| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dominik Pöltl, Stefan Schildknecht, Christiaan Karreman, Marcel Leis. Uncoupling of ATP-depletion and cell death in human dopaminergic neurons. Neurotoxicology. vol 33. issue 4. 2013-01-04. PMID:22206971. |
biochemical assays indicated that in the homogeneously differentiated cell cultures, mpp(+) was taken up by the dopamine transporter (dat). |
2013-01-04 |
2023-08-12 |
human |
| T Takahashi, M Naoi, T Nagats. Uptake of N-methyl-4-phenylpyridinium ion (MPP(+)) into PC12h pheochromocytoma cells. Neurochemistry international. vol 11. issue 1. 2012-10-02. PMID:20501147. |
the uptake by a high-affinity system was mediated by a carrier system common to dopamine and noradrenalin and mptp itself proved to be taken up by this system, which was further confirmed by the inhibition of the mpp(+) uptake by nomifensine and mazindol. |
2012-10-02 |
2023-08-12 |
Not clear |
| A Poli, O Gandolfi, P Roncada, T Guarnieri, R Lucchi, L Villan. Reversible effects of 1-methyl-4-phenylpyridinium ion (MPP(+)) on dopaminergic neurons in goldfish retina. Neurochemistry international. vol 15. issue 2. 2012-10-02. PMID:20504487. |
the effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) and 1-methyl-4-phenylpyridinium ion (mpp(+)) on the dopamine (da), norepinephrine (na) and serotonin (5-ht) levels in goldfish retina, was investigated. |
2012-10-02 |
2023-08-12 |
Not clear |
| A Poli, O Gandolfi, P Roncada, T Guarnieri, R Lucchi, L Villan. Reversible effects of 1-methyl-4-phenylpyridinium ion (MPP(+)) on dopaminergic neurons in goldfish retina. Neurochemistry international. vol 15. issue 2. 2012-10-02. PMID:20504487. |
a similar dopamine depletion was observed with mpp(+) (10 ?g). |
2012-10-02 |
2023-08-12 |
Not clear |
| T Aiuchi, Y Shirane, H Kinemuchi, Y Arai, S K Kim, K Nakaya, Y Nakamur. Effect of the tetraphenylboron ion on the inhibition of mitochondrial respiration in synaptosomes by the 1-methyl-4-phenylpyridinium ion (MPP(+)). Neurochemistry international. vol 17. issue 1. 2012-10-02. PMID:20504603. |
the present results confirm previous findings that nigrostriatal dopamine neurons, which selectively take up mpp(+) by the da transport system, may be more selectively damaged by concentrated mpp(+) than other neurons that essentially lack a transport system with poor permeability for mpp(+) through their neuronal membranes. |
2012-10-02 |
2023-08-12 |
mouse |
| S M Thomas, B H Anderto. Effects of methylphenylpyridinium and kainic acid on protein degradation in differentiated neuroblastoma cultures. Toxicology in vitro : an international journal published in association with BIBRA. vol 5. issue 2. 2012-10-02. PMID:20732013. |
protein degradation in human neuroblastoma cells was enhanced by both dopamine and iron when added with either mpp(+) or kainic acid using a low-glutamate medium. |
2012-10-02 |
2023-08-12 |
mouse |
| Clara Lemos, Ana Faria, Manuela Meireles, Fátima Martel, Rosário Monteiro, Conceição Calha. Thiamine is a substrate of organic cation transporters in Caco-2 cells. European journal of pharmacology. vol 682. issue 1-3. 2012-07-17. PMID:22387857. |
[(3)h]-t(+) uptake was found to be: 1) time-dependent, 2) na(+)- and cl(-)-dependent, 3) ph-dependent, with uptake increasing with a decrease in extracellular ph and decreasing with a decrease in intracellular ph, 4) inhibited by amiloride, 5) inhibited by the thiamine structural analogues oxythiamine and amprolium, 6) inhibited by the unrelated organic cations mpp(+), clonidine, dopamine, serotonin, 7) inhibited by the oct inhibitors decynium22 and progesterone. |
2012-07-17 |
2023-08-12 |
Not clear |
| Bernardino Ossola, Nadia Schendzielorz, Shih-Heng Chen, Gary S Bird, Raimo K Tuominen, Pekka T Männistö, Jau-Shyong Hon. Amantadine protects dopamine neurons by a dual action: reducing activation of microglia and inducing expression of GDNF in astroglia [corrected]. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21586298. |
second, our studies revealed that amantadine reduced both lps- and mpp(+)-induced toxicity of dopamine neurons through 1) the inhibition of the release of microglial pro-inflammatory factors, 2) an increase in expression of neurotrophic factors such as gdnf from astroglia. |
2012-05-25 |
2023-08-12 |
human |
| Richard B Rothman, John S Partilla, Michael H Baumann, Catrissa Lightfoot-Siordia, Bruce E Bloug. Studies of the biogenic amine transporters. 14. Identification of low-efficacy "partial" substrates for the biogenic amine transporters. The Journal of pharmacology and experimental therapeutics. vol 341. issue 1. 2012-05-04. PMID:22271821. |
[(3)h]1-methyl-4-phenylpyridinium (mpp(+)) was used to assess release from dopamine (da) and norepinephrine nerve terminals, whereas [(3)h]5-hydroxytryptamine (5-ht) was used to assess release from 5-ht nerve terminals. |
2012-05-04 |
2023-08-12 |
rat |
| Patricia Rojas, Norma Serrano-García, Omar N Medina-Campos, José Pedraza-Chaverri, Perla D Maldonado, Elizabeth Ruiz-Sánche. S-Allylcysteine, a garlic compound, protects against oxidative stress in 1-methyl-4-phenylpyridinium-induced parkinsonism in mice. The Journal of nutritional biochemistry. vol 22. issue 10. 2012-04-27. PMID:21190833. |
mice were pretreated with sac (125 mg/kg ip) daily for 17 days, followed by administration of mpp(+) (0.72 mg/kg icv), and were sacrificed 24 h later to evaluate lipid peroxidation, different antioxidant enzyme activities, spontaneous locomotor activity and dopamine (da) content. |
2012-04-27 |
2023-08-12 |
mouse |
| Ya-Ching Hsieh, Ross B Mounsey, Peter Teisman. MPP(+)-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 384. issue 2. 2011-12-12. PMID:21667279. |
mpp(+)-induced toxicity in the presence of dopamine is mediated by cox-2 through oxidative stress. |
2011-12-12 |
2023-08-12 |
Not clear |
| Ya-Ching Hsieh, Ross B Mounsey, Peter Teisman. MPP(+)-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 384. issue 2. 2011-12-12. PMID:21667279. |
in this study, we examined whether dopamine mediates 1-methyl-4-phenylpyridinium (mpp(+))-induced toxicity in primary ventral mesencephalic (vm) neurons, an in vitro model of pd, and if so, whether the protective effects of cox-2 inhibitors on dopamine mediated mpp(+)-induced vm neurotoxicity and vm dopaminergic cell apoptosis result from the reduction of ros. |
2011-12-12 |
2023-08-12 |
Not clear |
| Ya-Ching Hsieh, Ross B Mounsey, Peter Teisman. MPP(+)-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 384. issue 2. 2011-12-12. PMID:21667279. |
reserpine, a dopamine-depleting agent, significantly reduced vm neurotoxicity induced by mpp(+), whereas dopamine had an additive effect on mpp(+)-induced vm neurotoxicity and vm dopaminergic cell apoptosis. |
2011-12-12 |
2023-08-12 |
Not clear |
| Ya-Ching Hsieh, Ross B Mounsey, Peter Teisman. MPP(+)-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 384. issue 2. 2011-12-12. PMID:21667279. |
these results suggest that dopamine itself mediates mpp(+)-induced vm neurotoxicity and vm dopaminergic cell apoptosis in the presence of cox-2. |
2011-12-12 |
2023-08-12 |
Not clear |
| Takashi Okura, Sayaka Kato, Yusuke Takano, Takenori Sato, Atsushi Yamashita, Riyo Morimoto, Sumio Ohtsuki, Tetsuya Terasaki, Yoshiharu Deguch. Functional characterization of rat plasma membrane monoamine transporter in the blood-brain and blood-cerebrospinal fluid barriers. Journal of pharmaceutical sciences. vol 100. issue 9. 2011-10-27. PMID:21538354. |
[(3) h]mpp(+) transports into these cells were markedly inhibited by serotonin, dopamine, and cationic drugs. |
2011-10-27 |
2023-08-12 |
rat |
| Takashi Okura, Sayaka Kato, Yusuke Takano, Takenori Sato, Atsushi Yamashita, Riyo Morimoto, Sumio Ohtsuki, Tetsuya Terasaki, Yoshiharu Deguch. Functional characterization of rat plasma membrane monoamine transporter in the blood-brain and blood-cerebrospinal fluid barriers. Journal of pharmaceutical sciences. vol 100. issue 9. 2011-10-27. PMID:21538354. |
brain microdialysis studies revealed that the elimination across the bbb was significantly decreased by coperfusion of unlabelled mpp(+) , serotonin, or dopamine. |
2011-10-27 |
2023-08-12 |
rat |
| Prashant N Jethva, Jay R Kardani, Ipsita Ro. Modulation of α-synuclein aggregation by dopamine in the presence of MPTP and its metabolite. The FEBS journal. vol 278. issue 10. 2011-07-07. PMID:21410644. |
the aim of this study was to determine whether dopamine continues to have an adverse effect on the fibrillation of α-synuclein in the presence of mptp and its metabolite 1-methyl-4-phenylpyridinum ion (mpp(+) ). |
2011-07-07 |
2023-08-12 |
Not clear |
| Prashant N Jethva, Jay R Kardani, Ipsita Ro. Modulation of α-synuclein aggregation by dopamine in the presence of MPTP and its metabolite. The FEBS journal. vol 278. issue 10. 2011-07-07. PMID:21410644. |
for this, α-synuclein was incubated in the presence of mptp and mpp(+) along with dopamine. |
2011-07-07 |
2023-08-12 |
Not clear |
| Prashant N Jethva, Jay R Kardani, Ipsita Ro. Modulation of α-synuclein aggregation by dopamine in the presence of MPTP and its metabolite. The FEBS journal. vol 278. issue 10. 2011-07-07. PMID:21410644. |
in contrast to the effect of dopamine on the aggregation of α-synuclein alone, in the presence of mptp or mpp(+) , the aggregates formed are thioflavin t-positive and amyloidogenic. |
2011-07-07 |
2023-08-12 |
Not clear |
| Andreas Lehner, Margaret Johnson, Tyrell Simkins, Kelly Janis, Keith Lookingland, John Goudreau, Wilson Rumbeih. Liquid chromatographic-electrospray mass spectrometric determination of 1-methyl-4-phenylpyridine (MPP+) in discrete regions of murine brain. Toxicology mechanisms and methods. vol 21. issue 3. 2011-06-17. PMID:21142843. |
mptp is metabolized to 1-methyl-4-phenylpyridinium (mpp(+)), which is a mitochondrial toxicant of central dopamine (da) neurons. |
2011-06-17 |
2023-08-12 |
mouse |