| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xionghui Ding, Li Xiang, Ning Wang, Zhanbo Zhao, Xin Jin, Yanhui Sun, Wenjuan Duan, Shiqi Wang, Xianqing Ji. Vandetanib-induced inhibition of neuroblastoma cell migration and invasion is associated with downregulation of the SDF-1/CXCR4 axis and matrix metalloproteinase 14. Oncology reports. vol 31. issue 3. 2014-09-26. PMID:24399074. |
in addition, our data showed that the levels of c-x-c chemokine receptor type 4 (cxcr4) and matrix metalloproteinase 14 (mmp14) mrna expression in nb cell lines treated with vandetanib were significantly lower than those in the cells that were treated with vehicle (p<0.01) and similar results were obtained for protein levels as determined by western blotting and immunofluorescence analysis. |
2014-09-26 |
2023-08-12 |
human |
| H Lu, L Hu, L Yu, X Wang, A M Urvalek, T Li, C Shen, D Mukherjee, S K Lahiri, M S Wason, J Zha. KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer. Oncogene. vol 33. issue 22. 2014-07-22. PMID:23812425. |
we have recently demonstrated that klf8 expression enhances the activity but not expression of matrix metalloproteinase-2 (mmp2), the target substrate of mmp14. |
2014-07-22 |
2023-08-12 |
mouse |
| Florian Thuma, Honoré Ngora, Margot Zölle. The metastasis-associated molecule C4.4A promotes tissue invasion and anchorage independence by associating with the alpha6beta4 integrin. Molecular oncology. vol 7. issue 5. 2014-04-18. PMID:23727360. |
asml-c4.4akd cells display reduced migratory activity and impaired matrix protein degradation due to inefficient mmp14 activation; loss of drug-resistance is due to mitigated pi3k/akt pathway activation. |
2014-04-18 |
2023-08-12 |
rat |
| Florian Thuma, Honoré Ngora, Margot Zölle. The metastasis-associated molecule C4.4A promotes tissue invasion and anchorage independence by associating with the alpha6beta4 integrin. Molecular oncology. vol 7. issue 5. 2014-04-18. PMID:23727360. |
within this raft-located complex, mmp14 provokes focalized matrix degradation and mostly alpha6beta4 integrin promotes bad phosphorylation and upregulated bcl2 and bclxl expression. |
2014-04-18 |
2023-08-12 |
rat |
| Chun-Jun Li, Yu Liu, Yan Chen, Demin Yu, Kevin Jon Williams, Ming-Lin Li. Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke. The American journal of pathology. vol 182. issue 5. 2014-03-25. PMID:23499464. |
we found that mvs released from tse-exposed macrophages carry substantial gelatinolytic and collagenolytic activities that surprisingly can be predominantly attributed to a single transmembrane protease of the matrix metalloproteinase (mmp) superfamily (namely, mmp14). |
2014-03-25 |
2023-08-12 |
human |
| N Akanuma, I Hoshino, Y Akutsu, K Murakami, Y Isozaki, T Maruyama, G Yusup, W Qin, T Toyozumi, M Takahashi, H Suito, X Hu, N Sekino, H Matsubar. MicroRNA-133a regulates the mRNAs of two invadopodia-related proteins, FSCN1 and MMP14, in esophageal cancer. British journal of cancer. vol 110. issue 1. 2014-03-10. PMID:24196787. |
fscn1 and matrix metalloproteinase 14 (mmp14) are both invadopodia-related proteins. |
2014-03-10 |
2023-08-12 |
Not clear |
| Ikue Nakayama, Masahiko Shibazaki, Akiko Yashima-Abo, Fumiharu Miura, Toru Sugiyama, Tomoyuki Masuda, Chihaya Maesaw. Loss of HOXD10 expression induced by upregulation of miR-10b accelerates the migration and invasion activities of ovarian cancer cells. International journal of oncology. vol 43. issue 1. 2014-01-07. PMID:23670532. |
using epithelial ovarian cancer cell lines and primary tumors, we investigated whether mir‑10b and/or hotair can regulate the expression of hoxd10, and whether it permits gain of pro‑metastatic gene products, matrix metallopeptidase 14 (mmp14) and ras homolog family member c (rhoc). |
2014-01-07 |
2023-08-12 |
human |
| Jun-Wen Shi, Wei Liu, Ting-Ting Zhang, Sheng-Chun Wang, Xiao-Lin Lin, Jing Li, Jun-Shuang Jia, Hong-Fen Sheng, Zhi-Fang Yao, Wen-Tao Zhao, Zun-Lan Zhao, Rao-Ying Xie, Sheng Yang, Fei Gao, Quan-Rong Fan, Meng-Ya Zhang, Min Yue, Jin Yuan, Wei-Wang Gu, Kai-Tai Yao, Dong Xia. The enforced expression of c-Myc in pig fibroblasts triggers mesenchymal-epithelial transition (MET) via F-actin reorganization and RhoA/Rock pathway inactivation. Cell cycle (Georgetown, Tex.). vol 12. issue 7. 2013-10-21. PMID:23466707. |
qrt-pcr, immunofluorescence and western blot analysis illustrated that epithelial-like morphological changes were accompanied by the increased expression of epithelial markers [such as cell adhesion proteins (e-cadherin, α-catenin and bves), tight junction protein occludin and cytokeratins (krt8 and krt18)], the reduced expression of mesenchymal markers [vimentin, fibronectin 1 (fn1), snail1, collagen family of proteins (col1a1, col5a2) and matrix metalloproteinase (mmp) family (mmp12 and mmp14)] and the decreased cell motility and increased cell adhesion in c-myc-expressing pefs and pdfs. |
2013-10-21 |
2023-08-12 |
Not clear |
| Solange M Abdulnour-Nakhoul, Youhanna Al-Tawil, Alex A Gyftopoulos, Karen L Brown, Molly Hansen, Kathy F Butcher, Alexandra P Eidelwein, Robert A Noel, Edd Rabon, Allison Posta, Nazih L Nakhou. Alterations in junctional proteins, inflammatory mediators and extracellular matrix molecules in eosinophilic esophagitis. Clinical immunology (Orlando, Fla.). vol 148. issue 2. 2013-09-17. PMID:23792687. |
an extracellular matrix (ecm) gene array revealed upregulation of cd44 & cd54, and of ecm proteases (adamts1 & mmp14). |
2013-09-17 |
2023-08-12 |
Not clear |
| Ilya V Demidyuk, Andrey V Shubin, Eugene V Gasanov, Alexander M Kurinov, Vladimir V Demkin, Tatyana V Vinogradova, Marina V Zinovyeva, Alexander V Sass, Irina B Zborovskaya, Sergey V Kostro. Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios. PloS one. vol 8. issue 2. 2013-08-05. PMID:23409034. |
quantitative polymerase chain reaction was used for the first time to analyze mrna levels of all pc genes as well as matrix metalloproteinase genes mmp2 and mmp14, which are substrates of pcs, in 30 matched pairs of samples of human lung cancer tumor and adjacent tissues without pathology. |
2013-08-05 |
2023-08-12 |
human |
| Hidetoshi Mori, Alvin T Lo, Jamie L Inman, Jordi Alcaraz, Cyrus M Ghajar, Joni D Mott, Celeste M Nelson, Connie S Chen, Hui Zhang, Jamie L Bascom, Motoharu Seiki, Mina J Bissel. Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1. Development (Cambridge, England). vol 140. issue 2. 2013-02-21. PMID:23250208. |
because the cell membrane-bound matrix metalloproteinase mmp14 is known to play a key role in cancer cell invasion, we hypothesized that it could also be centrally involved in integrating signals for mammary epithelial cells (mecs) to navigate the collagen 1 (cl-1)-rich stroma of the mammary gland. |
2013-02-21 |
2023-08-12 |
mouse |
| Ye-hai Liu, Ping-zhang Tang, Zhi-hua Liu, Zhen-gang Xu, Yong-fa Qi, Ai-dong Li, Fang Ding, Li-yong Zhang, Ai-ping Lu. [Gene expression of matrix metalloproteinase 14 in laryngeal squamous cell carcinoma]. Zhonghua er bi yan hou ke za zhi. vol 39. issue 8. 2013-02-11. PMID:15563089. |
to investigate the role of expression of matrix metallo-proteinase 14 (mmp14) in laryngeal carcinomas and the relationship between mmp14 expression and the laryngeal biological behavior. |
2013-02-11 |
2023-08-12 |
Not clear |
| Linlin Yang, Yuan Chen, Tiantian Cui, Thomas Knösel, Qing Zhang, Kai Frederik Albring, Otmar Huber, Iver Peterse. Desmoplakin acts as a tumor suppressor by inhibition of the Wnt/β-catenin signaling pathway in human lung cancer. Carcinogenesis. vol 33. issue 10. 2013-01-18. PMID:22791817. |
furthermore, overexpression of dsp enhanced expression of plakoglobin (γ-catenin), resulting in decreased t-cell factor/lymphoid enhancer factor (tcf/lef)-dependent transcriptional activity and reduced expression of the wnt/β-catenin target genes axin2 and matrix metalloproteinase mmp14. |
2013-01-18 |
2023-08-12 |
human |
| A V Mali, U V Wagh, M V Hegde, S S Chandorkar, S V Surve, M V Patol. In vitro anti-metastatic activity of enterolactone, a mammalian lignan derived from flax lignan, and down-regulation of matrix metalloproteinases in MCF-7 and MDA MB 231 cell lines. Indian journal of cancer. vol 49. issue 1. 2012-12-31. PMID:22842186. |
actin cytoskeleton is involved in actin-based cell adhesion, cell motility, and matrix metalloproteinases(mmps) mmp2, mmp9, mmp11 and mmp14 are responsible for cell invasion in breast cancer metastasis. |
2012-12-31 |
2023-08-12 |
human |
| Danielle Gray, Nunzianda Frascione, Barbara Danie. Development of an immunoassay for the differentiation of menstrual blood from peripheral blood. Forensic science international. vol 220. issue 1-3. 2012-12-03. PMID:22306189. |
three different targets were evaluated: matrix metalloproteinase 14 (mmp14), oestrogen receptor α (erα), and fibrinogen. |
2012-12-03 |
2023-08-12 |
Not clear |
| B Blairanne Williams, V Ashley Cantrell, Nathan A Mundell, Andrea C Bennett, Rachel E Quick, Jason R Jesse. VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration. Journal of cell science. vol 125. issue Pt 9. 2012-10-23. PMID:22357946. |
during gastrulation, the membrane type-1 matrix metalloproteinase (mt1-mmp or mmp14) is required for pcp and convergence and extension cell movements. |
2012-10-23 |
2023-08-12 |
zebrafish |
| B Blairanne Williams, Nathan Mundell, Julie Dunlap, Jason Jesse. The planar cell polarity protein VANGL2 coordinates remodeling of the extracellular matrix. Communicative & integrative biology. vol 5. issue 4. 2012-10-15. PMID:23060953. |
we recently reported that the pcp protein vang-like 2 (vangl2) regulates the endocytosis and cell surface level of membrane type-1 matrix metalloproteinase (mmp14 or mt1-mmp). |
2012-10-15 |
2023-08-12 |
human |
| Bàrbara Castellana, Daniel Escuin, Gloria Peiró, Bárbara Garcia-Valdecasas, Tania Vázquez, Cristina Pons, Maitane Pérez-Olabarria, Agustí Barnadas, Enrique Lerm. ASPN and GJB2 Are Implicated in the Mechanisms of Invasion of Ductal Breast Carcinomas. Journal of Cancer. vol 3. 2012-10-02. PMID:22514560. |
the genes upregulated in idc samples, and probably associated with invasion, were related to the epithelial-mesenchymal transition (aspn, thbs2, fn1, sparc, and col11a1), cellular adhesion (gjb2), cell motility and progression (plaur, plau, bgn, adamts16, and enpp2), extracellular matrix degradation (mmp11, mmp13, and mmp14), and growth/proliferation (st6gal2). |
2012-10-02 |
2023-08-12 |
mouse |
| Ida K Lund, Morten G Rasch, Signe Ingvarsen, Jesper Pass, Daniel H Madsen, Lars H Engelholm, Niels Behrendt, Gunilla Høyer-Hanse. Inhibitory Monoclonal Antibodies against Mouse Proteases Raised in Gene-Deficient Mice Block Proteolytic Functions in vivo. Frontiers in pharmacology. vol 3. 2012-10-02. PMID:22754528. |
mabs against proteins involved in extracellular proteolysis, including plasminogen activators urokinase plasminogen activator (upa), tissue-type plasminogen activator (tpa), their inhibitor pai-1, the upa receptor (upar), two matrix metalloproteinases (mmp9 and mmp14), as well as the collagen internalization receptor uparap, have been developed. |
2012-10-02 |
2023-08-12 |
mouse |
| Qing-hui Zhou, Xiu-feng Huang, Jin-hua Wang, Chao-wen Lin, Yuan-yuan Yang, Chang-sheng Huang, Lian-tao Wu, Yu-mei W. [Association of MMP14 gene polymorphisms and osteoporosis in Zhuang men from Baise region of Guangxi]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 29. issue 3. 2012-09-11. PMID:22678797. |
to assess the association between membrane type 1 matrix metalloproteinase gene (mt1-mmp, mmp14) polymorphisms and osteoporosis in zhuang men from baise region of guangxi. |
2012-09-11 |
2023-08-12 |
Not clear |