All Relations between mpp and dopamine

Publication Sentence Publish Date Extraction Date Species
Dominik Pöltl, Stefan Schildknecht, Christiaan Karreman, Marcel Leis. Uncoupling of ATP-depletion and cell death in human dopaminergic neurons. Neurotoxicology. vol 33. issue 4. 2013-01-04. PMID:22206971. biochemical assays indicated that in the homogeneously differentiated cell cultures, mpp(+) was taken up by the dopamine transporter (dat). 2013-01-04 2023-08-12 human
T Takahashi, M Naoi, T Nagats. Uptake of N-methyl-4-phenylpyridinium ion (MPP(+)) into PC12h pheochromocytoma cells. Neurochemistry international. vol 11. issue 1. 2012-10-02. PMID:20501147. the uptake by a high-affinity system was mediated by a carrier system common to dopamine and noradrenalin and mptp itself proved to be taken up by this system, which was further confirmed by the inhibition of the mpp(+) uptake by nomifensine and mazindol. 2012-10-02 2023-08-12 Not clear
A Poli, O Gandolfi, P Roncada, T Guarnieri, R Lucchi, L Villan. Reversible effects of 1-methyl-4-phenylpyridinium ion (MPP(+)) on dopaminergic neurons in goldfish retina. Neurochemistry international. vol 15. issue 2. 2012-10-02. PMID:20504487. the effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) and 1-methyl-4-phenylpyridinium ion (mpp(+)) on the dopamine (da), norepinephrine (na) and serotonin (5-ht) levels in goldfish retina, was investigated. 2012-10-02 2023-08-12 Not clear
A Poli, O Gandolfi, P Roncada, T Guarnieri, R Lucchi, L Villan. Reversible effects of 1-methyl-4-phenylpyridinium ion (MPP(+)) on dopaminergic neurons in goldfish retina. Neurochemistry international. vol 15. issue 2. 2012-10-02. PMID:20504487. a similar dopamine depletion was observed with mpp(+) (10 ?g). 2012-10-02 2023-08-12 Not clear
T Aiuchi, Y Shirane, H Kinemuchi, Y Arai, S K Kim, K Nakaya, Y Nakamur. Effect of the tetraphenylboron ion on the inhibition of mitochondrial respiration in synaptosomes by the 1-methyl-4-phenylpyridinium ion (MPP(+)). Neurochemistry international. vol 17. issue 1. 2012-10-02. PMID:20504603. the present results confirm previous findings that nigrostriatal dopamine neurons, which selectively take up mpp(+) by the da transport system, may be more selectively damaged by concentrated mpp(+) than other neurons that essentially lack a transport system with poor permeability for mpp(+) through their neuronal membranes. 2012-10-02 2023-08-12 mouse
S M Thomas, B H Anderto. Effects of methylphenylpyridinium and kainic acid on protein degradation in differentiated neuroblastoma cultures. Toxicology in vitro : an international journal published in association with BIBRA. vol 5. issue 2. 2012-10-02. PMID:20732013. protein degradation in human neuroblastoma cells was enhanced by both dopamine and iron when added with either mpp(+) or kainic acid using a low-glutamate medium. 2012-10-02 2023-08-12 mouse
Clara Lemos, Ana Faria, Manuela Meireles, Fátima Martel, Rosário Monteiro, Conceição Calha. Thiamine is a substrate of organic cation transporters in Caco-2 cells. European journal of pharmacology. vol 682. issue 1-3. 2012-07-17. PMID:22387857. [(3)h]-t(+) uptake was found to be: 1) time-dependent, 2) na(+)- and cl(-)-dependent, 3) ph-dependent, with uptake increasing with a decrease in extracellular ph and decreasing with a decrease in intracellular ph, 4) inhibited by amiloride, 5) inhibited by the thiamine structural analogues oxythiamine and amprolium, 6) inhibited by the unrelated organic cations mpp(+), clonidine, dopamine, serotonin, 7) inhibited by the oct inhibitors decynium22 and progesterone. 2012-07-17 2023-08-12 Not clear
Bernardino Ossola, Nadia Schendzielorz, Shih-Heng Chen, Gary S Bird, Raimo K Tuominen, Pekka T Männistö, Jau-Shyong Hon. Amantadine protects dopamine neurons by a dual action: reducing activation of microglia and inducing expression of GDNF in astroglia [corrected]. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21586298. second, our studies revealed that amantadine reduced both lps- and mpp(+)-induced toxicity of dopamine neurons through 1) the inhibition of the release of microglial pro-inflammatory factors, 2) an increase in expression of neurotrophic factors such as gdnf from astroglia. 2012-05-25 2023-08-12 human
Richard B Rothman, John S Partilla, Michael H Baumann, Catrissa Lightfoot-Siordia, Bruce E Bloug. Studies of the biogenic amine transporters. 14. Identification of low-efficacy "partial" substrates for the biogenic amine transporters. The Journal of pharmacology and experimental therapeutics. vol 341. issue 1. 2012-05-04. PMID:22271821. [(3)h]1-methyl-4-phenylpyridinium (mpp(+)) was used to assess release from dopamine (da) and norepinephrine nerve terminals, whereas [(3)h]5-hydroxytryptamine (5-ht) was used to assess release from 5-ht nerve terminals. 2012-05-04 2023-08-12 rat
Patricia Rojas, Norma Serrano-García, Omar N Medina-Campos, José Pedraza-Chaverri, Perla D Maldonado, Elizabeth Ruiz-Sánche. S-Allylcysteine, a garlic compound, protects against oxidative stress in 1-methyl-4-phenylpyridinium-induced parkinsonism in mice. The Journal of nutritional biochemistry. vol 22. issue 10. 2012-04-27. PMID:21190833. mice were pretreated with sac (125 mg/kg ip) daily for 17 days, followed by administration of mpp(+) (0.72 mg/kg icv), and were sacrificed 24 h later to evaluate lipid peroxidation, different antioxidant enzyme activities, spontaneous locomotor activity and dopamine (da) content. 2012-04-27 2023-08-12 mouse
Ya-Ching Hsieh, Ross B Mounsey, Peter Teisman. MPP(+)-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 384. issue 2. 2011-12-12. PMID:21667279. mpp(+)-induced toxicity in the presence of dopamine is mediated by cox-2 through oxidative stress. 2011-12-12 2023-08-12 Not clear
Ya-Ching Hsieh, Ross B Mounsey, Peter Teisman. MPP(+)-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 384. issue 2. 2011-12-12. PMID:21667279. in this study, we examined whether dopamine mediates 1-methyl-4-phenylpyridinium (mpp(+))-induced toxicity in primary ventral mesencephalic (vm) neurons, an in vitro model of pd, and if so, whether the protective effects of cox-2 inhibitors on dopamine mediated mpp(+)-induced vm neurotoxicity and vm dopaminergic cell apoptosis result from the reduction of ros. 2011-12-12 2023-08-12 Not clear
Ya-Ching Hsieh, Ross B Mounsey, Peter Teisman. MPP(+)-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 384. issue 2. 2011-12-12. PMID:21667279. reserpine, a dopamine-depleting agent, significantly reduced vm neurotoxicity induced by mpp(+), whereas dopamine had an additive effect on mpp(+)-induced vm neurotoxicity and vm dopaminergic cell apoptosis. 2011-12-12 2023-08-12 Not clear
Ya-Ching Hsieh, Ross B Mounsey, Peter Teisman. MPP(+)-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 384. issue 2. 2011-12-12. PMID:21667279. these results suggest that dopamine itself mediates mpp(+)-induced vm neurotoxicity and vm dopaminergic cell apoptosis in the presence of cox-2. 2011-12-12 2023-08-12 Not clear
Takashi Okura, Sayaka Kato, Yusuke Takano, Takenori Sato, Atsushi Yamashita, Riyo Morimoto, Sumio Ohtsuki, Tetsuya Terasaki, Yoshiharu Deguch. Functional characterization of rat plasma membrane monoamine transporter in the blood-brain and blood-cerebrospinal fluid barriers. Journal of pharmaceutical sciences. vol 100. issue 9. 2011-10-27. PMID:21538354. [(3) h]mpp(+) transports into these cells were markedly inhibited by serotonin, dopamine, and cationic drugs. 2011-10-27 2023-08-12 rat
Takashi Okura, Sayaka Kato, Yusuke Takano, Takenori Sato, Atsushi Yamashita, Riyo Morimoto, Sumio Ohtsuki, Tetsuya Terasaki, Yoshiharu Deguch. Functional characterization of rat plasma membrane monoamine transporter in the blood-brain and blood-cerebrospinal fluid barriers. Journal of pharmaceutical sciences. vol 100. issue 9. 2011-10-27. PMID:21538354. brain microdialysis studies revealed that the elimination across the bbb was significantly decreased by coperfusion of unlabelled mpp(+) , serotonin, or dopamine. 2011-10-27 2023-08-12 rat
Prashant N Jethva, Jay R Kardani, Ipsita Ro. Modulation of α-synuclein aggregation by dopamine in the presence of MPTP and its metabolite. The FEBS journal. vol 278. issue 10. 2011-07-07. PMID:21410644. the aim of this study was to determine whether dopamine continues to have an adverse effect on the fibrillation of α-synuclein in the presence of mptp and its metabolite 1-methyl-4-phenylpyridinum ion (mpp(+) ). 2011-07-07 2023-08-12 Not clear
Prashant N Jethva, Jay R Kardani, Ipsita Ro. Modulation of α-synuclein aggregation by dopamine in the presence of MPTP and its metabolite. The FEBS journal. vol 278. issue 10. 2011-07-07. PMID:21410644. for this, α-synuclein was incubated in the presence of mptp and mpp(+) along with dopamine. 2011-07-07 2023-08-12 Not clear
Prashant N Jethva, Jay R Kardani, Ipsita Ro. Modulation of α-synuclein aggregation by dopamine in the presence of MPTP and its metabolite. The FEBS journal. vol 278. issue 10. 2011-07-07. PMID:21410644. in contrast to the effect of dopamine on the aggregation of α-synuclein alone, in the presence of mptp or mpp(+) , the aggregates formed are thioflavin t-positive and amyloidogenic. 2011-07-07 2023-08-12 Not clear
Andreas Lehner, Margaret Johnson, Tyrell Simkins, Kelly Janis, Keith Lookingland, John Goudreau, Wilson Rumbeih. Liquid chromatographic-electrospray mass spectrometric determination of 1-methyl-4-phenylpyridine (MPP+) in discrete regions of murine brain. Toxicology mechanisms and methods. vol 21. issue 3. 2011-06-17. PMID:21142843. mptp is metabolized to 1-methyl-4-phenylpyridinium (mpp(+)), which is a mitochondrial toxicant of central dopamine (da) neurons. 2011-06-17 2023-08-12 mouse