| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liliana Mendieta, Berenice Venegas, Natalia Moreno, Aleidy Patricio, Isabel Martínez, José Aguilera, Ilhuicamina Daniel Limó. The carboxyl-terminal domain of the heavy chain of tetanus toxin prevents dopaminergic degeneration and improves motor behavior in rats with striatal MPP(+)-lesions. Neuroscience research. vol 65. issue 1. 2009-09-03. PMID:19523997. |
our aim was to evaluate the effects of local administration of hc-tetx on motor behavior and the dopamine (da) levels in the striatum of mpp(+)-treated rats. |
2009-09-03 |
2023-08-12 |
rat |
| Richard B Rothman, Christina M Dersch, Subramaniam Ananthan, John S Partill. Studies of the biogenic amine transporters. 13. Identification of "agonist" and "antagonist" allosteric modulators of amphetamine-induced dopamine release. The Journal of pharmacology and experimental therapeutics. vol 329. issue 2. 2009-05-22. PMID:19244097. |
in the present study, we report that sori-9804 and sori-20040, at doses that do not alter release, partially inhibited d-amphetamine-induced dat-mediated release of [(3)h]1-methyl-4-phenylpyridinium (mpp(+))or[(3)h]dopamine from striatal synaptosomes ("dat-mediated da release") in a dose-dependent manner. |
2009-05-22 |
2023-08-12 |
Not clear |
| Melissa I Torres-Altoro, Kellie J White, Gustavo J Rodríguez, David E Nichols, Eric L Barke. Helix XI contributes to the entrance of the serotonin transporter permeation pathway. Protein science : a publication of the Protein Society. vol 17. issue 10. 2009-02-12. PMID:18628241. |
the sodium-dependent transporters for dopamine, norepinephrine, and serotonin that regulate neurotransmission, also translocate the neurotoxin 1-methyl-4-phenylpyridinium (mpp(+)). |
2009-02-12 |
2023-08-12 |
human |
| Shih-Ya Hung, Houng-Chi Liou, Kai-Hsiang Kang, Ruey-Meei Wu, Chun-Chiang Wen, Wen-Mei F. Overexpression of heme oxygenase-1 protects dopaminergic neurons against 1-methyl-4-phenylpyridinium-induced neurotoxicity. Molecular pharmacology. vol 74. issue 6. 2008-12-16. PMID:18799798. |
seven days after injection of mpp(+) and ad-ho-1, the brain was isolated for immunostaining and for measurement of dopamine content and inflammatory cytokines. |
2008-12-16 |
2023-08-12 |
human |
| Shih-Ya Hung, Houng-Chi Liou, Kai-Hsiang Kang, Ruey-Meei Wu, Chun-Chiang Wen, Wen-Mei F. Overexpression of heme oxygenase-1 protects dopaminergic neurons against 1-methyl-4-phenylpyridinium-induced neurotoxicity. Molecular pharmacology. vol 74. issue 6. 2008-12-16. PMID:18799798. |
it was found that overexpression of ho-1 significantly increased the survival rate of dopaminergic neurons; reduced the production of tumor necrosis factor alpha (tnf-alpha) and interleukin-1beta (il-1beta) in substantia nigra; antagonized the reduction of striatal dopamine content induced by mpp(+); and also up-regulated brain-derived neurotrophic factor (bdnf) and glial cell line-derived neurotrophic factor (gdnf) expression in substantia nigra. |
2008-12-16 |
2023-08-12 |
human |
| Shih-Ya Hung, Houng-Chi Liou, Kai-Hsiang Kang, Ruey-Meei Wu, Chun-Chiang Wen, Wen-Mei F. Overexpression of heme oxygenase-1 protects dopaminergic neurons against 1-methyl-4-phenylpyridinium-induced neurotoxicity. Molecular pharmacology. vol 74. issue 6. 2008-12-16. PMID:18799798. |
on the other hand, inhibition of ho enzymatic activity by zinc protoporphyrin-ix facilitated the mpp(+)-induced rotatory behavior and enhanced the reduction of dopamine content. |
2008-12-16 |
2023-08-12 |
human |
| Toshio Obata, Shigehiro Takahashi, Yoshitomo Kashiwagi, Shunichiro Kubot. Protective effect of captopril and enalaprilat, angiotensin-converting enzyme inhibitors, on para-nonylphenol-induced *OH generation and dopamine efflux in rat striatum. Toxicology. vol 250. issue 2-3. 2008-11-06. PMID:18611425. |
in this study we examined the antioxidant effects of angiotensin-converting enzyme inhibitors (captopril or enalaprilat) on para-nonylphenol (nonylphenol) and 1-methyl-4-phenylpyridinium ion (mpp(+))-induced hydroxyl radical (*oh) formation and dopamine (da) efflux in extracellular fluid of rat striatum, using a microdialysis technique. |
2008-11-06 |
2023-08-12 |
rat |
| D Shyamali Wimalasena, Rohan P Perera, Bruce J Heyen, Inoka S Balasooriya, Kandatege Wimalasen. Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: a structure-activity study. Journal of medicinal chemistry. vol 51. issue 4. 2008-05-19. PMID:18220329. |
in the present study we have synthesized and characterized a number of mptp and mpp(+) derivatives that are suitable for the comparative neurotoxicity and complex i inhibition versus dopamine metabolism perturbation studies. |
2008-05-19 |
2023-08-12 |
cattle |
| Chun-Hung Lin, Jui-Yen Huang, Cheng-Hsin Ching, Jih-Ing Chuan. Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats. Journal of pineal research. vol 44. issue 2. 2008-05-05. PMID:18289173. |
because the uptake of mpp(+) is mediated by the dopamine transporter (dat), we used a cell-permeable rotenone-induced pd model to investigate the role of dat and dopamine d2 receptor (d2r) on dopaminergic neuronal loss. |
2008-05-05 |
2023-08-12 |
rat |
| Rebecca Banerjee, Sen Sreetama, Karuppagounder S Saravanan, Sailendra Nath Dey, Kochupurackal P Mohanakuma. Apoptotic mode of cell death in substantia nigra following intranigral infusion of the parkinsonian neurotoxin, MPP+ in Sprague-Dawley rats: cellular, molecular and ultrastructural evidences. Neurochemical research. vol 32. issue 7. 2007-09-17. PMID:17401660. |
in the present study we investigated the nuclear morphology of cells in the substantia nigra pars compacta (snpc) region of rats following unilateral intranigral infusion of the active metabolite, 1-methyl-4-phenyl pyridinium ion (mpp(+)), which resulted in a dose-dependent and prolonged dopamine depletion in the ipsilateral striatum. |
2007-09-17 |
2023-08-12 |
rat |
| C C Chiueh, T Andoh, A R Lai, E Lai, G Krishn. Neuroprotective strategies in Parkinson's disease: protection against progressive nigral damage induced by free radicals. Neurotoxicity research. vol 2. issue 2-3. 2007-07-09. PMID:16787846. |
(.-)no and s-nitrosoglutathione (gsno) protect nigral neurons against oxidative stress caused by 1-methyl-4-phenylpyridinium (mpp(+)), dopamine, ferrous citrate, hemoglobin, sodium nitroprusside and peroxynitrite. |
2007-07-09 |
2023-08-12 |
human |
| C C Chiueh, T Andoh, A R Lai, E Lai, G Krishn. Neuroprotective strategies in Parkinson's disease: protection against progressive nigral damage induced by free radicals. Neurotoxicity research. vol 2. issue 2-3. 2007-07-09. PMID:16787846. |
mpp(+), the toxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), increases the nigral uptake of iron complexes and dopamine overflow leading to the generation of (.-)oh, protein oxidation, lipid peroxidation, and associated retrograde degeneration. |
2007-07-09 |
2023-08-12 |
human |
| Mona Bains, Joanne C Cousins, James L Robert. Neuroprotection by estrogen against MPP+-induced dopamine neuron death is mediated by ERalpha in primary cultures of mouse mesencephalon. Experimental neurology. vol 204. issue 2. 2007-06-26. PMID:17320868. |
we also found that 17beta-estradiol protects dopamine neurons from injury induced by the complex i inhibitor, 1-methyl-4-phenyl pyridinium (mpp(+)) in a time- and er-dependent manner. |
2007-06-26 |
2023-08-12 |
mouse |
| T Obat. Nitric oxide and MPP+-induced hydroxyl radical generation. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 9. 2007-05-02. PMID:16463115. |
although the [k(+)](o)-induced depolarization enhances the formation of (*)oh product due to mpp(+), the (*)oh generation via nos activation may be unrelated the dopamine (da)-induced (*)oh generation. |
2007-05-02 |
2023-08-12 |
Not clear |
| Timothy M Fountaine, Richard Wade-Martin. RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport. Journal of neuroscience research. vol 85. issue 2. 2007-03-29. PMID:17131421. |
rna interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from mpp(+) toxicity and reduces dopamine transport. |
2007-03-29 |
2023-08-12 |
human |
| Timothy M Fountaine, Richard Wade-Martin. RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport. Journal of neuroscience research. vol 85. issue 2. 2007-03-29. PMID:17131421. |
knockdown does, however, confer resistance to the dopamine transporter (dat)-dependent neurotoxin n-methyl-4-phenylpyridinium (mpp(+)). |
2007-03-29 |
2023-08-12 |
human |
| Timothy M Fountaine, Richard Wade-Martin. RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport. Journal of neuroscience research. vol 85. issue 2. 2007-03-29. PMID:17131421. |
these results show that rnai-mediated alpha-synuclein knockdown alters cellular dopamine homeostasis in human cells and may suggest a mechanism for the increased survival in the presence of mpp(+), a toxin used extensively to model parkinson's disease. |
2007-03-29 |
2023-08-12 |
human |
| Rebecca Banerjee, Sen Sreetama, Karuppagounder S Saravanan, Goutam Chandra, Sailendra Nath De, Kochupurackal P Mohanakuma. Intrastriatal infusion of the Parkinsonian neurotoxin, MPP(+), induces damage of striatal cell nuclei in Sprague-Dawley rats. Journal of chemical neuroanatomy. vol 32. issue 2-4. 2007-03-19. PMID:16822645. |
its neurotoxically active metabolite, 1-methyl-4-phenyl pyridinium (mpp(+)), has been examined in the present study to verify whether administration of the neurotoxin that depletes about 70% of the striatal dopamine (da) can cause damage to nuclear components of the cells at the terminal region, the striatum. |
2007-03-19 |
2023-08-12 |
rat |
| Jinghong Kou, David C Klorig, Jeffrey R Bloomquis. Potentiating effect of the ATP-sensitive potassium channel blocker glibenclamide on complex I inhibitor neurotoxicity in vitro and in vivo. Neurotoxicology. vol 27. issue 5. 2006-10-31. PMID:16725203. |
we measured the ability of mitochondrial inhibitors of complexes i (rotenone, mpp(+), and hpp(+)), ii (amdro), iv (na cyanide), and an uncoupler (dinoseb) to release preloaded dopamine from murine striatal synaptosomes. |
2006-10-31 |
2023-08-12 |
mouse |
| Rui Li, Ning Peng, Xu-Ping Li, Wei-Dong L. (-)-Epigallocatechin gallate regulates dopamine transporter internalization via protein kinase C-dependent pathway. Brain research. vol 1097. issue 1. 2006-10-06. PMID:16733047. |
dopamine transporter (dat) provides not only an integral component of dopaminergic neurotransmission but also a molecular gateway for the accumulation of some neurotoxins such as 1-methyl-4-phenylpyridinium (mpp(+)), a metabolite of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (mptp). |
2006-10-06 |
2023-08-12 |
Not clear |