| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Blairanne Williams, V Ashley Cantrell, Nathan A Mundell, Andrea C Bennett, Rachel E Quick, Jason R Jesse. VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration. Journal of cell science. vol 125. issue Pt 9. 2012-10-23. PMID:22357946. |
during gastrulation, the membrane type-1 matrix metalloproteinase (mt1-mmp or mmp14) is required for pcp and convergence and extension cell movements. |
2012-10-23 |
2023-08-12 |
zebrafish |
| B Blairanne Williams, Nathan Mundell, Julie Dunlap, Jason Jesse. The planar cell polarity protein VANGL2 coordinates remodeling of the extracellular matrix. Communicative & integrative biology. vol 5. issue 4. 2012-10-15. PMID:23060953. |
we recently reported that the pcp protein vang-like 2 (vangl2) regulates the endocytosis and cell surface level of membrane type-1 matrix metalloproteinase (mmp14 or mt1-mmp). |
2012-10-15 |
2023-08-12 |
human |
| Bàrbara Castellana, Daniel Escuin, Gloria Peiró, Bárbara Garcia-Valdecasas, Tania Vázquez, Cristina Pons, Maitane Pérez-Olabarria, Agustí Barnadas, Enrique Lerm. ASPN and GJB2 Are Implicated in the Mechanisms of Invasion of Ductal Breast Carcinomas. Journal of Cancer. vol 3. 2012-10-02. PMID:22514560. |
the genes upregulated in idc samples, and probably associated with invasion, were related to the epithelial-mesenchymal transition (aspn, thbs2, fn1, sparc, and col11a1), cellular adhesion (gjb2), cell motility and progression (plaur, plau, bgn, adamts16, and enpp2), extracellular matrix degradation (mmp11, mmp13, and mmp14), and growth/proliferation (st6gal2). |
2012-10-02 |
2023-08-12 |
mouse |
| Ida K Lund, Morten G Rasch, Signe Ingvarsen, Jesper Pass, Daniel H Madsen, Lars H Engelholm, Niels Behrendt, Gunilla Høyer-Hanse. Inhibitory Monoclonal Antibodies against Mouse Proteases Raised in Gene-Deficient Mice Block Proteolytic Functions in vivo. Frontiers in pharmacology. vol 3. 2012-10-02. PMID:22754528. |
mabs against proteins involved in extracellular proteolysis, including plasminogen activators urokinase plasminogen activator (upa), tissue-type plasminogen activator (tpa), their inhibitor pai-1, the upa receptor (upar), two matrix metalloproteinases (mmp9 and mmp14), as well as the collagen internalization receptor uparap, have been developed. |
2012-10-02 |
2023-08-12 |
mouse |
| Qing-hui Zhou, Xiu-feng Huang, Jin-hua Wang, Chao-wen Lin, Yuan-yuan Yang, Chang-sheng Huang, Lian-tao Wu, Yu-mei W. [Association of MMP14 gene polymorphisms and osteoporosis in Zhuang men from Baise region of Guangxi]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 29. issue 3. 2012-09-11. PMID:22678797. |
to assess the association between membrane type 1 matrix metalloproteinase gene (mt1-mmp, mmp14) polymorphisms and osteoporosis in zhuang men from baise region of guangxi. |
2012-09-11 |
2023-08-12 |
Not clear |
| G Daniel Grass, Momka Bratoeva, Bryan P Tool. Regulation of invadopodia formation and activity by CD147. Journal of cell science. vol 125. issue Pt 3. 2012-09-06. PMID:22389410. |
invadopodia are actin-based, lipid-raft-enriched membrane protrusions containing membrane-type-1 matrix metalloproteinase (mt1-mmp; also known as matrix metalloproteinase 14; mmp14) and several signaling proteins. |
2012-09-06 |
2023-08-12 |
Not clear |
| Kui Ming Chan, Hoi Leong Xavier Wong, Guoxiang Jin, Baohua Liu, Renhai Cao, Yihai Cao, Kaisa Lehti, Karl Tryggvason, Zhongjun Zho. MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis. Developmental cell. vol 22. issue 6. 2012-08-31. PMID:22632802. |
mmp14 encodes a membrane-tethered metalloproteinase mt1-mmp, capable of remodeling the extracellular matrix and modulating receptors on the cell surface. |
2012-08-31 |
2023-08-12 |
Not clear |
| Gabriele Loers, Tatjana Makhina, Ute Bork, Andrea Dörner, Melitta Schachner, Ralf Kleen. The interaction between cell adhesion molecule L1, matrix metalloproteinase 14, and adenine nucleotide translocator at the plasma membrane regulates L1-mediated neurite outgrowth of murine cerebellar neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 11. 2012-05-01. PMID:22423112. |
we also show that l1 interacts with the ant binding partner matrix metalloprotease 14 (mmp14) and that the ant proteins bind directly to the l1 interaction partner glyceraldehyde-3-phosphate dehydrogenase (gapdh). |
2012-05-01 |
2023-08-12 |
mouse |
| Feng Shi, Jane Sottil. MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin. Journal of cell science. vol 124. issue Pt 23. 2012-04-19. PMID:22159414. |
our data show that membrane type matrix metalloproteinase 1 (mt1-mmp; also known as mmp14) is a crucial regulator of fibronectin turnover. |
2012-04-19 |
2023-08-12 |
Not clear |
| Danielle A Murphy, Sara A Courtneidg. The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. Nature reviews. Molecular cell biology. vol 12. issue 7. 2011-09-28. PMID:21697900. |
the key proteins in these structures include the actin regulators cortactin and neural wiskott-aldrich syndrome protein (n-wasp), the adaptor proteins tyr kinase substrate with four sh3 domains (tks4) and tyr kinase substrate with five sh3 domains (tks5), and the metalloprotease membrane type 1 matrix metalloprotease (mt1mmp; also known as mmp14). |
2011-09-28 |
2023-08-12 |
human |
| S D Galiacy, P Fournié, D Massoudi, E Ancèle, J-C Quintyn, A Erraud, I Raymond-Letron, F Rolling, F Malecaz. Matrix metalloproteinase 14 overexpression reduces corneal scarring. Gene therapy. vol 18. issue 5. 2011-08-22. PMID:21160532. |
we overexpressed a fibril collagenase (matrix metalloproteinase 14 (mmp14)) to prevent collagen deposition in the scar tissue. |
2011-08-22 |
2023-08-12 |
mouse |
| Guoxiang Jin, Fengju Zhang, Kui Ming Chan, Hoi Leong Xavier Wong, Baohua Liu, Kathryn S E Cheah, Xinguang Liu, Cornelia Mauch, Depei Liu, Zhongjun Zho. MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development. The EMBO journal. vol 30. issue 11. 2011-08-02. PMID:21572390. |
here, we show that loss of membrane-type 1 matrix metalloproteinase (mt1-mmp, mmp14), a cell surface protease expressed in bone marrow stromal cells (bmscs), increases notch signalling in hpcs and specifically impairs b-lymphocyte development. |
2011-08-02 |
2023-08-12 |
Not clear |
| Ken-ichi Hanada, Qiong J Wang, Takashi Inozume, James C Yan. Molecular identification of an MHC-independent ligand recognized by a human {alpha}/{beta} T-cell receptor. Blood. vol 117. issue 18. 2011-07-05. PMID:21300979. |
first, matrix metalloproteinase 14 (mmp14) expressed on rcc cells releases membrane-bound trail expressed by the t cell; then, soluble trail binds to its receptor dr4 (trail-r1), which is expressed on tumor cells, and this trail-dr4 complex is recognized by the tcr through a complementarity-determining region 3α (cdr3α)-mediated interaction. |
2011-07-05 |
2023-08-12 |
human |
| Alampady K Shanbhogue, Srinivasa R Prasad, Naoki Takahashi, Raghunandan Vikram, Dushyant V Sahan. Recent advances in cytogenetics and molecular biology of adult hepatocellular tumors: implications for imaging and management. Radiology. vol 258. issue 3. 2011-06-02. PMID:21339346. |
while the β catenin signaling pathway is associated with well- and moderately differentiated hccs, mutations involving p53 (tumor protein 53 gene), mmp14 (matrix metalloproteinase 14 gene), and rhoc (ras homolog gene family, member c) are associated with larger tumor size, higher tumor grade with resultant shortened tumor-free survival, and poor prognosis. |
2011-06-02 |
2023-08-12 |
Not clear |
| Chiara Cazzin, Silvia Mion, Fabrizio Caldara, Joseph M Rimland, Enrico Domenic. Microarray analysis of cultured rat hippocampal neurons treated with brain derived neurotrophic factor. Molecular biology reports. vol 38. issue 2. 2011-05-26. PMID:20535563. |
in addition, the expression of genes apolipoprotein e (apoe), delta-6 fatty acid desaturase (fads2) and matrix metalloproteinase 14 (mmp14), which play a role in neuronal remodelling, was also enhanced. |
2011-05-26 |
2023-08-12 |
rat |
| Yang Liu, Eleanor B Carson-Walter, Anna Cooper, Bethany N Winans, Mahlon D Johnson, Kevin A Walte. Vascular gene expression patterns are conserved in primary and metastatic brain tumors. Journal of neuro-oncology. vol 99. issue 1. 2010-10-11. PMID:20063114. |
most of these genes localize to the cell surface (cxcr7, pv1) or extracellular matrix (col1a1, col3a1, col4a1, col6a2, mmp14, pxdn) and were selectively expressed by the microvasculature. |
2010-10-11 |
2023-08-12 |
Not clear |
| Surabhi Dangi-Garimella, Amanda J Redig, Mario A Shields, Mohammed A Siddiqui, Hidayatullah G Munsh. Rho-ROCK-myosin signaling mediates membrane type 1 matrix metalloproteinase-induced cellular aggregation of keratinocytes. The Journal of biological chemistry. vol 285. issue 36. 2010-10-05. PMID:20605790. |
membrane type 1-matrix metalloproteinase (mt1-mmp, mmp14), which is associated with extracellular matrix (ecm) breakdown in squamous cell carcinoma (scc), promotes tumor formation and epithelial-mesenchymal transition. |
2010-10-05 |
2023-08-12 |
mouse |
| Nor E Sounni, Kerstin Dehne, Leon van Kempen, Mikala Egeblad, Nesrine I Affara, Ileana Cuevas, Jane Wiesen, Simon Junankar, Lidiya Korets, Jake Lee, Jennifer Shen, Charlotte J Morrison, Christopher M Overall, Stephen M Krane, Zena Werb, Nancy Boudreau, Lisa M Coussen. Stromal regulation of vessel stability by MMP14 and TGFbeta. Disease models & mechanisms. vol 3. issue 5-6. 2010-09-02. PMID:20223936. |
we identified a novel pathway regulating vessel stability in tissues that involves matrix metalloproteinase 14 (mmp14) and transforming growth factor beta 1 (tgfbeta(1)). |
2010-09-02 |
2023-08-12 |
mouse |
| Gang Liu, Catherine L Atteridge, Xuanjun Wang, Ashley D Lundgren, Jennifer D W. The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases. Journal of immunology (Baltimore, Md. : 1950). vol 184. issue 7. 2010-04-27. PMID:20208009. |
the membrane type matrix metalloproteinase mmp14 mediates constitutive shedding of mhc class i chain-related molecule a independent of a disintegrin and metalloproteinases. |
2010-04-27 |
2023-08-12 |
Not clear |
| Kristen A Wieghaus, Erwin P Gianchandani, Rebekah A Neal, Mikell A Paige, Milton L Brown, Jason A Papin, Edward A Botchwe. Phthalimide neovascular factor 1 (PNF1) modulates MT1-MMP activity in human microvascular endothelial cells. Biotechnology and bioengineering. vol 103. issue 4. 2009-07-27. PMID:19326468. |
subsequently, we probe this data set and identify three specific tgf-beta-induced genes with regulation by pnf1 conserved over multiple timepoints-amyloid beta (a4) precursor protein (app), early growth response 1 (egr-1), and matrix metalloproteinase 14 (mmp14 or mt1-mmp)-that are also implicated in angiogenesis. |
2009-07-27 |
2023-08-12 |
human |