation. Synapse (New York, N.Y.). vol 45. issue 2. 2002-08-08. PMID:12112399. |
neuronal activity in the hippocampus and the nucleus accumbens (nac) depend on serotonergic (5-ht) transmission. |
2002-08-08 |
2023-08-12 |
rat |