| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Obat. Dopamine efflux by MPTP and hydroxyl radical generation. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 9. 2002-11-06. PMID:12203043. |
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) produces a parkinsonian syndrome after its conversion to 1-methyl-4-phenylpyridine (mpp(+)) by b-form monoamine oxidase (mao) in the brain, which is one of the most potent dopamine (da)-releasing agents. |
2002-11-06 |
2023-08-12 |
Not clear |
| Filip A Paczkowski, Heinz Bönisch, Lesley J Bryan-Lluk. Pharmacological properties of the naturally occurring Ala(457)Pro variant of the human norepinephrine transporter. Pharmacogenetics. vol 12. issue 2. 2002-08-20. PMID:11875370. |
the ala(457)pro variant showed a six- to 10-fold decrease in affinity for the substrates dopamine and 1-methyl-4-phenylpyridinium (mpp(+)). |
2002-08-20 |
2023-08-12 |
human |
| M B O'Byrne, K F Tipto. Inhibition of the neuronal isoform of nitric oxide synthase significantly attenuates 1-methyl-4-phenylpyridinium (MPP(+)) toxicity in vitro. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 5-6. 2002-08-06. PMID:12111451. |
significant decreases in levels of dopamine and its metabolites 3,4-dihyroxyphenylacetic acid (dopac) and homovanillic acid were observed following incubation of slices with 25 microm mpp(+). |
2002-08-06 |
2023-08-12 |
Not clear |
| Toshio Obat. Role of hydroxyl radical formation in neurotoxicity as revealed by in vivo free radical trapping. Toxicology letters. vol 132. issue 2. 2002-07-16. PMID:12044541. |
mpp(+) is a highly potent dopaminbergic-releasing agents and dopamine (da) autoxidation catalyzed by iron and oxidative stress may be involved in the pathogenesis of parkinson's disease. |
2002-07-16 |
2023-08-12 |
Not clear |
| Chung Soo Lee, Jeong Ho Han, Yoon Young Jang, Jin Ho Song, Eun Sook Ha. Differential effect of catecholamines and MPP(+) on membrane permeability in brain mitochondria and cell viability in PC12 cells. Neurochemistry international. vol 40. issue 4. 2002-04-05. PMID:11792467. |
the present study examined the effect of dopamine, 6-hydroxydopamine (6-ohda), and mpp(+) on the membrane permeability transition in brain mitochondria and on viability in pc12 cells. |
2002-04-05 |
2023-08-12 |
Not clear |
| F A Paczkowski, L J Bryan-Lluk. Tyrosine residue 271 of the norepinephrine transporter is an important determinant of its pharmacology. Brain research. Molecular brain research. vol 97. issue 1. 2002-04-04. PMID:11744160. |
the effects of the mutations on net function were examined by expressing the mutant and wildtype nets in cos-7 cells and measuring the k(m) and v(max) for uptake of the substrates, [3h]norepinephrine, [3h]mpp(+) and [3h]dopamine, the k(d) and b(max) for [3h]nisoxetine binding and the k(i) of the inhibitors, nisoxetine, desipramine and cocaine, for inhibition of [3h]norepinephrine uptake. |
2002-04-04 |
2023-08-12 |
human |
| S Barc, G Page, L Barrier, A Piriou, B Fauconnea. Impairment of the neuronal dopamine transporter activity in MPP(+)-treated rat was not prevented by treatments with nitric oxide synthase or poly(ADP-ribose) polymerase inhibitors. Neuroscience letters. vol 314. issue 1-2. 2002-01-07. PMID:11698152. |
impairment of the neuronal dopamine transporter activity in mpp(+)-treated rat was not prevented by treatments with nitric oxide synthase or poly(adp-ribose) polymerase inhibitors. |
2002-01-07 |
2023-08-12 |
rat |
| S Barc, G Page, L Barrier, A Piriou, B Fauconnea. Impairment of the neuronal dopamine transporter activity in MPP(+)-treated rat was not prevented by treatments with nitric oxide synthase or poly(ADP-ribose) polymerase inhibitors. Neuroscience letters. vol 314. issue 1-2. 2002-01-07. PMID:11698152. |
an intranigral injection of 10 microg mpp(+) in rat induced a decrease of about 30% of the neuronal dopamine transporter (dat) activity 21 days after lesion. |
2002-01-07 |
2023-08-12 |
rat |
| S Barc, G Page, L Barrier, A Piriou, B Fauconnea. Impairment of the neuronal dopamine transporter activity in MPP(+)-treated rat was not prevented by treatments with nitric oxide synthase or poly(ADP-ribose) polymerase inhibitors. Neuroscience letters. vol 314. issue 1-2. 2002-01-07. PMID:11698152. |
based on the hypothesis that mptp/mpp(+) neurotoxicity involves the nitric oxide (no) production and/or an activation of poly(adp-ribose) polymerase (parp), we investigated the preventive effects of a treatment either with l-name, a no synthase (nos) inhibitor or 3-aminobenzamide, a parp inhibitor on the reduction of dopamine uptake induced by mpp(+). |
2002-01-07 |
2023-08-12 |
rat |
| R A González-Polo, A Mora, N Clemente, G Sabio, F Centeno, G Soler, J M Fuente. Mechanisms of MPP(+) incorporation into cerebellar granule cells. Brain research bulletin. vol 56. issue 2. 2002-01-04. PMID:11704348. |
we have studied the implication of various membrane transporter systems on mpp(+) neurotoxicity, including the dopamine transporter system (dat) and cationic amino acid transporters (cat). |
2002-01-04 |
2023-08-12 |
cat |
| R A González-Polo, A Mora, N Clemente, G Sabio, F Centeno, G Soler, J M Fuente. Mechanisms of MPP(+) incorporation into cerebellar granule cells. Brain research bulletin. vol 56. issue 2. 2002-01-04. PMID:11704348. |
we have showed a partial protection against mpp(+) toxicity when the dopamine transporter is inhibited by 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]4-(3-phenylpropyl)piperazinedihydrochloride (gbr-12909). |
2002-01-04 |
2023-08-12 |
cat |
| P Scholze, H H Sitte, E A Singe. Substantial loss of substrate by diffusion during uptake in HEK-293 cells expressing neurotransmitter transporters. Neuroscience letters. vol 309. issue 3. 2001-12-04. PMID:11514069. |
human embryonic kidney 293 (hek-293) cells stably transfected with the human serotonin (5-ht) or dopamine transporter (hsert, hdat), or the rat gaba transporter gat-1 were incubated with saturating concentrations of transporter substrates (hsert: [(3)h]5-ht, [(3)h]n-methyl-phenyl-pyridinium (mpp+); hdat: [(3)h]dopamine, [(3)h]mpp(+); rgat: [(3)h]gaba). |
2001-12-04 |
2023-08-12 |
human |
| P Scholze, H H Sitte, E A Singe. Substantial loss of substrate by diffusion during uptake in HEK-293 cells expressing neurotransmitter transporters. Neuroscience letters. vol 309. issue 3. 2001-12-04. PMID:11514069. |
uptake velocities decreased significantly over time for [(3)h]5-ht and [(3)h]dopamine (already visible at 1 min), but not for [(3)h]mpp(+) or [(3)h]gaba. |
2001-12-04 |
2023-08-12 |
human |
| P Scholze, H H Sitte, E A Singe. Substantial loss of substrate by diffusion during uptake in HEK-293 cells expressing neurotransmitter transporters. Neuroscience letters. vol 309. issue 3. 2001-12-04. PMID:11514069. |
fractional effluxes were (% min(-1)) 1.27, 0.72, 0.27 and 0.08 for [(3)h]5-ht, [(3)h]dopamine, [(3)h]mpp(+) and [(3)h]gaba, respectively. |
2001-12-04 |
2023-08-12 |
human |
| M Inazu, N Kubota, H Takeda, K Oguchi, M Koizumi, S Kimura, T Matsumiy. Methyl-4-phenylpyridinium (MPP(+))-evoked dopamine release from rat striatal slices: possible roles of voltage-dependent calcium channels and reverse dopamine transport. Neurochemistry international. vol 39. issue 3. 2001-11-01. PMID:11434982. |
methyl-4-phenylpyridinium (mpp(+))-evoked dopamine release from rat striatal slices: possible roles of voltage-dependent calcium channels and reverse dopamine transport. |
2001-11-01 |
2023-08-12 |
rat |
| C Fonck, M Baudr. Toxic effects of MPP(+) and MPTP in PC12 cells independent of reactive oxygen species formation. Brain research. vol 905. issue 1-2. 2001-09-20. PMID:11423095. |
all toxins tested (mptp, mpp(+), tbhp and 6-ohda) caused a dose-dependent decrease in [(3)h]dopamine ((3)h-da) uptake in pc12 cultures. |
2001-09-20 |
2023-08-12 |
Not clear |
| T Obata, Y Yamanaka, H Kinemuchi, L Orelan. Release of dopamine by perfusion with 1-methyl-4-phenylpyridinium ion (MPP(+)) into the striatum is associated with hydroxyl free radical generation. Brain research. vol 906. issue 1-2. 2001-09-13. PMID:11430875. |
release of dopamine by perfusion with 1-methyl-4-phenylpyridinium ion (mpp(+)) into the striatum is associated with hydroxyl free radical generation. |
2001-09-13 |
2023-08-12 |
rat |
| T Obata, S Kubot. Protective effect of tamoxifen on 1-methyl-4-phenylpyridine-induced hydroxyl radical generation in the rat striatum. Neuroscience letters. vol 308. issue 2. 2001-09-13. PMID:11457566. |
mpp(+) (5 mm) enhanced generation of hydroxyl radicals with concomitant increased efflux of dopamine. |
2001-09-13 |
2023-08-12 |
rat |
| T Obata, S Kubot. Protective effect of tamoxifen on 1-methyl-4-phenylpyridine-induced hydroxyl radical generation in the rat striatum. Neuroscience letters. vol 308. issue 2. 2001-09-13. PMID:11457566. |
tamoxifen (100 microm) significantly attenuated dopamine efflux induced by mpp(+). |
2001-09-13 |
2023-08-12 |
rat |
| T Obata, S Kubot. Protective effect of tamoxifen on 1-methyl-4-phenylpyridine-induced hydroxyl radical generation in the rat striatum. Neuroscience letters. vol 308. issue 2. 2001-09-13. PMID:11457566. |
the result in the present study is the first demonstration showing the protective effect of tamoxifen on hydroxyl radical generation induced by mpp(+) by suppressing dopamine efflux. |
2001-09-13 |
2023-08-12 |
rat |