| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andreas Lehner, Margaret Johnson, Tyrell Simkins, Kelly Janis, Keith Lookingland, John Goudreau, Wilson Rumbeih. Liquid chromatographic-electrospray mass spectrometric determination of 1-methyl-4-phenylpyridine (MPP+) in discrete regions of murine brain. Toxicology mechanisms and methods. vol 21. issue 3. 2011-06-17. PMID:21142843. |
simultaneous measurement of the mptp active metabolite mpp(+) and dopamine (da) in the brain would be helpful in mechanistic studies of this neurotoxin. |
2011-06-17 |
2023-08-12 |
mouse |
| Ken Hon-Hung Kwok, Philip Wing-Lok Ho, Andrew Chi-Yuen Chu, Jessica Wing-Man Ho, Hui-Fang Liu, David Chi-Wai Yiu, Koon-Ho Chan, Michelle Hiu-Wai Kung, David Boyer Ramsden, Shu-Leong H. Mitochondrial UCP5 is neuroprotective by preserving mitochondrial membrane potential, ATP levels, and reducing oxidative stress in MPP+ and dopamine toxicity. Free radical biology & medicine. vol 49. issue 6. 2011-03-15. PMID:20600837. |
mpp(+) and dopamine exposure for 6h reduced mmp and increased superoxide levels. |
2011-03-15 |
2023-08-12 |
human |
| Ken Hon-Hung Kwok, Philip Wing-Lok Ho, Andrew Chi-Yuen Chu, Jessica Wing-Man Ho, Hui-Fang Liu, David Chi-Wai Yiu, Koon-Ho Chan, Michelle Hiu-Wai Kung, David Boyer Ramsden, Shu-Leong H. Mitochondrial UCP5 is neuroprotective by preserving mitochondrial membrane potential, ATP levels, and reducing oxidative stress in MPP+ and dopamine toxicity. Free radical biology & medicine. vol 49. issue 6. 2011-03-15. PMID:20600837. |
atp levels in ucp5-overexpressing cells were preserved under mpp(+) and dopamine toxicity, comparable to levels in untreated vector controls. |
2011-03-15 |
2023-08-12 |
human |
| Ken Hon-Hung Kwok, Philip Wing-Lok Ho, Andrew Chi-Yuen Chu, Jessica Wing-Man Ho, Hui-Fang Liu, David Chi-Wai Yiu, Koon-Ho Chan, Michelle Hiu-Wai Kung, David Boyer Ramsden, Shu-Leong H. Mitochondrial UCP5 is neuroprotective by preserving mitochondrial membrane potential, ATP levels, and reducing oxidative stress in MPP+ and dopamine toxicity. Free radical biology & medicine. vol 49. issue 6. 2011-03-15. PMID:20600837. |
mpp(+) and dopamine exposure induced ucp5 mrna transcription but did not decrease transcript degradation, as inhibition of transcription by actinomycin-d abolished induction by either toxin. |
2011-03-15 |
2023-08-12 |
human |
| QingJia Meng, Dirk W Luchtman, Bouchaib El Bahh, Jeffrey A Zidichouski, Jun Yang, Cai Son. Ethyl-eicosapentaenoate modulates changes in neurochemistry and brain lipids induced by parkinsonian neurotoxin 1-methyl-4-phenylpyridinium in mouse brain slices. European journal of pharmacology. vol 649. issue 1-3. 2011-03-03. PMID:20868657. |
mpp(+) also depleted striatal dopamine levels and increased dopamine turnover, and depleted noradrenaline levels in the frontal cortex. |
2011-03-03 |
2023-08-12 |
mouse |
| Peng Wang, Le Niu, Xiao-Dong Guo, Li Gao, Wei-Xin Li, Dong Jia, Xue-Lian Wang, Lian-Ting Ma, Guo-Dong Ga. Gypenosides protects dopaminergic neurons in primary culture against MPP(+)-induced oxidative injury. Brain research bulletin. vol 83. issue 5. 2011-02-23. PMID:20615455. |
it was found that gps pretreatment, cotreatment or posttreatment significantly and dose-dependently attenuated mpp(+)-induced oxidative damage, reduction of dopamine uptake, loss of tyrosine hydrolase (th)-immunopositive neurons and degeneration of th-immunopositive neurites. |
2011-02-23 |
2023-08-12 |
Not clear |
| Vicky Lahaie-Collins, Julie Bournival, Marilyn Plouffe, Julie Carange, Maria-Grazia Martinol. Sesamin modulates tyrosine hydroxylase, superoxide dismutase, catalase, inducible NO synthase and interleukin-6 expression in dopaminergic cells under MPP+-induced oxidative stress. Oxidative medicine and cellular longevity. vol 1. issue 1. 2011-01-28. PMID:19794909. |
we used 1-methyl-4-phenyl-pyridine (mpp(+)) ion, the active metabolite of the potent parkinsonism-causing toxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, to produce oxidative stress and neurodegeneration in neuronal pc12 cells, which express dopamine, as well as neurofilaments. |
2011-01-28 |
2023-08-12 |
Not clear |
| Sarah K Kidd, Jay S Schneide. Protection of dopaminergic cells from MPP+-mediated toxicity by histone deacetylase inhibition. Brain research. vol 1354. 2011-01-03. PMID:20654591. |
although the pathophysiological processes involved in dopamine (da) neuron degeneration in parkinson's disease (pd) are not completely known, apoptotic cell death has been suggested to be involved and can be modeled in daergic cell lines using the mitochondrial toxin 1-methyl-4-phenylpyridinium (mpp(+)). |
2011-01-03 |
2023-08-12 |
human |
| Horace T B Ho, Joanne Wan. Tyrosine 112 is essential for organic cation transport by the plasma membrane monoamine transporter. Biochemistry. vol 49. issue 36. 2010-11-03. PMID:20687515. |
the six tyrosines and one tryptophan in this region were each mutated to alanine followed by analysis of the mutant's membrane localization and transport activity toward 1-methyl-4-phenylpyridinium (mpp(+)), serotonin (5-ht), and dopamine. |
2010-11-03 |
2023-08-12 |
Not clear |
| Horace T B Ho, Joanne Wan. Tyrosine 112 is essential for organic cation transport by the plasma membrane monoamine transporter. Biochemistry. vol 49. issue 36. 2010-11-03. PMID:20687515. |
tryptophan substitution at y112 partially restored transport activity toward 5-ht and dopamine but severely impaired mpp(+) transport. |
2010-11-03 |
2023-08-12 |
Not clear |
| Banthit Chetsawang, Jirapa Chetsawang, Piyarat Govitrapon. Protection against cell death and sustained tyrosine hydroxylase phosphorylation in hydrogen peroxide- and MPP-treated human neuroblastoma cells with melatonin. Journal of pineal research. vol 46. issue 1. 2010-09-21. PMID:18507712. |
in addition, the reduction of phosphorylation of tyrosine hydroxylase, the rate limiting enzyme in dopamine synthesis, and phosphorylation of cyclic amp responsive element-binding protein by h(2)o(2) and mpp(+) was also diminished by melatonin. |
2010-09-21 |
2023-08-12 |
human |
| F Pérez-Sánchez, M Milán, P Buendía, M Cano-Jaimez, S Ambrosio, A Rosenthal, I Fariña. Prosurvival effect of human wild-type alpha-synuclein on MPTP-induced toxicity to central but not peripheral catecholaminergic neurons isolated from transgenic mice. Neuroscience. vol 167. issue 2. 2010-06-17. PMID:20156526. |
surprisingly, cultured transgenic ventral mesencephalic fetal dopaminergic neurons exhibit complete resistance to cell death induced by 1-methyl-4-phenylpyridinium ion (mpp(+)) intoxication, without changes in dopamine transporter (dat) surface levels. |
2010-06-17 |
2023-08-12 |
mouse |
| Andrew Chi-Yuen Chu, Philip Wing-Lok Ho, Ken Hon-Hung Kwok, Jessica Wing-Man Ho, Koon-Ho Chan, Hui-Fang Liu, Michelle Hiu-Wai Kung, David Boyer Ramsden, Shu-Leong H. Mitochondrial UCP4 attenuates MPP+ - and dopamine-induced oxidative stress, mitochondrial depolarization, and ATP deficiency in neurons and is interlinked with UCP2 expression. Free radical biology & medicine. vol 46. issue 6. 2009-12-07. PMID:19150400. |
we explored the neuroprotective role of ucp4 with its stable overexpression in sh-sy5y cells, after exposure to either mpp(+) or dopamine to induce atp deficiency and oxidative stress. |
2009-12-07 |
2023-08-12 |
Not clear |
| Andrew Chi-Yuen Chu, Philip Wing-Lok Ho, Ken Hon-Hung Kwok, Jessica Wing-Man Ho, Koon-Ho Chan, Hui-Fang Liu, Michelle Hiu-Wai Kung, David Boyer Ramsden, Shu-Leong H. Mitochondrial UCP4 attenuates MPP+ - and dopamine-induced oxidative stress, mitochondrial depolarization, and ATP deficiency in neurons and is interlinked with UCP2 expression. Free radical biology & medicine. vol 46. issue 6. 2009-12-07. PMID:19150400. |
cells overexpressing ucp4 proliferated faster in normal cultures and after exposure to mpp(+) and dopamine. |
2009-12-07 |
2023-08-12 |
Not clear |
| Dingzhen Luo, Quanbin Zhang, Haomin Wang, Yanqiu Cui, Zuoli Sun, Jian Yang, Yan Zheng, Jun Jia, Fen Yu, Xuan Wang, Xiaomin Wan. Fucoidan protects against dopaminergic neuron death in vivo and in vitro. European journal of pharmacology. vol 617. issue 1-3. 2009-11-30. PMID:19545563. |
here we investigated the effect of fucoidan treatment on locomoter activities of animals, striatal dopamine and its metabolites and survival of nigral dopaminergic neurons in mptp-induced animal model of parkinsonism in c57/bl mice in vivo and on the neuronal damage induced by 1-methyl-4-phenylpyridinium (mpp(+)) in vitro, and to study the possible mechanisms. |
2009-11-30 |
2023-08-12 |
mouse |
| Stefan Schildknecht, Dominik Pöltl, Daniel M Nagel, Florian Matt, Diana Scholz, Julie Lotharius, Nathalie Schmieg, Alberto Salvo-Vargas, Marcel Leis. Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells. Toxicology and applied pharmacology. vol 241. issue 1. 2009-11-04. PMID:19647008. |
block of the dopamine transporter by gbr 12909 or mazindol completely abrogated mpp(+) toxicity. |
2009-11-04 |
2023-08-12 |
human |
| Seema Singh, Kavita Singh, Satya Prakash Gupta, Devendra Kumar Patel, Vinod Kumar Singh, Raj Kumar Singh, Mahendra Pratap Sing. Effect of caffeine on the expression of cytochrome P450 1A2, adenosine A2A receptor and dopamine transporter in control and 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyridine treated mouse striatum. Brain research. vol 1283. 2009-10-23. PMID:19520064. |
tyrosine hydroxylase immunoreactivity, levels of dopamine and 1-methyl 4-phenylpyridinium ion (mpp(+)), expressions of cyp1a2, adenosine a(2a) receptor and dat and cyp1a2 catalytic activity were measured in control and treated mouse brain. |
2009-10-23 |
2023-08-12 |
mouse |
| Seema Singh, Kavita Singh, Devendra Kumar Patel, Chetna Singh, Chandishwar Nath, Vinod Kumar Singh, Raj Kumar Singh, Mahendra Pratap Sing. The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection. Rejuvenation research. vol 12. issue 3. 2009-09-22. PMID:19594327. |
tyrosine hydroxylase (th)-immunoreactivity in the substantia nigra, the expression of nicotinic acetylcholine receptors (nachrs) alpha6 and alpha4, dopamine content, and 1-methyl-4-phenylpyridinium ion (mpp(+)) level in the striatum were measured to confirm the mptp-induced pd phenotype and nicotine-mediated neuroprotection. |
2009-09-22 |
2023-08-12 |
mouse |
| Seema Singh, Kavita Singh, Devendra Kumar Patel, Chetna Singh, Chandishwar Nath, Vinod Kumar Singh, Raj Kumar Singh, Mahendra Pratap Sing. The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection. Rejuvenation research. vol 12. issue 3. 2009-09-22. PMID:19594327. |
cyp2d22 and nachrs expressions were measured in the striatum by rt-pcr/western blotting and dopamine level; cyp2d22 catalytic activity and mpp(+) content were determined by high-performance liquid chromatography (hplc). |
2009-09-22 |
2023-08-12 |
mouse |
| Seema Singh, Kavita Singh, Devendra Kumar Patel, Chetna Singh, Chandishwar Nath, Vinod Kumar Singh, Raj Kumar Singh, Mahendra Pratap Sing. The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection. Rejuvenation research. vol 12. issue 3. 2009-09-22. PMID:19594327. |
mptp increased dopaminergic neuronal degeneration and the striatal mpp(+) level and reduced striatal dopamine content; it attenuated expression/activity of cyp2d22 and nachrs that were significantly restored in nicotine-treated animals. |
2009-09-22 |
2023-08-12 |
mouse |