| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P K Sonsalla, G D Zeevalk, L Manzino, A Giovanni, W J Nickla. MK-801 fails to protect against the dopaminergic neuropathology produced by systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice or intranigral 1-methyl-4-phenylpyridinium in rats. Journal of neurochemistry. vol 58. issue 5. 1992-05-11. PMID:1560247. |
(1991), the extended treatment of rats with mk-801 did not prevent mpp(+)-induced cell loss in the infused substantia nigra pars compacta or the dopamine depletion in the ipsilateral neostriatum at 7-11 days after mpp+ infusion. |
1992-05-11 |
2023-08-11 |
mouse |
| A Vaccari, M Del Zompo, F Melis, G L Gessa, Z L Rossett. Interaction of 1-methyl-4-phenylpyridinium ion and tyramine with a site putatively involved in the striatal vesicular release of dopamine. British journal of pharmacology. vol 104. issue 3. 1992-04-16. PMID:1797320. |
tetrabenazine, an established ligand for the vesicular catecholamine carrier, potently inhibited [3h]-tyramine binding, tyramine-provoked striatal efflux of dopamine and the fast component of mpp(+)-induced dopamine release. |
1992-04-16 |
2023-08-11 |
Not clear |
| T D Buckma. Toxicity of MPTP and structural analogs in clonal cell lines of neuronal origin expressing B type monoamine oxidase activity. Molecular and chemical neuropathology. vol 15. issue 2. 1992-03-09. PMID:1776993. |
inhibitors of serotonin and dopamine uptake, which have been found to protect against mptp toxicity in vivo, were generally ineffective in the cell cultures, with the exception of a marginal increase in survival of mpp(+)-treated 140-3 cells in the presence of the serotonin uptake inhibitor fluoxetine. |
1992-03-09 |
2023-08-11 |
mouse |
| D J Sirinathsinghji, S B Dunnett, A J Northrop, B J Morri. Experimental hemiparkinsonism in the rat following chronic unilateral infusion of MPP+ into the nigrostriatal dopamine pathway--III. Reversal by embryonic nigral dopamine grafts. Neuroscience. vol 37. issue 3. 1991-01-08. PMID:2247221. |
autoradiographic analysis of [125i]sulpiride binding to striatal sections showed a 27% increase in dopamine d2 receptor density in the ipsilateral striatum of mpp(+)-lesioned animals. |
1991-01-08 |
2023-08-11 |
rat |
| D J Sirinathsinghji, S B Dunnett, A J Northrop, B J Morri. Experimental hemiparkinsonism in the rat following chronic unilateral infusion of MPP+ into the nigrostriatal dopamine pathway--III. Reversal by embryonic nigral dopamine grafts. Neuroscience. vol 37. issue 3. 1991-01-08. PMID:2247221. |
this increase in d2 receptor density was completely abolished by the dopamine grafts so that the d2 receptor density in the grafted striatum was similar to the contralateral striatum of mpp(+)-lesioned animals. |
1991-01-08 |
2023-08-11 |
rat |
| J A Javitch, S H Snyde. Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP. European journal of pharmacology. vol 106. issue 2. 1985-04-26. PMID:6335692. |
uptake of mpp(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, mptp. |
1985-04-26 |
2023-08-12 |
Not clear |