| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Obata, Y Yamanak. Nitric oxide enhances MPP(+)-induced hydroxyl radical generation via depolarization activated nitric oxide synthase in rat striatum. Brain research. vol 902. issue 2. 2001-08-09. PMID:11384616. |
dopamine (da; 10 microm) also increased the levels of dhba due to mpp(+). |
2001-08-09 |
2023-08-12 |
rat |
| S Barc, G Page, B Fauconneau, L Barrier, F Hugue. A new in vitro approach for investigating the MPTP effect on DA uptake. Neurochemistry international. vol 38. issue 3. 2001-04-19. PMID:11099783. |
previous studies have shown that dopamine (da) uptake was decreased after preincubation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) or 1-methyl-4-phenylpyridinium (mpp(+)) in in vitro slice and synaptosome models. |
2001-04-19 |
2023-08-12 |
rat |
| J Bas, M Calopa, M Mestre, D G Molleví, B Cutillas, S Ambrosio, E Buendi. Lymphocyte populations in Parkinson's disease and in rat models of parkinsonism. Journal of neuroimmunology. vol 113. issue 1. 2001-02-08. PMID:11137586. |
in addition, we performed striatal dopamine depletion in rats with either mpp(+) or 6-ohda, showing that mpp(+) but not 6-ohda can increase cd4(+)cd25(+) lymphocytes. |
2001-02-08 |
2023-08-12 |
rat |
| J Lotharius, K L O'Malle. The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity. The Journal of biological chemistry. vol 275. issue 49. 2001-01-18. PMID:10969076. |
the present study indicates that mpp(+)-induced ros formation is not mitochondrial in origin but results from intracellular dopamine (da) oxidation. |
2001-01-18 |
2023-08-12 |
Not clear |
| K Pong, S R Doctrow, M Baudr. Prevention of 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neurons. Brain research. vol 881. issue 2. 2001-01-04. PMID:11036157. |
exposure of cultures to 10 microm mpp(+) reduced dopamine (da) uptake and the number of tyrosine hydroxylase immunoreactive (thir) neurons to 56 and 52% of control, while exposure to 30 microm 6-ohda reduced da uptake and the number of thir neurons to 58 and 59% of control, respectively. |
2001-01-04 |
2023-08-12 |
Not clear |
| S Moussaoui, M C Obinu, N Daniel, M Reibaud, V Blanchard, A Imperat. The antioxidant ebselen prevents neurotoxicity and clinical symptoms in a primate model of Parkinson's disease. Experimental neurology. vol 166. issue 2. 2001-01-04. PMID:11085889. |
moreover, ebselen inhibits mpp(+)-induced toxicity in pc12 cells, without interacting with the dopamine uptake system. |
2001-01-04 |
2023-08-12 |
rat |
| T Obata, Y Yamanak. Methamphetamine enhances 1-methyl-4-phenylpyridinium ion-induced hydroxyl radical generation in the rat striatum. Neuroscience letters. vol 292. issue 1. 2000-10-25. PMID:10996448. |
we determined the methamphetamine (ma), a potent dopamine (da) releaser, enhances 1-methyl-4-phenylpyridinium ion (mpp(+))-induced hydroxyl radical (&z.rad;oh) generation in the rat striatum. |
2000-10-25 |
2023-08-12 |
rat |
| J M Van Kampen, E G McGeer, A J Stoess. Dopamine transporter function assessed by antisense knockdown in the rat: protection from dopamine neurotoxicity. Synapse (New York, N.Y.). vol 37. issue 3. 2000-10-06. PMID:10881039. |
recent studies have implicated the dopamine transporter in the uptake of both this neurotoxin and its metabolite, mpp(+), as well as another experimental neurotoxin, 6-hydroxydopamine. |
2000-10-06 |
2023-08-12 |
rat |
| J M Van Kampen, E G McGeer, A J Stoess. Dopamine transporter function assessed by antisense knockdown in the rat: protection from dopamine neurotoxicity. Synapse (New York, N.Y.). vol 37. issue 3. 2000-10-06. PMID:10881039. |
in these studies we examined the role of the dopamine transporter in the neurotoxicity of both mpp(+) and 6-hydroxydopamine in the rat brain using in vivo administration of phosphorothioate antisense oligonucleotides targeting dopamine transporter mrna. |
2000-10-06 |
2023-08-12 |
rat |
| J M Van Kampen, E G McGeer, A J Stoess. Dopamine transporter function assessed by antisense knockdown in the rat: protection from dopamine neurotoxicity. Synapse (New York, N.Y.). vol 37. issue 3. 2000-10-06. PMID:10881039. |
unilateral pretreatment with dopamine transporter antisense prior to bilateral intrastriatal infusion of either mpp(+) or 6-hydroxydopamine resulted in asymmetrical striatal (3)h-win 35-428 binding and dopamine content as well as significant apomorphine-induced ipsilateral rotations, suggesting neuroprotection of nigrostriatal neurons on the antisense-treated side. |
2000-10-06 |
2023-08-12 |
rat |
| J M Van Kampen, E G McGeer, A J Stoess. Dopamine transporter function assessed by antisense knockdown in the rat: protection from dopamine neurotoxicity. Synapse (New York, N.Y.). vol 37. issue 3. 2000-10-06. PMID:10881039. |
thus, the dopamine transporter appears to play a critical role in determining susceptibility to the experimental neurotoxins mpp(+) and 6-hydroxydopamine. |
2000-10-06 |
2023-08-12 |
rat |
| M Arvin, L Fedorkova, K A Disshon, D E Dluzen, R E Leipheime. Estrogen modulates responses of striatal dopamine neurons to MPP(+): evaluations using in vitro and in vivo techniques. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924688. |
estrogen modulates responses of striatal dopamine neurons to mpp(+): evaluations using in vitro and in vivo techniques. |
2000-09-20 |
2023-08-12 |
rat |
| M Arvin, L Fedorkova, K A Disshon, D E Dluzen, R E Leipheime. Estrogen modulates responses of striatal dopamine neurons to MPP(+): evaluations using in vitro and in vivo techniques. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924688. |
in vitro superfusion and in vivo electrochemistry were used to investigate the role of estrogen in modulating mpp(+)-induced dopamine output in the corpus striatum and nucleus accumbens of ovariectomized female rats. |
2000-09-20 |
2023-08-12 |
rat |
| M Arvin, L Fedorkova, K A Disshon, D E Dluzen, R E Leipheime. Estrogen modulates responses of striatal dopamine neurons to MPP(+): evaluations using in vitro and in vivo techniques. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924688. |
for in vitro superfusion experiments, dopamine and dihydroxyphenylacetic acid release were determined using hplc with electrochemical detection from superfusion of corpus striatum fragments with kreb's ringer phosphate buffer pulsed with mpp(+) alone or mpp(+) with estrogen. |
2000-09-20 |
2023-08-12 |
rat |
| M Arvin, L Fedorkova, K A Disshon, D E Dluzen, R E Leipheime. Estrogen modulates responses of striatal dopamine neurons to MPP(+): evaluations using in vitro and in vivo techniques. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924688. |
dopamine release was stimulated by pressure ejection of mpp(+) alone or in combination with estrogen through glass micropipettes fastened to the electrodes. |
2000-09-20 |
2023-08-12 |
rat |
| M Arvin, L Fedorkova, K A Disshon, D E Dluzen, R E Leipheime. Estrogen modulates responses of striatal dopamine neurons to MPP(+): evaluations using in vitro and in vivo techniques. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924688. |
dopamine output from superfusion chambers which received infusion of mpp(+) with estrogen showed significantly lower output of dopamine compared with chambers which received mpp(+) alone. |
2000-09-20 |
2023-08-12 |
rat |
| M Arvin, L Fedorkova, K A Disshon, D E Dluzen, R E Leipheime. Estrogen modulates responses of striatal dopamine neurons to MPP(+): evaluations using in vitro and in vivo techniques. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924688. |
data from the electrochemistry experiments demonstrated that estrogen significantly reduced both the amplitude and clearance rates of the mpp(+)-evoked dopamine signal in both the corpus striatum and nucleus accumbens. |
2000-09-20 |
2023-08-12 |
rat |
| M Arvin, L Fedorkova, K A Disshon, D E Dluzen, R E Leipheime. Estrogen modulates responses of striatal dopamine neurons to MPP(+): evaluations using in vitro and in vivo techniques. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924688. |
results of this study demonstrate that: (1) mpp(+) evokes striatal dopamine release and this effect is significantly reduced in the presence of estrogen as determined by both in vivo electrochemistry and in vitro superfusion: (2) similar, albeit attenuated effects are observed in the nucleus accumbens as determined with in vivo electrochemistry; (3) estrogen acts to inhibit the clearance of dopamine in both the striatum and nucleus accumbens; and (4) estrogen may function as a neuroprotectant by reducing the uptake of neurotoxin into dopaminergic neurons. |
2000-09-20 |
2023-08-12 |
rat |
| K A Disshon, D E Dluze. Estrogen reduces acute striatal dopamine responses in vivo to the neurotoxin MPP+ in female, but not male rats. Brain research. vol 868. issue 1. 2000-08-04. PMID:10841892. |
the effects of in vivo estrogen treatment upon mpp(+)-induced dopamine (da) release were determined using in vivo microdialysis in female and male rats. |
2000-08-04 |
2023-08-12 |
rat |
| R G Staal, K A Hogan, C L Liang, D C German, P K Sonsall. In vitro studies of striatal vesicles containing the vesicular monoamine transporter (VMAT2): rat versus mouse differences in sequestration of 1-methyl-4-phenylpyridinium. The Journal of pharmacology and experimental therapeutics. vol 293. issue 2. 2000-06-21. PMID:10772999. |
significant differences exist in the sensitivity of mice and rats to the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) that cannot be explained by differences in exposure to or uptake of 1-methyl-4-phenylpyridinium (mpp(+)) into dopamine (da) neurons. |
2000-06-21 |
2023-08-12 |
mouse |