| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christian Pifl, Maya Khorchide, Alexandra Kattinger, Harald Reither, John Hardy, Oleh Hornykiewic. alpha-Synuclein selectively increases manganese-induced viability loss in SK-N-MC neuroblastoma cells expressing the human dopamine transporter. Neuroscience letters. vol 354. issue 1. 2004-02-26. PMID:14698476. |
there was no difference between cells expressing alpha-synuclein and control cells after exposure to dopamine, mpp(+) or fecl(2). |
2004-02-26 |
2023-08-12 |
human |
| Jaturaporn Chagkutip, Roxanne A Vaughan, Piyarat Govitrapong, Manuchair Ebad. 1-Methyl-4-phenylpyridinium-induced down-regulation of dopamine transporter function correlates with a reduction in dopamine transporter cell surface expression. Biochemical and biophysical research communications. vol 311. issue 1. 2004-01-21. PMID:14575693. |
we have shown that dopamine transporter (dat) is required for mpp(+)-mediated cytotoxicity in hek-293 cells stably transfected with human dat. |
2004-01-21 |
2023-08-12 |
human |
| Jaturaporn Chagkutip, Roxanne A Vaughan, Piyarat Govitrapong, Manuchair Ebad. 1-Methyl-4-phenylpyridinium-induced down-regulation of dopamine transporter function correlates with a reduction in dopamine transporter cell surface expression. Biochemical and biophysical research communications. vol 311. issue 1. 2004-01-21. PMID:14575693. |
furthermore, mpp(+) produced a concentration- and time-dependent reduction in the uptake of [3h]dopamine. |
2004-01-21 |
2023-08-12 |
human |
| Dhanasekharan Muralikrishnan, Supriti Samantaray, Kochupurackal P Mohanakuma. D-deprenyl protects nigrostriatal neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity. Synapse (New York, N.Y.). vol 50. issue 1. 2003-12-12. PMID:12872288. |
to achieve this goal we studied the effects of d-deprenyl on: (1).oh production in a fenton reaction; (2) mptp-induced.oh generation and dopamine (da) depletion in vivo, employing a sensitive hplc-electrochemical procedure; and (3) formation of mpp(+) in vivo in the striatum following systemic administration of mptp, employing an hplc-photodiode array detection system. |
2003-12-12 |
2023-08-12 |
mouse |
| Dhanasekharan Muralikrishnan, Supriti Samantaray, Kochupurackal P Mohanakuma. D-deprenyl protects nigrostriatal neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity. Synapse (New York, N.Y.). vol 50. issue 1. 2003-12-12. PMID:12872288. |
the potency of d-deprenyl to scavenge mptp-induced.oh in vivo and to render protection against the dopaminergic neurotoxicity without affecting dopamine turnover, mao-b activity, or formation of mpp(+) in the brain indicates a direct involvement of.oh in the neurotoxic action of mptp and antioxidant effect in the neuroprotective action of deprenyl. |
2003-12-12 |
2023-08-12 |
mouse |
| C J van der Schyf, K Castagnoli, S Palmer, L Hazelwood, N Castagnol. Melatonin fails to protect against long-term MPTP-induced dopamine depletion in mouse striatum. Neurotoxicity research. vol 1. issue 4. 2003-11-12. PMID:12835094. |
mptp is bioactivated by brain monoamine oxidase b (mao-b) to its neurotoxic pyridinium metabolite 1-methyl-4-phenylpyridinium (mpp(+)) which destroys dopaminergic nerve terminals leading to the depletion of neostriatal dopamine (da) and 3,4-dihydroxyphenylacetic acid (dopac). |
2003-11-12 |
2023-08-12 |
mouse |
| Shaik Shavali, Manuchair Ebad. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), an endogenous neurotoxin, induces dopaminergic cell death through apoptosis. Neurotoxicology. vol 24. issue 3. 2003-09-02. PMID:12782106. |
similar to mpp(+), 1bntiq significantly decreased [3h]dopamine uptake. |
2003-09-02 |
2023-08-12 |
human |
| Supriti Samantaray, Kochupurackal P Mohanakuma. Calcium channel agonist, (+/-)-Bay K8644, causes an immediate increase in the striatal 1-methyl-4-phenylpyridinium level following systemic administration of the dopaminergic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, in Balb/c mice. Neuroscience letters. vol 346. issue 1-2. 2003-09-02. PMID:12850550. |
we used hplc-photodiode array detection, hplc-electrochemical detection and spectrofluorimetric procedures to measure striatal mpp(+) and dopamine (da) and for the assay of monoamine oxidase-b (mao-b) activity, respectively. |
2003-09-02 |
2023-08-12 |
mouse |
| Carlos Fonck, Michel Baudr. Rapid reduction of ATP synthesis and lack of free radical formation by MPP+ in rat brain synaptosomes and mitochondria. Brain research. vol 975. issue 1-2. 2003-07-28. PMID:12763610. |
mptp is metabolized in the brain to mpp(+), which is taken up into dopaminergic neurons via the dopamine transporter and assumed to impair mitochondrial function. |
2003-07-28 |
2023-08-12 |
rat |
| Carlos Fonck, Michel Baudr. Rapid reduction of ATP synthesis and lack of free radical formation by MPP+ in rat brain synaptosomes and mitochondria. Brain research. vol 975. issue 1-2. 2003-07-28. PMID:12763610. |
fccp, mpp(+) and rotenone caused a rapid but stable decrease in [3h]dopamine (da) uptake by striatal synaptosomes. |
2003-07-28 |
2023-08-12 |
rat |
| Chung Soo Lee, Eun Hyang Song, Se Young Park, Eun Sook Ha. Combined effect of dopamine and MPP+ on membrane permeability in mitochondria and cell viability in PC12 cells. Neurochemistry international. vol 43. issue 2. 2003-06-13. PMID:12620283. |
the present study examined the combined effect of dopamine and 1-methyl-4-phenylpyridinium (mpp(+)) on the membrane permeability in isolated brain mitochondria and on cell viability in pc12 cells. |
2003-06-13 |
2023-08-12 |
Not clear |
| Chung Soo Lee, Eun Hyang Song, Se Young Park, Eun Sook Ha. Combined effect of dopamine and MPP+ on membrane permeability in mitochondria and cell viability in PC12 cells. Neurochemistry international. vol 43. issue 2. 2003-06-13. PMID:12620283. |
mpp(+) increased effect of dopamine against the swelling, membrane potential, and ca(2+) transport in isolated mitochondria, which was not inhibited by the addition of antioxidant enzymes (sod and catalase). |
2003-06-13 |
2023-08-12 |
Not clear |
| Chung Soo Lee, Eun Hyang Song, Se Young Park, Eun Sook Ha. Combined effect of dopamine and MPP+ on membrane permeability in mitochondria and cell viability in PC12 cells. Neurochemistry international. vol 43. issue 2. 2003-06-13. PMID:12620283. |
dopamine or mpp(+) caused the decrease in transmembrane potential, increase in reactive oxygen species, depletion of gsh, and cell death in pc12 cells. |
2003-06-13 |
2023-08-12 |
Not clear |
| Chung Soo Lee, Eun Hyang Song, Se Young Park, Eun Sook Ha. Combined effect of dopamine and MPP+ on membrane permeability in mitochondria and cell viability in PC12 cells. Neurochemistry international. vol 43. issue 2. 2003-06-13. PMID:12620283. |
antioxidant enzymes reduced each effect of dopamine and mpp(+) against pc12 cells. |
2003-06-13 |
2023-08-12 |
Not clear |
| Chung Soo Lee, Eun Hyang Song, Se Young Park, Eun Sook Ha. Combined effect of dopamine and MPP+ on membrane permeability in mitochondria and cell viability in PC12 cells. Neurochemistry international. vol 43. issue 2. 2003-06-13. PMID:12620283. |
co-addition of dopamine and mpp(+) caused the decrease in the transmembrane potential and increase in the formation of reactive oxygen species in pc12 cells, in which they showed an additive effect. |
2003-06-13 |
2023-08-12 |
Not clear |
| Chung Soo Lee, Eun Hyang Song, Se Young Park, Eun Sook Ha. Combined effect of dopamine and MPP+ on membrane permeability in mitochondria and cell viability in PC12 cells. Neurochemistry international. vol 43. issue 2. 2003-06-13. PMID:12620283. |
dopamine plus mpp(+)-induced the depletion of gsh and cell death in pc12 cells were not decreased by the addition of antioxidant enzymes, rutin, diethylstilbestrol, and ascorbate. |
2003-06-13 |
2023-08-12 |
Not clear |
| Chung Soo Lee, Eun Hyang Song, Se Young Park, Eun Sook Ha. Combined effect of dopamine and MPP+ on membrane permeability in mitochondria and cell viability in PC12 cells. Neurochemistry international. vol 43. issue 2. 2003-06-13. PMID:12620283. |
the n-acetylcysteine, n-phenylthiourea, and 5-hydroxyindole decreased the cell death and the formation of dopamine quinone and melanin induced by co-addition of dopamine and mpp(+), whereas deprenyl and chlorgyline did not show an inhibitory effect. |
2003-06-13 |
2023-08-12 |
Not clear |
| Chung Soo Lee, Eun Hyang Song, Se Young Park, Eun Sook Ha. Combined effect of dopamine and MPP+ on membrane permeability in mitochondria and cell viability in PC12 cells. Neurochemistry international. vol 43. issue 2. 2003-06-13. PMID:12620283. |
the results suggest that co-addition of dopamine and mpp(+) shows an enhancing effect on the change in mitochondrial membrane permeability and cell death, which may be accomplished by toxic quinone and melanin derived from the mpp(+)-stimulated dopamine oxidation. |
2003-06-13 |
2023-08-12 |
Not clear |
| Krishnamurthy Sairam, Karuppagounder S Saravanan, Rebecca Banerjee, Kochupurackal P Mohanakuma. Non-steroidal anti-inflammatory drug sodium salicylate, but not diclofenac or celecoxib, protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats. Brain research. vol 966. issue 2. 2003-04-29. PMID:12618347. |
we evaluated the hydroxyl radical (*oh) scavenging action of nonsteroidal anti-inflammatory drugs (nsaids), sodium salicylate (sa), diclofenac and celecoxib in fenton's reaction and their neuroprotective effects in 1-methyl-4-phenylpyridinium (mpp(+))-induced striatal dopamine (da) depletion in rats. |
2003-04-29 |
2023-08-12 |
rat |
| Sylvie Gélinas, Maria-Grazia Martinol. Neuroprotective effect of estradiol and phytoestrogens on MPP+-induced cytotoxicity in neuronal PC12 cells. Journal of neuroscience research. vol 70. issue 1. 2002-11-22. PMID:12237867. |
by western blot, we demonstrated that administration of mpp(+) alone decrease dopamine transporter expression, while treatments with mpp(+) together with 17alpha-estradiol, 17beta-estradiol, quercetin, or resveratrol could restore dopamine transporter protein expression to control levels. |
2002-11-22 |
2023-08-12 |
Not clear |