| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R G Staal, P K Sonsall. Inhibition of brain vesicular monoamine transporter (VMAT2) enhances 1-methyl-4-phenylpyridinium neurotoxicity in vivo in rat striata. The Journal of pharmacology and experimental therapeutics. vol 293. issue 2. 2000-06-21. PMID:10773000. |
dopamine neurons from various animal species differ in sensitivity to the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) or 1-methyl-4-phenylpyridinium (mpp(+)). |
2000-06-21 |
2023-08-12 |
mouse |
| N Yoshinaga, T Murayama, Y Nomur. Apoptosis induction by a dopaminergic neurotoxin, 1-methyl-4-phenylpyridinium ion (MPP(+)), and inhibition by epidermal growth factor in GH3 cells. Biochemical pharmacology. vol 60. issue 1. 2000-06-16. PMID:10807952. |
previously we reported that mpp(+) is incorporated via the dopamine transport system and causes delayed cell death in gh3 cells, a clonal strain from the rat anterior pituitary. |
2000-06-16 |
2023-08-12 |
rat |
| D Frechilla, R Insausti, P Ruiz-Golvano, A García-Osta, M P Rubio, J M Almendral, J Del Rí. Implanted BDNF-producing fibroblasts prevent neurotoxin-induced serotonergic denervation in the rat striatum. Brain research. Molecular brain research. vol 76. issue 2. 2000-06-05. PMID:10762706. |
bdnf-producing cells prevented the striatal 5-ht loss induced by local administration of either 5,7-dht or mpp(+), as well as the striatal dopamine (da) loss induced by the latter neurotoxin. |
2000-06-05 |
2023-08-12 |
human |
| S H Lee, M Y Chang, K H Lee, B S Park, Y S Lee, H R Chin, Y S Le. Importance of valine at position 152 for the substrate transport and 2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane binding of dopamine transporter. Molecular pharmacology. vol 57. issue 5. 2000-05-25. PMID:10779370. |
human and bovine dopamine transporters (dat) demonstrate discrete functional differences in dopamine (da), 1-methyl-4-phenylpyridium (mpp(+)) transport, and cocaine analog binding. |
2000-05-25 |
2023-08-12 |
human |
| J Boada, B Cutillas, T Roig, J Bermúdez, S Ambrosi. MPP(+)-induced mitochondrial dysfunction is potentiated by dopamine. Biochemical and biophysical research communications. vol 268. issue 3. 2000-03-22. PMID:10679305. |
mpp(+)-induced mitochondrial dysfunction is potentiated by dopamine. |
2000-03-22 |
2023-08-12 |
rat |
| J Boada, B Cutillas, T Roig, J Bermúdez, S Ambrosi. MPP(+)-induced mitochondrial dysfunction is potentiated by dopamine. Biochemical and biophysical research communications. vol 268. issue 3. 2000-03-22. PMID:10679305. |
mpp(+), the major metabolite of the parkinsonism-inducing compound mptp, responsible for the destruction of the nigrostriatal pathway in primates and rodents, has been assayed in isolated rat liver mitochondria in the presence of physiological concentrations of dopamine or analogous concentrations of melanin-dopamine. |
2000-03-22 |
2023-08-12 |
rat |
| J Boada, B Cutillas, T Roig, J Bermúdez, S Ambrosi. MPP(+)-induced mitochondrial dysfunction is potentiated by dopamine. Biochemical and biophysical research communications. vol 268. issue 3. 2000-03-22. PMID:10679305. |
5 microm mpp(+) in the presence of 70 microm dopamine or melanin-dopamine, but not alone, decreased the heat production and oxygen consumption of a mitochondrial suspension activated with succinate and adp. |
2000-03-22 |
2023-08-12 |
rat |
| J Boada, B Cutillas, T Roig, J Bermúdez, S Ambrosi. MPP(+)-induced mitochondrial dysfunction is potentiated by dopamine. Biochemical and biophysical research communications. vol 268. issue 3. 2000-03-22. PMID:10679305. |
both dopamine and oxidized dopamine plus mpp(+) also decreased the mitochondrial reductive power measured with mtt. |
2000-03-22 |
2023-08-12 |
rat |
| J Boada, B Cutillas, T Roig, J Bermúdez, S Ambrosi. MPP(+)-induced mitochondrial dysfunction is potentiated by dopamine. Biochemical and biophysical research communications. vol 268. issue 3. 2000-03-22. PMID:10679305. |
mitochondrial swelling was observed, associated with an increase in membrane mitochondrial potential, as a synergistic effect between low concentrations of mpp(+) and dopamine. |
2000-03-22 |
2023-08-12 |
rat |
| J Boada, B Cutillas, T Roig, J Bermúdez, S Ambrosi. MPP(+)-induced mitochondrial dysfunction is potentiated by dopamine. Biochemical and biophysical research communications. vol 268. issue 3. 2000-03-22. PMID:10679305. |
it is suggested that cytosolic dopamine, by itself or via its autooxidation products, may play a relevant role in the mitochondrial toxicity of mpp(+). |
2000-03-22 |
2023-08-12 |
rat |
| D E Schmidt, M H Ebert, J C Lynn, W O Whetsel. Attenuation of 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity by deprenyl in organotypic canine substantia nigra cultures. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 8-9. 1998-02-26. PMID:9451719. |
this study was undertaken to evaluate the neuroprotective effects of deprenyl in mpp(+)-treated cultures by measuring changes in the levels of hva as an indicator of dopamine release and metabolism by dopaminergic neurons and to correlate this indication of dopaminergic function with morphological evidence of survival or loss of dopaminergic neurons in mature csn cultures. |
1998-02-26 |
2023-08-12 |
Not clear |
| D E Schmidt, M H Ebert, J C Lynn, W O Whetsel. Attenuation of 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity by deprenyl in organotypic canine substantia nigra cultures. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 8-9. 1998-02-26. PMID:9451719. |
thus the neuroprotective effects of deprenyl on mpp(+)-induced reduction of hva levels in living cultures appears similar to the effects of deprenyl on dopamine levels and tyrosine hydroxylase activity reported by others in cultures previously exposed to deprenyl and mpp+. |
1998-02-26 |
2023-08-12 |
Not clear |
| D G Hom, D Jiang, E J Hong, J Q Mo, J K Anderse. Elevated expression of glutathione peroxidase in PC12 cells results in protection against methamphetamine but not MPTP toxicity. Brain research. Molecular brain research. vol 46. issue 1-2. 1997-08-05. PMID:9191089. |
hydrogen peroxide has also been reported to be produced via inhibition of nadh dehydrogenase by mpp + formed during oxidation of mptp by mao-b and by dopamine auto-oxidation following ma-induced dopamine release from synaptic vesicles within nerve terminals. |
1997-08-05 |
2023-08-12 |
mouse |
| K Matsubara, T Idzu, Y Kobayashi, T Gonda, H Okunishi, K Kimur. Differences in dopamine efflux induced by MPP+ and beta-carbolinium in the striatum of conscious rats. European journal of pharmacology. vol 315. issue 2. 1997-04-03. PMID:8960877. |
cocaine, 3 microm, intensified the 2,9-me2 nh(+)-induced increase in extracellular dopamine and slightly attenuated the mpp(+)-induced efflux. |
1997-04-03 |
2023-08-12 |
rat |
| D Boismenu, O Mamer, L Ste-Marie, L Vachon, J Montgomer. In vivo hydroxylation of the neurotoxin, 1-methyl-4-phenylpyridinium, and the effect of monoamine oxidase inhibitors: electrospray-MS analysis of intra-striatal microdialysates. Journal of mass spectrometry : JMS. vol 31. issue 10. 1996-12-30. PMID:8916419. |
the production of hydroxyl radicals correlates with the mpp(+)-driven dopamine release which presumably leads to increased metabolism via monoamine oxidase or increased dopamine autoxidation. |
1996-12-30 |
2023-08-12 |
rat |
| R M Wu, D L Murphy, C C Chiue. Neuronal protective and rescue effects of deprenyl against MPP+ dopaminergic toxicity. Journal of neural transmission. General section. vol 100. issue 1. 1996-09-26. PMID:8748663. |
coadministration of deprenyl (4.2 nmol) with mpp+ into the substantia nigra protected against mpp(+)-induced moderate (20-50%) but not severe (over 70%) nigral injury as reflected in striatal dopamine reductions. |
1996-09-26 |
2023-08-12 |
Not clear |
| b' S O Bachurin, N V Lukoianov, L N Petrova, L S Soliakov, S E Tkachenko, O A Raevski\\xc4\\xa. [Inhibition of the dopamine reuptake system by analogs of the neurotoxic metabolite MPP (1-methyl-4-phenylpyridine). The structure-activity relationship]. Doklady Akademii nauk. vol 346. issue 4. 1996-07-16. PMID:8640134.' |
[inhibition of the dopamine reuptake system by analogs of the neurotoxic metabolite mpp (1-methyl-4-phenylpyridine). |
1996-07-16 |
2023-08-12 |
Not clear |
| T S Smith, R H Swerdlow, W D Parker, J P Bennet. Reduction of MPP(+)-induced hydroxyl radical formation and nigrostriatal MPTP toxicity by inhibiting nitric oxide synthase. Neuroreport. vol 5. issue 18. 1995-05-04. PMID:7535121. |
inhibition of nitric oxide synthase reduced mpp(+)-induced hydroxyl radical formation in striatum and mptp toxicity to nigrostriatal dopamine terminals, but did not interfere with inhibition of complex-i activity. |
1995-05-04 |
2023-08-12 |
Not clear |
| A Boireau, J M Miquet, P Dubédat, M Meunier, A Dobl. Riluzole and experimental parkinsonism: partial antagonism of MPP(+)-induced increase in striatal extracellular dopamine in rats in vivo. Neuroreport. vol 5. issue 16. 1995-03-30. PMID:7865766. |
riluzole and experimental parkinsonism: partial antagonism of mpp(+)-induced increase in striatal extracellular dopamine in rats in vivo. |
1995-03-30 |
2023-08-12 |
rat |
| K Sriram, K S Pai, V Ravindranat. Protection and potentiation of 1-methyl-4-phenylpyridinium-induced toxicity by cytochrome P450 inhibitors and inducer may be due to the altered uptake of the toxin. Journal of neurochemistry. vol 64. issue 3. 1995-03-17. PMID:7861152. |
mpp(+)-induced toxicity was abolished by pretreatment of the slices with inhibitors of monoamine oxidase (mao; pargyline and deprenyl) or inhibitors of p450 (piperonyl butoxide or skf-525a) or dopamine uptake blocker (gbr-12909), as measured by the activity of nadh-dh in slices and leakage of lactate dehydrogenase from the slice into the medium. |
1995-03-17 |
2023-08-12 |
mouse |