| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshio Obat. Endogenous semicarbazide-sensitive amine oxidase (SSAO) inhibitor increases 1-methyl-4-phenylpyridinium ion (MPP+)-induced dopamine efflux by immobilization stress in rat striatum. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 24. issue 5. 2006-09-18. PMID:16725303. |
the present study examined whether or not immobilization stress (immo)-inducible semicarbazide-sensitive amine oxidase (ssao) inhibitor by separated gel filtration from 105,000 g supernate in rat brain cytosol contribute to the dopamine (da) efflux by 1-methyl-4-phenylpyridinium ion (mpp(+)) in the rat striatum. |
2006-09-18 |
2023-08-12 |
rat |
| Yan-Jing Yang, Qing-Min Wang, Li-Fang Hu, Xiu-Lan Sun, Jian-Hua Ding, Gang H. Iptakalim alleviated the increase of extracellular dopamine and glutamate induced by 1-methyl-4-phenylpyridinium ion in rat striatum. Neuroscience letters. vol 404. issue 1-2. 2006-09-18. PMID:16781057. |
the present study examined the effect of iptakalim (ipt), a novel atp-sensitive potassium (k(atp)) channel opener (kco), on 1-methyl-4-phenylpyridinium ion (mpp(+))-induced dopamine (da) and glutamate efflux in extracellular fluid of rat striatum, using microdialysis technique. |
2006-09-18 |
2023-08-12 |
rat |
| Ana Muñoz, Pablo Rey, Maria J Guerra, Estefania Mendez-Alvarez, Ramon Soto-Otero, Jose L Labandeira-Garci. Reduction of dopaminergic degeneration and oxidative stress by inhibition of angiotensin converting enzyme in a MPTP model of parkinsonism. Neuropharmacology. vol 51. issue 1. 2006-09-11. PMID:16678218. |
captopril did not reduce striatal mpp(+) levels, mao-b activity or dopamine transporter activity, which may reduce mptp neurotoxicity. |
2006-09-11 |
2023-08-12 |
mouse |
| Vincenzo Di Matteo, Massimo Pierucci, Giuseppe Di Giovanni, Angelo Di Santo, Andreina Poggi, Arcangelo Benigno, Ennio Esposit. Aspirin protects striatal dopaminergic neurons from neurotoxin-induced degeneration: an in vivo microdialysis study. Brain research. vol 1095. issue 1. 2006-09-05. PMID:16712818. |
rat striata were perfused with 1 mm mpp(+) or 6-ohda for 10 min, causing peak levels of dopamine (da) in the dialytic fluid, after 40 min. |
2006-09-05 |
2023-08-12 |
rat |
| Toshio Obat. Tamoxifen protect against hydroxyl radical generation induced by phenelzine in rat striatum. Toxicology. vol 222. issue 1-2. 2006-06-08. PMID:16500014. |
infusion of phenelzine (100 microm or 0.1 nmol/microl/min) into the striatum drastically increased dopamine (da) efflux and the oh formation, trapped as 2,3-dhba by the possible increased production of mpp(+). |
2006-06-08 |
2023-08-12 |
rat |
| Toshio Obat. Imidaprilat, an angiotensin-converting enzyme inhibitor exerts neuroprotective effect via decreasing dopamine efflux and hydroxyl radical generation induced by bisphenol A and MPP+ in rat striatum. Brain research. vol 1071. issue 1. 2006-06-05. PMID:16406270. |
the present study examined the ability of antioxidant effects of angiotensin-converting enzyme (ace) inhibitor, imidaprilat, on the synergistic effect of bisphenol a and 1-methyl-4-phenylpyridinium ion (mpp(+))-induced hydroxyl radical (*oh) formation and dopamine (da) efflux in extracellular fluid of rat striatum. |
2006-06-05 |
2023-08-12 |
rat |
| Vera Lehmensiek, Eva-Maria Tan, Stefan Liebau, Thomas Lenk, Heinz Zettlmeisl, Johannes Schwarz, Alexander Storc. Dopamine transporter-mediated cytotoxicity of 6-hydroxydopamine in vitro depends on expression of mutant alpha-synucleins related to Parkinson's disease. Neurochemistry international. vol 48. issue 5. 2006-06-01. PMID:16406146. |
mutant (a30p and a53t) alpha-synuclein isoforms cause increased vulnerability of cells towards various toxic insults and enhance dopamine transporter (dat)-mediated toxicity of the selective dopaminergic neurotoxin and mitochondrial complex i inhibitor mpp(+) in vitro. |
2006-06-01 |
2023-08-12 |
human |
| Juan Zhen, Nianhang Chen, Maarten E A Reit. Differences in interactions with the dopamine transporter as revealed by diminishment of Na(+) gradient and membrane potential: dopamine versus other substrates. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16122767. |
in heterologous cells expressing the dopamine transporter (dat), simultaneous elevation of intracellular na(+) and depolarization of the membrane with gramicidin reduced the potency of various dat substrates, including dopamine, d-amphetamine, beta-phenethylamine, p-tyramine, and mpp(+), in inhibiting binding of the cocaine analog [(3)h]cft, with the greatest reduction observed for d-amphetamine. |
2006-03-10 |
2023-08-12 |
rat |
| Z Xu, D Cawthon, K A McCastlain, H M Duhart, G D Newport, H Fang, T A Patterson, W Slikker, S F Al. Selective alterations of transcription factors in MPP+-induced neurotoxicity in PC12 cells. Neurotoxicology. vol 26. issue 4. 2005-10-19. PMID:16112330. |
mpp(+) (1-methyl-4-phenylpyridinium; the active metabolite of the neurotoxin mptp (1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine)) depletes dopamine (da) content and elicits cell death in pc12 cells. |
2005-10-19 |
2023-08-12 |
Not clear |
| B Jakobsen, J B Gramsbergen, A Møller Dall, C Rosenblad, J Zimme. Characterization of organotypic ventral mesencephalic cultures from embryonic mice and protection against MPP toxicity by GDNF. The European journal of neuroscience. vol 21. issue 11. 2005-08-24. PMID:15978005. |
we characterized organotypic ventral mesencephalic (vm) cultures derived from embryonic day 12 (e12) mice (cbl57/bl6) in terms of number of dopaminergic neurons, cell soma size and dopamine production in relation to time in vitro and tested the effects of 1-methyl-4-phenylpyridinium (mpp(+)) and glial derived neurotrophic factor (gdnf) to validate this novel culture model. |
2005-08-24 |
2023-08-12 |
mouse |
| B Jakobsen, J B Gramsbergen, A Møller Dall, C Rosenblad, J Zimme. Characterization of organotypic ventral mesencephalic cultures from embryonic mice and protection against MPP toxicity by GDNF. The European journal of neuroscience. vol 21. issue 11. 2005-08-24. PMID:15978005. |
in one-week-old cultures (5 microm mpp(+), 2 days) gdnf provided potent neuroprotection with dopamine contents reaching control levels and number of tyrosine hydroxylase (th)(+) cells up to 80% of control, but in three-week-old cultures (10 microm mpp(+), 2 days) the protective potential of gdnf was markedly reduced. |
2005-08-24 |
2023-08-12 |
mouse |
| R Moaddel, R Yamaguchi, P C Ho, S Patel, C-P Hsu, V Subrahmanyam, I W Waine. Development and characterization of an immobilized human organic cation transporter based liquid chromatographic stationary phase. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 818. issue 2. 2005-06-23. PMID:15734168. |
columns were created using both stationary phases, and frontal displacement chromatography experiments were conducted using [(3)h]-methyl phenyl pyridinium ([(3)h]-mpp(+)) as the marker ligand and mpp(+), verapamil, quinidine, quinine, nicotine, dopamine and vinblastin as the displacers. |
2005-06-23 |
2023-08-12 |
human |
| G Gille, S-T Hung, H Reichmann, W-D Rausc. Oxidative stress to dopaminergic neurons as models of Parkinson's disease. Annals of the New York Academy of Sciences. vol 1018. 2004-08-18. PMID:15240412. |
dopamine agonists show a capacity to counteract mpp(+)-toxicity. |
2004-08-18 |
2023-08-12 |
Not clear |
| Steven B Foster, Monika Z Wrona, Jilin Han, Glenn Dryhurs. The parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) mediates release of l-3,4-dihydroxyphenylalanine (l-DOPA) and inhibition of l-DOPA decarboxylase in the rat striatum: a microdialysis study. Chemical research in toxicology. vol 16. issue 10. 2004-07-19. PMID:14565778. |
early steps in the neurotoxic mechanism evoked by mpp(+) include a profound dopaminergic energy impairment, which mediates a massive release of dopamine (da), glutathione (gsh), and cysteine (cysh). |
2004-07-19 |
2023-08-12 |
human |
| Kerry B Goralski, Kenneth W Rento. Brain inflammation enhances 1-methyl-4-phenylpyridinium-evoked neurotoxicity in rats. Toxicology and applied pharmacology. vol 196. issue 3. 2004-05-27. PMID:15094308. |
a single injection of mpp(+) into the median forebrain bundle followed 48 h later and produced a reduction in striatal dopamine content that was dose- and time-dependent. |
2004-05-27 |
2023-08-12 |
rat |
| Kerry B Goralski, Kenneth W Rento. Brain inflammation enhances 1-methyl-4-phenylpyridinium-evoked neurotoxicity in rats. Toxicology and applied pharmacology. vol 196. issue 3. 2004-05-27. PMID:15094308. |
two-days after 5 microg of mpp(+) was administered, a 90% decrease in striatal dopamine content was observed in saline- and lps-pretreated rats. |
2004-05-27 |
2023-08-12 |
rat |
| Kerry B Goralski, Kenneth W Rento. Brain inflammation enhances 1-methyl-4-phenylpyridinium-evoked neurotoxicity in rats. Toxicology and applied pharmacology. vol 196. issue 3. 2004-05-27. PMID:15094308. |
however, 4 and 7 days after 5 microg mpp(+) treatment, striatal dopamine recovered up to 70-80% of control values in saline-pretreated rats but remained depressed (80-90%) in rats treated with lps. |
2004-05-27 |
2023-08-12 |
rat |
| Alexander Storch, Yu-I Hwang, Debra A Gearhart, J Warren Beach, Edward J Neafsey, Michael A Collins, Johannes Schwar. Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake. Journal of neurochemistry. vol 89. issue 3. 2004-05-19. PMID:15086525. |
consistently, only 2[n]-methylated betacs were transported into the cell through the dat with up to five times greater k(m) and 12-220 times smaller v(max) values compared with dopamine and mpp(+). |
2004-05-19 |
2023-08-12 |
human |
| Christian Pifl, Maya Khorchide, Alexandra Kattinger, Harald Reither, John Hardy, Oleh Hornykiewic. alpha-Synuclein selectively increases manganese-induced viability loss in SK-N-MC neuroblastoma cells expressing the human dopamine transporter. Neuroscience letters. vol 354. issue 1. 2004-02-26. PMID:14698476. |
the established or potentially toxic agents implicated in the nigral cell death in parkinson's disease, dopamine, 1-methyl-4-phenylpyridinium (mpp(+)), iron, and manganese, were examined as to their effects on the viability of cells overexpressing alpha-synuclein. |
2004-02-26 |
2023-08-12 |
human |
| Christian Pifl, Maya Khorchide, Alexandra Kattinger, Harald Reither, John Hardy, Oleh Hornykiewic. alpha-Synuclein selectively increases manganese-induced viability loss in SK-N-MC neuroblastoma cells expressing the human dopamine transporter. Neuroscience letters. vol 354. issue 1. 2004-02-26. PMID:14698476. |
cells were exposed for 24-72 h to 1-10 microm dopamine, 0.1-3 microm mpp(+), 0.1-1 mm fecl(2) or 30-300 microm mncl(2) added to the culture medium. |
2004-02-26 |
2023-08-12 |
human |