| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard H Barnes, Takeshi Akama, Miina K Öhman, Moon-Sook Woo, Julian Bahr, Stephen J Weiss, Daniel T Eitzman, Tae-Hwa Chu. Membrane-Tethered Metalloproteinase Expressed by Vascular Smooth Muscle Cells Limits the Progression of Proliferative Atherosclerotic Lesions. Journal of the American Heart Association. vol 6. issue 7. 2018-04-30. PMID:28735290. |
unlike secreted-type mmps, a member of the membrane-type mmp family, mt1-mmp (membrane-type 1 mmp; mmp14), mediates pericellular extracellular matrix degradation that is indispensable for maintaining physiological extracellular matrix homeostasis. |
2018-04-30 |
2023-08-13 |
mouse |
| Anthony K McNeel, Jeff D Ondrak, Olivia L Amundson, Tara H Fountain, Elane C Wright, Katherine J Whitman, Carol G Chitko-McKown, Shuna A Jones, Chadwick C Chase, Robert A Cushma. Timing of transcriptomic and proteomic changes in the bovine placentome after parturition. Theriogenology. vol 100. 2018-04-11. PMID:28708523. |
relative transcript abundance of matrix metalloprotease 14 (mmp14) tended to increase with time (p = 0.06). |
2018-04-11 |
2023-08-13 |
cattle |
| Weiliang Chen, Tongliang Xia, Donghai Wang, Bin Huang, Peng Zhao, Jian Wang, Xun Qu, Xingang L. Human astrocytes secrete IL-6 to promote glioma migration and invasion through upregulation of cytomembrane MMP14. Oncotarget. vol 7. issue 38. 2018-03-26. PMID:27613828. |
membrane type 1 matrix metalloproteinase (mmp14) originating from glioma cells was identified in qrt-pcr as the most highly up-regulated member of the mmp family of genes (~ 3 fold, p < 0.05) in this system. |
2018-03-26 |
2023-08-13 |
human |
| Hao Qiu, Xu Xu, Min Liu, Zerong Wang, Yaqin Yuan, Chunliang Liu, Lan Xu, Shiliang W. RNA interference-mediated silencing of ppGalNAc-T1 and ppGalNAc-T2 inhibits invasion and increases chemosensitivity potentially by reducing terminal α2,3 sialylation and MMP14 expression in triple‑negative breast cancer cells. Molecular medicine reports. vol 15. issue 6. 2018-03-05. PMID:28393207. |
in addition, immunoprecipitation assays demonstrated that downregulation of ppgalnac‑t1 led to a reduction in the number of terminal α2,3 sialic acids on o‑linked glycans of the matrix metalloproteinase‑14 (mmp14) glycoprotein. |
2018-03-05 |
2023-08-13 |
Not clear |
| Cheng-Ning Yang, Min-Fang Wu, Chung-Chih Liu, Wei-Hung Jung, Yu-Chin Chang, Wang-Pao Lee, Young-Ji Shiao, Chia-Lin Wu, Horng-Huei Liou, Sze-Kwan Lin, Chih-Chiang Cha. Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia. Human molecular genetics. vol 26. issue 20. 2018-03-05. PMID:29016849. |
ctgf enhanced extracellular aβ degradation via membrane-bound matrix metalloproteinase-14 (mmp14) in glia and extracellular mmp13 in neurons. |
2018-03-05 |
2023-08-13 |
drosophila_melanogaster |
| Jochen Neuhaus, Eric Schiffer, Ferdinando Mannello, Lars-Christian Horn, Roman Ganzer, Jens-Uwe Stolzenbur. Protease Expression Levels in Prostate Cancer Tissue Can Explain Prostate Cancer-Associated Seminal Biomarkers-An Explorative Concept Study. International journal of molecular sciences. vol 18. issue 5. 2018-02-12. PMID:28471417. |
we found differential gene expression of chymase (cma1), matrix metalloproteinases (mmp3, mmp7), and upregulation of mmp14 and tissue inhibitors (timp1 and timp2) in bph. |
2018-02-12 |
2023-08-13 |
Not clear |
| David C Morris, Julia L Popp, Leung K Tang, Holly C Gibbs, Emily Schmitt, Sankar P Chaki, Briana C Bywaters, Alvin T Yeh, Weston W Porter, Robert C Burghardt, Rola Barhoumi, Gonzalo M River. Nck deficiency is associated with delayed breast carcinoma progression and reduced metastasis. Molecular biology of the cell. vol 28. issue 24. 2018-01-19. PMID:28954862. |
we show that nck advances breast carcinoma cell invasion by regulating actin dynamics at invadopodia and enhancing focalized extracellular matrix proteolysis by directing the delivery and accumulation of mmp14 at the cell surface. |
2018-01-19 |
2023-08-13 |
Not clear |
| Georgina S Butler, Andrea R Connor, Nor Eddine Sounni, Ulrich Eckhard, Charlotte J Morrison, Agnès Noël, Christopher M Overal. Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2). Matrix biology : journal of the International Society for Matrix Biology. vol 59. 2018-01-05. PMID:27471094. |
degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (mmp14) substrates: ccn3 (nov) and ccn5 (wisp2). |
2018-01-05 |
2023-08-13 |
Not clear |
| b' P Urban, M Rabajdov\\xc3\\xa1, B Velik\\xc3\\xa1, I \\xc5\\xa0pakov\\xc3\\xa1, B Boler\\xc3\\xa1zska, M Marekov\\xc3\\xa. [The Importance of MITF Signaling Pathway in the Regulation of Proliferation and Invasiveness of Malignant Melanoma]. Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti. vol 29. issue 5. 2017-12-05. PMID:27739313.' |
mitf-m is also involved in matrix metalloproteinase 14 (mmp14) activity, which is responsible for shape changes in melanocytes and increases in their motility and invasiveness. |
2017-12-05 |
2023-08-13 |
human |
| M Swayampakula, P C McDonald, M Vallejo, E Coyaud, S C Chafe, A Westerback, G Venkateswaran, J Shankar, G Gao, E M N Laurent, Y Lou, K L Bennewith, C T Supuran, I R Nabi, B Raught, S Dedha. The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion. Oncogene. vol 36. issue 45. 2017-12-01. PMID:28692057. |
high confidence proteins identified include metabolic transporters, β1 integrins, integrin-associated protein cd98hc and matrix metalloprotease 14 (mmp14). |
2017-12-01 |
2023-08-13 |
Not clear |
| Tammy N Jessen, Jason R Jesse. VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix. Experimental cell research. vol 361. issue 2. 2017-11-29. PMID:29097183. |
using an in vitro cell culture model system, we previously showed that human vangl2 negatively regulates membrane type-1 matrix metalloproteinase (mmp14) and activation of secreted matrix metalloproteinase 2 (mmp2). |
2017-11-29 |
2023-08-13 |
human |
| Anh Tuan Nguyen, Joanne Chia, Manon Ros, Kam Man Hui, Frederic Saltel, Frederic Bar. Organelle Specific O-Glycosylation Drives MMP14 Activation, Tumor Growth, and Metastasis. Cancer cell. vol 32. issue 5. 2017-11-27. PMID:29136507. |
unlike its golgi-localized counterpart, er-g1 glycosylates the matrix metalloproteinase mmp14, a process required for tumor expansion. |
2017-11-27 |
2023-08-13 |
mouse |
| Yankun Liu, Yingnan Zhang, Haidong Wu, Yufeng Li, Yi Zhang, Min Liu, Xin Li, Hua Tan. miR-10a suppresses colorectal cancer metastasis by modulating the epithelial-to-mesenchymal transition and anoikis. Cell death & disease. vol 8. issue 4. 2017-11-20. PMID:28383561. |
furthermore, matrix metalloproteinase 14 (mmp14) and actin gamma 1 (actg1) were validated as target genes of mir-10a in crc cells. |
2017-11-20 |
2023-08-13 |
Not clear |
| Syndia Lazarus, Hsu-Wen Tseng, Felicity Lawrence, Maria A Woodruff, Emma L Duncan, Allison R Petti. Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders. The American journal of pathology. vol 187. issue 9. 2017-09-14. PMID:28675805. |
multicentric carpal-tarsal osteolysis; multicentric osteolysis, nodulosis, and arthropathy; and winchester syndromes, skeletal dysplasias characterized by carpal/tarsal and epiphyseal abnormalities, are caused by mutations in v-maf musculoaponeurotic fibrosarcoma oncogene ortholog b (mafb), matrix metalloproteinase (mmp) 2, and mmp14, respectively; however, the underlying pathophysiology is unclear. |
2017-09-14 |
2023-08-13 |
mouse |
| Tamar Y Feinberg, R Grant Rowe, Thomas L Saunders, Stephen J Weis. Functional roles of MMP14 and MMP15 in early postnatal mammary gland development. Development (Cambridge, England). vol 143. issue 21. 2017-09-11. PMID:27633994. |
currently, branching morphogenesis is thought to depend on the mobilization of the membrane-anchored matrix metalloproteinases mmp14 (mt1-mmp) and mmp15 (mt2-mmp), which drive epithelial cell invasion by remodeling the extracellular matrix and triggering associated signaling cascades. |
2017-09-11 |
2023-08-13 |
mouse |
| Ghodratolah Naseh, Mahyar Mohammadifard, Mahtab Mohammadifar. Upregulation of cyclin-dependent kinase 7 and matrix metalloproteinase-14 expression contribute to metastatic properties of gastric cancer. IUBMB life. vol 68. issue 10. 2017-08-11. PMID:27562173. |
the aim of this study was to evaluate the protein and mrna expressions of matrix metalloproteinase-14 (mmp14) and cdk7 in gastric cancer (gc) tissues. |
2017-08-11 |
2023-08-13 |
Not clear |
| Kirtiman Srivastava, Adam Pickard, Simon McDade, Dennis J McCanc. p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK signalling. Oncotarget. vol 8. issue 10. 2017-07-07. PMID:26001294. |
in addition, specific inhibition of fak (pf573228) or src (dasatinib) activities mitigated invasion and attenuated the expression/activity of matrix metalloproteinase 14 (mmp14), a pivotal mmp in the mmp activation cascade. |
2017-07-07 |
2023-08-13 |
human |
| Kirtiman Srivastava, Adam Pickard, Simon McDade, Dennis J McCanc. p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK signalling. Oncotarget. vol 8. issue 10. 2017-07-07. PMID:26001294. |
depletion of src, fak or akt in the invasive cells normalised the expression/activity of c-jun and mmp14, thus implicating the src-fak/akt/ap-1 signalling in mmp14-mediated extra-cellular matrix remodelling. |
2017-07-07 |
2023-08-13 |
human |
| Kyu-Yeon Han, Jin-Hong Chang, Hyun Lee, Dimitri T Aza. Proangiogenic Interactions of Vascular Endothelial MMP14 With VEGF Receptor 1 in VEGFA-Mediated Corneal Angiogenesis. Investigative ophthalmology & visual science. vol 57. issue 7. 2017-06-12. PMID:27327585. |
matrix metalloproteinase 14 (mmp14) has been shown to be required for corneal angiogenesis. |
2017-06-12 |
2023-08-13 |
Not clear |
| Marcin Stawowczyk, Max D Wellenstein, Sharrell B Lee, Shira Yomtoubian, Anna Durrans, Hyejin Choi, Navneet Narula, Nasser K Altorki, Dingcheng Gao, Vivek Mitta. Matrix Metalloproteinase 14 promotes lung cancer by cleavage of Heparin-Binding EGF-like Growth Factor. Neoplasia (New York, N.Y.). vol 19. issue 2. 2017-05-04. PMID:28013056. |
matrix metalloproteinase 14 (mmp14), a membrane-bound proteinase, was significantly up-regulated in the tumor epithelial cells and intratumoral myeloid compartments in both mouse and human nsclc. |
2017-05-04 |
2023-08-13 |
mouse |