| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin H Nam, Eun S Park, So-Yoon Won, Yu A Lee, Kyoung I Kim, Jae Y Jeong, Jeong Y Baek, Eun J Cho, Minyoung Jin, Young C Chung, Byoung D Lee, Sung Hyun Kim, Eung-Gook Kim, Kyunghee Byun, Bonghee Lee, Dong Ho Woo, C Justin Lee, Sang R Kim, Eugene Bok, Yoon-Seong Kim, Tae-Beom Ahn, Hyuk Wan Ko, Saurav Brahmachari, Olga Pletinkova, Juan C Troconso, Valina L Dawson, Ted M Dawson, Byung K Ji. TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF. Brain : a journal of neurology. vol 138. issue Pt 12. 2016-05-04. PMID:26490328. |
here we report that transient receptor potential vanilloid 1 (trpv1) on astrocytes mediates endogenous production of ciliary neurotrophic factor (cntf), which prevents the active degeneration of dopamine neurons and leads to behavioural recovery through cntf receptor alpha (cntfrα) on nigral dopamine neurons in both the mpp(+)-lesioned or adeno-associated virus α-synuclein rat models of parkinson's disease. |
2016-05-04 |
2023-08-13 |
human |
| Chamila C Kadigamuwa, Viet Q Le, Kandatege Wimalasen. 2, 2'- and 4, 4'-Cyanines are transporter-independent in vitro dopaminergic toxins with the specificity and mechanism of toxicity similar to MPP⁺. Journal of neurochemistry. vol 135. issue 4. 2016-02-16. PMID:26094622. |
specific uptake through dopamine transporter followed by the inhibition of the mitochondrial complex-i have been accepted as the cause of the specific dopaminergic toxicity of 1-methyl-4-phenylpyridinium (mpp(+) ). |
2016-02-16 |
2023-08-13 |
Not clear |
| Andrew G Yee, Sun-Min Lee, Morag R Hunter, Michelle Glass, Peter S Freestone, Janusz Lipsk. Effects of the Parkinsonian toxin MPP+ on electrophysiological properties of nigral dopaminergic neurons. Neurotoxicology. vol 45. 2015-10-13. PMID:25193392. |
after longer exposure (>10-20 min), mpp(+) produced a late phase of inhibition which mainly involved activation of katp channels, and required uptake of the toxin via dopamine transporter. |
2015-10-13 |
2023-08-13 |
rat |
| YuYing Huang, JunFang Chen, Ying Chen, YingHan Zhuang, Mu Sun, Thomas Behnisc. The neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) alters hippocampal excitatory synaptic transmission by modulation of the GABAergic system. Frontiers in cellular neuroscience. vol 9. 2015-08-24. PMID:26300734. |
moreover, the hippocampus contains dopaminergic fibers, which are projecting from the ventral tegmental area, sn and pars compacta and contain the whole machinery required for dopamine synthesis making them sensitive to mptp and mpp(+). |
2015-08-24 |
2023-08-13 |
mouse |
| Se Joon Choi, Anne Panhelainen, Yvonne Schmitz, Kristin E Larsen, Ellen Kanter, Min Wu, David Sulzer, Eugene V Mosharo. Changes in neuronal dopamine homeostasis following 1-methyl-4-phenylpyridinium (MPP+) exposure. The Journal of biological chemistry. vol 290. issue 11. 2015-05-29. PMID:25596531. |
1-methyl-4-phenylpyridinium (mpp(+)), the active metabolite of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, selectively kills dopaminergic neurons in vivo and in vitro via a variety of toxic mechanisms, including mitochondrial dysfunction, generation of peroxynitrite, induction of apoptosis, and oxidative stress due to disruption of vesicular dopamine (da) storage. |
2015-05-29 |
2023-08-13 |
mouse |
| Yi-Hsien Tsou, Ching-Ting Shih, Cheng-Hsin Ching, Jui-Yen Huang, Chauying J Jen, Lung Yu, Yu-Min Kuo, Fong-Sen Wu, Jih-Ing Chuan. Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity. Experimental neurology. vol 263. 2015-02-09. PMID:25286336. |
we found that mpp(+) induced early decreases in total glutathione level and nrf2/γgclc (catalytic subunit of γgcl) expression, but late upregulation of ho-1 expression in association with loss of nigral dopaminergic neurons and downregulation of tyrosine hydroxylase and dopamine transporter expression in the striatum. |
2015-02-09 |
2023-08-13 |
rat |
| Tiziana Alberio, Heather Bondi, Flavia Colombo, Isabella Alloggio, Luisa Pieroni, Andrea Urbani, Mauro Fasan. Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis. Molecular bioSystems. vol 10. issue 6. 2015-01-13. PMID:24675778. |
the combination of two orthogonal proteomic approaches, two-dimensional electrophoresis and shotgun proteomics (proteomexchange dataset pxd000838), was used to highlight the specific pathways perturbed by the increase of intracellular dopamine, in comparison with those perturbed by a specific mitochondrial toxin (4-methylphenylpyridinium, mpp(+)), a neurotoxin causing parkinsonism-like symptoms in animal models. |
2015-01-13 |
2023-08-12 |
human |
| Tiziana Alberio, Heather Bondi, Flavia Colombo, Isabella Alloggio, Luisa Pieroni, Andrea Urbani, Mauro Fasan. Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis. Molecular bioSystems. vol 10. issue 6. 2015-01-13. PMID:24675778. |
proteins altered by mpp(+) did not completely overlap with those affected by dopamine treatment. |
2015-01-13 |
2023-08-12 |
human |
| Tiziana Alberio, Heather Bondi, Flavia Colombo, Isabella Alloggio, Luisa Pieroni, Andrea Urbani, Mauro Fasan. Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis. Molecular bioSystems. vol 10. issue 6. 2015-01-13. PMID:24675778. |
in particular, the mpp(+) target complex i component nadh dehydrogenase [ubiquinone] iron-sulfur protein 3 was not affected by dopamine together with 26 other proteins. |
2015-01-13 |
2023-08-12 |
human |
| Brent J Ryan, Lara L Lourenço-Venda, Mark J Crabtree, Ashley B Hale, Keith M Channon, Richard Wade-Martin. α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease. Free radical biology & medicine. vol 67. 2015-01-06. PMID:24148766. |
we have previously demonstrated that sirna-mediated knockdown of α-syn lowers the activity of both dopamine transporter and nos activity and protects dopaminergic neuron-like cells from mpp(+) toxicity. |
2015-01-06 |
2023-08-12 |
human |
| Ana María Espinosa-Oliva, Rocío M de Pablos, Marti Santiag. In vivo effect of apomorphine and haloperidol on MPP neurotoxicity. Pharmacology. vol 93. issue 3-4. 2015-01-02. PMID:24556705. |
forty-eight hours after surgery (day 2), 1 mmol/l of mpp(+) was perfused for 15 min in all groups of animals and the output of dopamine was measured. |
2015-01-02 |
2023-08-12 |
Not clear |
| Tao Chen, Yue-fan Yang, Peng Luo, Wei Liu, Shu-hui Dai, Xin-rui Zheng, Zhou Fei, Xiao-fan Jian. Homer1 knockdown protects dopamine neurons through regulating calcium homeostasis in an in vitro model of Parkinson's disease. Cellular signalling. vol 25. issue 12. 2014-12-03. PMID:24036210. |
the aim of this study was to investigate the effects of homer1 knockdown on mpp(+) induced neuronal injury in cultured dopamine (da) neurons. |
2014-12-03 |
2023-08-12 |
Not clear |
| Milind Geed, Debapriya Garabadu, Ausaf Ahmad, Sairam Krishnamurth. Silibinin pretreatment attenuates biochemical and behavioral changes induced by intrastriatal MPP+ injection in rats. Pharmacology, biochemistry, and behavior. vol 117. 2014-09-25. PMID:24345573. |
silibinin (100 and 200 mg/kg) protected against mpp(+)-induced dopamine depletion in striatum. |
2014-09-25 |
2023-08-12 |
rat |
| Milind Geed, Debapriya Garabadu, Ausaf Ahmad, Sairam Krishnamurth. Silibinin pretreatment attenuates biochemical and behavioral changes induced by intrastriatal MPP+ injection in rats. Pharmacology, biochemistry, and behavior. vol 117. 2014-09-25. PMID:24345573. |
hence, silibinin exhibited neuroprotective effect in the mpp(+) induced striatal toxicity augmenting dopamine levels. |
2014-09-25 |
2023-08-12 |
rat |
| A Masi, R Narducci, E Landucci, F Moroni, G Mannaion. MPP(+) -dependent inhibition of Ih reduces spontaneous activity and enhances EPSP summation in nigral dopamine neurons. British journal of pharmacology. vol 169. issue 1. 2014-09-05. PMID:23323755. |
mpp(+) -dependent inhibition of ih reduces spontaneous activity and enhances epsp summation in nigral dopamine neurons. |
2014-09-05 |
2023-08-12 |
Not clear |
| A Masi, R Narducci, E Landucci, F Moroni, G Mannaion. MPP(+) -dependent inhibition of Ih reduces spontaneous activity and enhances EPSP summation in nigral dopamine neurons. British journal of pharmacology. vol 169. issue 1. 2014-09-05. PMID:23323755. |
we tackled this issue by probing the effects of an acute application of mpp(+) on substantia nigra pars compacta (snc) dopamine (da) neurons. |
2014-09-05 |
2023-08-12 |
Not clear |
| Jinbo Chen, Xuezhen Wang, Xiangming Yi, Yuan Wang, Qingxin Liu, Ruli G. Induction of KLF4 contributes to the neurotoxicity of MPP + in M17 cells: a new implication in Parkinson's disease. Journal of molecular neuroscience : MN. vol 51. issue 1. 2014-03-12. PMID:23370975. |
in this study, klf4 was found to be increased in both a time-dependent manner and a dose-dependent manner in response to the incubation with 1-methyl-4-phenylpyridinium (mpp+) in human dopamine neuroblastoma m17 cells, suggesting a potential role in mpp + -induced neurotoxicity. |
2014-03-12 |
2023-08-12 |
human |
| Joanna A Korecka, Ronald E van Kesteren, Eva Blaas, Sonia O Spitzer, Jorke H Kamstra, August B Smit, Dick F Swaab, Joost Verhaagen, Koen Bosser. Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PloS one. vol 8. issue 5. 2014-01-10. PMID:23724009. |
in addition, we show that ra differentiated sh-sy5y cells express the dopamine and noradrenalin neurotransmitter transporters that are responsible for uptake of mpp(+), a well known daergic cell toxicant. |
2014-01-10 |
2023-08-12 |
Not clear |
| Takafumi Sai, Kazuyuki Uchida, Hiroyuki Nakayam. Involvement of monoamine oxidase-B in the acute neurotoxicity of MPTP in embryonic and newborn mice. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 4. 2013-09-26. PMID:22281418. |
in the present study, we attempted to reveal the involvement of monoamine oxidase b (mao-b) in the metabolism of mptp to mpp(+) and dopamine transporter (dat) in the neuronal cellular uptake of mpp(+) during the acute toxicity of mptp in both embryonic and newborn mice. |
2013-09-26 |
2023-08-12 |
mouse |
| Dominic J Hare, Paul A Adlard, Philip A Doble, David I Finkelstei. Metallobiology of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Metallomics : integrated biometal science. vol 5. issue 2. 2013-07-12. PMID:23322189. |
mptp is metabolised to the 1-methyl-4-phenylpyridinium ion (mpp(+)) in glia, after which it enters the neuron via the dopamine transporter and results in elevated levels of oxidative stress. |
2013-07-12 |
2023-08-12 |
human |